Digital Commons Network^™

The Talk Of Unwed Adolescent Fathers Of Mexican Origin: A Discourse Analysis, Jose Arturo Jaime

Open Access Theses & Dissertations

Since the 1970s, changing family and marriage trends in the United States have led to a dramatic 41% increase in the rate of unwed parents also known as fragile families, i.e., those at high risk of living in poverty and/or disintegrating (McLanahan, Garfinkel, Mincy, & Donahue, 2013, p.3). By 2011, more than 20 million children (28%) lived in biological father-absent homes and one-fourth, or five million, of these children were Hispanic of any race (U.S. Census Bureau, 2012). Recent studies suggest a clear disparity in cognitive, behavioral and health outcomes for children who live with single or cohabiting parents when …

Mechanisms To Mitigate Neurodegeneration By Maintaining Mitochondrial Health, Parijat Kabiraj

Open Access Theses & Dissertations

Cerebral accumulation of amyloidogenic protein aggregates is most frequently observed in the pathogenesis of neurodegenerative diseases. Recent studies showed prion like spreading of beta amyloid (A beta) in Alzheimer's disease (AD) and alpha synuclein protein in Parkinson's disease (PD) brain. Failure or compromise to the chaperone activity of protein disulfide isomerase (PDI) is also been reported as a major factor of aggregate formation. Nitrosative stress mediated S-nitrosylation (SNO) of protein disulfide isomerase (PDI), a housekeeping oxidoreductase, has been implicated in the pathogenesis of sporadic PD and AD. Mitochondrial dysfunction, leading to elevated levels of reactive oxygen species (ROS), is associated …

Revision Of The Ant Genus Bothroponera (Hymenoptera: Formicidae: Ponerinae) From The African Continent, Abdulmeneem Joma

Open Access Theses & Dissertations

Abstract (chapter 1)

The Afrotropical ants in the genus Bothroponera include the pumicosa, talpa, and sulcata species complexes. Species in the Bothroponera pumicosa species complex are mainly distributed in the southern part of Africa. This group of ants is characterized by having coarsely foveolate sculpture and by having either a raised a "v" or "u" shaped anterior medial area of the clypeus (anteclypeus), with or without a carina. The mandibles have 7 teeth in the majority of species and 8 teeth in the others. The eyes are relatively large. The scapes usually do not reach the posterior lateral corner of …

Glycine Transporter 2: Expression And Interactions In The Central Nervous System., Shweta Lavania

Open Access Theses & Dissertations

Glycine is an important inhibitory neurotransmitter that is localized in the caudal areas of the nervous system and plays an important role in mediating many important functions related to breathing, spinal reflexes, nociception etc. Termination of neurotransmission is achieved by the re-uptake of glycine back into the pre- synaptic neuron and neighboring glial cells by the two glycine transporters namely Glycine transporter 1 (GlyT1) and Glycine transporter 2 (GlyT2). These transporters play an essential role in regulating glycinergic inhibition in the central nervous system by controlling the duration and intensity of neurotransmission and therefore the efficacy of synaptic inhibition as …

P90/Cip2a Regulates Lung Cancer Cell Proliferation And Cell Apoptosis Via The Akt Signaling Pathway, Ningjing Lei

Open Access Theses & Dissertations

Cancerous inhibitor of PP2A (CIP2A) is an intracellular endogenous protein phosphatase 2A (PP2A) inhibitor with oncogenic activities. Initially identified as a tumor-associated antigen (TAA) in gastric and liver cancer patients, CIP2A was overexpressed in a variety of cancer types. And the overexpression of CIP2A in cancer cell is associated with increased cell proliferation and decreased cell apoptosis. However, the mechanism of CIP2A in cancer progression is still poorly understood. Here, we reported the evidence that CIP2A can regulate AKT phosphorylation at S473 under growth factor stimulation and our results also showed that CIP2A might regulate cell proliferation and cell apoptosis …

Characterization Of Membrane Interaction Of Mycobacterium Tuberculosis Esat-6, Yue Ma

Open Access Theses & Dissertations

Mycobacterium tuberculosis (Mtb) targets alveolar macrophages and has a high tolerance to the macrophage's antimicrobial effectors, such as low pH, reactive oxygen species, and reactive nitrogen species. It has been reported and widely accepted that Mtb disarms macrophages through arresting the normal maturation process of the phagosomes. Inhibition of phagosome-lysosome fusion and phagosome acidification is an effective survival strategy at the early stage of infection. This behavior allows Mtb to remain and replicate within the phagosomes of macrophages. At the later stage of infection, the pathogen translocates from the phagolysosomal compartments into the cytosol of host cells by phagolysosomal rupture. …

Structural Investigation Of The Molecular Chaperonin Tf55 From Thermophilic Archaeon Sulfolobus Solfataricus, Sanjay Kumar Molugu

Open Access Theses & Dissertations

Chaperonins are ubiquitous multi-subunit macromolecules that mediate the folding and assembly of certain proteins that cannot fold properly in vivo. The Archaea bacterium Sulfolobus solfataricus encodes for three chaperonin complexes formed from three different, but closely related subunits named alpha,betaand Gamma. These subunits form a homo-18mer composed of all beta subunits at temperatures ranging between 80oC-85oC, a hetero-16mer composed of alpha and beta subunits at temperatures ranging between 70oC-75oC and a hetero 18mer composed of alpha, beta and gamma subunits at temperatures of 60oC. Structures exist for the chaperonin TF55 all-beta complex and for the TF55 alpha-beta complex but not …

Functional Genomic And Proteomic Analysis Of Highly Drug Resistant Chronic Myeloid Leukemia, Derrick Matthew Oaxaca

Open Access Theses & Dissertations

Chronic Myeloid Leukemia (CML) has served as a model for how cancer can be selectively targeted with advanced forms of chemotherapies known as kinase inhibitors. Such new therapies have significantly altered the field of oncology and have led to monumental increases in both survival rates and quality of life for cancer patients. However, approximately one-third of CML patients will go on to develop drug resistance against major kinase inhibitors. Along with this, other cancers are showing increased incidences of drug resistance. Understanding how these cancers, such as CML, overcome drug sensitivity is of major importance within the clinic. To predict …

Redemption Store, Tia Palsole

Open Access Theses & Dissertations

This Thesis attempts to articulate the difficulties inherent in mother-daughter relationships through short literary fiction where the protagonists are either mothers, daughters, or both. The short stories are set in two fictional southern towns in North Carolina and South Carolina and use interrelated characters and settings to enhance the sense of connectivity, as well as to highlight occurrences of disconnection and isolation.

The ten short stories are arranged chronologically, beginning in the 1930s and culminating with the final story, set in 2013. Recurring characters provide continuity and structure to the collection. Thematic elements emphasize socioeconomic, racial, and gender inequities of …

Effects Of Cerium Oxide Nanoparticles In Cereals: Insights Into The Toxicity Mechanisms And Macromolecular Modifications, Cyren Mendoza Rico

Open Access Theses & Dissertations

Despite the inundation of studies on the interaction of engineered nanomaterials (ENMs) with plants, investigations involving complete life cycle (i.e from seedling establishment to full maturity) are still lacking. Assessments on the nutritional value of plants cultivated to full maturity in ENMs-treated soil are also missing. Cerium oxide nanoparticles (nCeO2) have significant interactions with plants; however, there are no life cycle studies yet on their implications in cereals like rice (Oryza sativa L.), wheat (Triticum aestivum L.), and barley (Hordeum vulgare L.). These cereals are globally important crops that support the economic activity, and nutritional and health needs of billions …

Design And Development Of Implantable And Remote Controlled Distraction Osteogenesis Device For Limb Lengthening Practice In Children, Mario Eduardo Rodriguez De La O

Open Access Theses & Dissertations

Recent technology improvements have been positively affecting medical industry in recent years since procedures and equipment are more precise and reliable. Nevertheless, there are still surgical procedures and medical devices that not fully address specific needs according to medical experts. One of those necessities is focused on options available for children patients when subjected to a surgical procedure named distraction osteogenesis. In general, distraction osteogenesis is performed when skeletal deformities need to be corrected or when bone lengthening is required, typically a mechanism is utilized to elongate bone at a controlled rate. The existing osteodistraction methods for limb lengthening and …

Biofuel Feedstock Optimization Considering Different Land Cover Scenarios And Watershed Impacts, Rodney Wayne Vance

Open Access Theses & Dissertations

With an increased demand for renewable energy production, especially the conversion of biomass to biofuels, perennial grasses are gaining interest as a renewable source of biofuel feedstocks. Identifying the trade-offs between bioenergy crop cultivation and nutrient runoff, erosion, and water requirements will be important as the demand for these crops continues to grow. The primary objective of this study is develop an integrated optimal control model that estimates the potential effects on water quality and demand and soil erosion from cultivating switchgrass and other perennial grasses instead of conventional crops at the watershed scale. The Soil and Water Assessment Tool …

Exploring The Hydrogeologic Controls On Brackish Water And Its Suitability For Use In Hydraulic Fracturing: The Dockum Aquifer, Midland Basin, Texas, Francisco Ruben Reyes

Open Access Theses & Dissertations

Water scarcity in arid regions can limit or impede certain hydrocarbon production activities, such as hydraulic fracturing and well drilling. The Midland Basin, a major oil-producing area in semi-arid far west Texas and the eastern sub-basin of the Permian Basin, is already impacted by limited freshwater availability. A typical tight oil well in the Midland Basin requires ~3.8–11.4 × 103 m3 of water per fracture treatment (Nicot et al., 2012). Despite draught conditions and limited resources, data for 2011 indicate freshwater comprises ~70% of the water used in hydraulic fracturing in the Midland basin. Thus, the Midland Basin represents an …

Isomerase Activity Of Candida Rugosa Lipase In Conversion Of Racemic Ibuprofen To (S)-Ibuprofen, Saideh Sadat Mortazavi

Open Access Theses & Dissertations

The Candida rugosa lipase-catalyzed Dynamic Kinetic Resolution of racemic ibuprofen methyl ester was optimal at pH 7.6 to produce (S)-ibuprofen in 72 hours. The concentration of various buffers for these reactions ranged from 0.2 to 0.5 M. The commercial lipase was found to be acidic altering the final pH of the reaction mixtures. Dimethylformamide co-solvent maintained the reaction pH better than dimethylsulfoxide, with evidence of the latter functioning as an oxidizing agent. Lower concentrations of ibuprofen methyl ester and higher stirring rates led to faster conversions. The minimal amount of lipase needed was 20 mg/mL buffer. Reaction of (R)-ibuprofen methyl …

Exploring The Hydrogeologic Controls On Brackish Water And Its Suitability For Use In Hydraulic Fracturing: The Dockum Aquifer, Midland Basin Texas, Francisco Ruben Reyes

Open Access Theses & Dissertations

Water scarcity in arid regions can limit or impede certain hydrocarbon production activities, such as hydraulic fracturing and well drilling. The Midland Basin, a major oil-producing area in semi-arid far west Texas and the eastern sub-basin of the Permian Basin, is already impacted by limited freshwater availability. A typical tight oil well in the Midland Basin requires ~3.8-11.4 x 103 m3 of water per fracture treatment (Nicot et al., 2012). Despite draught conditions and limited resources, data for 2011 indicate freshwater comprises ~70% of the water used in hydraulic fracturing in the Midland basin. Thus, the Midland Basin represents an …

Use Of Cosine Modulated Filter Bank To Quantify Human Muscle Fatigue Using Electromyography Signals Obtained During Isometric Voluntary Contractions, Liza Stephanie Rodriguez

Open Access Theses & Dissertations

As technology continues to advance, there continues to be an interest in applying engineering theories to solve medical problems. Technology has allowed researchers to investigate the properties and characteristics of the human body in hopes of emulating their complexities. The rising interest in the study of biopotentials for use in prosthetic limbs, exoskeletons and machine interfacing has led to a necessity to validate that the understanding of these signals is accurate. The study of biopotentials generated by muscles via a method known as electromyography (EMG) has improved the understanding of effects of rehabilitative treatments, assisted in diagnosing diseases, control of …

Determination Of The Uptake And Effects Of Tio2 Nanoparticles In Cucumber (Cucumis Sativus), Alia D. Servin

Open Access Theses & Dissertations

The profuse use of nanoparticles (NPs) in consumer products has raised concerns about their impacts in environmental and human health and possible transfer into the food chain through plants. Cucumber (Cucumis sativus L.) is a widely cultivated garden vegetable that could be in contact with NPs through biosolids. In this Dissertation research, the impact of TiO2 NPs was evaluated in cucumber plants grown in hydroponics and sandy loam soil. Hydroponically grown plants were treated for 15 days with 0-4000 mg/L of TiO2 NPs, and their vegetative tissues were studied using synchrotron micro X-Ray Fluorescence (micro-XRF) and Micro X-ray Absorption Near …

A Robust Algorithm For Estimating The Balance Of Autonomic Nervous System With Application To Mental Fatigue Detection Using Photoplethysmographic (Ppg) Signals, Ajay Kumar Verma

Open Access Theses & Dissertations

Spectral- and time-domain analysis of Heart Rate Variability (HRV) signal is widely used as a quantitative marker of the Autonomic Nervous System (ANS) activity. A robust algorithm was developed to derive HRV from photoplethysmographic (PPG) signals, to compute FFT- and AR-based spectra of these HRV signals, and to determine time- and frequency-domain features. This algorithm has detrending, sample-rate reductions, false-peak removal, automatic peak detection, peak-to-peak (P-P) interval detection and correction, time-domain feature extraction, HRV signal generation, and spectral-domain feature extraction from the HRV signal. Adapting to the very low spectral contents of the input PPG signal is very helpful in …

Toward A Theory Of Productivity Problems In Graduate Student Writing, Craig Wynne

Open Access Theses & Dissertations

This case study focuses on the productivity problems that faced the dissertation/thesis writing practices of fourteen graduate students at a public university on the U.S./Mexico border. The author facilitated a series of group sessions designed to help graduate students in various disciplines cultivate awareness of Donald Murray's notion of "writing as process," as well as knowledge of writer's block and writing anxiety. Sessions also served to cultivate positive self-talk with relation to the writing process, an introduction to mindfulness meditation, and basic time management skills. Four types of data were collected: 1. field notes from participant discussion during workshop sessions; …

North Korean Supernotes: Nuclear Arms Financed By Counterfeit Currency, Michael Yatskievych

Open Access Theses & Dissertations

Michael Yatskievych, University of Texas at El Paso

Abstract of Master's Thesis, Submitted 21 May 2014:

North Korean Supernotes: Nuclear Arms Financed By Counterfeit Currency

The primary purpose of this study was to evaluate whether DPRK is producing high quality counterfeit US currency, supernotes, and has determined to what extent supernotes are financing North Korea's emerging nuclear arms program.

The application of Analysis of Competing Hypotheses, ACH, satisfied this study's purpose by meeting the following objectives: the development of multiple hypotheses in an attempt to explain a supernote-nuclear arms program link, assessing evidence from assorted sources, providing a diagnostic weighing …

Grassland Sustainability In Kentucky: Case Studies Quantifying The Effects Of Climate Change On Slug Herbivory In Pastures And Different Home Lawn Systems On Turf Greenhouse Gas Emissions, Daniel Adam Weber

Theses and Dissertations--Plant and Soil Sciences

Grasslands comprise the greatest biome by land area, are sensitive to environmental factors affected by climate change, and can impact future climate change through their ability to store and release greenhouse gasses (GHGs). I performed two studies: 1) evaluated the effects of increased temperature and precipitation on slug herbivory/abundance and pasture forage production; 2) quantified different homeowner lawn system effects on soil-to-atmosphere GHG emissions. Climate change will likely affect pasture forage production, with implications for slug herbivory and abundance. I found little evidence that slugs have or will have significant effects on pasture production or plant community. Warming altered the …

The Role Of Surface Chemistry In The Toxicity Of Manufactured Cerium Dioxide Nanomaterials To Caenorhabditis Elegans, Emily Kay Oostveen

Theses and Dissertations--Plant and Soil Sciences

Manufactured CeO₂ nanomaterials (CeO₂-MNMs) are used for a wide variety of applications including diesel fuel additives and chemical/mechanical planarization media. To test the effects of CeO₂-MNM surface coating charge on to model organism Caenorhabditis elegans, we synthesized 4 nm CeO₂ with cationic (DEAE-), anionic (CM-), and neutral (DEX) coatings. In L3 nematodes exposed for 24 hours, DEAE-CeO₂ induced lethality at lower concentrations than CM- or DEX-CeO₂. Feeding slightly decreased CeO₂ toxicity, regardless of coating. In L2 nematodes exposed for 48 hours with feeding, DEAE-CeO₂ caused lethality at the …

Understanding The Chemical Gymnastics Of Enzyme-Catalyzed 1’-1 And 1’-3 Triterpene Linkages, Stephen A. Bell

Theses and Dissertations--Plant and Soil Sciences

Squalene synthase (SS) is an essential enzyme in eukaryotic systems responsible for an important branch point in isoprenoid metabolism that leads to sterol formation. The mechanistic complexity of SS has made it a difficult enzyme to study. The green alga Botryococcus braunii race B possesses several squalene synthase-like (SSL) enzymes that afford a unique opportunity to study the complex mechanism of triterpene biosynthesis. SSL-1 catalyzes presqualene diphosphate (PSPP) formation, which can either be converted to squalene by SSL-2 or botryococcene by SSL-3. A rationally designed mutant study of B. braunii squalene synthase (BbSS) and SSL-3 was conducted to understand structure-function …

Understanding The Role Of Membrane Localized Ugt80b1 Encoding For Udp-Glucose: Sterol Glucosyltransferase In Plant Development, Meera Nair

Theses and Dissertations--Plant and Soil Sciences

Sterols have been identified as major components of membrane lipids that are part of specialized membrane domains necessary for organizing events such as polar protein targeting and signal transduction in plants, fungi and animals. However a common modification of sterols is the addition of sugar moieties via glycosylation abundantly found in plants. An exact physiological role for such diversification of sterols in plants is still unknown. Using reverse genetics and transcriptomics we show that UDP-glucose: sterol glucosyltransferase encoded by UGT80B1 is necessary for correct epidermal patterning in Arabidopsis root. Patterning of hair cells (trichoblasts) and non-hair cells (atrichoblasts) in the …

Coronavirus Proteases As Therapeutic Targets: Development Of Biosensors To Detect Inhibition Of Protease Activity And Separation Of The Multiple Functions Of Coronavirus Papain-Like Proteases, Andrew Kilianski

Dissertations

Coronaviruses are important human pathogens and have the potential to severely impact public health on an international scale. The emergence of SARS-CoV and MERS-CoV highlight the need for research to identify antivirals and vaccines against coronaviruses. To develop therapeutics against current and potentially emergent coronaviruses, I utilized two approaches targeting the proteases encoded within all coronaviruses. The papain-like protease and 3C-like protease of coronaviruses are responsible for cleaving viral polyproteins early during infection, and this step is required for viral replication. To quantitatively assess the inhibition by small-molecule compounds on MERS-CoV protease activity, I developed a luciferase-based biosensor to monitor …

The Restorative Justice Talking Circle Process With Probation Officers: A Phenomenological Approach, Constance Marie Sheehan

Dissertations

Restorative justice seeks to bring together stakeholders in the justice system by acknowledging harm caused by offending behavior and finding ways to repair that harm. The activities associated with restorative justice create the potential for meaningful and positive outcomes for all stakeholders within the system. Restorative justice asks, what is the harm?, who are the stakeholders?, and, how can the harm best be repaired? A particular restorative practice - the talking circle - is a common practice of restorative justice efforts. The potential for restorative justice practices, like the talking circle, is developing of a new way of understanding for …

A Revision Of Centaurea Sect. Centaurea (Asteraceae) From Iran, Massoud Ranjbar, Kazem Negaresh

Turkish Journal of Botany

A taxonomic review of Centaurea L. sect. Centaurea (Asteraceae) in Iran was carried out. Seven taxa are recognized and 1 of them is described as a new species: Centaurea joharchii Ranjbar & Negaresh. This new species has been described and illustrated from Khorasan Province, SE Iran. A new combination is proposed: C. kermanshahensis (Wagenitz) Ranjbar & Negaresh. In addition, C. aggregata Fisch. & C.A.Mey. ex DC. subsp. aggregata is typified and C. diffusa Lam. is reported here as a new record for Iran. Finally, a key to all species of the section Centaurea in Iran is provided.

Employee Wellness, Health Risk Assessment, Modifiable Health Risk, Pen-3 Model, Worksite Culture, Worksite Envirmonent, Stephanie R. Keteyian-Stacy

Master's Theses and Doctoral Dissertations

This study used an online Health Risk Appraisal (HRA) to assess individual employee health and eight additional statements to assess the worksite health "culture" of Eastern Michigan University. It was hypothesized there will be a relationship between EMU employees’ levels of self-reported health risk and their perceptions of supportiveness of the worksite environment and health culture. The results indicated the relationship between health risks of participants and perception of supportiveness of the worksite culture was not significant (p >.05). Of the employees that participated, the top three risk factors identified were body weight (20%), stress (14%), and blood pressure (10%). …

The Natural Complexity Of Patent Eligibility, Jacob S. Sherkow

Articles & Chapters

It has long been assumed that the doctrine of patent eligibility’s prohibition of patents on “laws of nature,” “natural phenomena,” and “products of nature” rests on legalistic interpretations of those terms. But there is good reason to doubt this assumption. Since the doctrine’s inception, the Supreme Court has yet to provide any framework, formula, or factors explaining these “natural” terms. Rather, the Court has increasingly fixated on a list of scientific tropes, such as gravity, the heat of the Sun, and extracted metals, that it believes are true examples of “natural laws,” “phenomena,” and “products.”

An actual examination of scientific …

Preliminary Injunctions Post-Mayo And Myriad, Jacob S. Sherkow

Articles & Chapters

The Supreme Court's recent interest in patentable subject matter has had several, unexpected downstream effects on preliminary injunctions in patent disputes.

The Supreme Court has recently expressed increased interest in patent eligibility, or patentable subject matter, the doctrine that limits the types of inventions eligible for patenting. Its two decisions, Mayo Collaborative Services v. Prometheus Laboratories, Inc., in 2012, and Association for Molecular Pathology v. Myriad Genetics, Inc., in 2013, represented the first broad restrictions on patentable subject matter in over thirty years. And later this term, the Court will decide yet another patent eligibility case: Alice Corp. v. CLS …