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2014

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Cardiac Extracellular Proteome Profiling And Membrane Topology Analysis Using Glycoproteomics, Yuan Tian, Tejaswi Koganti, Zhihao Yao, Presley Cannon, Punit Shah, Laura Pietrovito, Alessandra Modesti, Paul Aiyetan, Kristine Deleon-Pennell, Yonggang Ma, Ganesh V. Halade, Chindo Hicks, Hui Zhang, Merry L. Lindsey Jan 2014

Cardiac Extracellular Proteome Profiling And Membrane Topology Analysis Using Glycoproteomics, Yuan Tian, Tejaswi Koganti, Zhihao Yao, Presley Cannon, Punit Shah, Laura Pietrovito, Alessandra Modesti, Paul Aiyetan, Kristine Deleon-Pennell, Yonggang Ma, Ganesh V. Halade, Chindo Hicks, Hui Zhang, Merry L. Lindsey

Internal Medicine Faculty Publications

Purpose: Extracellular proteins are easily accessible, which presents a subproteome of molecular targets that have high diagnostic and therapeutic potential. Efforts have been made to catalog the cardiac extracellular matridome and analyze the topology of identified proteins for the design of therapeutic targets. Although many bioinformatics tools have been developed to predict protein topology, topology has been experimentally validated for only a very small portion of membrane proteins. The aim of this study was to use a glycoproteomics and MS approach to identify glycoproteins in the extracellular matridome of the infarcted left ventricle (LV) and provide experimental evidence for topological …

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Streptococcus Pneumoniae Translocates Into The Myocardium And Forms Unique Microlesions That Disrupt Cardiac Function, Armand O. Brown, Beth Mann, Geli Gao, Jane S. Hankins, Jessica Humann, Jonathan Giardina, Paola Faverio, Marcos I. Restrepo, Ganesh V. Halade, Eric M. Mortensen, Merry L. Lindsey, Martha Hanes, Kyle I. Happel, Steve Nelson, Gregory J. Bagby, Jose A. Lorent, Pablo Cardinal, Rosario Granados, Andres Esteban, Claude J. Lesaux, Elaine I. Tuomanen, Carlos J. Orihuela Jan 2014

Streptococcus Pneumoniae Translocates Into The Myocardium And Forms Unique Microlesions That Disrupt Cardiac Function, Armand O. Brown, Beth Mann, Geli Gao, Jane S. Hankins, Jessica Humann, Jonathan Giardina, Paola Faverio, Marcos I. Restrepo, Ganesh V. Halade, Eric M. Mortensen, Merry L. Lindsey, Martha Hanes, Kyle I. Happel, Steve Nelson, Gregory J. Bagby, Jose A. Lorent, Pablo Cardinal, Rosario Granados, Andres Esteban, Claude J. Lesaux, Elaine I. Tuomanen, Carlos J. Orihuela

Internal Medicine Faculty Publications

Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by the occurrence of an adverse cardiac event; these are primarily new or worsened heart failure and cardiac arrhythmia. Herein, we describe previously unrecognized microscopic lesions (microlesions) formed within the myocardium of mice, rhesus macaques, and humans during bacteremic Streptococcus pneumoniae infection. In mice, invasive pneumococcal disease (IPD) severity correlated with levels of serum troponin, a marker for cardiac damage, the development of aberrant cardiac electrophysiology, and the number and size of cardiac microlesions. Microlesions were prominent in the ventricles, vacuolar in appearance with extracellular pneumococci, and remarkable due …

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Narrowing The Gender Pay Gap By Providing Equal Opportunities: The Need For Tenured Female Professors In Higher Stem Institutions In An Effort To Recast Gender Norms, Claire R. Rollor Jan 2014

Narrowing The Gender Pay Gap By Providing Equal Opportunities: The Need For Tenured Female Professors In Higher Stem Institutions In An Effort To Recast Gender Norms, Claire R. Rollor

Student Articles and Papers

No abstract provided.

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Uri Undergraduate And Graduate Course Catalog 2014-2015, University Of Rhode Island Jan 2014

Uri Undergraduate And Graduate Course Catalog 2014-2015, University Of Rhode Island

URI Course Catalogs Archive

This is a downloadable PDF version of the University of Rhode Island course catalog.

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Histoplasmosis Presenting As Granulomatous Hepatitis: Case Report And Review Of The Literature, Nancy A. Rihana, Manasa Kandula, Ana Velez, Kumud Dahal, Edward B. O’Neill Jan 2014

Histoplasmosis Presenting As Granulomatous Hepatitis: Case Report And Review Of The Literature, Nancy A. Rihana, Manasa Kandula, Ana Velez, Kumud Dahal, Edward B. O’Neill

Internal Medicine Faculty Publications

Background. Histoplasma capsulatum is the most common endemic mycosis in the United States and is a frequent cause of opportunistic infection in immunodeficient hosts. Histoplasmosis is most often self-limiting and goes unrecognized in the immunocompetent population but can progress to disseminated histoplasmosis in patients with an impaired immune system. Liver involvement as a part of disseminated histoplasmosis which usually originates in the lung is well known. However, extrapulmonary hepatic histoplasmosis as a primary manifestation is extremely rare. Case Presentation. We report a rare case of histoplasmosis that presented as persistent fever and abnormal liver function tests in a …

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2014 Caap, Southwestern Oklahoma State University Jan 2014

2014 Caap, Southwestern Oklahoma State University

Assessment Center Reports

Collegiate Assessment of Academic Proficiency (CAAP) reports produced by the SWOSU Assessment Center

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Human Rights Standards Concerning Transnational Corporations And Other Business Entities, David Weissbrodt Jan 2014

Human Rights Standards Concerning Transnational Corporations And Other Business Entities, David Weissbrodt

Minnesota Journal of International Law, Vols 1-28:1 (1992-2019)

No abstract provided.

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The Separate Spheres Ideology: An Improved Empirical And Litigation Approach To Family Responsibilities Discrimination, Andrea L. Miller Jan 2014

The Separate Spheres Ideology: An Improved Empirical And Litigation Approach To Family Responsibilities Discrimination, Andrea L. Miller

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

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Crowdsourcing Clinical Trials, Jonathan J. Darrow Jan 2014

Crowdsourcing Clinical Trials, Jonathan J. Darrow

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

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Making Patents Useful, Sean B. Seymore Jan 2014

Making Patents Useful, Sean B. Seymore

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

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Family Assimilation Demands And Sexual Minority Youth, Orly Rachmilovitz Jan 2014

Family Assimilation Demands And Sexual Minority Youth, Orly Rachmilovitz

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

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Substituted Compliance And Systemic Risk: How To Make A Global Market In Derivatives Regulation, Sean J. Griffith Jan 2014

Substituted Compliance And Systemic Risk: How To Make A Global Market In Derivatives Regulation, Sean J. Griffith

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

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Changing Course To Navigate The Patent Safe Harbor Post-Momenta, Emily M. Wessels Jan 2014

Changing Course To Navigate The Patent Safe Harbor Post-Momenta, Emily M. Wessels

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

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Status Update: Adapting The Stored Communications Act To A Modern World, Jake Vandelist Jan 2014

Status Update: Adapting The Stored Communications Act To A Modern World, Jake Vandelist

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

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Maneuvering The Headwinds Facing Offshore Wind Development In The Great Lakes: Amending The Coastal Zone Management Act, Sarah Schenck Jan 2014

Maneuvering The Headwinds Facing Offshore Wind Development In The Great Lakes: Amending The Coastal Zone Management Act, Sarah Schenck

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

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A Genealogy Of The Crc, Ashleigh Barnes Jan 2014

A Genealogy Of The Crc, Ashleigh Barnes

Minnesota Journal of International Law, Vols 1-28:1 (1992-2019)

No abstract provided.

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Who Are The Mothers Who Need Safe Haven Laws? An Empirical Investigation Of Mothers Who Kill, Abandon, Or Safely Surrender Their Newborns, 29 Wis. J.L. Gender & Soc'y 213 (2014), Diane S. Kaplan Jan 2014

Who Are The Mothers Who Need Safe Haven Laws? An Empirical Investigation Of Mothers Who Kill, Abandon, Or Safely Surrender Their Newborns, 29 Wis. J.L. Gender & Soc'y 213 (2014), Diane S. Kaplan

UIC Law Open Access Faculty Scholarship

Who are the Mothers who kill their infants at birth? Why do they kill? How do they kill? Once the infant is disposed of, what becomes of the Mother? Neonaticide is the killing of a newborn within the first twenty-four hours of birth. In response to the discovery of thirteen abandoned newborns, Texas passed the first Safe Haven law in 1999. Within nine years, all states enacted similar laws. The purpose of Safe Haven Laws is to deter neonaticidal behaviors by allowing Mothers who are bearing unwanted pregnancies to legally surrender their newborns with anonymity and immunity from prosecution. The …

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Twilight: The Unveiling Of Victims, Stalking, And Domestic Violence, 21 Cardozo J. L. & Gender 39 (2014), Susan L. Brody Jan 2014

Twilight: The Unveiling Of Victims, Stalking, And Domestic Violence, 21 Cardozo J. L. & Gender 39 (2014), Susan L. Brody

UIC Law Open Access Faculty Scholarship

No abstract provided.

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Defining Traditional American Indian Identity Through Anishinaabe Cultural Perspective, Joshua Edward Maudrie Jan 2014

Defining Traditional American Indian Identity Through Anishinaabe Cultural Perspective, Joshua Edward Maudrie

All Graduate Theses, Dissertations, and Other Capstone Projects

This study addresses the question of American Indian Identity, specifically, what makes an Indian an Indian from a traditional Anishinaabe Indian cultural perspective? Perspectives were gained through life experiences as an active member of Anishinaabe Indian communities in Wisconsin, Minnesota and Michigan, as well as traditional cultural ceremonies. There are two primary reasons for this study: first to provide insight into the traditional cultural perspective of American Indian identity for non-Indians and its relevancy in present day; and second, to start a discussion within tribal nations about utilizing their traditional culture in governance and membership issues. For this Qualitative study, …

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Complex Value Choices At The Environment-Energy Interface, Hari M. Osofsky Jan 2014

Complex Value Choices At The Environment-Energy Interface, Hari M. Osofsky

Articles

This dilemma of environment-energy decisions that have major positives and negatives from either a health or ecosystem perspective poses an important ethical challenge that this Essay explores. Namely, in many cases, one can value humans, species, and ecosystems, and still not be able to resolve the best way forward. The Essay focuses in particular on a core problem at the environment-energy interface: people demand cheap and reliable energy, which pushes us towards new technology or the massive expansion of existing technology, both of which carry risks and possibilities for a cleaner future. The Essay considers this dilemma in the U.S. …

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Hybrid Energy Governance, Hari M. Osofsky, Hannah J. Wiseman Jan 2014

Hybrid Energy Governance, Hari M. Osofsky, Hannah J. Wiseman

Articles

This Article develops a novel theory of energy governance and uses it to assess how institutional innovation can help meet critical challenges. Energy law is substantively complex and deeply fragmented. Each energy sector - including fuel extraction and pipelines, electricity generation and transmission, and transportation - has its own legal regime and federalism approach; confusion often exists at moments of crisis about how much authority federal, state, and local regulators have in these areas. The complexity and fragmentation of energy law are particularly problematic because the energy system faces major transitions due to emerging technology, more unpredictable and extreme weather …

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The Geography Of Solving Global Environmental Problems: Reflections On Polycentric Efforts To Address Climate Change, Hari M. Osofsky Jan 2014

The Geography Of Solving Global Environmental Problems: Reflections On Polycentric Efforts To Address Climate Change, Hari M. Osofsky

Articles

This essay considers how we might fit local efforts to address climate change, especially those by very small, suburban cities, within models for solving "global problems." While acknowledging the need for more action on climate change at international, national, and state levels, and regional ones in between, this essay explores how different types of cities, as they participate in multilevel networks, can provide models for action and complement efforts to address climate change through the treaty regime. Using a diverse group of suburbs in the Twin Cities metropolitan region making innovative climate change and sustainability efforts as a case example, …

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Winter Commencement, 2014, Marshall University Jan 2014

Winter Commencement, 2014, Marshall University

Marshall University Commencement

Program for the 2014 Winter Commencement of Marshall University.

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'Some Of Us Just Like To Read' : Lady Gaga's Pastiche And The Rhizome, Anthony Amettis Jan 2014

'Some Of Us Just Like To Read' : Lady Gaga's Pastiche And The Rhizome, Anthony Amettis

Honors Capstones

“’Some of Us Just Like to Read’: Lady Gaga’s Pastiche and the Rhizome” explores intersections of network theory, new media, contemporary art and visual culture, and post-modern critical discourses. It attempts to characterize the productive tendencies of contemporary pop culture, using Lady Gaga as a lens through which these tendencies can be observed. It pays particular attention to the correlation(s) between the structure of the Internet, the exchange of texts and images within such a structure, and how Lady Gaga embodies this dynamic. This paper demonstrates, through both a critique of the concept of pastiche under current cultural conditions and …

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The Best And Worst Of All That God And Man Can Do": Paternalistic Perceptions On The Intellectually Disabled At Florida's Sunland Institutions., Bethany Dickens Jan 2014

The Best And Worst Of All That God And Man Can Do": Paternalistic Perceptions On The Intellectually Disabled At Florida's Sunland Institutions., Bethany Dickens

Electronic Theses and Dissertations

Historians have studied mental institutions in the mid-20th century; however, few have discussed them within the context of the period's paternalistic social movements and perceptions. Florida's Sunland program provides a lens for studying the parental role the institutions and general public took toward the intellectually disabled. Specifically, administrators saw residents of the Sunland Training Centers and Hospitals as perpetual children, trapped in an "eternal childhood." The institution was presented as a family unit, abiding by 1950s ideals of the companionate household. When the Sunlands proved generally unsuccessful, Florida's communities began to supplement their efforts. The social movements of the 1960s …

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The Spatial Relationship Between Labor, Cultural Migration, And The Development Of Folk Music In The American South: A Digital Visualization Project, Robert Clarke Jan 2014

The Spatial Relationship Between Labor, Cultural Migration, And The Development Of Folk Music In The American South: A Digital Visualization Project, Robert Clarke

Electronic Theses and Dissertations

This Digital/Public History visualization thesis project explores how three factors-Atlantic migration patterns, demographics, and socioeconomic systems-influenced the development of folk music in the southern United States from the 18th century through the 20th century. A large body of written scholarship exists addressing plantation economies, the slave trade, and folk music. Digital technology, however, creates new opportunities for analyzing the geo-temporal aspects contained within the numerous archival resources such as census and migration records, field recordings, economic data, diaries, and other personal records. The written portion of the thesis addresses the historiography, research findings, and the process of creating the visualization …

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2014 Spring Commencement, Georgia Southern University Jan 2014

2014 Spring Commencement, Georgia Southern University

Commencement Programs

No abstract provided.

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Study Of The Formation And Control Of Disinfection By-Products Originating From A Surface Water Supply On The Volcanic Island Of Guam, Erica Laberge Jan 2014

Study Of The Formation And Control Of Disinfection By-Products Originating From A Surface Water Supply On The Volcanic Island Of Guam, Erica Laberge

Electronic Theses and Dissertations

Three oxidants have been evaluated for use as alternative chemical pretreatments for Fena Lake, a surface water that supplies the U.S. Navy's Public Water System (PWS) on the volcanic island of Guam. The study consisted of two investigative components. The first and primary component included a bench-scale evaluation to study the effects of different pre-oxidant chemicals on the formation of chlorinated disinfection by-products (DBPs). The second and ancillary component included a series of water treatment and distribution system management studies that analyzed DBP formation within the treatment plant and water distribution system. The goal of this research was to reduce …

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An Unsupervised Consensus Control Chart Pattern Recognition Framework, Siavash Haghtalab Jan 2014

An Unsupervised Consensus Control Chart Pattern Recognition Framework, Siavash Haghtalab

Electronic Theses and Dissertations

Early identification and detection of abnormal time series patterns is vital for a number of manufacturing. Slide shifts and alterations of time series patterns might be indicative of some anomaly in the production process, such as machinery malfunction. Usually due to the continuous flow of data monitoring of manufacturing processes requires automated Control Chart Pattern Recognition(CCPR) algorithms. The majority of CCPR literature consists of supervised classification algorithms. Less studies consider unsupervised versions of the problem. Despite the profound advantage of unsupervised methodology for less manual data labeling their use is limited due to the fact that their performance is not …

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Automatic Detection Of Brain Functional Disorder Using Imaging Data, Soumyabrata Dey Jan 2014

Automatic Detection Of Brain Functional Disorder Using Imaging Data, Soumyabrata Dey

Electronic Theses and Dissertations

Recently, Attention Deficit Hyperactive Disorder (ADHD) is getting a lot of attention mainly for two reasons. First, it is one of the most commonly found childhood behavioral disorders. Around 5-10% of the children all over the world are diagnosed with ADHD. Second, the root cause of the problem is still unknown and therefore no biological measure exists to diagnose ADHD. Instead, doctors need to diagnose it based on the clinical symptoms, such as inattention, impulsivity and hyperactivity, which are all subjective. Functional Magnetic Resonance Imaging (fMRI) data has become a popular tool to understand the functioning of the brain such …

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