Digital Commons Network^™

Board Of Regents Meeting Materials, December 5, 2014, Eastern Michigan University

Board of Regents Meeting Materials

No abstract provided.

Board Of Regents Meeting Materials, October 7, 2014, Eastern Michigan University

Board of Regents Meeting Materials

No abstract provided.

Faculty Senate Minutes, March 19, 2014, Faculty Senate

Faculty Senate Minutes and Reports

No abstract provided.

Measuring Brain Iron In Healthy Controls And Accessing Venous Abnormalities In Parkinson's Disease Using Mri, Manju Liu

Wayne State University Dissertations

Iron plays a key role in a number of brain cellular processes. However, abnormal brain iron regulation correlates with a number of neurodegenerative diseases such as Parkinson's disease, multiple sclerosis and so forth. To further elucidate the involvement of iron in neurodegenerative disorders, a robust in vivo quantitative non-invasive assessment of normal brain iron deposition over time is essential. A variety of magnetic resonance imaging (MRI) methods have been used to quantify iron both in vivo and in vitro non-invasively. We first created the baseline of phase value and ∆R2^* as a function of age in seven gray matter nuclei. …

Isolation And Characterization Of Natural Antimicrobials From Plant And Marine Organisms, Corene Barbara Canning

Wayne State University Dissertations

Antibiotic agents have been found to have a limited lifespan due to the ability of microrganisms to develop antimicrobial resistance. In this study a number extracts of plant and marine organisms were evaluated for their antimicrobial activity against a number of high priority pathogens. Bioassay-guided fractionation of four extracts led to the identification of compounds with inhibitory activity; including one previously unknown compound. Compounds were evaluated through a variety of techniques including broth microdilution assay to determine each compound's MIC and MBC. The majority of the compounds showed antimicrobial activity equal to, if not better than, the commonly used antimicrobial …

Individual Differences In Pyschological Evaluations Of Electoral Risk: Furthering The Explanation Of The Gender Gap In Candidate Emergence, Jennie Sweet-Cushman

Wayne State University Dissertations

Despite decades of movement towards gender parity in other aspects of American society (e.g. education, business), women remain significantly underrepresented in the political realm. Electoral bias against women cannot be blamed; when women run, women win. However, women don't seek political office in high numbers. This project builds on previous examinations of the gender gap in political ambition by proposing that a contributing factor to the likelihood someone will seek political office is their perception of electoral risk. While there have been no studies of gender-based differences in psychological response to electoral risk, differences in risk assessment have been documented …

Characterization Of Bacteriophages From Environmental Water Samples And The Potential Of Bacteriophages Tailspike Proteins (Tsp) In Bacteria Detection, Gayathri Upeksha Gunathilaka

Wayne State University Theses

ABSTRACT

CHARACTERIZATION OF BACTERIOPHAGES FROM ENVIRONMENTAL WATER SAMPLES AND THE POTENTIAL OF BACTERIOPHAGES TAILSPIKE PROTEINS (TSP) IN BACTERIA DETECTION

by

GAYATHRI UPEKSHA GUNATHILAKA

May 2014

Advisor: Dr. Yifan Zhang

Major: Nutrition and Food Science

Degree: Master of Science

The high abundance of phage in the environment and their specificity with the bacteria host make them an excellent tool for bacteria detection. To characterize phage specific to Salmonella and E. coli from water samples in the Southeastern Michigan and to develop a novel bacterial detection method using phage, environmental water samples were collected from rivers and waste water treatment plant (WWTP) …

Defying Mandatory Motherhood: The Social Experiences Of Childfree Women, Braelin E. Settle

Wayne State University Theses

Research suggests motherhood is central to a woman's adult identity. In 2000, however, almost twice as many women ages 40-44 were childless than in 1980. Scholarship points to the social, economic, and attitudinal factors shaping the dramatic increase in the number of childfree women, many of whom are white, educated beyond high school, and upper-middle class. This qualitative case study focuses on the growing social phenomenon of childfree women in the United States. Using in-depth interviews, I examine the reasons behind women's decisions to remain childfree and the experiences of being childfree in their everyday lives. I focus on the …

Saudi Arabian Students In Detroit Use Natural Health Products More So Than Other University Students In Detroit, Samiah Naji Alqahtani

Wayne State University Theses

Natural Health Products (NHP), are defined as products that derive from organisms and may include supplements and herbal/traditional remedies. Prior research indicates that females use NHP more than males. We have unpublished data to show that students use NHP for health maintenance with significantly different use of NHP by Native/Aboriginal students vs. other students. Less is known about Saudi students. We hypothesize that: (1) There are gender differences in NHP used; and (2) There are geo-ethnic differences in NHP used. We also determine the predictor variables that influence NHP use by students. Students from Wayne State University (n=560; 193 …

The Phenotypic Analysis Of The Knockdown Of The Sin3a Complex Components And Their Role In Recruitment And Cell Proliferation, Kelly Ann Laity

Wayne State University Theses

The SIN3A-RPD3 complex components have previously been identified in Drosophila melanogaster. The role of these components in SIN3A function and recruitment was not known. Polytene chromosome analysis following RNAi knockdown was performed to determine if any of the complex members affect the ability of SIN3A to bind to chromatin. The complex components effect on cell proliferation was also examined through clonal analysis of imaginal wing discs. The results of this work implicate a role of several members of the SIN3A complex for proper recruitment and localization to chromatin. All of the SIN3A complex members had some varying effect on cell …

Present Futures: Possibilities For Selfhood At A Community Mental Health Center In Detroit, Michigan, Talia Gordon

Wayne State University Theses

Since the 1990s, recovery-oriented approaches to mental illness have become the dominant paradigm in contemporary U.S. non-clinical institutional settings. Central to the recovery paradigm is a discourse of self-determination that separates psychiatric pathology from personhood and expects those diagnosed to enact and manage themselves as autonomous subjects - as empowered, responsible, independent, and transformable. For many individuals, however, everyday experiences of illness are at odds with expectations for recovery, defined as a "process of change" through which the self is continuously worked upon and improved (SAMHSA 2011). One particularly popular non-clinical recovery modality is the Clubhouse model of psychosocial rehabilitation …

Site-Directed Mutagenesis Of Conserved Amino Acids Residues In N5-Carboxyaminoimidazole Ribonucleotide Mutase: Converting N5-Cair Mutase Into Aminoimidazole Ribonnucleotide Carboxylase & Developing A High-Throughput Screening Assay For The Discovery Of N5-Carboxyaminoimidazole Ribonucleotide Mutase, Zhiwen Shi

Wayne State University Theses

The de novo purine biosynthesis pathway plays a critical role in providing new purines to the cell. Previous studies have shown differences between the human and bacterial pathways which suggests that pathway may be a potential target for antibiotic drug discovery. Three critical enzymes are involved in the pathway divergence. In the bacterial pathway, N5-CAIR synthetase (PurK) first converts AIR to N5-CAIR, which is then transformed into CAIR catalyzed by the enzyme N5-CAIR mutase (Class I PurE). In the human pathway, AIR carboxylase (Class II PurE) catalyzes the direct conversion of AIR to CAIR. Class I and Class II PurEs …

Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury, Yi Dong

Wayne State University Dissertations

Mitochondrial fusion and fission, collectively termed mitochondrial dynamics, are among the core mechanisms responsible for maintaining mitochondrial health and functional integrity. Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission. Recent studies suggest that i) mitochondrial dynamics, particularly, mitochondrial fission, serves as a mediator of cell fate in the setting of ischemia-reperfusion (IR) injury, and, ii) inhibition of DRP1 and mitochondrial fission provides cardioprotection against IR injury. However, the precise role of DRP1 translocation to mitochondria in the pathogenesis of myocardial ischemia-reperfusion injury has not been established.

Using an established model of hypoxia-reoxygenation (HR) in cultured HL-1 cardiomyocytes, …

Characterization And Identification Of Novel Regulators Of The Synthesis Of Phospholipids, Cunqi Ye

Wayne State University Dissertations

Phospholipids are the most abundant lipids in cell membranes. The synthesis of phospholipids is crucial for cellular membrane biogenesis and nearly all aspects of cellular processes. Understanding the regulation of synthesis of phospholipids is beneficial to our fundamental knowledge of cell biology as well as human health.

Regulation of the synthesis of phospholipids is intensively studied in the yeast S. cerevisiae. Most notably, the synthesis of phospholipids is coordinated with the synthesis of inositol, a precursor of inositol-containing lipids, by controlling expression of the genes encoding phospholipid biosynthetic enzymes. In addition to this well-characterized regulatory circuit controlled by the …

Lost In Translation: Statistical Inference In Court, Erica Beecher-Monas

Law Faculty Research Publications

No abstract provided.

Adoption And The Limits Of Contract In Victorian Adoption Case Law And George Eliot's Silas Marner, Sarah Abramowicz

Law Faculty Research Publications

No abstract provided.

Democratic Education And Local School Governance, Justin R. Long

Law Faculty Research Publications

No abstract provided.

The Composition And Stability Of The Vaginal Microbiota Of Normal Pregnant Women Is Different From That Of Non-Pregnant Women, Roberto Romero, Sonia S. Hassan, Pawel Gajer, Adi L. Tarca, Douglas W. Fadrosh, Lorraine Nikita, Marisa Galuppi, Ronald F. Lamont, Piya Chaemsaithong, Jezid Miranda, Tinnakorn Chaiworapongsa, Jacques Ravel

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

This study was undertaken to characterize the vaginal microbiota throughout normal human pregnancy using sequence-based techniques. We compared the vaginal microbial composition of non-pregnant patients with a group of pregnant women who delivered at term.

Results

A retrospective case–control longitudinal study was designed and included non-pregnant women (n = 32) and pregnant women who delivered at term (38 to 42 weeks) without complications (n = 22). Serial samples of vaginal fluid were collected from both non-pregnant and pregnant patients. A 16S rRNA gene sequence-based survey was conducted using pyrosequencing to characterize the structure and stability of the vaginal …

Higher Bmi Is Associated With Reduced Brain Volume In Heart Failure, Michael L. Alosco, Adam M. Brickman, Mary Spitznagel, Atul Narkhede, Erica Y. Griffith, Naftali Raz, Ronald Cohen, Lawrence H. Sweet, Lisa H. Colbert, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Heart failure (HF) patients are at risk for structural brain changes due to cerebral hypoperfusion. Past work shows obesity is linked with reduced cerebral blood flow and associated with brain atrophy in healthy individuals, although its effects on the brain in HF are unclear. This study examined the association among body mass index (BMI), cerebral perfusion, and brain volume in HF patients.

Results

Eighty HF patients underwent transcranial Doppler sonography to quantify cerebral blood flow velocity of the middle cerebral artery (CBF-V of the MCA) and brain magnetic resonance imaging (MRI) to quantify total brain, total and subcortical …

Age-Friendly Environments And Self-Rated Health: An Exploration Of Detroit Elders, Amanda J. Lehning, Richard J. Smith, Ruth E. Dunkle

Social Work Faculty Publications

While a number of organizations and government entities have encouraged the development of more “age-friendly” environments, to date there has been limited research linking these environment features to elder outcomes. Using a representative sample of older adults living in Detroit, this study examined the association between age-friendly environment factors and self-rated health. Results indicated that access to health care, social support, and community engagement were each associated with better self-rated health, while neighborhood problems were associated with poorer self-rated health. Moreover, individual-level income and education no longer predicted self-rated health once age-friendly environment factors were taken into account. These findings …

Identifying Appropriate Sanctions For Youth Sexual Behavior: The Impact Of Age, Gender, And Sexual Orientation, Erin B. Comartin, Poco D. Kernsmith, Roger M. Kernsmith

Social Work Faculty Publications

Although statutory rape laws were initially developed to protect youth from coercion by adults, youth are sometimes also prosecuted under these laws. This article investigates public attitudes regarding sanctions for youth engaging in sexual behaviors with peers. Hierarchical linear modeling was used to determine if age and gender of the offending youth, and sexual orientation of the relationship,has an impact on the public's level of agreement for sanctioning youth for three types of sexual behavior: intercourse, oral sex, or touching. The study participants (N= 757) were drawn from the general population of adult Michigan residents; the sample was racially representative …

Characterisation Of The Vaginal Microflora Of Human Immunodeficiency Virus (Hiv) Positive And Negative Women In A Sub-Urban Population Of Kenya, Teresa N. Kiama, Rita Verhelst, Paul M. Mbugua, Mario Vaneechoutte, Hans Verstraelen, Benson Estambale, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Lactobacilli predominate normal vaginal microflora and are important in maintenance of vaginal health. The current study set out to identify and compare culture isolates of vaginal microflora of human immunodeficiency virus (HIV) positive (HIV+ ) and HIV negative (HIV- ) women at different phases during menstrual cycle from a sub-urban population of Kenya. Seventy four (74) women, 41 HIV+ and 33 HIV- , followed up two consecutive menstrual cycles, had high vaginal swabs taken to prepare Gram stains for six visits and anaerobic cultures for four. All 751 isolates identified by t-DNA polymerase chain reaction (PCR) belong to 51 species. …

Graduate Catalog, Georgia Southern University

Graduate Catalogs

No abstract provided.

Georgia Southern Magazine, Georgia Southern University

Georgia Southern Magazine

• Blink of an Eye
• First Class
• Double Major
• The Ride

Exhibition Catalogue — Imprints And Impressions: Milestones In Human Progress, Paul H. Benson, Sandra A. Yocum, Mark Masthay, Donald J. Polzella

Supplemental Media

Exhibition catalogue for Imprints and Impressions: Milestones in Human Progress — Highlights from the Rose Rare Book Collection. Includes an introduction by Kathleen M. Webb, dean of University Libraries; essays about the impact of the exhibition's books on modern inquiry, the humanities, the sciences, and the social sciences; and photographs of the works in the exhibit.

Identifying Factors Associated With The Uptake Of Prevention Of Mother To Child Hiv Transmission Programme In Tigray Region, Ethiopia: A Multilevel Modeling Approach, Wondwossen Lerebo, Steven Callens, Debra Jackson, Christina Zarowsky, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Prevention of mother to child HIV transmission (PMTCT) remains a challenge in low and middle-income countries. Determinants of utilization occur – and often interact - at both individual and community levels, but most studies do not address how determinants interact across levels. Multilevel models allow for the importance of both groups and individuals in understanding health outcomes and provide one way to link the traditionally distinct ecological- and individual-level studies. This study examined individual and community level determinants of mother and child receiving PMTCT services in Tigray region, Ethiopia.

Methods: A multistage probability sampling method was used for this …

Yerba Mate (Ilex Paraguariensis) Production, Agricultural Change, And Livelihood Security In Southeastern Paraguay, Mason Robert Bradbury

Graduate Student Theses, Dissertations, & Professional Papers

Smallholders in Southeastern Paraguay are threatened by the advance of mechanized farming, environmental degradation, and limited access to credit and inputs. Agroforestry initiatives have been proposed as a way to increase smallholder livelihood security in the face of such vulnerability. Yerba mate (Ilex paraguariensis) is a tree crop native to Paraguay that may be grown in agroforestry systems. While prices paid to farmers for yerba mate have increased in recent years, spurring interest and adoption of yerba mate production among some farmers, to this date, there have been no analyses of the effects that yerba mate production may have on …

Reflections On Presumed Incompetent: The Intersections Of Race And Class For Women In Academia Symposium--The Plenary Panel, Maritza I. Reyes, Angela Mae Kupenda, Angela Onwuachi-Willig, Stephanie M. Wildman, Adrien K. Wing

Journal Articles

Presumed Incompetent was produced thanks to the vision and commitment of its editors: Dr. Gabriella Gutiérrez y Muhs, Dr. Yolanda Flores Niemann, Carmen G. González, and Angela P. Harris. This symposium came to fruition because the Berkeley Journal of Gender, Law & Justice invited the two law professor editors, Professor Harris and Professor González, to convene a distinguished group of scholars from Canada and the United States to expand and deepen the conversation initiated by the book. The very successful day-long symposium and the publication of the resulting articles were made possible by the resources, time, and dedication provided by …

The Conceits Of Our Legal Imagination: Legal Fictions And The Concept Of Deemed Authorship, Alina Ng Boyte

Journal Articles

Legal fictions contain embedded nuggets of information about social reality and reveal important aspects of human society. However, the use of legal fictions may also obscure important information or fundamental questions about law and its role in shaping society. These fictions become institutionalized without a clear understanding of their function. When that happens, fallacious assumptions about human behavior and social relationships transform into binding principles that set the course for future legal development, potentially resulting in legal rules that are completely dissociated from social, historical, or cultural reality. This article explores the concept of deemed authorship as a legal fiction …

Deconstruction, Abjection, And Meaning In Contemporary Art: World Trends And The Byu Museum Of Art, Kirsti Ringger

BYU Studies

Visit any contemporary art exhibition in the world. You might be shocked, but it is unlikely that you will be surprised. You will probably see something huge and imposing—in fact, almost everything will be BIG. There will be appropriated pop culture images and graffiti, found objects in installation, photographs of the artist (probably in serial), and definitely electronics—video and neon and interactive computer-ish things. Perhaps there will be some naked people (and if there are, they will probably be posted all over the city as exhibition advertisements). There will be large-scale photographic social commentary, and, inevitably, there will be a …