Digital Commons Network^™

Cxcr7 Expression Disrupts Endothelial Cell Homeostasis And Causes Ligand-Dependent Invasion, Jennifer Totonchy, Lisa Clepper, Kevin G. Phillips, Owen J. T. Mccarty, Ashlee V. Moses

Pharmacy Faculty Articles and Research

The homeostatic function of endothelial cells (EC ) is critical for a number of physiological processes including vascular integrity, immunity, and wound healing. Indeed, vascular abnormalities resulting from EC dysfunction contribute to the development and spread of malignancies. The alternative SDF-1/CXCL12 receptor CXCR7 is frequently and specifically highly expressed in tumor-associated vessels. In this study, we investigate whether CXCR7 contributes to vascular dysfunction by specifically examining the effect of CXCR7 expression on EC barrier function and motility. We demonstrate that CXCR7 expression in EC results in redistribution of CD31/PECAM-1 and loss of contact inhibition. Moreover, CXCR7+ EC are deficient in …

Synthesis And Evaluation Of Cytotoxic Activity Of Substituted N-(9-Oxo-9h-Xanthen-4-Yl) Benzenesulfonamides, Somayeh Motavallizadeh, Asal Fallah-Tafti, Saeedeh Maleki, Amir Nasrolahi Shirazi, Mahboobeh Pordeli, Maliheh Safavi, Sussan Kabudanian Ardestani, Shaaban Asd, Rakesh Tiwari, Donghoon Oh, Abbas Shafiee, Alireza Foroumadi, Keykavous Parang, Tahmineh Akbarzadeh

Pharmacy Faculty Articles and Research

Several novel N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides derivatives were prepared as potential antiproliferative agents. The in vitro antiproliferative activity of the synthesized compounds was investigated against a panel of tumor cell lines including breast cancer cell lines (MDA-MB-231, T-47D) and neuroblastoma cell line (SK-N-MC) using MTT colorimetric assay. Etoposide, a well-known anticancer drug, was used as a positive standard drug. Among synthesized compounds, 4-methoxy-N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamide (5i) showed the highest antiproliferative activity against MDA-MB-231, T-47D, and SK-N-MC cells. Furthermore, pentafluoro derivatives 5a and 6a exhibited higher antiproliferative activity than doxorubicin against human leukemia cell line (CCRF-CEM) and breast adenocarcinoma (MDA-MB-468) cells. Structure-activity relationship studies revealed that …

The Status Of Neurolaw: A Plea For Current Modesty And Future, Cautious Optimism, Stephen J. Morse

Court Review: Journal of the American Judges Association

In a 2002 editorial published in The Economist, the following warning was given: “Genetics may yet threaten privacy, kill autonomy, make society homogeneous and gut the concept of human nature. But neuroscience could do all of these things first.”1 The genome was fully sequenced in 2001, and there has not been one resulting major advance in therapeutic medicine since. Thus, even in its most natural applied domain—medicine—genetics has not had the far-reaching consequences that were envisioned.2 The same has been true of various other sciences that were predicted to revolutionize the law, including behavioral psychology, sociology, and psychodynamic psychology, to …

Court Review: The Journal Of The American Judges Association 50:2 (2014)- Whole Issue

Court Review: Journal of the American Judges Association

ARTICLES

44 Brain Imaging for Judges: An Introduction to Law and Neuroscience.

52 Evidentiary Incommensurability: A Preliminary Exploration of the Problem of Reasoning from General Scientific Data to Individualized Legal Decision-Making.

62 The Admissibility of Brain Scans in Criminal Trials: The Case of Positron Emission Tomography.

70 Should the Science of Adolescent Brain Development Inform Public Policy?.

78 Pain as Fact and Heuristic: How Pain Neuroimaging Illuminates Moral Dimensions of Law.

94 The Status of NeuroLaw: A Plea for Current Modesty and Future, Cautious Optimism.

ESSAY

104 Keeping Up with Neurolaw: What to Know and Where to Look.

DEPARTMENTS

42 …

Should The Science Of Adolescent Brain Development Inform Public Policy?, Laurence Steinberg

Court Review: Journal of the American Judges Association

The science of adolescent brain development is making its way into the national conversation. As an early researcher in the field, I regularly receive calls from journalists asking how the science of adolescent brain development should affect the way society treats teenagers. I have been asked whether this science justifies raising the driving age, outlawing the solitary confinement of incarcerated juveniles, excluding 18-year-olds from the military, or prohibiting 16-year-olds from serving as lifeguards on the Jersey Shore. Explicit reference to the neuroscience of adolescence is slowly creeping into legal and policy discussions as well as popular culture. The U.S. Supreme …

Brain Imaging For Judges: An Introduction To Law And Neuroscience, Owen D. Jones, Joshua W. Buckholtz, Jeffrey D. Schall, René Marois

Court Review: Journal of the American Judges Association

It has become increasingly common for brain images to be proffered as evidence in civil and criminal litigation.1 This article offers some general guidelines to judges about how to understand brain-imaging studies—or at least avoid misunderstanding them. (An appendix annotating a published brain imaging study, in order to illustrate and explain, with step-by step commentary, is available in the full text online.2)

Brain images are offered in legal proceedings for a variety of purposes, as Professors Carter Snead and Gary Marchant have usefully surveyed.3 On the civil side, neuro imaging has been offered in constitutional, personal injury, disability benefit, and …

Objectivity: A Feminist Revisit, Katharine T. Bartlett

Faculty Scholarship

No abstract provided.

Lipopolysaccharide In Marine Bathing Water; A Potential Real-Time Biomarker Of Bacterial Contamination And Relevance To Human Health, Anas Akram Sattar

School of Biomedical Sciences Theses

The quality of marine bathing water is currently assessed by monitoring the levels of faecal indicator bacteria. Among other drawbacks, results are retrospective using the traditional culture based methods. A rapid method is thus needed as an early warning to bathers for bacterial contamination in marine bathing waters. Total lipopolysaccharide (LPS) was chosen here as a potential general biomarker for bacterial contamination. Levels of total LPS, measured using a Kinetic QCL™ Limulus Amebocyte Lysate (LAL) assay, highly correlated with enumerated Escherichia coli and Bacteroides species. Levels of LPS in excess of 50 EU mL-1 were found to equate with water …

Deep-Sea Octopus (Graneledone Boreopacifica) Conducts The Longest-Known Egg-Brooding Period Of Any Animal, Bruce Robison, Brad Seibel, Jeffrey Drazen

Marine Science Faculty Publications

Octopuses typically have a single reproductive period and then they die (semelparity). Once a clutch of fertilized eggs has been produced, the female protects and tends them until they hatch. In most shallow-water species this period of parental care can last from 1 to 3 months, but very little is known about the brooding of deep-living species. In the cold, dark waters of the deep ocean, metabolic processes are often slower than their counterparts at shallower depths. Extrapolations from data on shallow-water octopus species suggest that lower temperatures would prolong embryonic development periods. Likewise, laboratory studies have linked lower temperatures …

Sarucallis Kahawaluokalani (Kirkaldy) (Hemiptera: Aphididae), A New Invasive Aphid On San Andres Island And Mainland Colombia, With Notes On Other Adventive Species, Takumasa Kondo, Ronald Simbaqueba Cortés

Insecta Mundi

The crape myrtle aphid Sarucallis kahawaluokalani (Kirkaldy) (Hemiptera: Aphididae) collected on Lagerstroemia indica (Lythraceae) is herein reported as a new invasive species in the city of Palmira, State of Valle del Cauca, and on San Andres island, in the State of San Andres, Old Providence and Santa Catalina, Colombia. The species is illustrated and diagnosed. A brief review of recent invasive species in Colombia, i.e., Ceroplastes rubens Maskell (Hemiptera: Coccidae), Crypticerya multicicatrices Kondo and Unruh (Hemiptera: Monophlebidae) [invasive on the island of San Andres], Diaphorina citri Kuwayama (Hemiptera: Liviidae), Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), Maconellicoccus hirsutus (Green) (Hemiptera: Pseudococcidae) and …

Expanded Concept Of The Milliped Family Spirobolidae (Diplopoda: Spirobolida: Spirobolidea): Proposals Of Aztecolini N. Tribe And Floridobolinae/Ini And Tylobolini N. Stats.; Re)Descriptions Of Floridobolus And F. Penneri, Both Causey, 1957, And F. Orini N. Sp.; Hypotheses On Origins And Affinities, Rowland M. Shelley, Samuel D. Floyd

Insecta Mundi

The endemic Floridian milliped genus, Floridobolus Causey, 1957, more closely related to tylobolinines in the western United States (US), Mexico, and Guatemala than syntopic spirobolines, is incorporated into Spirobolidae (Spirobolida: Spirobolidea). With taxonomic priority by one year, its monotypic family is reduced to Floridobolinae, n. stat., comprising Floridobolini and Tylobolini, n. stats., the counterpart to Spirobolinae, comprising Spirobolini and Aztecolini, n. tribe; relationships are Floridobolini + (Tylobolini + (Aztecolini + Spirobolini)). Like F. penneri Causey, 1957, 208 km (130 mi) to the south in the Lake Wales Ridge, Polk and Highlands counties (cos.), F. orini n. sp., inhabits …

Reversal Of Precedence For Scarabaeus Monoceros Nicolson, 1776, In Favor Of Scarabaeus Oblongus Palisot De Beauvois, 1807 To Stabilize The Nomenclature Of Strategus Oblongus (Palisot De Beauvois) From Hispaniola (Coleoptera: Scarabaeidae: Dynastinae), Brett C. Ratcliffe

Insecta Mundi

The rediscovery of an older available name threatens the stability of the long accepted name of Strategus oblongus (Palisot de Beauvois, 1807) (Coleoptera: Scarabaeidae) from Hispaniola. Using Article 23.9 of the International Code of Zoological Nomenclature, Scarabaeus monoceros Nicolson, 1776 is designated a nomen oblitum to maintain nomenclatural stability while its junior synonym, Scarabaeus oblongus Palisot de Beauvois, 1807, is designated a nomen protectum.

Notes On Diochus Erichson, Lissohypnus Casey, And Oxybleptes Smetana (Coleoptera: Staphylinidae) In Florida, Including A Description Of A New Species Of Lissohypnus, J. H. Frank, S. L. Kelly, D. T. Almquist

Insecta Mundi

The known range of Oxybleptes meridionalis Smetana (Coleoptera: Staphylinidae) is expanded in Florida, USA, from Indian River and Manatee counties to now include Brevard, Highlands, Orange, Seminole and Volusia. Oxybleptes davisi (Notman) is confi rmed to exist in Florida, with records from Leon, Liberty and Wakulla counties in the Panhandle, and Orange County in central Florida. Lissohypnus texanus Casey is newly reported from Florida. A new species, Lissohypnus fullertoni, is described from Florida. Diochus schaumii Kraatz reverts to this original spelling; its widespread form in Florida is identical to that in the northeastern USA.

A New Species Of Nephus Mulsant (Coleoptera: Coccinellidae) In Florida, Vince Golia, Austin Golia

Insecta Mundi

A new species of Nephus Mulsant (Coleoptera: Coccinellidae) from southern Florida is described: Nephus (Nephus) alyssae. This represents the first member of the subgenus Nephus reported in the southeastern United States. Florida species previously placed in the genus Nephus, now placed in Scymnobius Casey, are compared with the new species.

Geographical Distribution And Phenotypic Variation Of Anovia Punica Gordon (Coleoptera: Coccinellidae: Noviini), A Predatory Ladybeetle Of Fl Uted Scales (Hemiptera: Coccoidea: Monophlebidae), Guillermo González, Takumasa Kondo

Insecta Mundi

The ladybeetle Anovia sp. (Coleoptera: Coccinellidae: Noviini), known as an important natural enemy of the Colombian fluted scale, Crypticeria muticicatrices Kondo and Gullan (Hemiptera: Coccoidea: Monophlebidae) is here identified as A. punica Gordon, 1972, and reported for the first time from Peru. Here we provide information and illustrations of the great variation in color and dorsal patterns of A. punica found in Colombia and Peru.

An Updated And Annotated Checklist Of The Hedylidae And Hesperiidae (Lepidoptera) Of Trinidad, West Indies, Matthew J.W. Cock

Insecta Mundi

A revised checklist for the butterfly families Hedylidae and Hesperiidae (Lepidoptera) of Trinidad (Trinidad and Tobago) is presented, bringing nomenclature in line with modern usage, and indicating synonyms from earlier lists and papers. The following are new records for Trinidad: Thessia athesis (Hewitson), Bungalotis clusia Evans, Sarmientoia eriopis (Hewitson), Pellicia tyana toza Evans, Quadrus contubernalis contubernalis (Mabille) and Decinea decinea derisor (Mabille). The checklist includes two species of Hedylidae and 314 species of 157 genera of Hesperiidae, comprising 87 species of 37 genera of Eudaminae, 73 species of 41 genera of Pyrginae, and 154 species of 80 genera of Hesperiinae.

South American Coccinellidae (Coleoptera), Part Xvi: Systematic Revision Of Brachiacantha Dejean (Coccinellinae: Hyperaspidini), Robert D. Gordon, Claudio Canepari, Guy A. Hanley

Insecta Mundi

Brachiacantha Dejean (Coccinellinae: Hyperaspidini), containing 49 species, is discussed, species described, illustrations provided, and a key to all recognized taxa included. Coccinella octopustulata F., Cleothera groendali Mulsant, Hyperaspis argentinica Weise, Hyperaspis blandula Weise, and Hyperaspis egae Crotch are transferred to Brachiacantha. Cleothera billoti parva Mulsant is recognized as a valid species and transferred to Brachiacantha. Brachiacantha arrowi Brèthes, Brachiacantha australe Leng, Brachiacantha manni Nunenmacher, and Brachiacantha propria Kirsch are recognized as synonyms of Brachiacantha groendali (Mulsant). A total of 29 new species of Brachiacantha are described; B. amber, B. anita, B. april, B. cathy, B. clara, B. charlotte, B. …

A Revision Of The Genus Purenleon Stange (Neuroptera: Myrmeleontidae: Nemoleontini), Robert B. Miller, Lionel A. Stange

Insecta Mundi

Twenty six species of the genus Purenleon Stange (Neuroptera: Myrmeleontidae: Nemoleontini) are recognized from the New World, of which ten are described as new species: P. oaxacae, P. fernandezi, P. tibialis, P. adamsi, P. andinus, P. apache, P. aztecus, P. cavei, P. farri and P. toltecus. Neotypes are designated for Psammoleon banksi Esben-Petersen 1933 and for Formicaleo inaequalis Navás 1913. The larvae of sixteen species have been reared and are described with data on their biologies. The genus is subdivided into three species groups based mostly on leg structure. The inscriptus group consists of five species, the tibialis …

A Revision Of The Octocoral Genus Ovabunda Alderslade, 2001 (Anthozoa, Octocorallia, Xeniidae), Catherine S. Mcfadden, Yehuda Benayahu, Anna Halász, Dafna Aharonovich, Robert Toonen

All HMC Faculty Publications and Research

The family Xeniidae (Octocorallia) constitutes an abundant benthic component on many Indo-West Pacific coral reefs and is ecologically important in the Red Sea. The genus Ovabunda Alderslade, 2001 was recently established to accommodate previous Xenia species with sclerites comprised of a mass of minute corpuscle-shaped microscleres. The aim of the present study was to examine type material of Xenia species in order to verify their generic affiliation. We present here a comprehensive account of the genus Ovabunda, using scanning electron microscopy to depict sclerite microstructure. We assign three Xenia species to the genus: O. ainex comb. n., O. …

A New Species Of Ovabunda (Octocorallia, Xeniidae) From The Andaman Sea, Thailand With Notes On The Biogeography Of This Genus, Catherine S. Mcfadden, Michael P. Janes, Thanongsak Chanmethakul

All HMC Faculty Publications and Research

A survey of xeniid octocorals was carried out in the waters off Southwestern Thailand in September, 2007. Microscopic investigation of the colonies revealed that three specimens belonged to the genus Ovabunda. Gross morphological examination is presented here accompanied by scanning electron micrographs of the sclerites. Molecular phylogenetic analysis showed identical genotypes at mtMutS, COI, and 28S rDNA for all three specimens and supports their generic assignment. Colony size and shape, sclerite size, and pinnule arrangement differ from nominal species of Ovabunda and thus a new species, O. andamanensis is introduced here. This work also presents a new …

Geographic Analysis Of West Nile Virus In The Upper Minnesota River Valley: A Gis And Multi-Temporal Remote Sensing Approach, Matthew Moore

All Graduate Theses, Dissertations, and Other Capstone Projects

Throughout human evolution civilizations have been faced with implications from infectious diseases caused by various environmental factors. This connection was recognized as far back as the 5th century by Hippocrates and since several key advances have been realized and will be addressed in this an environmental and physical geography of disease. Arthropod or vector-borne viruses are among the most common pathogens introduced into the modern human population. West Nile Virus is considered endemic in most parts of the world and appeared in the United States in 1999 with 62 confirmed cases in an urban New York location. Since its first …

Plum Run Restoration Of The Culvert In The Gordon Natural Area, Israel Berrios, Katie Walston, Kristen Koller

Biology Student Work

No abstract provided.

Plum Run Stream Restoration, Krista Egolf, Brittney Semone, Shelby Garner

Biology Student Work

No abstract provided.

Transwomen, The Prison-Industrial Complex, And Human Rights: Neoliberalism And Trans-Resistance, Emmi Bevensee

Societies Without Borders

This article introduces complexity into understandings around the relationships between human rights, being transgender, and interacting with the prison-industrial complex. It looks at struggles and interventions against neoliberal mainstream agendas that do not address the underlying causes of state violence against transpeople, especially trans women of color. This essay employs in-depth research and analysis primarily employing the lens and tools of intersectional subalternity, personal experience, and extensive community activism around these complex issues to show that human rights struggles that do not challenge neoliberal politics generally fail to meet the needs of trans people facing massive structural violence with the …

Citizen Science: The Law And Ethics Of Public Access To Medical Big Data, Sharona Hoffman

Faculty Publications

Patient-related medical information is becoming increasingly available on the Internet, spurred by government open data policies and private sector data sharing initiatives. Websites such as HealthData.gov, GenBank, and PatientsLikeMe allow members of the public to access a wealth of health information. As the medical information terrain quickly changes, the legal system must not lag behind. This Article provides a base on which to build a coherent data policy. It canvasses emergent data troves and wrestles with their legal and ethical ramifications.

Publicly accessible medical data have the potential to yield numerous benefits, including scientific discoveries, cost savings, the development of …

The U.S. Senate Immigration Reform Bill And The Need For Amendments Before Passing, Nicholas J. Ferraro

Law Student Scholarship

No abstract provided.

Judy Malloy's Seat At The (Database) Table: A Feminist Reception History Of Early Hypertext Literature, Kathi Inman Berens

English Faculty Publications and Presentations

When Robert Coover anointed Michael Joyce the ‘granddaddy’ of hypertext literature in a 1992 New York Times article, it could scarcely have been imagined that this pronouncement would come to define the origin of electronic literature. This short article examines the human and machinic operations obscuring Judy Malloy's Uncle Roger, a hypertext that predates afternoon. Malloy's reputation was stunted because Uncle Roger was algorithmically invisible, a factor that became increasingly important as the Web's commercial capacities matured. afternoon's endurance can be traced to its ISBN, which made afternoon easy for readers to find and united disparate stewards in preserving access …

Sampling For Effective Ex Situ Plant Conservation, Edward O. Guerrant Jr., Kayri Havens, Pati Vitt

Environmental Science and Management Faculty Publications and Presentations

Sampling a whole flora or any significant subset for ex situ conservation purposes is a complex, long-term proposition. Thus, it is important to consider what constitutes an adequate sample not only for all taxa as a whole but also for each taxon individually as well as how to strategically schedule collection over time. There are five basic sampling questions: from which species to collect, from how many and which populations, from how many and which individuals, how many and what kind of propagules to collect, and, finally, at what point is the desired sample size too great for a population …

Winter Climate Change Affects Growing-Season Soil Microbial Biomass And Activity In Northern Hardwood Forests, Jorge Durán, Jennifer L. Morse, Peter M. Groffman, John L. Campbell, Lynn M. Christenson, Charles T. Driscoll, Timothy J. Fahey, Melany C. Fisk, Mryon J. Mitchell, Pamela H. Templer

Environmental Science and Management Faculty Publications and Presentations

Understanding the responses of terrestrial ecosystems to global change remains a major challenge of ecological research. We exploited a natural elevation gradient in a northern hardwood forest to determine how reductions in snow accumulation, expected with climate change, directly affect dynamics of soil winter frost, and indirectly soil microbial biomass and activity during the growing season. Soils from lower elevation plots, which accumulated less snow and experienced more soil temperature variability during the winter (and likely more freeze/thaw events), had less extractable inorganic nitrogen (N), lower rates of microbial N production via potential net N mineralization and nitrification, and higher …

Ethical Decision-Making In Moral Dilemmas, Tyler Pendleton

Honors Projects

Humans are constantly making decisions. Often times, the rules or “heuristics” that guide our decisions are not explicitly known to us simply because their formation within our mental processes is ambiguous. These heuristics can be multiply activated when concerning moral issues. Although our decisions are evident in such cases, the origins of justifying such decisions are not. It is essential to parse out the sociocultural variations that may contribute to moral decision-making. This project aims to present the findings of participants who reacted to the morally-challenging Trolley Problem. Participants were tested on one of eight conditions that examined aspects of …