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2014

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Isolation And Structural Elucidation Of Cancer Therapeutic Agents In Rhamnaecae Ziziphus Obtusifolia, Matthew Woll, Dr. Noel Owen Feb 2014

Isolation And Structural Elucidation Of Cancer Therapeutic Agents In Rhamnaecae Ziziphus Obtusifolia, Matthew Woll, Dr. Noel Owen

Journal of Undergraduate Research

Many important and useful biological compounds are found in plants. Extensive work has been done on evaluating anti-cancer 1, 2, anti-malarial 3, and anti-viral 4 properties of plants. The Yaqui Indians of northern Mexico have traditionally used many natural products to cure various diseases. Gloria Moroyoqui, the daughter of a Yaqui Indian shaman (medicine man) explained to us some of the plants and their uses as medicine. The Yaqui Indians have used Rhamnacae ziziphus obtusifolia, commonly known as graythorn, as a cancer chemotherapeutic agent.

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Emu Today, February 19, 2014, Eastern Michigan University Feb 2014

Emu Today, February 19, 2014, Eastern Michigan University

EMU Today

No abstract provided.

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2014 February 19, College Curriculum Review Committee Meeting Minutes, State University Of New York At Cortland Feb 2014

2014 February 19, College Curriculum Review Committee Meeting Minutes, State University Of New York At Cortland

University Curriculum Review Committee

College Curriculum Review Committee Meeting Minutes February 19, 2014

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B Cell Tolerance In Health And Disease, Murali Gururajan, Vishal J. Sindhava, Subbarao Bondada Feb 2014

B Cell Tolerance In Health And Disease, Murali Gururajan, Vishal J. Sindhava, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

B lymphocyte receptors are generated randomly during the bone marrow developmental phase of B cells. Hence, the B cell repertoire consists of both self and foreign antigen specificities necessitating specific tolerance mechanisms to eliminate self-reactive B cells. This review summarizes the major mechanisms of B cell tolerance, which include clonal deletion, anergy and receptor editing. In the bone marrow presentation of antigen in membrane bound form is more effective than soluble form and the role of dendritic cells in this process is discussed. Toll like receptor derived signals affect activation of B cells by certain ligands such as nucleic acids …

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Gene Expression Profiling In Winged And Wingless Cotton Aphids, Aphis Gossypii (Hemiptera: Aphididae), Xiaowei Yang, Xiaoxia Liu, Xiangli Xu, Zhen Li, Yisong Li, Dongyan Song, Tian Yu, Fang Zhu, Qingwen Zhang, Xuguo Zhou Feb 2014

Gene Expression Profiling In Winged And Wingless Cotton Aphids, Aphis Gossypii (Hemiptera: Aphididae), Xiaowei Yang, Xiaoxia Liu, Xiangli Xu, Zhen Li, Yisong Li, Dongyan Song, Tian Yu, Fang Zhu, Qingwen Zhang, Xuguo Zhou

Entomology Faculty Publications

While trade-offs between flight capability and reproduction is a common phenomenon in wing dimorphic insects, the molecular basis is largely unknown. In this study, we examined the transcriptomic differences between winged and wingless morphs of cotton aphids, Aphis gossypii, using a tag-based digital gene expression (DGE) approach. Ultra high-throughput Illumina sequencing generated 5.30 and 5.39 million raw tags, respectively, from winged and wingless A. gossypii DGE libraries. We identified 1,663 differentially expressed transcripts, among which 58 were highly expressed in the winged A. gossypii, whereas 1,605 expressed significantly higher in the wingless morphs. Bioinformatics tools, including Gene Ontology, …

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Volume 51, Number 27: February 19, 2014, University Of North Dakota Feb 2014

Volume 51, Number 27: February 19, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

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Organizing Disability: Producing Knowledge In A University Accommodations Office, Shelby Forbes Feb 2014

Organizing Disability: Producing Knowledge In A University Accommodations Office, Shelby Forbes

USF Tampa Graduate Theses and Dissertations

As it is generally conceived, knowledge belongs to the individual: we imagine how a lightbulb suddenly illuminates above the scientist's head, a muse whispers in the philosopher's ear, cogs slide into place as wheels turn in the thinker's mind, and, "Eureka!" an idea is born. As an individualistic experience, knowledge is secure in the repository of the mind, a "steel trap" as it is so often referred, which can only be breached by the most sophisticated and precise methods. From these popular representations of knowledge, one can extrapolate further to conclude that knowledge is not made, it is received. All …

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Convergent Surface Water Distributions In U.S. Cities, Meredith K. Steele, James B. Heffernan, Neil D. Bettez, Jeannine Cavender-Bares, Peter M. Groffman, J. Morgan Grove, Sharon J. Hall, Sarah E. Hobbie, Kelli L. Larson, Jennifer L. Morse, Christopher Neill, Kristen C. Nelson, Jarlath O'Neil-Dunne, Laura A. Ogden, Diane E. Pataki, Colin Polsky, Rinku Roy Chowdhury Feb 2014

Convergent Surface Water Distributions In U.S. Cities, Meredith K. Steele, James B. Heffernan, Neil D. Bettez, Jeannine Cavender-Bares, Peter M. Groffman, J. Morgan Grove, Sharon J. Hall, Sarah E. Hobbie, Kelli L. Larson, Jennifer L. Morse, Christopher Neill, Kristen C. Nelson, Jarlath O'Neil-Dunne, Laura A. Ogden, Diane E. Pataki, Colin Polsky, Rinku Roy Chowdhury

Environmental Science and Management Faculty Publications and Presentations

Earth's surface is rapidly urbanizing, resulting in dramatic changes in the abundance, distribution and character of surface water features in urban landscapes. However,the scope and consequences of surface water redistribution at broad spatialscales are not well understood. We hypothesized that urbanization would lead to convergent surface water abundance and distribution: in other words, cities will gain or lose water such that they become more similar to each other than are their surrounding natural landscapes. Using a database of more than 1 million water bodies and 1 million km of streams, we compared the surface water of 100 US cities with …

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Male Prostitution & Equal Protection: An Enforcement Dilemma, Thayne D. Stoddard Feb 2014

Male Prostitution & Equal Protection: An Enforcement Dilemma, Thayne D. Stoddard

Duke Journal of Gender Law & Policy

No abstract provided.

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Bax Induced Apoptosis Under Control Of The Tk1 Promoter, Scott A. Witt, Dr. Kim L. O'Neill Feb 2014

Bax Induced Apoptosis Under Control Of The Tk1 Promoter, Scott A. Witt, Dr. Kim L. O'Neill

Journal of Undergraduate Research

The human body has an automatic system for eliminating unwanted cells. When it is time for a cell to be removed, it is given a signal to divide up its parts into discrete packages and send them to other cells to be recycled. The cell eventually disintegrates. This process is called apoptosis, or programmed cell death. Every cell in the body has the mechanism, but only the ones receiving the signal will die. Sometimes, certain cells lose the ability to undergo programmed cell death. The result is a group of unwanted cells that refuse to die properly-cancer.

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Conservation Of The Che And Pho Systems In Escherichia Coli, Kimberly B. Zumbrennen, Dr. William R. Mccleary Feb 2014

Conservation Of The Che And Pho Systems In Escherichia Coli, Kimberly B. Zumbrennen, Dr. William R. Mccleary

Journal of Undergraduate Research

Bacteria live in a continuously changing environment. In order to survive, bacteria must monitor nutrients, acidity, temperature, osmolarity, etc. The use of two-component systems to sense and respond to these environmental changes is a common motif observed in a wide variety of organisms. A two-component system consists of two main proteins, a sensor and a response regulator(2). The sensor protein is a trans-membrane protein which monitors environmental fluctuations and activates the response regulator through phosphorylation. The response regulator contains two domains, the receiver module and the output domain. The receiver module is phosphorylated and dephosphorylated by the sensor protein. Communication …

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Minutes, Arts & Sciences Professional Standards Commitee Meeting, Tuesday, February 18, 2014, Arts & Sciences Professional Standards Committee Feb 2014

Minutes, Arts & Sciences Professional Standards Commitee Meeting, Tuesday, February 18, 2014, Arts & Sciences Professional Standards Committee

Professional Standards Committee Minutes

No abstract provided.

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Grand Valley Forum, Volume 038, Number 21, February 18, 2014, Grand Valley State University Feb 2014

Grand Valley Forum, Volume 038, Number 21, February 18, 2014, Grand Valley State University

2013-2014, Volume 38

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

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The Utah Statesman, February 18, 2014, Utah State University Feb 2014

The Utah Statesman, February 18, 2014, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

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The Prospector, February 18, 2014, Utep Student Publications Feb 2014

The Prospector, February 18, 2014, Utep Student Publications

The Prospector

Headline: I Get By With a Little Help From My Voters

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A Novel Radiation-Induced P53 Mutation Is Not Implicated In Radiation Resistance Via A Dominant-Negative Effect., Yunguang Sun, Carey Jeanne Myers, Adam Dicker Md, Phd, Bo Lu, Md Feb 2014

A Novel Radiation-Induced P53 Mutation Is Not Implicated In Radiation Resistance Via A Dominant-Negative Effect., Yunguang Sun, Carey Jeanne Myers, Adam Dicker Md, Phd, Bo Lu, Md

Department of Radiation Oncology Faculty Papers

Understanding the mutations that confer radiation resistance is crucial to developing mechanisms to subvert this resistance. Here we describe the creation of a radiation resistant cell line and characterization of a novel p53 mutation. Treatment with 20 Gy radiation was used to induce mutations in the H460 lung cancer cell line; radiation resistance was confirmed by clonogenic assay. Limited sequencing was performed on the resistant cells created and compared to the parent cell line, leading to the identification of a novel mutation (del) at the end of the DNA binding domain of p53. Levels of p53, phospho-p53, p21, total caspase …

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Determining The Mechanism Of How The 2,4-Dichlorophenoxyacetic Acid Pathway Of Plasmid Pjp4 In Ralstonia Eutropha Evolves To Degrade Phenoxyacetic Acid As A Sole Carbon Source, David Schlesinger, Dr. Alan R. Harker Feb 2014

Determining The Mechanism Of How The 2,4-Dichlorophenoxyacetic Acid Pathway Of Plasmid Pjp4 In Ralstonia Eutropha Evolves To Degrade Phenoxyacetic Acid As A Sole Carbon Source, David Schlesinger, Dr. Alan R. Harker

Journal of Undergraduate Research

Being that the scope of this project was much larger than anticipated I was unable to complete my research in its entirety. However I did make substantial progress and was able to answer many of my original questions.

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The Effects Of Interleukin-1a, Interleukin-6 And Tumor Necrosis Factor- A On The Growth Of Human H295r Cells, Tara Leigh Nelson, Dr. Allan M. Judd Feb 2014

The Effects Of Interleukin-1a, Interleukin-6 And Tumor Necrosis Factor- A On The Growth Of Human H295r Cells, Tara Leigh Nelson, Dr. Allan M. Judd

Journal of Undergraduate Research

Cytokines are extracellular signaling proteins or peptides that act as local mediators in cell-cell communication. They regulate several endocrine systems and function in the immune process. These agents mediate cellular proliferation within endocrine tissues, regulate hormone secretion, and control aspects of inflammation (1). Interleukin-1a (IL- 1a), IL-6 and tumor necrosis factor-a (TNF-a) are present in normal adrenal glands of rats, bovine and humans. They stimulate and inhibit adrenal hormones. Growth and differentiation of the adrenal gland may also be affected by cytokines. The study of the effects of these cytokines is important because adrenal tumors may cause hypersecretion of the …

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Phylogenetic Analysis Of Crayfish Using Astacin, Crystal Komm, Dr. Keith A. Crandall Feb 2014

Phylogenetic Analysis Of Crayfish Using Astacin, Crystal Komm, Dr. Keith A. Crandall

Journal of Undergraduate Research

Astacin is a zinc-endopeptidase, originally described as a unique enzyme and first sequenced from the crayfish Astacus astacus (Geier 97). This project aimed to gather several Astacin gene sequences from multiple taxa of crayfish and to submit them to phylogenetic analysis using PAUP (Swofford 98). PAUP would then generate trees displaying the most probable evolutionary relationships among taxa based on variation in the Astacin gene sequences.

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Bis-Quaternary Ammonium Cyclophane Compounds That Interact With Neuronal Nicotinic Acetylcholine Receptors, Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Davis D. Allen, Zhenfa Zheng, Paul Lockman Feb 2014

Bis-Quaternary Ammonium Cyclophane Compounds That Interact With Neuronal Nicotinic Acetylcholine Receptors, Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Davis D. Allen, Zhenfa Zheng, Paul Lockman

Pharmaceutical Sciences Faculty Patents

Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

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Enhancing Transdermal Delivery Of Opioid Antagonists And Agonists Using Codrugs Linked To Bupropion Or Hydroxybupropion, Audra L. Stinchcomb, Peter A. Crooks, Mohamad O. Hamad, Paul K. Kiptoo Feb 2014

Enhancing Transdermal Delivery Of Opioid Antagonists And Agonists Using Codrugs Linked To Bupropion Or Hydroxybupropion, Audra L. Stinchcomb, Peter A. Crooks, Mohamad O. Hamad, Paul K. Kiptoo

Pharmaceutical Sciences Faculty Patents

The present invention is directed to novel codrugs comprising bupropion or hydroxybupropion and an opioid antagonist or an opioid agonist joined together by chemical bonding. The codrugs provide a significant increase in the transdermal flux across human skin, as compared to the basic opioid antagonist or opioid agonist.

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Faculty Senate Resolution 14-01, Louisiana State University And Agricultural & Mechanical College Feb 2014

Faculty Senate Resolution 14-01, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Faculty Senate Resolution on correcting and replacing the 'Smoke-Free Campus' committee; failed to advance to discussion, not adopted.

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Independent Murine Biosynthesis Of Threonine: Expression Of A Complete Bacterial Biosynthetic Pathway In Mice, Ryan D. Mcallister, Dr. David Kooyman Feb 2014

Independent Murine Biosynthesis Of Threonine: Expression Of A Complete Bacterial Biosynthetic Pathway In Mice, Ryan D. Mcallister, Dr. David Kooyman

Journal of Undergraduate Research

Threonine is one of the 20 common amino acids found in nature. It is a limiting factor for the growth of many non-ruminant animals such as swine and mice and must be obtained from their diet. When threonine is absent from the diet of these animals, the other amino acids present cannot be fully utilized. The result is poor conversion of plant to animal protein (1). We proposed producing transgenic mice using the genes from the known five-step bacterial pathway for threonine synthesis (2). The introduction of these bacterial pathways to mice would eliminate the need for dietary supplementation of …

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Transmission Electron Microscopy Study Of Tobacco Seed Endosperm Transformed With Zein Protein Genes From Zea Mays, Susan Eldredge, Dr. Craig E. Coleman Feb 2014

Transmission Electron Microscopy Study Of Tobacco Seed Endosperm Transformed With Zein Protein Genes From Zea Mays, Susan Eldredge, Dr. Craig E. Coleman

Journal of Undergraduate Research

Zein proteins represent the prolamin (alcohol soluble) fraction of maize storage proteins. Zeins constitute approximately 50 percent of the total seed protein in maize, and therefore greatly affect the overall amino acid balance of the maize grain (1).

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Molecular Evolution Among Populations Of The Silky Pocket Mouse (Parognathus Flavus), Taylor Maxwell, Dr. Duke Rogers Feb 2014

Molecular Evolution Among Populations Of The Silky Pocket Mouse (Parognathus Flavus), Taylor Maxwell, Dr. Duke Rogers

Journal of Undergraduate Research

Mexico is classified as a “megadiversity” country, which means that it has more species of plants and animals than the vast majority of other countries in the world. For example, there are ca. 4,750 species of mammals known to science, and more than one of every seven can be found in Mexico. The reasons that Mexico has so much biodiversity are complex, but in part, it is due to the fact that the region is climatically and topographically diverse. Habitats range from lowland tropical rain forest in the south to dry deserts in the north with a multitude of intervening …

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Synthesis Of Bioconjugate Dimers Used To Probe The Structure Of Pglycoprotein, Emily Parker, Dr. Merritt B. Andrus Feb 2014

Synthesis Of Bioconjugate Dimers Used To Probe The Structure Of Pglycoprotein, Emily Parker, Dr. Merritt B. Andrus

Journal of Undergraduate Research

Chemotherapy is one of the primary treatments for cancer today. A patient’s life may depend on its efficacy, so when he or she develops multi-drug resistance (MDR) the results can be devastating. MDR, a clinical condition manifested by the failure of chemotherapy, is primarily due to the expression of P-glycoprotein (Pgp), a membrane-bound small molecule transport protein which is found normally in some cells but is greatly over expressed in drug resistant cancer cells1. It is believed that after chemotherapy drugs diffuse into the cell, Pgp effluxes them out using energy from ATP hydrolysis, thus imparting drug resistance.

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Bacterial Fingerprints, Kristilyn Rogers, Dr. Ron W. Leavitt Feb 2014

Bacterial Fingerprints, Kristilyn Rogers, Dr. Ron W. Leavitt

Journal of Undergraduate Research

Bordetellosis, or turkey coryza, is a highly contagious respiratory disease in poultry caused by Bordetella avium. Turkey growers worldwide are concerned with this disease which results in millions of dollars in losses annually to the turkey industry. Bordetellosis is readily transmitted through close contact with those already infected, or by exposure to contaminated litter or water. Infected turkeys experience, among other things, stunted growth and a predisposition for other infectious diseases. The mortality rate for bordetellosis is less than 10%. However, morbidity rates can reach 80-100% in young poults. Moreover, with concurrent infection of B. avium and Escherichia coli …

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Random Mutagenesis In Phob: A Proposed Study Of The Effects Of Mutations In Phosphate Regulation, Chad C. Lowe, Dr. William R. Mccleary Feb 2014

Random Mutagenesis In Phob: A Proposed Study Of The Effects Of Mutations In Phosphate Regulation, Chad C. Lowe, Dr. William R. Mccleary

Journal of Undergraduate Research

Within the prokaryotic cell, the intake of essential nutrients is continuously regulated by intracellular mechanisms. When fundamental nutrients become scarce, cellular stress responses are activated to enable the cell to survive in a harsh environment. Recent studies have shown a two-component regulatory mechanism which enhances Escherichia coli intracellular phosphate uptake in a phosphatepoor environment (5). This system, called the Pho system, consists of a sensor (PhoR) and an activator (PhoB). When environmental phosphate is limited, PhoR becomes autophosphorylated and in turn phosphorylates PhoB (4). The phosphorylated PhoB recognizes and binds to a consensus sequence called the “pho box” and …

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Effects Of Reverse Transcriptase And Protease Inhibitors On Lymphoid Tissue Viral Load In Murine Retrovirus Infection, Eric R. Griffiths, Dr. Greg Burton Feb 2014

Effects Of Reverse Transcriptase And Protease Inhibitors On Lymphoid Tissue Viral Load In Murine Retrovirus Infection, Eric R. Griffiths, Dr. Greg Burton

Journal of Undergraduate Research

During HIV infection, blocking viral replication has drastic effects on HIV immune complexes maintained on follicular dendritic cells (FDCs): HIV immune complexes quickly drop off FDCs to undetectable levels (1). This was a remarkable and unexpected finding since FDCs typically preserve trapped antigen for months to years. Furthermore, mice have been shown to carry infectious viral immune complexes on FDCs for periods of over nine months in the total absence of viral replication (2).

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Measles Virus And Its Interactions With Follicular Dendritic Cells, Michael J. Lloyd, Dr. Gregory F. Burton Feb 2014

Measles Virus And Its Interactions With Follicular Dendritic Cells, Michael J. Lloyd, Dr. Gregory F. Burton

Journal of Undergraduate Research

Measles virus continues to be a major cause of death in most third-world countries and a considerable threat to the health of every country. Infection with measles is thought to be associated with the fatal, late-infection disease subacute sclerosing panencephalitis (SSPE) (3). It is thought that Measles virus is retained by the body following infection until it mutates, crosses the blood-brain barrier to infect and destroy brain tissue, killing the host.

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