Digital Commons Network^™

Biosafety: Evaluation And Regulation Of Genetically Modified (Gm) Crops In The United States, Richard E. Goodman

Department of Food Science and Technology: Faculty Publications

This review of the safety assessment of genetically modified (GM) crops is focused primarily on the process and progress in the United States (US). It reviews the development of the safety evaluation process from the Asilomar conference in 1975 considering issues relevant to recombinant DNA technology, to discussions between the US government, academic and industrial scientists between 1984 and 1994 when the first GM crops were being field tested and evaluated commercial release for food and feed production. International guidelines were also reviewed for consistency with the US system. The overall process includes consideration of information relating to history of …

Advancing The Microbiome Research Community, Curtis Huttenhower, Rob Knight, C. Titus Brown, J. Gregory Caporaso, Jose C. Clemente, Dirk Gevers, Eric A. Franzosa, Scott T. Kelley, Dan Knights, Ruth E. Ley, Anup Mahurkar, Jacques Ravel, Scientists For Advancement Of Microbiome Research, Owen White, Jacques Izard

Department of Food Science and Technology: Faculty Publications

The human microbiome has become a recognized factor in promoting and maintaining health. We outline opportunities in interdisciplinary research, analytical rigor, standardization, and policy development for this relatively new and rapidly developing field. Advances in these aspects of the research community may in turn advance our understanding of human microbiome biology.

It is now widely recognized that disturbances in our normal microbial populations may be linked to acute infections such as Clostridium difficile and to chronic diseases such as heart disease, cancer, obesity, and autoimmune disorders. This has prompted substantial interest in the microbiome from both basic and clinical perspectives. …

Dangerous Mating Systems: Signal Complexity, Signal Content And Neural Capacity In Spiders, Marie E. Herberstein, Anne E. Wignall, Eileen Hebets, Jutta M. Schneider

Eileen Hebets Publications

Spiders are highly efficient predators in possession of exquisite sensory capacities for ambushing prey, combined with machinery for launching rapid and determined attacks. As a consequence, any sexually motivated approach carries a risk of ending up as prey rather than as a mate. Sexual selection has shaped courtship to effectively communicate the presence, identity, motivation and/or quality of potential mates, which help ameliorate these risks. Spiders communicate this information via several sensory channels, including mechanical (e.g. vibrational), visual and/or chemical, with examples of multimodal signaling beginning to emerge in the literature. The diverse environments that spiders inhabit have further shaped …

Multimodal Sensory Reliance In The Nocturnal Homing Of The Amblypygid Phrynus Pseudoparvulus (Class Arachnida, Order Amblypygi)?, Eileen A. Hebets, Alfonso Aceves-Aparicio, Samuel Aguilar-Argüello, Verner P. Bingman, Ignacio Escalante, Eben J. Gering, David R. Nelson, Jennifer Rivera, José Ángel Sánchez-Ruiz, Laura Segura-Hernández, Virginia Settepani, Daniel D. Wiegmann, Jay A. Stafstrom

Eileen Hebets Publications

Like many other nocturnal arthropods, the amblypygid Phrynus pseudoparvulus is capable of homing. The environment through which these predators navigate is a dense and heterogeneous tropical forest understory and the mechanism(s) underlying their putatively complex navigational abilities are presently unknown. This study explores the sensory inputs that might facilitate nocturnal navigation in the amblypygid P. pseudoparvulus. Specifically, we use sensory system manipulations in conjunction with field displacements to examine the potential involvement of multimodal—olfactory and visual—stimuli in P. pseudoparvulus’ homing behavior. In a first experiment, we deprived individuals of their olfactory capacity and displaced them to the opposite side of …

Genetics Of The Pig Tapeworm In Madagascar Reveal A History Of Human Dispersal And Colonization, Tetsuya Yanagida, Jean-François Carod, Yasuhito Sako, Minoru Nakao, Eric P. Hoberg, Akira Ito

Harold W. Manter Laboratory of Parasitology: Faculty Publications

An intricate history of human dispersal and geographic colonization has strongly affected the distribution of human pathogens. The pig tapeworm Taenia solium occurs throughout the world as the causative agent of cysticercosis, one of the most serious neglected tropical diseases. Discrete genetic lineages of T. solium in Asia and Africa/Latin America are geographically disjunct; only in Madagascar are they sympatric. Linguistic, archaeological and genetic evidence has indicated that the people in Madagascar have mixed ancestry from Island Southeast Asia and East Africa. Hence, anthropogenic introduction of the tapeworm from Southeast Asia and Africa had been postulated. This study shows that …

A Meta-Analysis Of The Efficacy And Safety Of Managing Parotid And Submandibular Sialoliths Using Sialendoscopy Assisted Surgery, Fatima M. Jadu, Ahmed M. Jan

Saudi Medical Journal

OBJECTIVES: To review the available techniques and procedures for management of parotid and submandibular sialoliths with special emphasis on the efficacy and safety of the most commonly used combination of techniques; namely, sialendoscopy with conservative surgical removal of the stone. METHODS: A systematic search of the English literature using MEDLINE, EMBASE, and the Cochrane library databases were conducted at the Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia. Articles between the years 2004 and 2013 were selected on the basis of preset inclusion criteria. Then, they were reviewed against a checklist to assess the evidence of efficacy of therapy …

Evaluation Of Adjunctive Systemic Doxycycline With Non-Surgical Periodontal Therapy Within Type 2 Diabetic Patients, Abeer M. Al-Nowaiser, Hamad Al-Zoman, Jagan K. Baskaradoss, Asirvatham A. Robert, Khalid H. Al-Zoman, Abdulaziz M. Al-Sohail, Abdulaziz S. Al-Suwyed, Sebastian G. Ciancio, Sultan A. Al-Mubarak

Saudi Medical Journal

OBJECTIVES: To evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis. METHODS: This 9-month multi-center, randomized, parallel, single-blinded study was conducted from different hospitals in Riyadh, Saudi Arabia between April 2010 and December 2010. A total of 76 diabetic subjects with chronic periodontitis were randomized into 2 groups: control group (CG) received only scaling and root planing (SRP), and the treatment group (TG) receiving systemic doxycycline during the reevaluation visit 45 days after the completion of SRP. Probing pocket depth, clinical attachment level, gingival index, plaque index, and bleeding on probing were …

Evaluating Initial Spine Trauma Response: Injury Time To Trauma Center In Pa, Usa., James Harrop, Md, George M. Ghobrial, Md, Rohan Chitale, Md, Kelly Krespan, Laura Odorizzi, Tristan Fried, Mitchell Maltenfort, Phd, Murray Cohen, Md, Alex R. Vaccaro, Md

Department of Neurosurgery Faculty Papers

Historical perceptions regarding the severity of traumatic spinal cord injury has led to considerable disparity in triage to tertiary care centers. This article retrospectively reviews a large regional trauma database to analyze whether the diagnosis of spinal trauma affected patient transfer timing and patterns. The Pennsylvania Trauma database was retrospectively reviewed. All acute trauma patient entries for level I and II centers were categorized for diagnosis, mechanism, and location of injury, analyzing transportation modality and its influence on time of arrival. A total of 1162 trauma patients were identified (1014 blunt injuries, 135 penetrating injuries and 12 other) with a …

Differential Effects Of Intermittent Versus Continuous Haloperidol Treatment Throughout Adolescence On Haloperidol Sensitization And Social Behavior In Adulthood, Jun Gao, Ming Li

Department of Psychology: Faculty Publications

Animal work on the behavioral effects of antipsychotic treatment suggests that different dosing regimens could affect drug sensitivity differently, with an intermittent treatment regimen tending to cause a sensitization effect, while a continuous treatment causing a tolerance. In this study, we explored how haloperidol (HAL) sensitization induced throughout adolescence and tested in adulthood was differentially impacted by these two dosing regimens in the conditioned avoidance response (CAR) test.We also examined howthese two dosing regiments affected social interaction and social memory in adulthood. Male adolescent Sprague-Dawley rats were treated with HAL via either osmotic minipump(HAL-0.25 CONT; 0.25mgkg⁻¹ day⁻¹, …

White-Tailed Deer Response To Vehicle Approach: Evidence Of Unclear And Present Danger, Bradley F. Blackwelll, Thomas W. Seamans, Travis L. Devault

United States Department of Agriculture Wildlife Services: Staff Publications

The fundamental causes of animal-vehicle collisions are unclear, particularly at the level of animal detection of approaching vehicles and decision-making. Deer-vehicle collisions (DVCs) are especially costly in terms of animal mortality, property damage, and safety. Over one year, we exposed free-ranging white-tailed deer (Odocoileus virginianus) to vehicle approach under low ambient light conditions, from varying start distances, and vehicle speeds from 20 km/h to approximately 90 km/ h. We modeled flight response by deer to an approaching vehicle and tested four hypotheses: 1) flight-initiation distance (FID) would correlate positively with start distance (indicating a spatial margin of safety); …

A Comparison Of The Caulobacter Na1000 And K31 Genomes Reveals Extensive Genome Rearrangements And Differences In Metabolic Potential, Kurt Ash, Theta Brown, Tynetta Watford, Latia E. Scott, Craig Stephens, Bert Ely

Faculty Publications

The genus Caulobacter is found in a variety of habitats and is known for its ability to thrive in low-nutrient conditions. K31 is a novel Caulobacter isolate that has the ability to tolerate copper and chlorophenols, and can grow at 4°C with a doubling time of 40 h. K31 contains a 5.5 Mb chromosome that codes for more than 5500 proteins and two large plasmids (234 and 178 kb) that code for 438 additional proteins. A comparison of the K31 and the Caulobacter crescentus NA1000 genomes revealed extensive rearrangements of gene order, suggesting that the genomes had been randomly scrambled. …

Unh Welcomes New Faculty Members, Tracey Bentley

UNH Today Archive

No abstract provided.

The Anonymous Theology Of Modern Family, Conor M. Kelly

Theology Faculty Research and Publications

The popular television show Modern Family follows sitcom conventions and attempts to send a moral message about how relatives can live well together. An examination of the specific content of this message shows that it prioritizes self-giving love for the sake of forgiveness and reconciliation. This creates a recognizable parallel with the Christian conception of agape, and a discussion of this notion in the work of Karl Rahner in conjunction with his idea of the “anonymous Christian” allows for the identification of Modern Family’s moral vision as an anonymous theology of family ripe with theological significance and pedagogical potential.

Contractualizing Custody, Sarah Abramowicz

Fordham Law Review

     Many scholars otherwise in favor of the enforcement of family contracts agree that parent-child relationships should continue to prove the exception to any contractualized family law regime. This Article instead questions the continued refusal to enforce contracts concerning parental rights to children’s custody. It argues that the refusal to enforce such contracts contributes to a differential treatment of two types of families: those deemed “intact”—typically consisting of two married parents and their offspring—and those deemed non-intact. Intact families are granted a degree of freedom from government intervention, provided that there is no evidence that children are in any danger of …

The Effects Of Cannabidiol On The Electrical And Contractile Properties Of Cardiomyocytes, Ramez Ali Mansour

Theses

In earlier studies, cannabidiol (CBD), a major nonpsychotropic cannabinoid found in cannabis plant, has been shown to influence cardiovascular functions under various physiological and pathological conditions. In the present study, the effects of CBD on contractility and electrical properties of rat ventricular myocytes were investigated. Video edge detection was used to measure myocyte shortening. Intracellular Ca2+ was measured in cells loaded with the fluorescent indicator fura-2 AM. CBD (1 μM) caused a significant decrease in the amplitudes of electrically-evoked myocyte shortening and Ca2+ transients. However, the amplitudes of caffeine-evoked Ca2+ transients and the rate of recovery of electrically-evoked Ca2+ transients …

Distributed Event Detection In Sensor Networks Under Random Spatial Deployment, P. Zhang, G. Peters, I. Nevat, G. Xiao, Hwee-Pink Tan

Research Collection School Of Computing and Information Systems

We present a novel event detection algorithm in sensor networks for the case where the sensors are randomly deployed in space. In particular we consider a random sensors deployment according to a Homogeneous Finite Binomial Point Process. We first derive the optimal event detection decision rule. We then develop a novel algorithm to evaluate the intractable marginal likelihood based on the Gram-Charlier series expansion. We evaluate our algorithms through extensive Monte Carlo simulations. Simulation results present the detection and false alarm rates for different system parameters such as number of sensors deployed, deployment region size etc.

An International Short Course For Training Professionals As Effective Science Communicators, Dilshani Sarathchandra, Karim M. Maredia

Journal of Extension

Scholars have recognized a need for educational programs that prepare scientists, Extension practitioners, and other stakeholders to communicate science effectively. Such programs have the potential to increase public awareness and aid policy development. Having recognized this need, faculty at Michigan State University (MSU) developed an "international short course in science and technology communication" that was offered at MSU from 2010 to 2012. This article provides an overview of the design, implementation, and impact assessment of the course. We also share lessons learnt from this program and provide suggestions for other similar programs.

Utility Of On-Farm Research Reports, Harold D. Watters, Wm. Bruce Clevenger

Journal of Extension

The Ohio State University Agronomic Crops Team has published peer-reviewed on-farm research reports since 1997, with 10 years as an on-line publication. With 367 reports published to date, the Team reviewed the value and use of the material. Seven categories account for 74% of the reports, with fertility management the largest group. While some reports get widespread attention, this is often due to state specialist recognition. More needs to be done to promote the research results and the potential of the website to growers, industry, and other university users.

Factors Influencing Latino Participation In Community-Based Diabetes Education, Sarah L. Francis, Amber Noteman, Ruth Litchfield

Journal of Extension

An Extension diabetes program (DP) was revised for Latinos; however, participation was limited. Factors influencing low participation rates were examined. Five Latinos interested in the DP participated in a focus group discussion. Transcripts were analyzed for themes. Preferred education programs were multi-session, local, group classes led by an engaging teacher during the summer. Participants learned of the DP through friends and Extension; preferred marketing strategies were Spanish radio, local health clinics, and Spanish-print media. Attendance barriers included scheduling conflicts. Limited use of culturally preferred marketing and scheduling conflicts were likely barriers. Culturally appropriate programs should use culturally preferred marketing strategies …

Assessment Of The Adoption Of Agroforestry Technologies By Limited-Resource Farmers In North Carolina, Paula E. Faulkner, Bismark Owooh, Joshua Idassi

Journal of Extension

Agroforestry is a natural resource management system that integrates trees, forages, and livestock. The study reported here was conducted to determine farmers' knowledge about and willingness to adopt agroforestry technologies in North Carolina. The study reported participants were primarily older, male farmers, suggesting the need to attract more females and younger individuals to adopt agroforestry technologies. The increasing number of diversified farm operators presents a new audience for Extension educators to offer programs to improve limited-resource farmers' livelihood. The study recommends Extension training programs and information centers for farmers who need skills and knowledge to manage agroforestry technologies.

Crystal Structure Of (E)-13-{4-[(Z)-2-Cyano-2-(3,4,5-Trimethoxyphenyl)Ethenyl]Phenyl}Parthenolide Methanol Hemisolvate, Narsimha Reddy Penthala, Shobanbabu Bommagani, Venumadhav Janganati, Sean Parkin, Peter A. Crooks

Chemistry Faculty Publications

The title compound, C₃₃H₃₅NO₆ [systematic name: (Z)-3-(4-{(E)-[(E)-1a,5-dimethyl-9-oxo-2,3,7,7a-tetra­hydro­oxireno[2′,3′:9,10]cyclo­deca­[1,2-b]furan-8(1aH,6H,9H,10aH,10bH)-yl­idene]meth­yl}phen­yl)-2-(3,4,5-tri­meth­oxy­phen­yl)acrylo­ni­trile methanol hemisolvate], C₃₃H₃₅NO₆·0.5CH₃OH, was prepared by the reaction of (Z)-3-(4-iodo­phen­yl)-2-(3,4,5-tri­meth­oxy­phen­yl)acrylo­nitrile with parthenolide [systematic name: (E)-1a,5-dimethyl-8-methyl­ene-2,3,6,7,7a,8,10a,10b-octa­hy­dro­oxireno[2′,3′:9,10]cyclo­deca­[1,2-b]furan-9(1aH)-one] under Heck reaction conditions. The mol­ecule is built up from fused ten-, five- (lactone) and three-membered (epoxide) rings with a {4-[(Z)-2-cyano-2-(3,4,5-tri­meth­oxy­phen­yl)ethen­yl]phen­yl}methyl­idene group as a substituent. The 4-[(Z)-2-cyano-2-(3,4,5-tri­meth­oxy­phen­yl)ethen­yl]phenyl group on the parthenolide exocyclic double bond is …

Human Sexuality As A Critical Subfield In Social Work, Emily Mccave, Benjamin C. Shepard, Virginia Ramseyer Winter

Publications and Research

Human sexuality is of vital importance to social work practitioners, educators, and scholars. Yet historically, the profession’s leadership around it has waxed and waned, impacting practice. This article discusses the importance of human sexuality as a critical subfield within social work. It suggests that the mechanisms, namely textbooks, journals, and national conferences, for stimulating human sexuality social work scholarship are limited. The authors assert that the taboo of human sexuality limits the advancement of a cohesive professional discourse and contributes to the continued oppression of marginalized populations. Recommendations for providing better support for those who study, teach, and practice in …

Characterization Of Metal-Reducing Microorganisms In Walker Lake: A Terminal Saline Desert Lake, Memona Khan

Honors College Theses

Metal-reducing microorganisms are increasingly being recognized as an essential component of aquatic microbial ecosystems involved in decomposition of organic matter. Alkaliphilic microbial reduction from alkaline lakes is a little studied field and one particular ecosystem, Walker Lake, presents the opportunity to investigate alkaliphilic metal reducers in their native ecological setting. Walker lake is a terminal, saline, desert lake with pH 9.4, Walker Lake samples of surface and deep sediments and water column samples from 0, 10, 5, 15, 17.5, 19 m depths were cultured by serial dilution in synthetic Walker Lake medium and supplemented separately with Hydrous Ferric Oxide (HFO), …

Former Mentors' Perceptions Of The Faith-Based Approach To Reducing Recidivism Implemented By The Marinette-Menominee Jail Outreach, Inc., James Langteau

Doctoral Dissertations and Projects

The purpose of this qualitative, hermeneutic phenomenological study was to examine the impact of a faith-based approach to reduce recidivism. The theoretical frameworks guiding this study included the belief system and self-efficacy theories. Participants consisted of a convenience sample of 21 former mentors of the Marinette-Menominee Jail Outreach. The setting was a Christian non-profit organization serving the Marinette and Menominee County Jails located in rural northern Wisconsin and the Upper Peninsula of Michigan. Semistructured interviews, surveys, and a focus group provided data to illuminate common themes. Data analysis included highlighting significant statements from volunteer mentors who engaged offenders to effect …

Fetal Alcohol Spectrum Disorder: How Children Are Impacted Throughout Their Lives, Tytiana Davis

Research Papers

AN ABSTRACT OF THE RESEARCH PAPER

Tytiana Davis, for the Master of Science degree in Rehabilitation Counseling, presented on November 7, 2014, at Southern Illinois University Carbondale.

TITLE: FETAL ALCOHOL SPECTRUM DISORDER: HOW CHILDREN ARE IMPACTED THROUGHOUT THEIR LIVES

MAJOR PROFESSOR: Thomas D. Upton

The following research paper will be completed on the importance of Fetal Alcohol Spectrum -Disorder, and how children are possibly affected later in life and the impact it has on society. Fetal Alcohol Spectrum Disorder includes Full Blown Fetal Alcohol Syndrome (FAS), Partial Fetal Alcohol Syndrome (pFAS), Alcohol related neurodevelopmental disorder (ARND), Alcohol Related Birth Defects …

Saint Mary's Magazine - Fall 2014, Saint Mary's College Of California

Saint Mary's Magazine

No abstract provided.

A Comparative Assessment Of Hand Preference In Captive Red Howler Monkeys, Alouatta Seniculus And Yellow-Breasted Capuchin Monkeys, Sapajus Xanthosternos, Nasibah Sfar, Madhur Mangalam, Werner Kaumanns, Mewa Singh

Journal Articles

There are two major theories that attempt to explain hand preference in non-human primates–the ‘task complexity’ theory and the ‘postural origins’ theory. In the present study, we proposed a third hypothesis to explain the evolutionary origin of hand preference in non-human primates, stating that it could have evolved owing to structural and functional adaptations to feeding, which we refer to as the ‘niche structure’ hypothesis. We attempted to explore this hypothesis by comparing hand preference across species that differ in the feeding ecology and niche structure: red howler monkeys, Alouatta seniculus and yellow-breasted capuchin monkeys, Sapajus xanthosternos. The red …

Selective Elimination Of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 And Peitc, Kausar Begam Riaz Ahmed

Dissertations and Theses (Open Access)

Metastatic melanoma is amongst the most refractory of cancers. Drug resistance and lack of therapeutic selectivity are two main challenges to successful melanoma therapy. Herein, we investigated the mechanims of anticancer activity and therapeutic selectivity of two novel agents, 3β, 16β, 17α-trihydroxycholest-5-en-22-one 16-O-[2-O-4-methoxybenzoyl-β-D-xylopyranosyl]- [1→3]-2-O-acetyl-α-l-arabinopyranoside (OSW-1) and β-Phenylethyl Isothiocyanate (PEITC) in melanoma.

OSW-1 inhibited melanoma cell viability at nanomolar concentrations with minimal toxicity to normal melanocytes. Mechanistic studies revealed that OSW-1 suppressed Disialoganglioside 3 Synthase (GD3S) gene expression in melanoma cells, leading to inhibition of gangliosides GD3 and GD2. GD3 is an abundantly expressed melanoma …

Undoing Race? Reconciling Multiracial Identity With Equal Protection, Lauren Sudeall

Vanderbilt Law School Faculty Publications

The number of multiracial individuals in America, many of whom define their racial identity in different ways, has grown dramatically in recent years and continues to increase. From this demographic shift a movement seeking unique racial status for multiracial individuals has emerged. The multiracial movement is distinguishable from other race-based movements in that it is primarily driven by identity rather than the quest for political, social, or economic equality. It is not clear how equal protection doctrine, which is concerned primarily with state-created racial classifications, will or should accommodate multiracialism. Nor is it clear how to best reconcile the recognition …

The Language Of Mens Rea, Owen D. Jones, Matthew R. Ginther, Francis X. Shen, Richard J. Bonnie, Morris B. Hoffman, Rene Marois, Kenneth W. Simons

Vanderbilt Law School Faculty Publications

To be guilty of a crime, generally one must commit a bad act while in a culpable state of mind. But the language used to define, partition, and communicate the variety of culpable mental states (in Latin, mens rea) is crucially important. For depending on the mental state that juries attribute to him, a defendant can be convicted-for the very same act and the very same consequence-of different crimes, each with different sentences.

The influential Model Penal Code ("MPC") of 1962 divided culpable mental states into four now-familiar kinds: purposeful, knowing, reckless, and negligent.' Both before the MPC and since, …