Digital Commons Network^™

Café Conversations | Imagining International Justice, Feb 26, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Seminar | Investigating Nonprotein Coding Dna Transcription And Its Impact On Chromatin And Gene Regulation, Feb 10, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Seminar | Linking Behavior With Environmental Context And Reproductive Success, Feb 27, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Seminar | Invasive Plants And Native Amphibians The Implications For Amphibian Conservation In Eastern North America, Feb 24, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Seminar | The Little Things Matter A Tale Of Small Rnas And Small Proteins In Brucell, Feb 24, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Ecolunch | The Effect Of Behavioral Syndromes On Behavioral Plasticity And The Success Of Invasion In Xiphophorus Fishes, Feb 12, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

2014 Darwin Lecture Darwin Misperceptions What Evolution Isn't, Feb 17, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Seminar | Sexual Selection And Speciation In An Australian Bird, Feb 18, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Epc-Derived Microvesicles Protect Cardiomyocytes From Ang Ii-Induced Hypertrophy And Apoptosis, Shenhong Gu, Wei Zhang, Ji Chen, Ruilian Ma, Xiang Xiao, Xiaotang Ma, Zhen Yao, Yanfang Chen

Pharmacology and Toxicology Faculty Publications

Cell-released microvesicles (MVs) represent a novel way of cell-to-cell communication. Previous evidence indicates that endothelial progenitor cells (EPCs)-derived MVs can modulate endothelial cell survival and proliferation. In this study, we evaluated whether EPC-MVs protect cardiomyocytes (CMs) against angiotensin II (Ang II)-induced hypertrophy and apoptosis. The H9c2 CMs were exposed to Ang II in the presence or absence of EPC-MVs. Cell viability, apoptosis, surface area and β-myosin heavy chain (β-MHC) expression were analyzed. Meanwhile, reactive oxygen species (ROS), serine/threonine kinase (Akt), endothelial nitric oxide synthase (eNOS), and their phosphorylated proteins (p-Akt, p-eNOS) were measured. Phosphatidylinositol-3-kinase (PI3K) and NOS inhibitors were used …

Ecolunch | Examining The Relationship Among Foraging Style Rectricial Morphology And The Caudal Skeleton In Birds, Feb 5, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Mcb Seminar | Cnu Students And Awards, Feb 25, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Pb Neurotoxicity: Neuropsychological Effects Of Lead Toxicity, Lisa H. Mason, Jordan P. Harp, Dong Y. Han

Neurology Faculty Publications

Neurotoxicity is a term used to describe neurophysiological changes caused by exposure to toxic agents. Such exposure can result in neurocognitive symptoms and/or psychiatric disturbances. Common toxic agents include heavy metals, drugs, organophosphates, bacterial, and animal neurotoxins. Among heavy metal exposures, lead exposure is one of the most common exposures that can lead to significant neuropsychological and functional decline in humans. In this review, neurotoxic lead exposure's pathophysiology, etiology, and epidemiology are explored. In addition, commonly associated neuropsychological difficulties in intelligence, memory, executive functioning, attention, processing speed, language, visuospatial skills, motor skills, and affect/mood are explored.

Aortic Aneurysms In Loeys-Dietz Syndrome - A Tale Of Two Pathways?, Frank Davis, Debra L. Rateri, Alan Daugherty

Saha Cardiovascular Research Center Faculty Publications

Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by skeletal abnormalities, craniofacial malformations, and a high predisposition for aortic aneurysm. In this issue of the JCI, Gallo et al. developed transgenic mouse strains harboring missense mutations in the genes encoding type I or II TGF-β receptors. These mice exhibited several LDS-associated phenotypes. Despite being functionally defective, the mutated receptors enhanced TGF-β signaling in vivo, inferred by detection of increased levels of phosphorylated Smad2. Aortic aneurysms in these LDS mice were ablated by treatment with the Ang II type 1 (AT1) receptor antagonist losartan. The results from this …

Adp1 Affects Plant Architecture By Regulating Local Auxin Biosynthesis., Ruixi Li, Jieru Li, Genji Qin, Ondřej Novák, Aleš Pěnčík, Karin Ljung, Takashi Aoyama, Jingjing Liu, Angus Murphy, Hongya Gu, Tomohiko Tsuge, Li-Jia Qu

Department of Horticulture & Landscape Architecture Faculty Publications

Plant architecture is one of the key factors that affect plant survival and productivity. Plant body structure is established through the iterative initiation and outgrowth of lateral organs, which are derived from the shoot apical meristem and root apical meristem, after embryogenesis. Here we report that ADP1, a putative MATE (multidrug and toxic compound extrusion) transporter, plays an essential role in regulating lateral organ outgrowth, and thus in maintaining normal architecture of Arabidopsis. Elevated expression levels of ADP1 resulted in accelerated plant growth rate, and increased the numbers of axillary branches and flowers. Our molecular and genetic evidence demonstrated …

Prolyl-4-Hydroxylase Α Subunit 2 Promotes Breast Cancer Progression And Metastasis By Regulating Collagen Deposition, Gaofeng Xiong, Lei Deng, Jieqing Zhu, Piotr G. Rychahou, Ren Xu

Markey Cancer Center Faculty Publications

BACKGROUND: Increased collagen deposition provides physical and biochemical signals to support tumor growth and invasion during breast cancer development. Therefore, inhibition of collagen synthesis and deposition has been considered a strategy to suppress breast cancer progression. Collagen prolyl-4-hydroxylase α subunit 2 (P4HA2), an enzyme hydroxylating proline residues in -X-Pro-Gly- sequences, is a potential therapeutic target for the disorders associated with increased collagen deposition. However, expression and function of P4HA2 in breast cancer progression are not well investigated.

METHODS: Gene co-expression analysis was performed in the published microarray datasets to identify potential regulators of collagen I, III, and IV in human …

Sixteen Years Of Collaborative Learning Through Active Sense-Making In Physics (Clasp) At Uc Davis, Wendell Potter, David Webb, Cassandra Paul, Emily West, Mark Bowen, Brenda Weiss, Lawrence Coleman, Charles De Leone

Faculty Publications

This paper describes our large reformed introductory physics course at UC Davis, which bioscience students have been taking since 1996. The central feature of this course is a focus on sense-making by the students during the five hours per week discussion/labs in which the students take part in activities emphasizing peer-peer discussions, argumentation, and presentations of ideas. The course differs in many fundamental ways from traditionally taught introductory physics courses. After discussing the unique features of CLASP and its implementation at UC Davis, various student outcome measures are presented showing increased performance by students who took the CLASP course compared …

Gold(Iii)-Dithiocarbamato Peptidomimetics In The Forefront Of The Targeted Anticancer Therapy: Preclinical Studies Against Human Breast Neoplasia, Chiara Nardon, Sara M. Schmitt, Huanjie Yang, Jian Zuo, Delores Fregona, Q. Ping Dou

Oncology Faculty Publications

Since the serendipitous discovery of cisplatin, platinum-based drugs have become well-established antitumor agents, despite the fact that their clinical use is limited by many severe side-effects. In order to both improve the chemotherapeutic index and broaden the therapeutic spectrum of current drugs, our most recent anti-neoplastic agents, Au(III) complexes, were designed as carrier-mediated delivery systems exploiting peptide transporters, which are up-regulated in some cancers. Among all, we focused on two compounds and tested them on human MDA-MB-231 (resistant to cisplatin) breast cancer cell cultures and xenografts, discovering the proteasome as a major target both in vitro and in vivo. …

Molluscs From A Shallow-Water Whale-Fall And Their Affinities With Adjacent Benthic Communities On The Swedish West Coast, S Danise, S Dominici, Ag Glover, Tg Dahlgren

School of Geography, Earth and Environmental Sciences

We conducted a species-level study of molluscs associated with a 5-m long carcass of a minke whale at a depth of 125 m in the Kosterfjord (North Sea, Sweden). The whale-fall community was quantitatively compared with the community commonly living in the surrounding soft-bottom sediments. Five years after the deployment of the dead whale at the sea floor, the sediments around the carcass were dominated by the bivalve Thyasira sarsi, which is known to contain endosymbiotic sulphur-oxidizing bacteria, while background sediments were dominated by another thyasirid, T. equalis, less dependent on chemosynthesis for its nutrition. The Kosterfjord samples were further …

Comparison Of Human Adult Stem Cells From Adipose Tissue And Bone Marrow In The Treatment Of Experimental Autoimmune Encephalomyelitis, Julie A. Semon, Catherine Maness, Xiujuan Zhang, Steven A. Sharkey, Marc M. Beuttler, Forum S. Shah, Amitabh C. Pandey, Jeffrey M. Gimble, Shijia Zhang, For Full List Of Authors, See Publisher's Website.

Biological Sciences Faculty Research & Creative Works

Introduction. While administration of ex vitro culture-expanded stem cells has been used to study immunosuppressive mechanisms in multiple models of autoimmune diseases, less is known about the uncultured, nonexpanded stromal vascular fraction (SVF)-based therapy. The SVF is composed of a heterogeneous population of cells and has been used clinically to treat acute and chronic diseases, alleviating symptoms in a range of tissues and organs.

Methods. In this study, the ability of human SVF cells was compared with culture-expanded adipose stem cells (ASCs) and bone-derived marrow stromal cells (BMSCs) as a treatment of myelin oligodendrocyte glycoprotein (35-55)-induced experimental autoimmune encephalitis in …

Transplantation Of Autologous Adipose Stem Cells Lacks Therapeutic Efficacy In The Experimental Autoimmune Encephalomyelitis Model, Xiujuan Zhang, Annie C. Bowles, Julie A. Semon, Brittni A. Scruggs, Shijia Zhang, Amy L. Strong, Jeffrey M. Gimble, Bruce A. Bunnell

Biological Sciences Faculty Research & Creative Works

Multiple sclerosis (MS), characterized by chronic inflammation, demyelination, and axonal damage, is a complicated neurological disease of the human central nervous system. Recent interest in adipose stromal/stem cell (ASCs) for the treatment of CNS diseases has promoted further investigation in order to identify the most suitable ASCs. To investigate whether MS affects the biologic properties of ASCs and whether autologous ASCs from MS-affected sources could serve as an effective source for stem cell therapy, cells were isolated from subcutaneous inguinal fat pads of mice with established experimental autoimmune encephalomyelitis (EAE), a murine model of MS. ASCs from EAE mice and …

Snps For Parentage Testing And Traceability In Globally Diverse Breeds Of Sheep, Michael P. Heaton, Kreg A. Leymaster, Theodore S. Kalbfleisch, James W. Kihas, Shannon M. Clarke, John Mcewan, Jillian F. Maddox, Veronica Basnayake, Dustin T. Petrik, Barry Simpson, Timothy P. L. Smith, Carol G. Chitko-Mckown, International Sheep Genomics Consortium

Roman L. Hruska U.S. Meat Animal Research Center: Reports

DNA-based parentage determination accelerates genetic improvement in sheep by increasing pedigree accuracy. Single nucleotide polymorphism (SNP) markers can be used for determining parentage and to provide unique molecular identifiers for tracing sheep products to their source. However, the utility of a particular ‘‘parentage SNP’’ varies by breed depending on its minor allele frequency (MAF) and its sequence context. Our aims were to identify parentage SNPs with exceptional qualities for use in globally diverse breeds and to develop a subset for use in North American sheep. Starting with genotypes from 2,915 sheep and 74 breed groups provided by the International Sheep …

Undergraduate Catalogue 2014-2015, Seton Hall University

Undergraduate Catalogues

No abstract provided.

Technical Illustration: The Changes And Challenges Presented By Advancements In Technology, Cindy Caudill

Electronic Theses and Dissertations

This thesis investigates the changes and challenges technology has created in the field of technical illustration. Technical illustration includes the fields of technical drawing as well as scientific and medical illustration. Previously, technical illustrators learned and used traditional illustration methods, without the aid of computers. However, technology has rapidly entered the field and has changed the education, work environment, skills, and role of the technical illustrator. I note both the benefits and disadvantages that current technical illustrators are facing in their work. I explore both sides of the digital media and traditional art debate while focusing on the technical illustrator's …

Last Kind Word, Dianne Richardson

Electronic Theses and Dissertations

Last Kind Word is a novel that explores the ways people seek control and power in the face of the unknowable. Set in the fictional town of Thorpe, South Carolina, the story follows four main characters-Donna Neese, Melissa Burnside, Anthony Washington, and Jill McManus-struggling in the aftermath of biracial teenager Micah Burnside's disappearance. They search for a replacement for the lost connection to Micah and for a sense of control at a time when their lives seem to lack it, when other forces, be they people or circumstances or spirits, hold power over them. In the midst of this, the …

University Update - November 25, 2014, Academic Affairs

University Updates & Communications from the University President

Included in this update are:

• Part-Time Faculty Teaching Award
• Enrollment Management Updates
• Third Annual Helping Harvest
• Business Affairs Website Update
• Accreditation Update
• Women In Philanthropy Summit Update
• Ebola Task Force
• Holiday Open House

Pacs Bulletin 2014-2015, Program In Audiology And Communication Sciences

PACS News

No abstract provided.

Effects Of Invasive Winter Moth Defoliation On Tree Radial Growth In Eastern Massachusetts, Usa., Michael J. Simmons, Thomas D. Lee, Mark J. Ducey, Joseph S. Elkinton, George H. Boettner, Kevin J. Dodds

Natural Resources & the Environment

Abstract

Winter moth, Operophtera brumata L. (Lepidoptera: Geometridae), has been defoliating hardwood trees in eastern Massachusetts since the 1990s. Native to Europe, winter moth has also been detected in Rhode Island, Connecticut, eastern Long Island (NY), New Hampshire, and Maine. Individual tree impacts of winter moth defoliation in New England are currently unknown. Using dendroecological techniques, this study related annual radial growth of individual host (Quercus spp. and Acer spp.) trees to detailed defoliation estimates. Winter moth defoliation was associated with up to a 47% reduction in annual radial growth of Quercus trees. Latewood production of Quercus was reduced by …

Inhibition Of Methicillin-Resistant Staphylococcus Aureus-Induced Cytokines Mrna Production In Human Bone Marrow Derived Mesenchymal Stem Cells By 1,25-Dihydroxyvitamin D3, Aparna Maiti, William A. Jiranek

Orthopaedic Surgery Publications

Background Methicillin-resistant Staphylococcus aureus (MRSA) is the predominant cause of bone infection. Toll like receptors (TLRs) are an important segments of host response to infection and are expressed by a variety of cells including human mesenchymal stem cells (hMSCs). The active form of Vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has potent immunoregulatory properties, but the mechanism remains poorly understood. The genomic action of 1,25(OH)2D3 is mediated by vitamin D receptor (VDR), hormone-regulated transcription factor. VDR interacts with co-activators and co-repressors are associated with chromatin histone modifications and transcriptional regulation. The aim of our study is to explore MRSA-induced TLRs-mediated pro-inflammatory cytokines …

Genome-Wide And Gene-Based Association Studies Of Anxiety Disorders In European And African American Samples, Takeshi Otowa, Brion S. Maher, Steven H. Aggen, Joseph L. Mcclay, Edwin J. Van Den Oord, John M. Hettema

Psychiatry Publications

Anxiety disorders (ADs) are common mental disorders caused by a combination of genetic and environmental factors. Since ADs are highly comorbid with each other, partially due to shared genetic basis, studying AD phenotypes in a coordinated manner may be a powerful strategy for identifying potential genetic loci for ADs. To detect these loci, we performed genome-wide association studies (GWAS) of ADs. In addition, as a complementary approach to single-locus analysis, we also conducted gene- and pathway-based analyses. GWAS data were derived from the control sample of the Molecular Genetics of Schizophrenia (MGS) project (2,540 European American and 849 African American …

Pharmaceutical Patents After Actavis: The Challenge Of Promoting Innovation In The Pharmaceutical Industry, Emilia Rinaldi

Law Student Papers

No abstract provided.