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2014

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Synthesis And Biological Study Of Adenylyl Cyclase Inhibitors, Siyuan Sun, Zhishi Ye, Mingji Dai Aug 2014

Synthesis And Biological Study Of Adenylyl Cyclase Inhibitors, Siyuan Sun, Zhishi Ye, Mingji Dai

The Summer Undergraduate Research Fellowship (SURF) Symposium

Adenylyl cyclases (AC) is a critical family of enzymes which modulates the dynamic cellular level of cAMP, cyclic adenosine monophosphate. The study of cAMP showed that it is indispensable for the signal transduction cascades during many physiological processes, such as immune responses and metabolism which highly relate to cancers. Previous studies of AC inhibitors have been limited due to a lack of isoform-selective small molecule modulators. Selectivity of the molecules is imperative to the activation of only the desired AC inhibitor. The design of the described project was to test the structure activity relationship (SAR) by synthesizing a class of …

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The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu Aug 2014

The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu

The Summer Undergraduate Research Fellowship (SURF) Symposium


Amperometric lactate biosensors are used to detect lactate concentration in blood and tissues, which is integral in identifying cyanide poisoning, septic shock, and athletic condition. The construction of lactate biosensors with high sensitivity, selectivity, and stability is imperative to diagnose and determine these medical conditions. Lactate detection is currently limited to oxygen-rich environments due to the fact that oxygen is a limiting factor in the lactate reaction. To circumvent this problem, researchers have developed mediators or alternate, oxygen-free enzymes to improve sensitivity. In our study, ceria (CeO2) with high oxygen storage capacity (OSC) was introduced to the enzyme …

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Appropriate Development Of The Liver Treg Compartment Is Modulated By The Microbiota And Requires Tgf-Β And Myd88, Ann Maria, Kathryn A. English, James D. Gorham Aug 2014

Appropriate Development Of The Liver Treg Compartment Is Modulated By The Microbiota And Requires Tgf-Β And Myd88, Ann Maria, Kathryn A. English, James D. Gorham

Dartmouth Scholarship

Neither the early postnatal development of the liver Treg compartment nor the factors that regulate its development has been characterized. We compared the early developmental patterns of Treg cell accumulation in murine liver, thymus, and spleen. A FoxP3EGFP reporter mouse was employed to identify Treg cells. Mononuclear cells were isolated from organs postnatally, stained for CD4, and examined by flow cytometry to enumerate FoxP3+CD4hi cells. To assess roles for TGF-��1, MyD88, and TLR2, gene specific knockout pups were generated from heterozygous breeders. To test the role of commensal bacteria, pregnant dams were administered antibiotics during gestation and after parturition.The pattern …

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The Parthenon, August 7, 2014, Taylor Stuck Aug 2014

The Parthenon, August 7, 2014, Taylor Stuck

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

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Pengaruh Berbagai Komposisi Kompos Dalam Tiga Jenis Media Pembibitan Terhadap Pertumbuhan Bibit Asparagus Dalam Polibeg, F. Kholifah, Tino Mutiarawati Onggo, Wawan Sutari Aug 2014

Pengaruh Berbagai Komposisi Kompos Dalam Tiga Jenis Media Pembibitan Terhadap Pertumbuhan Bibit Asparagus Dalam Polibeg, F. Kholifah, Tino Mutiarawati Onggo, Wawan Sutari

Jurnal Kultivasi

Asparagus seeding need suitable medium composition in order that seedlings can grow well and proper to be planted.The experiment aims to study the effect of different seedlings medium and various compost compositions within the medium on growth of asparagus seedlings planted in polybag.The experiment was conducted in research station of Agriculture Faculty, Universitas Padjadjaran, Jatinangor, Sumedang, located at 730 m above the sea level, conducted from May 2013 up to August 2013. A factorial randomized blocks design was used with four replications. The First factor was different seedlings medium, which consisted of three levels: rice husk, rice husk charcoal and …

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Pengaruh Naungan Net Dan Interval Panen Terhadap Pertumbuhan Tanaman, Hasil, Dan Kualitas Hasil Buncis Cv. Kenya Di Jatinangor, Saphira Dechairani, Tino Mutiarawati Onggo, Wawan Sutari Aug 2014

Pengaruh Naungan Net Dan Interval Panen Terhadap Pertumbuhan Tanaman, Hasil, Dan Kualitas Hasil Buncis Cv. Kenya Di Jatinangor, Saphira Dechairani, Tino Mutiarawati Onggo, Wawan Sutari

Jurnal Kultivasi

Di daerah tropis seperti di Indonesia, intensitas cahaya dan temperatur udara yang tinggi menjadi masalah dalam penanaman buncis hasil introduksi dari daerah subtropis, umumnya tanaman buncis yang dimanfaatkan polong mudanya ditanam di dataran tinggi. Masalah dalam penanaman buncis dataran tinggi di dataran medium yang memiliki temperatur udara lebih tinggi dapat diatasi antara lain dengan penggunaan naungan net dan pengaturan interval panen. Percobaan ini bertujuan untuk mempelajari pengaruh naungan net dan interval panen yang dapat memberikan pertumbuhan, hasil dan kualitas hasil yang baik pada tanaman buncis Kenya. Percobaan ini dilaksanakan di Lahan Percobaan Laboratorium Kultur Terkendali Fakultas Pertanian Universitas Padjadjaran, Jatinangor …

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Eksplorasi Tanaman Jengkol Di Home Garden Kabupaten Ciamis, Jawa Barat, Yudithia Maxiselly, Debby Ustari Aug 2014

Eksplorasi Tanaman Jengkol Di Home Garden Kabupaten Ciamis, Jawa Barat, Yudithia Maxiselly, Debby Ustari

Jurnal Kultivasi

Jengkol plant is one commodity that has some health benefits other than as a food source such as a drug of hypoglycemia in diabetes mellitus. Therefore it is necessary for the exploration activities as the basis for future development. Exploration activities are the basis for determining the location of the natural resources potential. Exploration is also an activity that is able to enrich genetic resources to be developed in the future. The one of jengkol producing areas in West Java is Ciamis district. However there has been no large-scale plantations jengkol, jengkol newly developed individually in the form of a …

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The Culture Of Leaks Has To Change, But At What Expense To Congressional Oversight Of The Executive Branch? An Examination Of Title V. Of The Intelligence Authorization Act For Fiscal Year 2013, Roseanne Sessa Aug 2014

The Culture Of Leaks Has To Change, But At What Expense To Congressional Oversight Of The Executive Branch? An Examination Of Title V. Of The Intelligence Authorization Act For Fiscal Year 2013, Roseanne Sessa

Seton Hall Journal of Sports and Entertainment Law

No abstract provided.

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Phoenix And The New Satellite Paradigm Created By Hisat, Talbot Jaeger, Walter Mirczak Aug 2014

Phoenix And The New Satellite Paradigm Created By Hisat, Talbot Jaeger, Walter Mirczak

Small Satellite Conference

A satlet is a satellite architecture component into which the functional capabilities of a conventional spacecraft are decomposed and can then be aggregated back together to provide desired subsystem capabilities. NovaWurks has successfully developed satlet prototypes for the DARPA Phoenix program. These smaller disaggregated subsystem building blocks are called HISats, or Hyper-Integrated Satlets. By reassembling a sufficient amount of HISats and payloads, a spacecraft with the required capabilities can be formed by aggregation of their resources. HISats are distributed across a platform and interact through a variety of links. Removing some of the physical location dependencies between the resources of …

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Biosentinel: Monitoring Dna Damage Repair Beyond Low Earth Orbit On A 6u Nanosatellite, Brian Lewis, Robert Hanel, Sharmila Bhattacharya, Antonio Ricco, Elwood Agasid, Debra Reiss-Bubenheim, Tore Straume, Macarena Parra, Travis Boone, Sergio Santa Maria, Ming Tan, Robert Bowman, Matthew Sorgenfrei, Matthew Nehrenz, Marina Gandlin, Terry Lusby, Vanessa Kuroda, Craig Pires, Abraham Rademacher, Joshua Benton, Shang Wu, Benjamin Klamm, Charles Friedericks, Colleen Hake, Bobbie Gail Swan, Edward Semones, Scott Wheeler, C. Mark Ott, Susan Gavalas, Sarah Castro Aug 2014

Biosentinel: Monitoring Dna Damage Repair Beyond Low Earth Orbit On A 6u Nanosatellite, Brian Lewis, Robert Hanel, Sharmila Bhattacharya, Antonio Ricco, Elwood Agasid, Debra Reiss-Bubenheim, Tore Straume, Macarena Parra, Travis Boone, Sergio Santa Maria, Ming Tan, Robert Bowman, Matthew Sorgenfrei, Matthew Nehrenz, Marina Gandlin, Terry Lusby, Vanessa Kuroda, Craig Pires, Abraham Rademacher, Joshua Benton, Shang Wu, Benjamin Klamm, Charles Friedericks, Colleen Hake, Bobbie Gail Swan, Edward Semones, Scott Wheeler, C. Mark Ott, Susan Gavalas, Sarah Castro

Small Satellite Conference

We are designing and developing a “6U” nanosatellite as a secondary payload to fly aboard NASA’s Space Launch System (SLS) Exploration Mission (EM) 1, scheduled for launch in late 2017. For the first time in over forty years, direct experimental data from biological studies beyond low Earth orbit (LEO) will be obtained during BioSentinel’s 12 to 18-month mission. BioSentinel will measure the damage and repair of DNA in a biological organism and compare that to information from onboard physical radiation sensors. This data will be available for validation of existing models and for extrapolation to humans. The BioSentinel experiment will …

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Development Of “Turn-On” Fluorescent Nuclobase Mimics As Kiinase Inhibitors, Jyothi Dhuguru Aug 2014

Development Of “Turn-On” Fluorescent Nuclobase Mimics As Kiinase Inhibitors, Jyothi Dhuguru

Open Access Dissertations

Fluorescent probes are indispensable tools for biologists owing to the safe and non-invasive method of detection they offer with minimum perturbation of the cell under investigation. Despite all the advantages they offer, there are certain limitations for the use of fluorescent probes for live cell imaging such as phototoxicity to the cell, photobleaching or photoinstability, etc. Additionally, they require labeling with specific recognition units such as biomolecules like DNA, RNA or an antibody to render them specific to the target cell. In this context, “turn-on” fluorescent probes are advantageous, as they remain silent or inactive and become emissive only under …

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Intelligent And Adaptive Façade System: The Impact Of Intelligent And Adaptive Façade On The Performance And Energy Efficiency Of Buildings, Mohanned Al Thobaiti Aug 2014

Intelligent And Adaptive Façade System: The Impact Of Intelligent And Adaptive Façade On The Performance And Energy Efficiency Of Buildings, Mohanned Al Thobaiti

Open Access Theses

The integration of nature and technology always represents a rich combination of developed and innovative elements to serve the environment. Building performance depends not only on the operation of individual elements in the building but also on how they behave as integrated systems to satisfy the user demands. In architecture, usually projects are consist of different stages of design process, and several factors need to be considered among this cycle, such as climate, building shape, comfort levels, materials and systems, occupant health and security. Therefore, advanced technologies became a significant discourse that caught the interest of many professional fields. The …

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2014 August 6 -- Agenda And Attachments Aug 2014

2014 August 6 -- Agenda And Attachments

Agendas and Minutes

No abstract provided.

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2014 Augst 6 -- Minutes Aug 2014

2014 Augst 6 -- Minutes

Agendas and Minutes

No abstract provided.

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What Enables Size-Selective Trophy Hunting Of Wildlife?, Chris T. Darimont, K. Rosie Child Aug 2014

What Enables Size-Selective Trophy Hunting Of Wildlife?, Chris T. Darimont, K. Rosie Child

Big-Game and Trophy Hunting Collection

Although rarely considered predators, wildlife hunters can function as important ecological and evolutionary agents. In part, their influence relates to targeting of large reproductive adults within prey populations. Despite known impacts of sizeselective harvests, however, we know little about what enables hunters to kill these older, rarer, and presumably more wary individuals. In other mammalian predators, predatory performance varies with knowledge and physical condition, which accumulates and declines, respectively, with age. Moreover, some species evolved camouflage as a physical trait to aid in predatory performance. In this work, we tested whether knowledge-based faculty (use of a hunting guide with accumulated …

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Volume 51, Number 51: August 06, 2014, University Of North Dakota Aug 2014

Volume 51, Number 51: August 06, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

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Rural Wind Windfalls, K.K. Duvivier Aug 2014

Rural Wind Windfalls, K.K. Duvivier

Sturm College of Law: Faculty Scholarship

Wind power can provide rural communities with unexpected gains or “windfalls.” As one North Dakota farmer put it, “Who could have guessed that the air above our land might be worth money someday?” According to the National Renewable Energy Laboratory (NREL), the amount of installed wind electricity capacity in the United States increased by a factor of 25 between 2000 and 2012. The United States is second, behind only China, for the most wind electricity capacity in the world. In 2012, Kansas more than doubled its installed wind capacity by adding 1,441 MW to the 1,272 MW installed before that …

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‘Ready For The Science’—Destiny Awaits, Ohio University College Of Arts & Sciences Aug 2014

‘Ready For The Science’—Destiny Awaits, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

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Debarati Basu Named Donald Clippinger Graduate Fellow, Ohio University College Of Arts & Sciences Aug 2014

Debarati Basu Named Donald Clippinger Graduate Fellow, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

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Undergrads Present ‘Microhabitat Use Of The Big Levels Salamander’, Ohio University College Of Arts & Sciences Aug 2014

Undergrads Present ‘Microhabitat Use Of The Big Levels Salamander’, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

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International Internship Granted To Recent Uab Graduate, Staff Aug 2014

International Internship Granted To Recent Uab Graduate, Staff

Browse All News

No abstract provided.

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Blau Syndrome, The Prototypic Auto-Inflammatory Granulomatous Disease., Carine H Wouters, Anne Maes, Kevin P Foley, John Bertin, Carlos D Rose Aug 2014

Blau Syndrome, The Prototypic Auto-Inflammatory Granulomatous Disease., Carine H Wouters, Anne Maes, Kevin P Foley, John Bertin, Carlos D Rose

Department of Medicine Faculty Papers

Blau syndrome is a monogenic disease resulting from mutations in the pattern recognition receptor NOD2, and is phenotypically characterized by the triad of granulomatous polyarthritis, dermatitis and uveitis. This paper reviews briefly the classical clinical features of the disease, as well as more recently described extra-triad symptoms. From an ongoing prospective multicenter study, we provide new data on the natural history of Blau syndrome, focusing on functional status and visual outcome. We also present an update of the range of different NOD2 mutations found in Blau syndrome as well as recent data on morphologic and immunohistochemical characteristics of the Blau …

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The Geomagnetic Environment In Which Sea Turtle Eggs Incubate Affects Subsequent Magnetic Navigation Behaviour Of Hatchlings, Matthew J. Fuxjager, Kyla R. Davidoff, Lisa A. Mangiamele, Kenneth J. Lohmann Aug 2014

The Geomagnetic Environment In Which Sea Turtle Eggs Incubate Affects Subsequent Magnetic Navigation Behaviour Of Hatchlings, Matthew J. Fuxjager, Kyla R. Davidoff, Lisa A. Mangiamele, Kenneth J. Lohmann

Biological Sciences: Faculty Publications

Loggerhead sea turtle hatchlings (Caretta caretta) use regional magnetic fields as open-ocean navigational markers during trans-oceanic migrations. Little is known, however, about the ontogeny of this behaviour. As a first step towards investigating whether the magnetic environment in which hatchlings develop affects subsequent magnetic orientation behaviour, eggs deposited by nesting female loggerheads were permitted to develop in situ either in the natural ambient magnetic field or in a magnetic field distorted by magnets placed around the nest. In orientation experiments, hatchlings that developed in the normal ambient field oriented approximately south when exposed to a field that exists near the …

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Identification Of Functional Parameters For The Classification Of Older Female Fallers And Prediction Of ‘First-Time’ Fallers, Niklas König Ignasiak Aug 2014

Identification Of Functional Parameters For The Classification Of Older Female Fallers And Prediction Of ‘First-Time’ Fallers, Niklas König Ignasiak

Physical Therapy Faculty Articles and Research

Falls remain a challenge for ageing societies. Strong evidence indicates that a previous fall is the strongest single screening indicator for a subsequent fall and the need for assessing fall risk without accounting for fall history is therefore imperative. Testing in three functional domains (using a total 92 measures) were completed in 84 older women (60–85 years of age), including muscular control, standing balance, and mean and variability of gait. Participants were retrospectively classified as fallers (n = 38) or non-fallers (n = 42) and additionally in a prospective manner to identify first-time fallers (FTFs) (n = 6) within a …

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Imaging Luciferase-Expressing Viruses, Michael A. Barry, Shannon May, Eric A. Weaver Aug 2014

Imaging Luciferase-Expressing Viruses, Michael A. Barry, Shannon May, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

Optical imaging of luciferage gene expression has become a powerful tool to track cells and viruses in vivo in small animal models. Luciferase imaging has been used to study the location of infection by replication-defective and replication-competent viruses and to track changes in the distribution of viruses in mouse models. This approach has also been used in oncolytic studies as a non-invasive means to monitor the growth and killing of tumor cells modified with luciferase genes. In this chapter, we describe the techniques used for luciferase imaging as have been applied to track replication-defective and replication-competent adenoviruses in mouse and …

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Common Genetic Variants In The Hnf1b Gene Contribute To Diabetes And Multiple Cancers, Ke-Sheng Wang, Daniel Owusu, Yue Pan, Chun Xu Aug 2014

Common Genetic Variants In The Hnf1b Gene Contribute To Diabetes And Multiple Cancers, Ke-Sheng Wang, Daniel Owusu, Yue Pan, Chun Xu

Health & Biomedical Sciences Faculty Publications

Diabetes and cancers are major public health problems in the United States and in the world. Epidemiological studies have clearly demonstrated the associations and co morbidity between Type 2 Diabetes (T2D) and multiple cancers such as endometrial and prostate cancers. However, the mechanism of such associations has not been elucidated. Genetic variation is proposed to contribute to these diseases, and common genetic variants may explain part of the associations among these diseases. Single Nucleotide Polymorphisms (SNPs) rs4430796 and rs7501939 within the HNF1B/TCF2 gene (Gene ID: 6928) have been observed to be associated with T2D and endometrial and prostate cancers in …

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Investigation Of Sparse-Build Rapid Tooling By Fused Deposition Modeling, Osman Iyibilgin, Ming-Chuan Leu, Gregory Taylor, H. Li, K. Chandrashekhara Aug 2014

Investigation Of Sparse-Build Rapid Tooling By Fused Deposition Modeling, Osman Iyibilgin, Ming-Chuan Leu, Gregory Taylor, H. Li, K. Chandrashekhara

Mechanical and Aerospace Engineering Faculty Research & Creative Works

This paper describes the investigation of sparse-build tooling by Fused Deposition Modeling (FDM®) aimed at rapid tooling with reduction in the amount of material. Sparse-build test coupons having ULTEM as the material and varying air gap (sparse spacing), wall thickness, and cap thickness were fabricated using the sparse and sparse-double dense build styles of the Stratasys Fortus machine. The strengths and moduli of these coupons were measured in compression and flexure tests. The strength/mass ratio and modulus/mass ratio were compared among the various coupons, as well as with solid coupons, to investigate the effects of the two build styles and …

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A Further Look At Potential Impact Of Satlets On Design, Production, And Cost Of Satellite Systems, David Barnhart, Lisa Hill, Erin Fowler, Roger Hunter, Lucy Hoag, Brook Sullivan, Peter Will Aug 2014

A Further Look At Potential Impact Of Satlets On Design, Production, And Cost Of Satellite Systems, David Barnhart, Lisa Hill, Erin Fowler, Roger Hunter, Lucy Hoag, Brook Sullivan, Peter Will

Small Satellite Conference

For the past 50 years, the morphology for satellites has remained fundamentally unchanged despite evolutions in manufacturing, communications, and software occurring in other industries. Primary spacecraft support systems—power, attitude control, and others—are designed in the same way, whether in space telescopes, large communications satellites, interplanetary spacecraft, or Cubesats. This paradigm has been the status quo in spacecraft design and construction and has precluded any industry-wide, large-scale cost savings while maintaining performance. To change this trend and ensure performance and utility at low cost, that can scale, DARPA postulated the concept of a cellularized satellite, or “satlet,” as a satellite architectural …

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Students' Use Of Good Quality Learning Strategies: A Multi-Level Model Of Change Over Five Years Of Secondary School, Helen Askell-Williams, Michael J. Lawson Aug 2014

Students' Use Of Good Quality Learning Strategies: A Multi-Level Model Of Change Over Five Years Of Secondary School, Helen Askell-Williams, Michael J. Lawson

2009 - 2019 ACER Research Conferences

Concurrent Session Block 3

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A Case Study In Watershed-Based Plan Development And Implementation For The May River Watershed In Bluffton, South Carolina, Kimberly W. Jones, Ronald Bullman Aug 2014

A Case Study In Watershed-Based Plan Development And Implementation For The May River Watershed In Bluffton, South Carolina, Kimberly W. Jones, Ronald Bullman

Journal of South Carolina Water Resources

The Town of Bluffton, South Carolina was a one square mile coastal village until it experienced exponential growth in the early 2000s, and today is approximately 54 square miles. Until this recent growth, few sources of possible impairments to water quality were recognized within the watershed, and even fewer within close proximity to the river itself. In 2007, the Town was told by the S.C. Department of Health and Environmental Control (SCDHEC) that fecal coliform levels in the May River headwaters were increasing and in 2009 the river received a shellfish harvesting classification down-grade. In response to this down-grade, the …

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