Digital Commons Network^™

Fgf-2 Induces Neuronal Death Through Upregulation Of System Xc-, Xiaoqian Liu, Rebecca Albano, Doug Lobner

Biomedical Sciences Faculty Research and Publications

The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for glutathione production, and increased glutamate release. While increased intracellular glutathione can limit oxidative stress, the increased glutamate release can potentially lead to excitotoxicity to neurons. To test this hypothesis, mixed neuronal and glial cortical cultures were treated with FGF-2. Treatment with FGF-2 for 48 h caused a significant neuronal death in these cultures. Cell death was not observed in neuronal-enriched cultures, or astrocyte-enriched …

Jim Rockford Or Tony Soprano: Coastal Contrasts In American Suburbia, Carl Abbott

Urban Studies and Planning Faculty Publications and Presentations

Both in television shows such as The Rockford Files and The Sopranos and in the fiction of writers such as John Updike, Richard Ford, and Douglas Coupland, popular culture draws a distinction between Atlantic Coast and Pacific Coast suburbs. The differences revolve around two themes. The first concerns the roles of place and space. The second is the varying weight of history, often as manifested through families and social ties. Eastern suburbs and suburbanites are commonly depicted as embedded in place, rooted in time, and entangled in social networks. Western suburbs and suburbanites are often imagined as the opposite—isolated in …

Research & Strategic Partnerships: Quarterly Review, Volume 1, Issue 2, Portland State University. Research & Strategic Partnerships

Portland State Research Magazine

In this second issue of RSP’s Quarterly Review, we turn our attention to the Innovation and Intellectual Property office (IIP), which connects university research to companies both large and small. IIP Director Joe Janda works closely with faculty, students and staff who seek to get their discoveries into the commercial marketplace through licensing and the creation of startup companies. For a relatively youthful research enterprise like Portland State University’s, IIP’s successes to date have been remarkable.

The Review also highlights Social Determinants of Health (SDH), an initiative that exemplifies Portland State University’s ability to link research to the interests of …

Ecological Homogenization Of Urban Usa, Peter M. Groffman, Jeannine Cavender-Bares, Neil D. Bettez, J. Morgan Grove, Sharon J. Hall, James B. Heffernan, Sarah E. Hobbie, Kelli L. Larson, Jennifer L. Morse, Christopher Neill, Kristen C. Nelson, Jarlath O'Neil-Dunne, Diane E. Pataki, Colin Polsky, Rinku Roy Chowdhury, Meredith K. Steele

Environmental Science and Management Faculty Publications and Presentations

A visually apparent but scientifically untested outcome of land-use change is homogenization across urban areas, where neighborhoods in different parts of the country have similar patterns of roads, residential lots, commercial areas, and aquatic features. We hypothesize that this homogenization extends to ecological structure and also to ecosystem functions such as carbon dynamics and microclimate, with continental-scale implications. Further, we suggest that understanding urban homogenization will provide the basis for understanding the impacts of urban land-use change from local to continental scales. Here, we show how multi-scale, multi-disciplinary datasets from six metropolitan areas that cover the major climatic regions of …

Reproducing The Chinese Ancient Heroic Figure “Xiang Yu” Using 3d Graphics Technology, Ke Xiang

Theses

The ancient country of China has a long history. It has many fascinating historical stories, historical figures, and an elaborate history. For people who want to learn about Chinese history it can often seem overwhelming.

I am planning to find an easy and interesting approach for people who are interested in learning about Chinese history. The effective approach to communicate to people could be enhanced visuals depicting the rich his€tory of China.

Out of this long history, I decided to reproduce a Chinese ancient heroic figure with 3D graphics tech€nology. I will achieve this by using 3D modeling technology, using …

Aquatic Invasive Species Surveys Of Eastern Oregon Waterbodies In 2013 And 2014, Rich Miller, Mark D. Sytsma

Center for Lakes and Reservoirs Publications and Presentations

Early detection aquatic invasive species (AIS) surveys were conducted at 33 Eastern Oregon waterbodies during the summers of 2013 and 2014. Submerged aquatic plants, gastropods, bivalves, and crayfish were collected using a thatch rake, benthic dredge, plankton net, and modified minnow traps. Shoreline aquatic noxious weeds were noted when present and water quality characteristics were measured. Two AIS snail species, one AIS crayfish species, and five AIS plant species were detected during the surveys. Big-ear radix snails (Radix auricularia) were newly detected at 14 waterbodies distributed across the survey area. Chinese mystery snails (Cipangopaludina chinensis) were …

The Differential Interferon Responses Of Two Strains Of Stat1-Deficient Mice Do Not Alter Susceptibility To Hsv-1 And Vsv In Vivo, Sarah Katzenell, Yufei Chen, Zachary M. Parker, David A. Leib

Dartmouth Scholarship

Stat1 is a pivotal transcription factor for generation of the interferon (IFN)-dependent antiviral response. Two Stat1 knockout mouse lines have been previously generated, one deleted the N-terminal domain (ΔNTD) and one in the DNA-binding domain (ΔDBD). These widely-used strains are assumed interchangeable, and both are highly susceptible to various pathogens. In this study, primary cells derived from ΔNTD mice were shown to be significantly more responsive to IFN, and established an antiviral state with greater efficiency than cells derived from ΔDBD mice, following infection with vesicular stomatitis virus and herpes simplex virus type-1. Also, while mice from both strains succumbed …

The Bridge Newsletter Spring 2014, Missouri University Of Science And Technology

The Bridge Newsletter

-Reusing scrap tires
-Renaissance man
-Energy research published
-Follow your passion

Engaging The Religiously Committed Other: Anthropologists And Theologians In Dialogue, Eloise Meneses, Lindy Backues, David Bronkema, Eric Flett, Benjamin Hartley

Faculty Publications - George Fox School of Theology

Anthropology has two tasks: the scientific task of studying human beings and the instrumental task of promoting human flourishing. To date, the scientific task has been constrained by secularism, and the instrumental task by the philosophy and values of liberalism. These constraints have caused religiously based scholarship to be excluded from anthropology’s discourse, to the detriment of both tasks. The call for papers for the 2009 meetings of the American Anthropological Association (AAA) recognized the need to “push the field’s epistemological and presentational conventions” in order to reach anthropology’s various publics. Religious thought has much to say about the human …

A New Perspective On Trait Differences Between Native And Invasive Exotic Plants, A. Joshua Leffler, Jeremy J. James, Thomas A. Monaco, Roger L. Sheley

Natural Resource Management Faculty Publications

Functional differences between native and exotic species potentially constitute one factor responsible for plant invasion. Differences in trait values between native and exotic invasive species, however, should not be considered fixed and may depend on the context of the comparison. Furthermore, the magnitude of difference between native and exotic species necessary to trigger invasion is unknown. We propose a criterion that differences in trait values between a native and exotic invasive species must be greater than differences between co-occurring natives for this difference to be ecologically meaningful and a contributing factor to plant invasion. We used a meta-analysis to quantify …

A Genetic Algorithm Based Optimization Framework To Visualize, Evaluate, And Modify 3d Space Configurations In Desktop Vr, Magesh Chandramouli, Gary R. Bertoline

Computer Graphics Technology Faculty Publications

This paper presents the design and implementation of a Desktop VR (Virtual Reality) framework for generating and evaluating Pareto-optimal alternate 3D spatial configurations using GA (genetic algorithms). The 3-tier framework involves the generation of the Pareto-optimal plans using GA which are subsequently visualized first using a Java-based 2D Interface and finally in the form of a 3D VR scene. The search spaces (function domains) are extremely large in today’s multifaceted interior design situations, and the optimization procedure involves conflicting objective functions, and limitations in the form of constraint functions. The interior space allocation problem is formulated and implemented as the …

Don's Conference Notes: Open Access To Published Research: Current Status And Future Directions: An Nfais Workshop, Donald T. Hawkins

Against the Grain

No abstract provided.

From The Reference Desk: Reviews Of Reference Titles, Tom Gilson

Against the Grain

No abstract provided.

Pelikan's Antidisambiguation: Moirologists, Authority And The Academy, Michael P. Pelikan

Against the Grain

No abstract provided.

The Murray Ledger And Times, February 1, 2014, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Ucc Minutes, February 11, 2014, University Curriculum Council

UCC Agendas/Minutes

No abstract provided.

Video Means "I See": Media And Anthropological Instruction, Margaret Williamson Huber

Southern Anthropologist

The essays in this collection demonstrate that visual media are a more than acceptable substitute for introducing students to ethnographic practice, either on their own or as a complement to face-to-face enquiry.

Complete Issue, Journal Editors

Southern Anthropologist

No abstract provided.

Proposal Of Vibrionimonas Magnilacihabitans Gen. Nov., Sp. Nov., A Curved Gram Negative Bacterium Isolated From Lake Michigan Water, Richard A. Albert, Daniel Zitomer, Michael Dollhopf, Anne Schauer-Gimenez, Craig Struble, Michael King, Sona Son, Stefan Langer, Hans-Jürgen Busse

Civil and Environmental Engineering Faculty Research and Publications

A mesophilic bacterium appearing as curved rod-shaped cells was isolated from Lake Michigan water. It exhibited highest similarities with Sediminibacterium ginsengisoli DCY13^T (94.4 %); Sediminibacterium salmoneum NJ-44^T (93.6 %) and Hydrotalea flava CCUG 51397 ^T (93.1 %) while similarities with other recognized species were sym-homospermidine was the primary polyamine. The major cellular fatty acids were iso-C_15 : 1G, iso-C_15 : 0, iso-C_16 : 0 3-OH and iso-C_17 : 0 3-OH, with moderate amounts of iso-C_16 : 0. The presence of glycolipids differentiated the novel strains from related genera. The DNA …

Beyond Aristotelianism: Al-Farabi On Revelation, Humans And Animals In His On The Perfect State, Michael William Stark

Theses and Dissertations

In modern times, Aristotelian influence on Islamicate philosophical writing is exaggerated. Al-Fārābī did more than just copy Aristotle, he was an original thinker, and he may have sourced aspects of his thought and writing style from the Qurʾān. Consideration of al-Fārābī’s biography, works and historical context demonstrates his disinclination to base his writings on those of Aristotle. Al-Fārābī’s thoughts in the key area of revelation in al-Madīna al-fāḍila demonstrate his departure from ancient Greek belief in this area, although his use of individual reasoning also shows clearly his occasional disagreement with Islamic doctrine. Differences and commonalities between animals and humans …

Exploring The Atomic Structure And Conformational Flexibility Of A 320 Å Long Engineered Viral Fiber Using X-Ray Crystallography., Anshul Bhardwaj, Sherwood R Casjens, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Protein fibers are widespread in nature, but only a limited number of high-resolution structures have been determined experimentally. Unlike globular proteins, fibers are usually recalcitrant to form three-dimensional crystals, preventing single-crystal X-ray diffraction analysis. In the absence of three-dimensional crystals, X-ray fiber diffraction is a powerful tool to determine the internal symmetry of a fiber, but it rarely yields atomic resolution structural information on complex protein fibers. An 85-residue-long minimal coiled-coil repeat unit (MiCRU) was previously identified in the trimeric helical core of tail needle gp26, a fibrous protein emanating from the tail apparatus of the bacteriophage P22 virion. Here, …

First Report Of Curvularia Inaequalis And Bipolaris Spicifera Causing Leaf Blight Of Buffalograss In Nebraska, B. S. Amaradasa, K. Amundsen

Department of Agronomy and Horticulture: Faculty Publications

During the summer of 2011, foliar blight was observed on buffalograss (Buchloë dactyloides (Nutt.) Engelm.) lawns in Lincoln and Waverly, Nebraska. Disease symptoms were common when buffalograss was growing above 30°C and in drought conditions. Disease symptoms began as dark brown oblong leaf spots, followed by leaf tip dieback and eventual blighting of entire tillers. Leaf infections would progress into patches of thinning turf. Diseased leaf pieces were rinsed in distilled water and placed on 1.5% water agar. Two mitosporic fungal species having conidial morphology of Curvularia and Bipolaris were isolated. Colonies of Curvularia isolates grown on ¼× PDA …

Berm Method For Quantification Of Infiltration At The Plot Scale In High Conductivity Soils, Derek M. Heeren, Garey A. Fox, Daniel E. Storm

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Measuring infiltration at the plot scale is difficult, especially for high hydraulic conductivity soils. At the plot scale, the infiltration rate is usually calculated by comparing surface runoff to rainfall. Direct measurement of infiltration beyond the point scale is typically limited to locations where land forming (e.g., infiltration pond) has been performed or fields with basin irrigation systems. The standard method for field measurement of point-scale infiltration is the double ring infiltrometer, which is limited in size (typically 30 cm diameter). In this research, a new method is proposed that uses a temporary berm constructed of a water-filled 15-cm diameter …

Processed Sugars And Coronary Heart Disease, Sonya Lovingood

Graduate Research Projects

No abstract provided.

Role Of Peripheral Immune Response In Microglia Activation And Regulation Of Brain Chemokine And Proinflammatory Cytokine Responses Induced During Vsv Encephalitis, Christina D. Steel, Kimberly Breving, Susan Tavakoli, Woong-Ki Kim, Larry D. Sanford, Richard P. Ciavarra

Biological Sciences Faculty Publications

We report herein that neuroinvasion by vesicular stomatitis virus (VSV) activates microglia and induces a peripheral dendritic cell (DC)-dependent inflammatory response in the central nervous system (CNS). VSV neuroinvasion rapidly induces multiple brain chemokine and proinflammatory cytokine mRNAs that display bimodal kinetics. Peripheral DC ablation or T cell depletion suppresses the second wave of this response demonstrating that infiltrating T cells are primarily responsible for the bimodal characteristics of this response. The robust infiltrate associated with VSV encephalitis likely depends on sustained production of brain CCL19 and CCR7 expression on infiltrating inflammatory cells. © 2013 Elsevier B.V. All rights reserved.

Modulation Of Leukocyte Infiltration And Phenotype In Microporous Tissue Engineering Scaffolds Via Vector Induced Il-10 Expression, R. Michael Gower, Ryan M. Boehler, Samira M. Azarin, Christine F. Ricci, Joshua N. Leonard, Lonnie D. Shea

Faculty Publications

Biomaterial scaffolds are central to many tissue engineering strategies as they create a space for tissue growth and provide a support for cell adhesion and migration. However, biomaterial implantation results in unavoidable injury resulting in an inflammatory response, which can impair integration with the host and tissue regeneration. Toward the goal of reducing inflammation, we investigated the hypothesis that a lentiviral gene therapy-based approach to localized and sustained IL-10 expression at a scaffold could modulate the number, relative proportions, and cytokine production of infiltrating leukocyte populations. Flow cytometry was used to quantify infiltration of six leukocyte populations for 21 days …

Successful Treatment Of An Mtbe-Impacted Aquifer Using A Bioreactor Self-Colonized By Native Aquifer Bacteria, Kristin A. Hicks, Radomir Schmidt, Michael G. Nickelsen, Susan L. Boyle, Jeffrey M. Baker, Paul M. Tornatore, Krassimira R. Hristova, Kate M. Scow

Biological Sciences Faculty Research and Publications

A field-scale fixed bed bioreactor was used to successfully treat an MTBE-contaminated aquifer in North Hollywood, CA without requiring inoculation with introduced bacteria. Native bacteria from the MTBE-impacted aquifer rapidly colonized the bioreactor, entering the bioreactor in the contaminated groundwater pumped from the site, and biodegraded MTBE with greater than 99 % removal efficiency. DNA sequencing of the 16S rRNA gene identified MTBE-degrading bacteria Methylibium petroleiphilum in the bioreactor. Quantitative PCR showed M. petroleiphilum enriched by three orders of magnitude in the bioreactor above densities pre-existing in the groundwater. Because treatment was carried out by indigenous rather than introduced organisms, …

Sanctions Under The Eu's Generalised System Of Preferences (Gsp): Coherence By Accident?, Clara Portela, Jan Orbie

Research Collection School of Social Sciences

This article investigates the relationship between the European Union's withdrawal of trade benefits for developing countries under the Generalised System of Preferences (GSP) and its sanctions under the Common Foreign and Security Policy (CFSP). Our expectation is that GSP withdrawals and CFSP sanctions will not cohere. However, our research reveals that GSP suspension has been coherent with CFSP sanctions when the latter exist prior to the decision-making process on GSP sanctions and when the International Labour Organisation has set up a Commission of Inquiry condemning the country, as with Myanmar/Burma and Belarus. The presence of separate institutional frameworks explains the …

Bioelectrical Impedance Analysis As A Laboratory Activity: At The Interface Of Physics And The Body, Elliot Mylott, Ellynne Marie Kutschera, Ralf Widenhorn

Physics Faculty Publications and Presentations

We present a novel laboratory activity on RC circuits aimed at introductory physics students in life-science majors. The activity teaches principles of RC circuits by connecting ac-circuit concepts to bioelectrical impedance analysis (BIA) using a custom-designed educational BIA device. The activity shows how a BIA device works and how current, voltage, and impedance measurements relate to bioelectrical characteristics of the human body. From this, useful observations can be made including body water, fat-free mass, and body fat percentage. The laboratory is engaging to pre-health and life-science students, as well as engineering students who are given the opportunity to observe electrical …

Spectral Induced Polarization (Sip) Response Of Biodegraded Oil In Porous Media, Gamal Z. Abdel Aal, Estella A. Atekwana

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Laboratory experiments were conducted to investigate the effect of different oil saturation (0.2- 0.8), wetting conditions (water-wet and oil-wet), and the addition of asphaltene on the spectral induced polarization (SIP) response of biodegraded and fresh crude oil in sand columns. In the water-wet case, no significant differences were observed for both the fresh and biodegraded oil and both displayed an increase in the magnitude of the phase (φ) and decrease in the magnitudes of the real (σ′) and imaginary (σ″) conductivity components with increasing oil saturation. In this instance the SIP response is most likely controlled by the conduction and …