Digital Commons Network^™

The Glanville Fritillary Genome Retains An Ancient Karyotype And Reveals Selective Chromosomal Fusions In Lepidoptera, Virpi Ahola, Marian R. Goldsmith, Et Al

Biological Sciences Faculty Publications

Previous studies have reported that chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes varies widely from 5 to 223. Here we report the genome (393Mb) of the Glanville fritillary butterfly (Melitaea cinxia; Nymphalidae), a widely recognized model species in metapopulation biology and eco-evolutionary research, which has the putative ancestral karyotype of n¼31. Using a phylogenetic analyses of Nymphalidae and of other Lepidoptera, combined with orthologue-level comparisons of chromosomes, we conclude that the ancestral lepidopteran karyotype has been n¼31 for at least 140My. We show that fusion chromosomes have retained the ancestral chromosome segments and …

Regulatory Adaptations For Delivering Information: The Case Of Confession, Daniel Sznycer, Eric Schniter, John Tooby, Leda Cosmides

ESI Publications

Prior to, or concurrent with, the encoding of concepts into speech, the individual faces decisions about whether, what, when, how, and with whom to communicate. Compared to the existing wealth of linguistic knowledge however, we know little of the mechanisms that govern the delivery and accrual of information. Here we focus on a fundamental issue of communication: The decision whether to deliver information. Specifically, we study spontaneous confession to a victim. Given the costs of social devaluation, offenders are hypothesized to refrain from confessing unless the expected benefits of confession (e.g. enabling the victim to remedially modify their course of …

Transcriptome Profiling Of Spinal Muscular Atrophy Motor Neurons Derived From Mouse Embryonic Stem Cells., Miho Maeda, Ashlee W Harris, Brewster F Kingham, Casey J Lumpkin, Lynn M Opdenaker, Suzanne M Mccahan, Wenlan Wang, Matthew E R Butchbach

Department of Pediatrics Faculty Papers

Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected by the loss of the ubiquitously expressed SMN protein. Using a mouse embryonic stem cell (mESC) model for severe SMA, the RNA transcript profiles (transcriptomes) between control and severe SMA (SMN2+/+;mSmn-/-) mESC-derived MNs were compared in this study using massively parallel RNA sequencing (RNA-Seq). The MN differentiation efficiencies between control and severe SMA mESCs …

Some Preliminary Thoughts On The Law Of Neighbors, James C. Smith

Georgia Journal of International & Comparative Law

No abstract provided.

Domestic Solutions To The International Problem Of Water Scarcity: Singapore, A Case Study, Suzanne T. Lewis

Georgia Journal of International & Comparative Law

No abstract provided.

Maryland V. King And The Road Already Traveled: How The United Kingdome Tried--And Failed--To Balance State Interests With Privacy Rights, Courtney Coons Poole

Georgia Journal of International & Comparative Law

No abstract provided.

Fishing Moratoria And Securing Turfs: Creating Opportunities For Future Marine Resource Abundance In The Face Of Scarcity In Western Africa, Anastasia Telesetsky

Georgia Journal of International & Comparative Law

No abstract provided.

Resource Scarcity From An Applied Economic Perspective, José Cuesta

Georgia Journal of International & Comparative Law

No abstract provided.

International Law In A Time Of Scarcity: An Introduction, Harlan G. Cohen

Georgia Journal of International & Comparative Law

No abstract provided.

Racial And Ethnic Disparities In Time To Cure Of Incontinence Present At Nursing Home Admission, Donna Z. Bliss, Olga Gurvich, Kay Savik, Lynn Eberly, Susan Harms, Jean F. Wyman

Journal of Health Disparities Research and Practice

Abstract

As many as half of older people that are admitted to nursing homes (NHs) are incontinent of urine and/or feces. Not much is known about the rate of cure of incontinence present at NH admission, but available reports suggest the rate is low. There have been racial and ethnic disparities in incontinence treatment, but the role of disparities in the cure of incontinence is understudied. Using the Peters-Belson method and multilevel predictors, our findings showed that there were disparities in the time to cure of incontinence for Hispanic NH admissions. A significantly smaller proportion of older Hispanic admissions were …

Physicians' Attitudes About Recommending Surgery For Early Stage Lung Cancer And Possible Reasons For Racial Disparities, Franklin R. Mcguire

Journal of Health Disparities Research and Practice

PHYSICIANS’ ATTITUDES ABOUT RECOMMENDING SURGERY FOR EARLY STAGE LUNG CANCER AND POSSIBLE REASONS FOR RACIAL DISPARITIES

ABSTRACT

Purpose: Patient refusal for lung cancer surgery is significant, but other factors, such as negative framing of the treatment discussion, may be involved. Physician attitudes could influence the nuances of and therefore the conclusions of these discussions. We determined physicians’ attitudes and the influence it has on possible decisions against lung cancer surgery, particularly surgical rates for blacks, using a companion survey.

Methods: The study is a prospective, multicenter observational trial conducted at five sites in North and South Carolina from December …

American Indian Men's Perceptions Of Breast Cancer Screening For American Indian Women, Melissa K. Filippi, Joseph Pacheco, Aimee S. James, Travis Brown, Florence Ndikum-Moffor, Won S. Choi, K Allen Greiner, Christine M. Daley

Journal of Health Disparities Research and Practice

Screening, especially screening mammography, is vital for decreasing breast cancer incidence and mortality. Screening rates in American Indian women are low compared to other racial/ethnic groups. In addition, American Indian women are diagnosed at more advanced stages and have lower 5-year survival rate than others. To better address the screening rates of American Indian women, focus groups (N=8) were conducted with American Indian men (N=42) to explore their perceptions of breast cancer screening for American Indian women. Our intent was to understand men’s support level toward screening. Using a community-based participatory approach, focus groups were audio-taped, transcribed verbatim, and analyzed …

Turtle Power Down Under The Sea?: Comparative Domestic And International Legal Protection Of Marine Turtles By Australia And The United States, Marjorie Palmer

Georgia Journal of International & Comparative Law

No abstract provided.

The Fierce Green Fire: Vol 5 Issue 1, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

Chanticleer | September 4, 2014, Jacksonville State University

Chanticleer

No abstract provided.

Western News, Sept. 4, 2014, Western Michigan University

Western News (1972-2018)

Story highlights: Cooley Law, WMU affiliation finalized; Six to receive one of two Universitywide awards; All WMU campuses are now tobacco free; Faculty Senate announces leadership for 2014-16; On Campus with Dale Hagens.

Quantitative Factors Proposed To Influence The Prevalence Of Canine Tick-Borne Disease Agents In The United States, Roger W. Stich, Byron L. Blagburn, Dwight D. Bowman, Christopher Carpenter, M. Roberto Cortinas, Sidney A. Ewing, Desmond Foley, Janet E. Foley, Holly Gaff, Graham J. Hickling, R. Ryan Lash, Susan E. Little, Catherine Lund, Robert Lund, Thomas N. Mather, Glen R. Needham, William L. Nicholson, Julia Sharp, Andrea Varela-Stokes, Dongmei Wang

Plant Sciences and Entomology Faculty Publications

The Companion Animal Parasite Council hosted a meeting to identify quantifiable factors that can influence the prevalence of tick-borne disease agents among dogs in North America. This report summarizes the approach used and the factors identified for further analysis with mathematical models of canine exposure to tick-borne pathogens.

The Setonian, September 4, 2014, Seton Hall University

2014

No abstract provided.

Curriculum Subcommittee Agenda, September 4, 2014, Utah State University

Educational Policies Committee

Department of Agricultural Systems Technology and Education

• New Course
• Title Change
• Credit Hour, Grade Mode Change
• Title, Prerequisite, Course Description Change

Department of Nutrition, Dietetics and Food Science

• New Course

Department of Plants, Soils and Climate

• Credit Hour Change
• Prerequisite Change

Department of Art and Design

• New Course

Department of Theatre Arts

• Grade Mode Change

Department of Family, Consumer and Human Development

• New Course

Department of Health, Physical Education and Recreation

• Title Change
• Prerequisite Change

Department of Psychology

• Title, Prerequisite, Course Description Change

Department of Teacher Education and Leadership

• Course Description change
• Prerequisite Change

Department of Biological Engineering

• New Course …

Activation Of Dna Damage Checkpoint Pathways During Skeletal Myoblast Differentiation And Apoptosis, Mofetoluwa Oluwasanmi, Greg Kliment, Crystal M. Weyman

Undergraduate Research Posters 2014

A subset of skeletal myoblasts undergo apoptosis rather than differentiation when cultured in differentiation media (DM: absence of growth factors). While the muscle regulatory transcription factor MyoD is known to control the process of differentiation, our lab has recently discovered that MyoD is also controlling the apoptotic process in response to culture in DM by direct up-regulation of the pro-apoptotic Bcl2 family member PUMA. We similarly discovered that MyoD plays a role in the increased expression of PUMA and apoptosis in response to the DNA damaging agent, etoposide. This led to the hypothesis that culture in DM may lead to …

Fabrication And Characterization Of Cell Membrane, Ali Naserallah, Valentinas Gruzdys, Xue-Long Sun

Undergraduate Research Posters 2014

Cell membrane plays critical cellular functions in both physiological and pathological pathways and thus is important target for both basic and applied biomedical research. The domain structure features of cell membrane strongly affect the functions of membrane embedded biomolecules such as proteins and carbohydrates. However, understanding the structural aspects of membrane effects on the embedded biomolecule’s function have not been able easily to do due to limited approaches available. We have engaged in fabrication of cell membrane mimetic systems for functional analysis of membrane proteins and cell surface carbohydrates [1,2]. Thrombomodulin (TM), an endothelial integral membrane protein, plays central roles …

Cholesterol Conjugated Hdac Inhibitor As Novel Anticancer Agent, Paul Orefice, Jane Peterson, Bin Sun

Undergraduate Research Posters 2014

Histone deacetylase (HDAC) inhibitors are a class of promising new multifunctional anticancer agents. These agents are able to affect multiple epigenetic changes in aberrant cells. In addition to regulating the gene expression and transcription via chromatin remodeling, HDAC inhibitors can also modulate a variety of cellular functions including proliferation, differentiation, and apoptosis. Vorinostat (SuberAniloHydroxamic Acid, SAHA), the first HDAC inhibitor approved by FDA, inhibited the metastasis of various cancer cells. However, SAHA distributes in cancer tissue and normal tissue in a similar level. It will be ideal to selectively delivery SAHA into cancer cells. Rapidly growing cancer cells have a …

The Use Of Elastin-Like Polypeptides As A Drug Carrier Material: A Compatibility Study, Michael G. Price, John P. Gavin, Eric Helm, James T. Cole, Nolan Holland

Undergraduate Research Posters 2014

Stimuli responsive self-assembling nanoparticles of elastin-like polypeptides are promising platforms for targeted drug delivery and release. These particles spontaneously assemble from elastin-like polypeptide building blocks in solution. The nanoparticles stably self-assemble under specific temperature, salt, and pH conditions and can dissociate upon changing of these conditions. With appropriate design, the surface of the particles can be decorated with labels that cause them to accumulate in specific diseased tissues. In addition, the size of the particles is appropriate to minimize undesirable rapid clearance from the body. In this study, we are testing the ability of the elastin-like polypeptide core to store …

Ua12/2/1 College Heights Herald, Vol. 90, No. 4, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Pettway, Shantel. Step Up: National Pan-Hellenic Conference Greeks Participate in Annual Yard Show – Fraternities and Sororities
• Allen, Whitney. WKU Works to Improve LGBT-Friendly Reputation – Gays, Lesbians
• Voorhees, Jessica. Cultural Enhancement Series Enters 18^th Year
• Harney, LaShana. Student Government Association Holds First Meeting of the Semester in New Space – Downing University Center
• Pettway, Shantel. WKU Police Department Rules Aim to Keep WKU Safe
• Parker, Jacob. Find Positivity in the Little Things
• Is Your Hall Worth It? – Housing & Residence Life
• Holloway, Kae. Fast Fashion Stores …

Curriculum Subcommittee Minutes, September 4, 2014, Utah State University

Educational Policies Committee

Department of Agricultural Systems Technology and Education

• New Course
• Title Change
• Credit Hour, Grade Mode Change
• Title, Prerequisite, Course Description Change

Department of Nutrition, Dietetics and Food Science

• New Course

Department of Plants, Soils and Climate

• Credit Hour Change
• Prerequisite Change

Department of Art and Design

• New Course

Department of Theatre Arts

• Grade Mode Change

Department of Family, Consumer and Human Development

• New Course

Department of Health, Physical Education and Recreation

• Title Change
• Prerequisite Change

Department of Psychology

• Title, Prerequisite, Course Description Change

School of Teacher Education and Leadership

• Course Description change
• Prerequisite Change

Department of Biological Engineering

• New Course …

Enhanced Expression Of Codon Optimized Mycobacterium Avium Subsp. Paratuberculosis Antigens In Lactobacillus Salivarius, Christopher D. Johnston, John P. Bannatine, Rodney Govender, Lorraine Endersen, Daniel Pletzer, Helge Weingart, Aidan Coffey, Jim O'Mahony, Roy D. Sleator

Department of Biological Sciences Publications

It is well documented that open reading frames containing high GC content show poor expression in A+T rich hosts. Specifically, G+C-rich codon usage is a limiting factor in heterologous expression of Mycobacterium avium subsp. paratuberculosis (MAP) proteins using Lactobacillus salivarius. However, re-engineering opening reading frames through synonymous substitutions can offset codon bias and greatly enhance MAP protein production in this host. In this report, we demonstrate that codon-usage manipulation of MAP2121c can enhance the heterologous expression of the major membrane protein (MMP), analogous to the form in which it is produced natively by MAP bacilli. When heterologously over-expressed, antigenic determinants …

Lin28a Expression Reduces Sickling Of Cultured Human Erythrocytes, Jaira F. De Vasconcellos, Ross M. Fasano, Y. Terry Lee, Megha Kaushal, Colleen Burns, Emily Riehm Meier, Molly Anderson, Antoinette Rabel, Raul Braylan, David F. Stroncek, Jeffery L. Miller

Pediatrics Faculty Publications

Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with sickle cell disease (SCD) and the beta-thalassemias. It was recently reported that increased expression of LIN28 proteins or decreased expression of its target let-7 miRNAs enhances HbF levels in cultured primary human erythroblasts from adult healthy donors. Here LIN28A effects were studied further using erythrocytes cultured from peripheral blood progenitor cells of pediatric subjects with SCD. Transgenic expression of LIN28A was accomplished by lentiviral transduction in CD34(+) sickle cells cultivated ex vivo in serum-free medium. LIN28A over-expression (LIN28A-OE) increased HbF, reduced beta (sickle)-globin, and strongly suppressed …

Study To Examine How Healthy Moms Pass Deadly Bacteria To Infants, Traci Bratton

Browse All News

No abstract provided.

Uab To Host Annual Aarp Aging Policy Conference, Staff

Browse All News

No abstract provided.

The Daily Gamecock, Thursday, September 4, 2014, University Of South Carolina, Office Of Student Media

September

No abstract provided.