Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2014

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 1051 - 1080 of 25849

Full-Text Articles in Entire DC Network

Enhanced Backbone Dihedral Parameters For Protein Simulations, Carmenza Martinez Dec 2014

Enhanced Backbone Dihedral Parameters For Protein Simulations, Carmenza Martinez

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Molecular Dynamics (MD) and Monte Carlo (MC) simulations of biomolecules have become a supportive tool to experimental methods for structure refinement, protein folding, drug discovery and many more applications. This is due to the increase in computational power and necessity of finding a method capable of describing the forces at work in chemical systems without the need to do extensive quantum calculations. All of these are possible because of the classical definition of the potential force field function. The force field function is essential to perform MD simulations, since this equation carries the physical description of the molecules being studied. …

Go to article

Mechanism And Inhibition Of The Enoyl-Acp Reductases From Biodefense And Emerging Opportunistic Pathogens, Carla Maya Neckles Dec 2014

Mechanism And Inhibition Of The Enoyl-Acp Reductases From Biodefense And Emerging Opportunistic Pathogens, Carla Maya Neckles

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The enoyl-acyl-carrier-protein reductase (ENR) catalyzes the last reaction in the elongation cycle in the fatty acid biosynthesis type II (FAS-II) pathway. To date, there are four known ENR isoenzymes: FabI, FabK, FabL, and FabV. We have rigorously characterized the FabV ENR from Burkholderia mallei (BmFabV) and have shown that this enzyme catalyzes substrate reduction via an ordered bi-bi mechanism, in which NADH binds first to the enzyme followed by the enoyl substrate [Lu, H. (2010) Biochemistry 49, 1281-1289]. However, this pathogen contains both FabI and FabV ENRs, and mechanistic insights into ENR substrate recognition are lacking in pathogens that solely …

Go to article

Biophysical Insights Into The Initiation And Inhibition Of Amyloid Formation By Islet Amyloid Polypeptide, Hui Wang Dec 2014

Biophysical Insights Into The Initiation And Inhibition Of Amyloid Formation By Islet Amyloid Polypeptide, Hui Wang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Amyloid formation, the aggregation of normally soluble proteins or polypeptides into highly ordered beta-sheet structures, is a characteristic feature of many human diseases including Alzheimer's disease, Parkinson's disease and type 2 diabetes. I centered my research on islet amyloid polypeptide (IAPP), a neuroendocrine hormone that forms fibrillar amyloid deposits in the extracellular space of the pancreatic islets of Langerhans in type 2 diabetes. Although whether IAPP amyloid formation is a cause or consequence of the disease is controversial, the aggregation process has been shown to induce beta-cell apoptosis and reduce beta-cell mass, which is a hallmark feature of type 2 …

Go to article

Design, Synthesis, And Biological Evaluation Of Novel Taxoid-Based Drug Conjugates And Theranostic Imaging Agents Towards Tumor-Targeted Chemotherapy, Jacob G. Vineberg Dec 2014

Design, Synthesis, And Biological Evaluation Of Novel Taxoid-Based Drug Conjugates And Theranostic Imaging Agents Towards Tumor-Targeted Chemotherapy, Jacob G. Vineberg

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Cancer remains the second leading cause of death in the United States, accounting for nearly a quarter of all deaths, and is exceeded only by heart disease. Traditional chemotherapy uses highly potent cytotoxic agents to kill rapidly dividing cancer cells, relying on the premise that these fast-growing cancer cells are more likely to be killed by these drugs. Despite the profound impact of traditional chemotherapy, lack of tumor-specificity continues to be a serious issue for cancer treatment. Paclitaxel and docetaxel are among the most widely used chemotherapeutic agents, in particular against cancers such as ovarian, breast, lung, and Kaposi's sarcoma; …

Go to article

The Impact Of Children With And Without Developmental Disabilities On Relationship Satisfaction And The Parenting Alliance, Caitlin E. Walsh Dec 2014

The Impact Of Children With And Without Developmental Disabilities On Relationship Satisfaction And The Parenting Alliance, Caitlin E. Walsh

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Studies have shown that parents of children with ASD report greater negative impact of the child on family adaptation including financial stability, sibling relationships, and parents' social lives than parents of children with other chronic problems (e.g. | Down syndrome, ADHD, ODD). Parents of children with ASD also report increased marital discord and parent stress. Currently there are no studies examining differences in parent perceptions of child impact and how this factor may influence parental relationships, particularly parents' spousal relationships and agreement on co-parenting. In this study, 157 mothers of children with an Autism Spectrum Disorder (ASD), Down syndrome (DS), …

Go to article

Evidence For Genetic Contributions To Neurobehavioral Traits: Trait Fear/Fearlessness, Behavioral Inhibition, And The Late Positive Potential, Anna Ef Weinberg Dec 2014

Evidence For Genetic Contributions To Neurobehavioral Traits: Trait Fear/Fearlessness, Behavioral Inhibition, And The Late Positive Potential, Anna Ef Weinberg

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Psychiatric disorders are the most common and costly forms of disease and injury worldwide. Despite this, our ability to accurately identify and treat these disorders is limited, due in part to deficient understanding of the underlying mechanisms of dysfunction. The current study aimed to identify genetically-influenced neurobehavioral traits--individual differences evident in both self-report and neural response--that might help improve classification and treatment of mental disorders. Results from event-related potential (ERP) components sensitive to emotional content demonstrated that a) neural processing of emotional content is heritable, b) the heritable traits of heightened trait fear and behavioral disinhibition are associated with unique …

Go to article

The Influence Of Drought On The Ecological And Evolutionary Genomics Of Fungal Pathogenesis In An Annual Plant, Brassica Rapa, Niamh Breda O'Hara Dec 2014

The Influence Of Drought On The Ecological And Evolutionary Genomics Of Fungal Pathogenesis In An Annual Plant, Brassica Rapa, Niamh Breda O'Hara

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

There is growing evidence that populations are evolving rapidly in response to climate change. However, the potential cost associated with adapting, and the genetic basis of both rapid evolution and costs of adaptation remain largely unexplored. With climate change, drought is increasing in frequency and severity, widely affecting plant yield and fitness in agricultural and natural populations. For my dissertation, I integrated multiple approaches (field, greenhouse, lab and bioinformatic) to explore the ecological and evolutionary effects of drought on an agriculturally important plant-pathogen system: the annual herbaceous plant Brassica rapa (field mustard), and its fungal pathogen Alternaria brassicae. In a …

Go to article

Image Reconstruction Theory And Implementation For Low-Dose X-Ray Computed Tomography, Yan Liu Dec 2014

Image Reconstruction Theory And Implementation For Low-Dose X-Ray Computed Tomography, Yan Liu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The excessive X-ray radiation exposure during clinical examinations has been reported to be linked to increase lifetime risk of cancers in patients. Directly lower computed tomography (CT) dose without improving reconstruction technique will degrade the image quality and is not acceptable. The objective of this dissertation is investigating novel reconstruction methods to improve image quality in low-dose cases. In practice, it is usually more convenient to improve the conventional analytical methods by refining projection model and designing new filters due to the fast computing time and low computational complexity. However, the reconstructions from analytical methods are still sensitive to artifacts …

Go to article

Disability And The Young Adult Reader: How Has The Portrayal Of Disability Changed In The Last Fifty Years?, Sharon Munroe Hinkson Dec 2014

Disability And The Young Adult Reader: How Has The Portrayal Of Disability Changed In The Last Fifty Years?, Sharon Munroe Hinkson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Literature offers an opportunity to share in the lived experiences of others, experiences that as readers we may otherwise never personally encounter. Disability in our society is a reality, yet one that has not been fully embraced--not unlike issues with race, gender, age, or sexual orientation. Individuals begin to encounter many of these matters early in life, but as impressionable adolescents, a time when they begin to understand and navigate the world, often times they meet these experiences in books. Since books are an especially important part of how thoughts and attitudes are shaped, this paper seeks to analyze a …

Go to article

Pharmacological Targeting Of Mutant P53 - Hsf1 Feed Forward Circuit, Dun Li Dec 2014

Pharmacological Targeting Of Mutant P53 - Hsf1 Feed Forward Circuit, Dun Li

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tumor suppressor protein p53 responds to cellular stress by activating transcriptional and transcription-independent programs that induce apoptosis, growth arrest or senescence. Given its critical tumor suppressing role, p53 is often mutated in human cancers. Once altered by missense mutations in the DNA-binding domain, mutant p53 (mutp53) protein becomes highly stabilized in tumors, which is critical for mutp53′s oncogenic gain-of function. Current insight into the mechanism of tumor-specific stabilization of mutp53 is fragmentary and largely derived from ectopically constructed cell systems. We find that in human cancer cells endogenous mutp53, despite its ability to interact with MDM2, suffers from a profound …

Go to article

The Effects Of Cpg And Upa Dinucleotides On The Attenuation Of Poliovirus By Codon Pair Deoptimization, Malka Arabov Dec 2014

The Effects Of Cpg And Upa Dinucleotides On The Attenuation Of Poliovirus By Codon Pair Deoptimization, Malka Arabov

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Codon pair bias, the preferential pairing of certain codons over others, has been observed in all species analyzed ranging from bacteria to mammals. Previous research has shown that artificial coupling of underrepresented codon pairs (codon pair deoptimization) in viral genomes (such as poliovirus and influenza virus) reduces gene function and leads to virus death or attenuation. Although the reason for this phenomenon is unclear, increasing underrepresented codon pairs in an RNA viral coding region consequently increases the frequency of CpG and UpA dinucleotides. These dinucleotides are suppressed in a variety of species and may be responsible for attenuation by codon …

Go to article

The Adenovirus L4-22k Protein Serves As The Master Regulator To Coordinate Late Gene Expression And Viral Dna Packaging, Diana Guimet Dec 2014

The Adenovirus L4-22k Protein Serves As The Master Regulator To Coordinate Late Gene Expression And Viral Dna Packaging, Diana Guimet

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The adenovirus L4-22K protein is multifunctional and critical for different aspects of viral infection. Following DNA replication, increasing amounts of the L4-22K protein are observed prior to the appearance of other late viral proteins. We found that L4-22K controls viral gene expression at the post-transcriptional level and regulates the accumulation of the L4-33K protein, another critical viral regulator, at the level of alternative pre-mRNA splicing. This initiates an activation cascade of late viral proteins, while early genes are being turned off. To gain a better understanding of the mechanism of action of L4-22K, we sought to map the critical elements …

Go to article

Structural Change In Impact Altered Phyllosilicates As Detected By Laboratory Spectroscopy And Applied To The Remote Sensing Of The Surface Of Mars, Lonia Rachael Friedlander Dec 2014

Structural Change In Impact Altered Phyllosilicates As Detected By Laboratory Spectroscopy And Applied To The Remote Sensing Of The Surface Of Mars, Lonia Rachael Friedlander

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Atomic-scale mineral properties directly control detectable macroscopic properties. These include reactivity and stability as well as characteristic vibrational and electronic spectroscopic features. The connection between structure and spectroscopic properties in minerals is of fundamental importance to the interpretation of remote sensing data, especially in planetary science where ground-truth is very difficult. On planets without plate tectonics such as Mars, meteoritic impacts are a fundamental geologic process known to affect the structure of planetary surfaces, as well as their mineralogy. This work uses a wide range of laboratory spectroscopic techniques to detect and investigate structural change in impact-altered phyllosilicates. The analysis …

Go to article

The Blues Continuum: New York Calls - Naples Responds, Alessandro Buffa Dec 2014

The Blues Continuum: New York Calls - Naples Responds, Alessandro Buffa

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

My dissertation traces a form of call and response between New York City and Naples in the 1970s and 1980s. It foregrounds the importance of the `blues' in the traffic of sound, images and oppositional ideas between these two cities located on the same geographical parallel. The blues here is understood as a musical style and feeling, as well as an affect of trauma, loss, memory and an intimate relationship that artists and activists established with their city spaces in the age of the so called " urban crisis." It proposes a " blutopia," based on utopian/dystopian tensions that promote …

Go to article

Effects Of Ocean Acidification Combined With Hypoxia, Elevated Temperature, Or Restricted Food Supply On Early Life Stages Of The Forage Fish Menidia Beryllina, Menidia Menidia, And Cyprinodon Variegatus, Elizabeth Depasquale Dec 2014

Effects Of Ocean Acidification Combined With Hypoxia, Elevated Temperature, Or Restricted Food Supply On Early Life Stages Of The Forage Fish Menidia Beryllina, Menidia Menidia, And Cyprinodon Variegatus, Elizabeth Depasquale

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Estuarine organisms are experiencing many stressors related to climate change at an accelerated pace when compared to the open ocean. The co-occurrence of acidification and hypoxia has been observed during warmer months when many fish species spawn in temperate estuaries. Concurrently, estuarine systems can experience extreme temperatures during summer and dynamic levels of plankton. This study assessed the tolerance of early life stage estuarine fish to the co-occurrence of acidification with hypoxia, elevated temperatures, and varying levels of planktonic prey. Time to hatch, hatching rates, survival, and growth were quantified for larval Menidia beryllina, Menidia menidia, and Cyprinodon variegatus exposed …

Go to article

High-Throughput Single-Cell Copy Number Profiling For Cancer Heterogeneity Analysis, Taimour Baslan Dec 2014

High-Throughput Single-Cell Copy Number Profiling For Cancer Heterogeneity Analysis, Taimour Baslan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Intra-tumoral genetic heterogeneity has long been recognized, yet remains poorly understood. This has primarily been due to the lack of sensitive technologies to measure it. Genome wide analysis at the level of single cells has recently emerged as a powerful tool to dissect cancer genome heterogeneity. However, to be truly transformative, single cell approaches must accommodate the analysis of large numbers of single cells. Here, using integrative informatics and molecular biology approaches this study presents a robust, low-cost, and high-throughput method to retrieve the genome-wide copy number landscape of hundreds of single cancer cells. Application of the method to human …

Go to article

Missing-In-Metastasis Regulates Cell Motility And Invasion Via Ptpδ Mediated Changes In Src Activity, Fauzia Chaudhary Dec 2014

Missing-In-Metastasis Regulates Cell Motility And Invasion Via Ptpδ Mediated Changes In Src Activity, Fauzia Chaudhary

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Missing in Metastasis (MIM), also known as MTSS1, is a scaffold protein that is down-regulated in multiple metastatic cancer cell lines compared to non-metastatic counterparts. MIM regulates cytoskeletal dynamics and actin polymerization, and has been implicated in the control of cell motility and invasion. MIM has also been shown to bind to a receptor PTP, PTP-delta, an interaction that may provide a link between tyrosine phosphorylation-dependent signaling and metastasis. We used shRNA-mediated gene silencing to investigate the consequences of loss of MIM on the migration and invasion of the MCF10A mammary epithelial cell model of breast cancer. We observed that …

Go to article

Three Novel Rrna Methyltransferases In Mammalian Mitochondria, Ken Lee Dec 2014

Three Novel Rrna Methyltransferases In Mammalian Mitochondria, Ken Lee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Mammalian mitochondria maintain their double-stranded circular genome in DNA-protein complexes known as nucleoids, similar to bacteria. While bacterial and yeast mitochondrial nucleoids have been studied more extensively, much is unknown about the protein composition and events that occur at mammalian mitochondrial nucleoids. Recent work has identified many novel mitochondrial nucleoid proteins by mass spectrometry, however the functions of many of these proteins are not well understood. One of the interesting proteins identified by mass spectrometry is RNMTL1, a putative RNA methyltransferase. A search for related mitochondrial proteins in proteomic databases revealed MRM1 and MRM2 as potential RNA methyltransferases as well. …

Go to article

Molecular Mechanisms For Specific Kinase Inhibitors And Kinase Promiscuity Towards Inhibitors, George Georghiou Dec 2014

Molecular Mechanisms For Specific Kinase Inhibitors And Kinase Promiscuity Towards Inhibitors, George Georghiou

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Dysregulated kinase activity is implicated in a wide variety of diseases because of the central role of kinases in many cell signaling pathways. Currently all small molecule kinase inhibitors used clinically target the ATP-binding pocket, which is highly conserved among all kinases due to their common use of ATP. This high degree of conservation makes the pharmacological targeting of individual kinases difficult. However, it has been achieved with several drugs, the most famous of these being the Abl kinase inhibitor imatinib (Gleevec, Novartis). While a number of broad-spectrum kinase inhibitors are in clinical use, specific kinase inhibition is favorable to …

Go to article

The Role Of Tolc In Francisella Tularensis Virulence, Christopher Richard Doyle Dec 2014

The Role Of Tolc In Francisella Tularensis Virulence, Christopher Richard Doyle

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Francisella tularensis is a Gram-negative, facultative intracellular pathogen and the causative agent of tularemia. F. tularensis is a Tier 1 agent of bioterrorism that is highly lethal via the pulmonary route of infection. F. tularensis invades host cells, escapes the phagosome, and replicates in the cytosol prior to being released upon host cell death. The molecular mechanisms behind the virulence of F. tularensis are largely unknown. Among the described virulence factors of F. tularensis is a functional type I secretion system (T1SS). The T1SS is important for the secretion of virulence factors from the bacterial cytoplasm to the extracellular environment. …

Go to article

Identification Of Sporulation-Defective Genes And A Rab-Cascade Model For The Formation Of The Forespore Membrane In Schizosaccharomyces Pombe, Esma Ucisik-Akkaya Dec 2014

Identification Of Sporulation-Defective Genes And A Rab-Cascade Model For The Formation Of The Forespore Membrane In Schizosaccharomyces Pombe, Esma Ucisik-Akkaya

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In the fission yeast, Schizosaccharomyces pombe, environmental stress conditions such as nitrogen starvation induce mating of two haploid cells. The newly formed diploid cells immediately undergo meiosis and form spores, which are equivalent to gametes in higher organisms. The packaging of the haploid nuclei, which are formed after two rounds of meiosis, is achieved by the de novo formation of double membranes called forespore membranes, which form adjacent to the meiotic spindle pole bodies (SPBs). This work focuses on the initiation of the forespore membrane at the SPB and the genes that are required for the proper formation of the …

Go to article

Thalamocortical Input To The Primary Visual Cortex, Michelle Kloc Dec 2014

Thalamocortical Input To The Primary Visual Cortex, Michelle Kloc

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The lateral geniculate nucleus (LGN) is the region of the thalamus that innervates and relays sensory information to the primary visual cortex (V1). Thalamocortical (TC) input from the LGN drives the activity of V1, and underlies the health and function of the visual system. However, little is known about the synaptic properties of this input. LGN inputs innervate two layers, layer 4 (L4) and layer 6 (L6). This input has been examined functionally and anatomically, but the synaptic mechanisms of this input are poorly understood. The anatomy of the projection from the LGN to V1 encumbers the preparation of an …

Go to article

Democracy And Its Others, Jeffrey Harry Epstein Dec 2014

Democracy And Its Others, Jeffrey Harry Epstein

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Today's unprecedented levels of human migration present urgent challenges to traditional conceptualizations of national identity, nation-state sovereignty, and democratic citizenship. The instrumental valorization or vilification of foreignness for nationalistic ends has long-determined who is to be included within or excluded from " the people" of the democratic state. Against this instrumentalization, I argue that foreignness is an originary and constitutive element of democratic political identity which severs the links among nationality, citizenship, and democratic rights. Accordingly, a re-conceptualization of democratic rights is required that reflects the structural necessity of foreignness to democratic political identity. | 225 pages

Go to article

The Placiality Of Thought, Brian A. Irwin Dec 2014

The Placiality Of Thought, Brian A. Irwin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

All experience is embodied and, concomitantly, all experience is emplaced. It follows that abstract thought, as a mode of experience, is always emplaced. In what sense is this the case? Following the insights of Maurice Merleau-Ponty, this dissertation seeks to answer this question. A first key insight comes from Phenomenology of Perception: namely, the suggestion that every thought is a bodily experience, and that abstract thought expresses bodily capacities that, through imagination, enter into realms of the virtual. A second key insight comes from Merleau-Ponty's later philosophy, especially The Visible and the Invisible: this is his account of language as …

Go to article

Contextual Influences On Political Cognition, April Johnson Dec 2014

Contextual Influences On Political Cognition, April Johnson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation argues that electoral supply, as measured by the effective number of parties across U.S. Congressional districts, shapes the way in which individuals conceptualize and think about politics at a fundamental, cognitive level. Via socialization processes and repeated exposure over time, individuals nested within dissimilar supply environments learn to interact with political stimuli in ways which systematically differ. In contexts with traditionally less electoral supply, or a fewer number of viable parties, individuals become accustom to characterizing partisan dynamics in dichotomous, black and white terms. Alternatively, in contexts with more electoral supply individuals learn to view partisan dynamics as …

Go to article

Conflict And Cooperation As Social Responses To Ecological Change, Nicholas A. Seltzer Dec 2014

Conflict And Cooperation As Social Responses To Ecological Change, Nicholas A. Seltzer

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation examines ways the environment conditions individual incentives to participate in collective action. I hypothesize that as resources become scarce, individuals are more willing to participate in individually-costly collective action, including intragroup cooperation and intergroup hostility. The first and second of three studies establish a unit-of-selection based, game-theoretic foundation for intergroup conflict. The final study explores macro-level implications for the relationship between climate change and violence in Africa. For human beings and other highly social creatures, cooperation is the key adaptation with which we respond to environmental challenges. Faced with resource scarcity, group living becomes increasingly vital for individual …

Go to article

Attachment's Role In Social Support And Mentoring: An Investigation Among Collegiate Women, Alberto Herrera-Alcazar Dec 2014

Attachment's Role In Social Support And Mentoring: An Investigation Among Collegiate Women, Alberto Herrera-Alcazar

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Recent years have seen a concerted effort to increase the number of women pursuing Science, Technology, Engineering and Mathematics (STEM) fields. Although one approach to retention of undergraduates in STEM fields has been formal mentoring programs, other channels, such as naturally occurring mentor relationships, have served to retain students in science and other disciplines as well. The current project investigated the interplay between attachment representations of close relationships, social support and mentor relationships. The first aim was to examine the relationship between attachment and general facets of social support. The second aim was to assess benefits of mentor relationships on …

Go to article

Visual Association Mining Of Multivariate Data, Zhiyuan Zhang Dec 2014

Visual Association Mining Of Multivariate Data, Zhiyuan Zhang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The rapid development of information technology produces vast amounts of data with numerous attributes. These multi-dimensional datasets offer tremendous opportunities for studying existing behavioral patterns and for predicting future developments. However, the high-dimensional space exceeds human comprehension. More sophisticated visualization techniques than the arsenal of standard plots are needed. First, we introduce an interactive navigation technique to help the analysts explore within the multi-dimensional data spaces. We employ a network-based interface and pair it with a parallel coordinates plot. In the network interface, the dimensions form nodes that are connected by edges representing the strength of association between dimensions. The …

Go to article

University Of Dayton Magazine, Winter 2014-15, University Of Dayton Magazine Dec 2014

University Of Dayton Magazine, Winter 2014-15, University Of Dayton Magazine

University of Dayton Alumni Publications

This issue includes information about work UD students are doing in Africa, stories long told on campus, and the death penalty.

Go to article

Citizen Science Reveals Widespread Negative Effects Of Roads On Amphibian Distributions, Bradley J. Cosentino, David M. Marsh, Kara S. Jones, Joseph J. Apodaca, Christopher Bates, Jessica Beach, Karen H. Beard, Kelsie Becklin, Jane Margaret Bell, Christopher Crockett, George Fawson, Jennifer Fjelsted, Elizabeth A. Forys, Kristen S. Genet, Melanie Grover, Jaimie Holmes, Katherine Indeck, Nancy E. Karraker, Eran S. Kilpatrick, Tom A. Langen, Stephen G. Mugel, Alessandro Molina, James R. Vonesh, Ryan J. Weaver, Anisha Willey Dec 2014

Citizen Science Reveals Widespread Negative Effects Of Roads On Amphibian Distributions, Bradley J. Cosentino, David M. Marsh, Kara S. Jones, Joseph J. Apodaca, Christopher Bates, Jessica Beach, Karen H. Beard, Kelsie Becklin, Jane Margaret Bell, Christopher Crockett, George Fawson, Jennifer Fjelsted, Elizabeth A. Forys, Kristen S. Genet, Melanie Grover, Jaimie Holmes, Katherine Indeck, Nancy E. Karraker, Eran S. Kilpatrick, Tom A. Langen, Stephen G. Mugel, Alessandro Molina, James R. Vonesh, Ryan J. Weaver, Anisha Willey

Wildland Resources Faculty Publications

Landscape structure is important for shaping the abundance and distribution of amphibians, but prior studies of landscape effects have been species or ecosystem-specific. Using a large-scale, citizen science-generated database, we examined the effects of habitat composition, road disturbance, and habitat split (i.e. the isolation of wetland from forest by intervening land use) on the distribution and richness of frogs and toads in the eastern and central United States. Undergraduates from nine biology and environmental science courses collated occupancy data and characterized landscape structure at 1617 sampling locations from the North American Amphibian Monitoring Program. Our analysis revealed that anuran species …

Go to article

First Prev Next Last