Digital Commons Network^™

Tall Fescue Seed Extraction And Partial Purification Of Ergot Alkaloids, Huihua Ji, Franklin Fannin, J. Klotz, Lowell P. Bush

Kentucky Tobacco Research and Development Center Faculty Publications

Many substances in the tall fescue/endophyte association (Schedonorus arundinaceus/Epichloë coenophiala) have biological activity. Of these compounds only the ergot alkaloids are known to have significant mammalian toxicity and the predominant ergot alkaloids are ergovaline and ergovalinine. Because synthetically produced ergovaline is difficult to obtain, we developed a seed extraction and partial purification protocol for ergovaline/ergovalinine that provided a biologically active product. Tall fescue seed was ground and packed into several different sized columns for liquid extraction. Smaller particle size and increased extraction time increased efficiency of extraction. Our largest column was a 114 × 52 × …

Investigating Catalysis Through Quantum Mechanical Computations: An Analysis Of Phosphoryl Transfer Enzymes And Ccc-Nhc Pincer Complexes, Katherine Nicholls Leigh

Electronic Theses and Dissertations Archive

Chemical reactions are essential to the world we experience. Certain chemical reactions, though beneficial, occur at rates too slow to be practical. Catalysis, or the use of another species to increase the rate of a chemical reaction, is often utilized, allowing chemical reactions to become more beneficial. Catalysts increase reaction rates by lowering the amount of energy required to perform a reaction. Catalysis is abundant, as evidenced in nature in the form of enzymes, or in a myriad of non-biological processes such as chemical manufacturing and pharmaceutical materials. Phosphoryl transfer is a fundamental step in numerous processes central to life, …

Onsite Integrative Clinics: Acupuncture, Positive Patient Outcomes, And Frequency Of Provider Office Visits, Sherry Shoemaker Phd

Dissertations

Purpose and Aims. There is limited information about outcomes of care, resource utilization, and associated costs for patients who receive acupuncture in integrative health settings. The purpose of this study was to address this gap through the following aims: To examine: (1) changes in patient pain levels pre/post acupuncture treatments; (2) relationships between receiving acupuncture treatments (number of treatments, length of time, select demographic factors, (age, gender), pain level pre and post acupuncture treatments; (3) relationships between number of treatments, length of time, age, gender, pain level (pre/post acupuncture treatments) and provider visits (pre/post acupuncture treatments); and (4) relationship between …

Daily Eastern News: December 11, 2014, Eastern Illinois University

December

No abstract provided.

Effect Of Hydrogen Peroxide On The Biosynthesis Of Heme And Proteins: Potential Implications For The Partitioning Of Glu-TrnaGlu Between These Pathways, Carolina Farah, Gloria Levicán, Michael Ibba, Omar Orellana

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Glutamyl-tRNA (Glu-tRNA^Glu) is the common substrate for both protein translation and heme biosynthesis via the C5 pathway. Under normal conditions, an adequate supply of this aminoacyl-tRNA is available to both pathways. However, under certain circumstances, Glu-tRNA^Glu can become scarce, resulting in competition between the two pathways for this aminoacyl-tRNA. In Acidithiobacillus ferrooxidans, glutamyl-tRNA synthetase 1 (GluRS1) is the main enzyme that synthesizes Glu-tRNA^Glu. Previous studies have shown that GluRS1 is inactivated in vitro by hydrogen peroxide (H₂O₂). This raises the question as to whether H₂O₂ negatively affects …

A Critical Analysis Of Infant Mortality In Kalamazoo County, Audrey Jensen

Honors Theses

The following is a review of the state of infant and fetal health in Kalamazoo County in the 21st century. Since infant health is a marker for the effectiveness of health care, this review will analyze the leading causes of infant mortality in Kalamazoo County. Statistical indicators show that Kalamazoo County falls below both state and national IMR averages. The leading causes of infant mortality in Kalamazoo are considered preventable infant deaths. Therefore, this review will make recommendations for the reduction of IMR through the improvement of preventative prenatal healthcare practices.

The Birds Of Genome10k, Stephen J. O'Brien, David Haussler, Oliver A. Ryder

Biology Faculty Articles

Everyone loves the birds of the world. From their haunting songs and majesty of flight to dazzling plumage and mating rituals, bird watchers – both amateurs and professionals - have marveled for centuries at their considerable adaptations. Now, we are offered a special treat with the publication of a series of papers in dedicated issues of Science, Genome Biology and GigaScience (which also included pre-publication data release). These present the successful beginnings of an international interdisciplinary venture, the Avian Phylogenomics Project that lets us view, through a genomics lens, modern bird species and the evolutionary events that produced them.

Mono- And Digalactosyldiacylglycerol Lipids Function Nonredundantly To Regulate Systemic Acquired Resistance In Plants, Qing-Ming Gao, Keshun Yu, Ye Xia, M. B. Shine, Caixia Wang, Duroy Navarre, Aardra Kachroo, Pradeep Kachroo

Plant Pathology Faculty Publications

The plant galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) have been linked to the anti-inflammatory and cancer benefits of a green leafy vegetable diet in humans due to their ability to regulate the levels of free radicals like nitric oxide (NO). Here, we show that DGDG contributes to plant NO as well as salicylic acid biosynthesis and is required for the induction of systemic acquired resistance (SAR). In contrast, MGDG regulates the biosynthesis of the SAR signals azelaic acid (AzA) and glycerol-3-phosphate (G3P) that function downstream of NO. Interestingly, DGDG is also required for AzA-induced SAR, but MGDG is not. Notably, …

The Cowl - V.79 - N.13 - Dec 11, 2014

The Cowl

The Cowl - student newspaper of Providence College. Vol 79 - No. 13 - December 11, 2014. 28 pages.

Beneficial Effects Of Simulated Gastro-Intestinal Digests Of Fried Egg And Its Fractions On Blood Pressure, Plasma Lipids And Oxidative Stress In Spontaneously Hypertensive Rats, Forough Jahandideh, Kaustav Majumder, Subhadeep Chakrabarti, Jude S. Morton, Sareh Panahi, Susan Kaufman, Sandra T. Davidge, Jianping Wu

Department of Food Science and Technology: Faculty Publications

Background: We have previously characterized several antihypertensive peptides in simulated digests of cooked eggs and showed blood pressure lowering property of fried whole egg digest. However, the long-term effects of this hydrolysate and its fractions on blood pressure are not known. Therefore, the objectives of the study were to determine the effects of long term administration of fried whole egg hydrolysate and its fractions (i.e. egg white and egg yolk) on regulation of blood pressure and associated factors in cardiovascular disease such as plasma lipid profile and tissue oxidative stress.

Methods and Results: We used spontaneously hypertensive rats (SHR), an …

Safe Use Of Biological Degreasing Stations, Denis Bégin, Michel Gérin, Jacques Lavoie

Fiches

No abstract provided.

Developmental And Cultural Perspectives On Children’S Postoperative Pain Management At Home, Brooke N. Jenkins, Michelle A. Fortier

Psychology Faculty Articles and Research

Outpatient surgery is extremely common in children, and approximately 4 million children experience significant pain after surgery in the USA each year. Management of children's postoperative pain in the home setting is suboptimal and is impacted by characteristics of children and parents, as well as the larger family and cultural context. In particular, developmental status of the child, parental beliefs regarding pain expression and analgesic use in children, cultural values and language barriers can affect management of children's postoperative pain. Targeting the myriad barriers to children's pain management by capitalizing upon the use of tailored interventions may help bridge the …

Structure-Based Drug Design And Synthesis Of Anti-Infective And Anticancer Agents, Narendran Gummudipundi Dayanandan

Doctoral Dissertations

Resistance to antibiotics is on the rise at an alarming pace. The problem is exacerbated by the lack of new class of therapeutic agents and targets. Modes of resistance include alteration of drug target, modification of ligand, and reduction of the intracellular concentration of drug. Dihydrofolate reductase (DHFR) is a validated drug target for the treatment of infectious diseases and cancer. The binding of ligands to DHFR inhibits the downstream folate pathway that is vital for purine and thymidylate synthesis. Trimethoprim (TMP), a clinically used antifolate exhibits resistance in both gram-positive and gram-negative bacteria. In this thesis, methods have been …

Kenyon Collegian - December 11, 2014

The Kenyon Collegian

No abstract provided.

A Privileged Pedagogy For Privileged Students? A Preliminary Mixed-Methods Analysis Comparing First-Generation And Non-First-Generation College Students On Post-Evaluations Of Service-Learning Courses, Stephanie A. Wilsey, Jessica Friedrichs, Chrys Gabrich, Ting-Ting Chung

PRISM: A Journal of Regional Engagement

Service-learning is frequently described as a high-impact teaching activity that benefits students in numerous ways. However, fewer studies explore how underserved students respond to service-learning courses, and fewer still look specifically at first-generation college students. First generation college students face numerous documented obstacles to persisting and achieving in college, and a need exists for more systematic study of whether service-learning pedagogy supports or challenges first generation students as they face and overcome those obstacles. This study compared 260 undergraduate students, approximately half of whom were first-generation college students, and their self-reported gains in three student learning outcomes: academic enhancement, personal …

Bridges Beyond The Kala Pani: Transgressing Boundaries In Mootoo And Espinet, Johanna Garvey

Anthurium: A Caribbean Studies Journal

“Bridges Beyond the Kala Pani: Transgressing Boundaries in Mootoo and Espinet”

Abstract: Until recently, the kala pani or “dark waters” navigated by Indian subjects indentured and shipped to locations in the Caribbean remained largely unexplored. In the past decade, the fiction of authors such as Ramabai Espinet and Shani Mootoo, as well as scholarship by Brinda Mehta, Shalini Puri, M. Jacqui Alexander, and others, has begun to excavate Indo-Caribbean experience as well as to chart paths from places such as Trinidad to locations in the North, especially Canada. In considering issues of citizenship and belonging, texts by Espinet and Mootoo …

“We Are Jamaicans. We Are Brothers”: History, Brotherhood, And Independence In Kerry Young’S Pao, Tzarina T. Prater

Anthurium: A Caribbean Studies Journal

Kerry Young’s first Novel, Pao, is written in the “voice” of a Chinese Jamaican, a voice that exhibits little if no syntactical or grammatical difference from those with whom he works and lives in the underworld of Chinatown in Kingston, Jamaica. Pao, our central protagonist, arrives to Jamaica in 1938, a time of tremendous social upheaval. The novel charts Pao’s growing political consciousness through his romantic relationships with: the “improper” black prostitute and madam, Gloria Campbell, who is the site of romantic love, and the “proper” Fay Wong, daughter of a grocery store chain owner and link to respectability. …

Towards “That Republic In Which Complexions Do Not Matter”: Derek Walcott’S Drums And Colours Fifty Years On, Harold N. Mcdermott

Anthurium: A Caribbean Studies Journal

Derek Walcott’s three hour pageant, Drums and Colours, commissioned to celebrate the inauguration of the West Indian Federation was first performed at the West Indian Festival, April 25 – May 1, 1958. Some feel that the nationalist and didactic thrust of this early drama blunted it value as art. It is, however, the opinion of this paper that this play provides one of the earliest conceptual maps for Walcott’s orchestration of key thematic occupations such as the quarrel with history, racial and cultural syncretism and the evolution of a distinctive West Indian theatre style. Fifty years after the breakup of …

We Are...Marshall, December 10, 2014, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Deciphering Transcription And Methylation Specific To Late-Onset Alzheimer's Disease, Crystal Elizabeth Humphries

Open Access Dissertations

Alzheimer disease (AD) is the most common form of dementia affecting approximately 13% of individuals 65 and older. Rare variants in the Amyloid precursor protein, Presenilin 1, or Presenilin 2 genes primarily cause Early-Onset Alzheimer disease and comprise 2% of AD cases. Conversely, Late-Onset Alzheimer disease (LOAD) is much more complex and accounts for greater than 90% of AD cases. Recent transcriptome studies have shed light on molecular functions altered in LOAD. Many of these studies have consistently observed alterations within several pathways: synaptic transmission, inflammation, energy metabolism, myelination, and signal transduction. While αβ plaques and neurofibrillary tangles (NFTs) are …

Weekly News Digest 12/10/2014, Jenna Ray

Weekly Bulletin Archive

In This Issue:

● Students and Faculty Prepare for Final Exams

● Morris Named a Most Affordable Public College

● Garavaso’s Latest Book Released by Lexington

● Bailey-Johnson ’99 in Prairie Business 40 Under 40

Spartan Daily, December 10, 2014, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 143, Issue 41

Environmental Genomics And Transcriptomics Of Salpa Thompsoni And Population Genetic Variation Of Euphausia Superba In The Southern Ocean, Paola G. Batta Lona

Doctoral Dissertations

The Western Antarctic Peninsula (WAP) region, which is experiencing increased sea surface temperatures, is a highly productive region of the Southern Ocean, supporting dense populations of the salp Salpa thompsoni and krill Euphuasia superba.

Ecological data suggest that important species like salps and krill are being affected by climate change and that this effects on these planktonic species will have considerable consequences for the balance of the Southern Ocean ecosystem. The Antarctic krill E. superba is one of the best-studied marine zooplankton species in terms of population genetic diversity and structure. However few studies have discriminated life stages and examined …

The Lumberjack, December 10, 2014, The Lumberjack Staff

2014

The student newspaper of Humboldt State University

Jany, Roman, Gallegos-Ruiz, Long, Leh, Kohout Flc 14, Carmen Jany, Alexandru V. Roman, Thomas Long, Maria Gallegos-Ruiz, Amy Leh, Michal Kohout

Faculty Learning Communities

No abstract provided.

Strategic Insights: The Landpower Robot Revolution Is Coming, Steven Metz

Articles & Editorials

No abstract provided.

Thermoregulation Is For The Birds, Dec. 10, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

A Statistical Analysis Of The Role Of Critical-Thinking Games In College Students' Quantitative Reasoning, Melissa Radevicz

Honors Program Theses and Projects

Improving college students' quantitative reasoning is crucial to increase STEM-field retention rates. The National Survey of Student Engagement (NSSE), results indicate that "college students don't always get exposure to activities that develop [quantitative reasoning]" (Berrett & Sander, 2013). This study aimed to engage college students in quantitative reasoning through critical-thinking games. Phase 1, conducted in summer 2014 with a university research grant, involved a correlation analysis of the work of 133 college students enrolled in Elementary Statistics I, Chemical Principles II, Elements of Calculus, Pre-Calculus with Trigonometry, Multivariable Calculus, and Differential Equations. Participants held a variety of 39 different majors, …

Agricultural Drainage Tiles: An Overview Of Their Use, Benefits, And Effect On Hydrology And Water Quality, Brian B. Gedlinske

Other Faculty and Staff Publications

Agricultural drainage tiles (ADTs) have become an integral part of the Midwest’s economy by their ability to transform fine-grained, poorly drained soils into highly productive farmland. Because of their design and function, they also pose a number of detrimental consequences related to water quality, stream bank erosion, a loss of wetland areas, increased baseflows, and flooding intensity. This research paper explores how ADTs contribute to the agricultural pollutant loading problem experienced in Midwest streams. It also identifies new practices and technologies being pursued to mitigate their impact.

ADTs provide unique field-to-water pathways for a number of agricultural pollutants, the most …

Senate Meeting, December 10, 2014, Academic Senate

Academic Senate Minutes

No abstract provided.