Digital Commons Network^™

The Legacy, September 16, 2014, Lindenwood University

The Legacy (2007-2018)

Student Newspaper of Lindenwood University

The Murray Ledger And Times, September 16, 2014, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The Utah Statesman, September 16, 2014, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Parthenon, September 16, 2014, Codi Mohr

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

Mistranslation Of The Genetic Code, Adil Moghal, Kyle Mohler, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

During mRNA decoding at the ribosome, deviations from stringent codon identity, or “mistranslation,” are generally deleterious and infrequent. Observations of organisms that decode some codons ambiguously, and the discovery of a compensatory increase in mistranslation frequency to combat environmental stress have changed the way we view “errors” in decoding. Modern tools for the study of the frequency and phenotypic effects of mistranslation can provide quantitative and sensitive measurements of decoding errors that were previously inaccessible. Mistranslation with non‐protein amino acids, in particular, is an enticing prospect for new drug therapies and the study of molecular evolution.

Sesquiterpene Synthase Gene And Protein, Joe Chappell, Bryan T. Greenhagen

Plant and Soil Sciences Faculty Patents

The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention further provides nucleic acids comprising the nucleotide sequence coding for amino acid residues forming the tier 1 and tier 2 domains of CVS. The invention also provides for methods of making and using the nucleic acids and amino acids of the current invention.

High-Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis And Method Of Generating The Same, Chang-Guo Zhan, Hoon Cho, Hsin-Hsiung Tai

Pharmaceutical Sciences Faculty Patents

A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations thereby providing a screening method of possible BChE mutants by predicting which mutant will lead to a more stable transition state for a rate determining step. Site-directed mutagenesis, protein expression, and protein activity is conducted for mutants determined computationally as being good candidates for possible BChE mutants, i.e., ones predicted to have higher catalytic efficiency as compared with wild-type BChE. In addition, mutants A199S/A328W/Y332G, A199S/F227A/A328W/Y332G, A199S/S287G/A328W/Y332G, …

Tangram: A Comprehensive Toolbox For Mobile Element Insertion Detection, Jiantao Wu, Wan Ping Lee, Alistair Ward, Jerilyn A. Walker, Miriam K. Konkel, Mark A. Batzer, Gabor T. Marth

Faculty Publications

© 2014 Wu et al.; licensee BioMed Central Ltd. Background: Mobile elements (MEs) constitute greater than 50% of the human genome as a result of repeated insertion events during human genome evolution. Although most of these elements are now fixed in the population, some MEs, including ALU, L1, SVA and HERV-K elements, are still actively duplicating. Mobile element insertions (MEIs) have been associated with human genetic disorders, including Crohn's disease, hemophilia, and various types of cancer, motivating the need for accurate MEI detection methods. To comprehensively identify and accurately characterize these variants in whole genome next-generation sequencing (NGS) data, a …

Daily Eastern News: September 16, 2014, Eastern Illinois University

September

No abstract provided.

Inter-Calibration Of Satellite Passive Microwave Land Observations From Amsr-E And Amsr2 Using Overlapping Fy3b-Mwri Sensor Measurements, Jinyang Du, John S. Kimball, Jiancheng Shi, Lucas Alan Jones, Shengli Wu, Ruijing Sun, Hu Yang

Biological Sciences Faculty Publications

The development and continuity of consistent long-term data records from similar overlapping satellite observations is critical for global monitoring and environmental change assessments. We developed an empirical approach for inter-calibration of satellite microwave brightness temperature (T_b) records over land from the Advanced Microwave Scanning Radiometer for EOS (AMSR-E) and Microwave Scanning Radiometer 2 (AMSR2) using overlapping Tb observations from the Microwave Radiation Imager (MWRI). Double Differencing (DD) calculations revealed significant AMSR2 and MWRI biases relative to AMSR-E. Pixel-wise linear relationships were established from overlapping T_b records and used for calibrating MWRI and AMSR2 records to the AMSR-E …

Synthetic Mammalian Neuromuscular Junction And Method Of Making (Us), James Hickman, Xiufang Guo

UCF Patents

The next generation of system biology and drug discovery tools will be functional in vitro systems composed of human cells in defined serum-free systems. These functional in vitro systems will enable understanding beyond the single cell level directly to the human condition and enable the faster and least expensive translation of basic research to therapeutics. This study reports the first pure human-based in vitro Neuromuscular Junction (NMJ) system by demonstrating the co-culture of motoneurons and skeletal muscle (SKMs) derived from human stem cells, in a defined, serum-free medium and on a patternable non-biological surface.

The Current Volume 25 : Issue 4, Nova Southeastern University

Student Newspapers

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

• Police Raid Bars
• Opinions
• News
• Arts & Entertainment
• Classifieds & Puzzles
• Sports

A Cell-Based High-Throughput Screen For Novel Chemical Inducers Of Fetal Hemoglobin For Treatment Of Hemoglobinopathies, Kenneth R. Peterson, Flávia C. Costa, Halyna Fedosyuk, Renee Y. Neades, Allen M. Chazelle, Lesya Zelenchuk, Andrea H. Fonteles, Parmita Dalal, Anuradha Roy, Rathnam Chaguturu, Biaoru Li, Betty S. Pace

Faculty and Staff Publications

Decades of research have established that the most effective treatment for sickle cell disease (SCD) is increased fetal hemoglobin (HbF). Identification of a drug specific for inducing γ-globin expression in pediatric and adult patients, with minimal off-target effects, continues to be an elusive goal. One hurdle has been an assay amenable to a high-throughput screen (HTS) of chemicals that displays a robust γ-globin off-on switch to identify potential lead compounds. Assay systems developed in our labs to understand the mechanisms underlying the γ- to β-globin gene expression switch during development has allowed us to generate a cell-based assay that was …

Relations Of Water Quality, Land Use Nuffers, And Diatom Communities Of Connected Depressions Within The Cache River Watershed, Arkansas, Usa, David R. L. Burge

Student Theses and Dissertations

Over the past century, the Mississippi Alluvial Plain Ecoregion was altered from forest to agriculture. Associated with increased adjacent agriculture, water quality perturbations identified in Cache River connected depressions included elevated pH, DO, and conductivity. Non-metric Multidimensional Scaling indicated significant changes in the epidendric and benthic diatom communities in relation to conductivity and adjacent agriculture. The communities of less-impacted wetlands were dominated by species in the genera Eunotia, Gomphonema, and Pinnularia shifted towards communities dominated by Diadesmis contenta and Nitschia clausii in the more disturbed wetlands. Also, correlations among autecological metrics showed the relative abundance of planktonic diatoms increased and …

A Suite Of Early Eocene (~55 Ma) Climate Model Boundary Conditions, N. Herold, J. Buzan, M. Seton, A. Goldner, J. A. M. Green, R. D. Müller, P. Markwick, Matthew Huber

Department of Earth, Atmospheric, and Planetary Sciences Faculty Publications

We describe a set of early Eocene (~ 55 Ma) climate model boundary conditions constructed in a self-consistent reference frame and incorporating recent data and methodologies. Given the growing need for uniform experimental design within the Eocene climate modelling community and the challenges faced in simulating the prominent features of Eocene climate, we make publicly available our data sets of Eocene topography, bathymetry, tidal dissipation, vegetation, aerosol distributions and river runoff. Major improvements in our boundary conditions over previous efforts include the implementation of the ANTscape palaeotopography of Antarctica, more accurate representations of the Drake Passage and Tasman Gateway, as …

Engaging The Liminal: Indigenous Perceptions Within The Healthcare System, Karen J. Lottis

Nursing ETDs

It is well documented that there is decreased access and utilization of healthcare services by minority populations. The purpose of this study was to explore experiences with, and views of, the healthcare system among remotely situated First Nations people of coastal British Columbia (BC), to shed light on elements considered crucial to healthcare delivery. The study was conducted as a critical ethnography with an underlying framework of phenomenology and critical social theory. Multiple sources of data collection included private interviews, community observations, conversations, celebratory gatherings, participant-observer field notes, and the art and music of the people involved. Multiphase data management …

Two Classes Of Nucleic Acid Translocation Motors: Rotation And Revolution Without Rotation, Peixuan Guo, Ian Grainge, Zhengyi Zhao, Mario Vieweger

Markey Cancer Center Faculty Publications

Biomotors are extensively involved in biological processes including cell mitosis, bacterial binary fission, DNA replication, DNA repair, homologous recombination, Holliday junction resolution, RNA transcription, and viral genome packaging. Traditionally, they were classified into two categories including linear and rotation motors. In 2013, a third class of motor by revolution mechanism without rotation was discovered. In this issue of "Structure and mechanisms of nanomotors in the cells", four comprehensive reviews are published to address the latest advancements of the structure and motion mechanism of a variety of biomotors in archaea, animal viruses, bacteria, and bacteriophages.

Ancient Maya Regional Settlement And Inter-Site Analysis: The 2013 West-Central Belize Lidar Survey, Arlen F. Chase, Diane Z. Chase, Jaime J. Awe, John F. Weishampel, Gyles Iannone, Holley Moyes, Jason Yaeger, Kathryn Brown, Ramesh Shrestha, William Carter, Juan C. Fernandez-Diaz

Anthropology Faculty Research

No abstract provided.

Sophie D. Aberle And The United Pueblos Agency, 1935-1944, Kathlene Ferris

History ETDs

This thesis examines Aberle's administration in the coincided with the New Deal era and John Collier's administration of the Bureau of Indian Affairs. Aberle was a medical researcher and applied anthropologist who brought several years of field experience among the Pueblos to the UPA. Some opposition arose over her appointment, in part because she was a woman. More important, many Pueblos opposed the consolidation of several Pueblo agencies into one large agency, the United Pueblos Agency. The new agency encompassed the nineteen New Mexico pueblos and three small Navajo reservations. Some resistance to Aberle and the consolidated agency lasted throughout …

Circulating Tumor Cells As Early Predictors Of Metastatic Spread In Breast Cancer Patients With Limited Metastatic Dissemination., Mario Giuliano, Antonio Giordano, Summer Jackson, Ugo De Giorgi, Michal Mego, Evan N Cohen, Hui Gao, Simone Anfossi, Beverly C Handy, Naoto T Ueno, Ricardo H Alvarez, Sabino De Placido, Vicente Valero, Gabriel N Hortobagyi, James M Reuben, Massimo Cristofanilli

Department of Medical Oncology Faculty Papers

IntroductionTraditional factors currently used for prognostic stratification do not always predict adequately treatment response and disease evolution in advanced breast cancer patients. Therefore, the use of blood-based markers, such as circulating tumor cells (CTCs), represents a promising complementary strategy for disease monitoring. In this retrospective study, we explored the role of CTC counts as predictors of disease evolution in breast cancer patients with limited metastatic dissemination.Methods492 advanced breast cancer patients who had a CTC count assessed by CellSearch prior to starting a new line of systemic therapy were eligible for this analysis. Using the threshold of 5 cells/7.5 mL of …

Fear God And Dread Nought: Naval Arms Control And Counterfactual Diplomacy Before The Great War, James Kraska

Georgia Journal of International & Comparative Law

No abstract provided.

Snp-E: A New Method For Multiple Sequence Alignments Analysis And Accurate Single Nucleotide Polymorphism Evaluation, David A. Lightfoot, Naghmeh Hemmati, Larry A. Sholeh

Articles

Identification of single nucleotide polymorphisms (SNPs) and insertion-deletion mutations are important for discovering the connection between the genetic mutations and complex diseases. The objective of this study was to develop a sensitive and accurate computational method for SNP detection among Multiple Sequence Alignments (MSAs) to be run on Microsoft Office SuiteTM and WindowsTM. The SNP-Evaluator, was designed to simulate the process of human eye visual change-identification. Analysis of three 82-Kbp genomic loci derived from Sanger sequencing and the corresponding SNPs from 31 genomes from IlluminaTM sequencing of soybean (Glycine max L. Merr.) demonstrated that the SNP-E was an effective …

Car Wash Helps Club Raise Money, Matt Strohl

GWU-Today

Beta Beta Beta, the biology honors society on campus, hosted a car wash this past Saturday, September 13, at the Bank of the Ozarks. They did so in hopes of raising money for future projects and trips for the club.

Asenapine Sensitization From Adolescence To Adulthood And Its Potential Molecular Basis, Qing Shu, Rongyin Qin, Yingzhu Chen, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Asenapine is a new antipsychotic drug that induces a long-lasting behavioral sensitization in adult rats. The present study investigated the developmental impacts of adolescent asenapine treatment on drug sensitivity and on 3 proteins implicated in the action of antipsychotic drugs (i.e. Brainderived neurotrophic factor (BDNF), dopamine D₂ receptor, and ΔFosB) in adulthood. Male adolescent Sprague-Dawley rats (postnatal days, P 43-48) were first treated with asenapine (0.05, 0.10 or 0.20 mg/kg, sc) and tested in the conditioned avoidance or PCP (2.0 mg/kg, sc)-induced hyperlocomotion tasks for 5 days. After they became adults (∼P 76), asenapine sensitization was assessed in a …

The Statesman, V. 58, I. 04, Stony Brook University

Stony Brook Statesman-Sucolian

v. 58, i. 04

September 15, 2014, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Chanticleer, 2014-09-15, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Ada News - 09/15/2014, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Pge(2) Ep(3) Receptor Downregulates Cox-2 Expression In The Medullary Thick Ascending Limb Induced By Hypertonic Nacl, Shoujin Hao, Alejandra Hernandez, Mariana Quiroz-Munoz, Carlos Cespedes, Carlos P. Vio, Nicholas R. Ferreri

NYMC Faculty Publications

We tested the hypothesis that inhibition of EP3 receptors enhances cyclooxygenase (COX)-2 expression in the thick ascending limb (TAL) induced by hypertonic stimuli. COX-2 protein expression in the outer medulla increased approximately twofold in mice given free access to 1% NaCl in the drinking water for 3 days. The increase was associated with an approximate threefold elevation in COX-2 mRNA accumulation and an increase in PGE2 production by isolated medullary (m)TAL tubules from 77.3 ± 8.4 to 165.7 ± 10.8 pg/mg protein. Moreover, administration of NS-398 abolished the increase in PGE2 production induced by 1% NaCl. EP3 receptor mRNA levels …