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Articles 4591 - 4620 of 7500
Full-Text Articles in Entire DC Network
Natural Interventions And Hydrotherapy Workshop, Evelyn Kissinger
Natural Interventions And Hydrotherapy Workshop, Evelyn Kissinger
Andrews Agenda: Campus News
No abstract provided.
The Tiger Vol. 108 Issue 2 2014-01-24, Clemson University
The Tiger Vol. 108 Issue 2 2014-01-24, Clemson University
Tiger Newspapers
No abstract provided.
Supervised Categorical Principal Component Analysis For Genome-Wide Association Analyses, Meng Lu, Hye-Seung Lee, David Hadley, Jianhua Z. Huang, Xiaoning Qiao
Supervised Categorical Principal Component Analysis For Genome-Wide Association Analyses, Meng Lu, Hye-Seung Lee, David Hadley, Jianhua Z. Huang, Xiaoning Qiao
Computer Science and Engineering Faculty Publications
In order to have a better understanding of unexplained heritability for complex diseases in conventional Genome-Wide Association Studies (GWAS), aggregated association analyses based on predefined functional regions, such as genes and pathways, become popular recently as they enable evaluating joint effect of multiple Single-Nucleotide Polymorphisms (SNPs), which helps increase the detection power, especially when investigating genetic variants with weak individual effects. In this paper, we focus on aggregated analysis methods based on the idea of Principal Component Analysis (PCA). The past approaches using PCA mostly make some inherent genotype data and/or risk effect model assumptions, which may hinder the accurate …
Emu Today, January 24, 2014, Eastern Michigan University
Emu Today, January 24, 2014, Eastern Michigan University
EMU Today
No abstract provided.
Update On Ranolazine In The Management Of Angina., J Nicolás Codolosa, Subroto Acharjee, Vincent M. Figueredo, M.D.
Update On Ranolazine In The Management Of Angina., J Nicolás Codolosa, Subroto Acharjee, Vincent M. Figueredo, M.D.
Division of Cardiology Faculty Papers
Mortality rates attributable to coronary heart disease have declined in recent years, possibly related to changes in clinical presentation patterns and use of proven secondary prevention strategies. Chronic stable angina (CSA) remains prevalent, and the goal of treatment is control of symptoms and reduction in cardiovascular events. Ranolazine is a selective inhibitor of the late sodium current in myocytes with anti-ischemic and metabolic properties. It was approved by the US Food and Drug Administration in 2006 for use in patients with CSA. Multiple, randomized, placebo-controlled trials have shown that ranolazine improves functional capacity and decreases anginal episodes in CSA patients, …
The Bg News January 24, 2014, Bowling Green State University
The Bg News January 24, 2014, Bowling Green State University
BG News (Student Newspaper)
The BGSU campus student newspaper. January 24, 2014. Volume 93-Issue 56.
Legal And Ethical Responsibilities Following Brain Death: The Mcmath And Muñoz Cases, Lawrence O. Gostin
Legal And Ethical Responsibilities Following Brain Death: The Mcmath And Muñoz Cases, Lawrence O. Gostin
Georgetown Law Faculty Publications and Other Works
What are the legal and ethical implications of continuing to treat a brain dead patient? And may a hospital refuse to provide such treatment? These ethical and legal problems are raised in two recent cases. In the first Marlise Muñoz, a pregnant woman declared brain dead, was kept on life support against her family’s wishes due to the treating hospital’s interpretation of a Texas fetal protection law. In the other a hospital refused to treat Jahi McMath, a brain dead girl, despite her family's entreaties. The cases, at first, appear similar because in each case the hospital was refusing to …
A Longitudinal Study Of The Bidirectional Relations Between Internalizing Symptoms And Peer Victimization In Urban Adolescents, Tess Drazdowski
A Longitudinal Study Of The Bidirectional Relations Between Internalizing Symptoms And Peer Victimization In Urban Adolescents, Tess Drazdowski
Theses and Dissertations
The purpose of this study was to examine the bidirectional relations between anxious and depressive symptoms and two forms of peer victimization (i.e., overt and relational) within a sample of 358 predominantly African-American adolescents living in low-income urban areas across four years. Longitudinal path analyses tested progressively complex models for each type of victimization. For both overt and relational victimization the autoregressive model where only previous levels of each construct predicted future levels of the construct was the most parsimonious explanation. The best fitting model for both types of peer victimization suggested that internalizing symptoms helped to further explain future …
Prospect Hill: Skeletal Remains From A 19th-Century Methodist Cemetery, Newmarket, Ontario, S. Pfeiffer, J. C. Dudar, S. Austin
Prospect Hill: Skeletal Remains From A 19th-Century Methodist Cemetery, Newmarket, Ontario, S. Pfeiffer, J. C. Dudar, S. Austin
Northeast Historical Archaeology
During 1989-90, in response to disruption caused by a building site excavation in Newmarket, Ontario, archaeological and biological information was salvaged from a former church cemetery dating from 1824 or 1827 to 1879. The skeletal remains of 77 indivaduals indicate a population with high infant mortality and little access to medical or dental care. Nevertheless, the autopsy of a young pregnant woman and one gold dental filling indicate there was an incipient interest in biomedical that mechanisms be available to allow the salvage of as much historical and biological information as possible.
Emu Today, January 23, 2014, Eastern Michigan University
Emu Today, January 23, 2014, Eastern Michigan University
EMU Today
No abstract provided.
Sandspur, Vol 120, No 13, January 23, 2014, Rollins College
Sandspur, Vol 120, No 13, January 23, 2014, Rollins College
The Rollins Sandspur
Rollins College student newspaper, written by the students and published at Rollins College. The Sandspur started as a literary journal.
The Montclarion, January 23, 2014, The Montclarion
The Montclarion, January 23, 2014, The Montclarion
The Montclarion
Student Newspaper of Montclair State University
Expression Pattern And Biochemical Properties Of Zebrafish N-Acetylglutamate Synthase, Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka
Expression Pattern And Biochemical Properties Of Zebrafish N-Acetylglutamate Synthase, Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka
College of Science & Mathematics Departmental Research
The urea cycle converts ammonia, a waste product of protein catabolism, into urea. Because fish dispose ammonia directly into water, the role of the urea cycle in fish remains unknown. Six enzymes, N-acetylglutamate synthase (NAGS), carbamylphosphate synthetase III, ornithine transcarbamylase, argininosuccinate synthase, argininosuccinate lyase and arginase 1, and two membrane transporters, ornithine transporter and aralar, comprise the urea cycle. The genes for all six enzymes and both transporters are present in the zebrafish genome. NAGS (EC 2.3.1.1) catalyzes the formation of N-acetylglutamate from glutamate and acetyl coenzyme A and in zebrafish is partially inhibited by L-arginine. NAGS and other urea …
Expression Pattern And Biochemical Properties Of Zebrafish N-Acetylglutamate Synthase, Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka
Expression Pattern And Biochemical Properties Of Zebrafish N-Acetylglutamate Synthase, Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka
Genomics and Precision Medicine Faculty Publications
The urea cycle converts ammonia, a waste product of protein catabolism, into urea. Because fish dispose ammonia directly into water, the role of the urea cycle in fish remains unknown. Six enzymes, N-acetylglutamate synthase (NAGS), carbamylphosphate synthetase III, ornithine transcarbamylase, argininosuccinate synthase, argininosuccinate lyase and arginase 1, and two membrane transporters, ornithine transporter and aralar, comprise the urea cycle. The genes for all six enzymes and both transporters are present in the zebrafish genome. NAGS (EC 2.3.1.1) catalyzes the formation of N-acetylglutamate from glutamate and acetyl coenzyme A and in zebrafish is partially inhibited by L-arginine. NAGS and other urea …
Uab Study Hopes Vegetable Gardens Can Help Cancer Survivors, Alicia Rohan
Uab Study Hopes Vegetable Gardens Can Help Cancer Survivors, Alicia Rohan
Browse All News
No abstract provided.
Flyer News, Vol. 61, No. 15 (Jan. 22, 2014), University Of Dayton
Flyer News, Vol. 61, No. 15 (Jan. 22, 2014), University Of Dayton
Flyer News
Student-run newspaper of the University of Dayton.
Comparison Of The White-Nose Syndrome Agent Pseudogymnoascus Destructans To Cave-Dwelling Relatives Suggests Reduced Saprotrophic Enzyme Activity, Hannah T. Reynolds, Hazel A. Barton
Comparison Of The White-Nose Syndrome Agent Pseudogymnoascus Destructans To Cave-Dwelling Relatives Suggests Reduced Saprotrophic Enzyme Activity, Hannah T. Reynolds, Hazel A. Barton
KIP Articles
No abstract provided.
Volume 51, Number 23: January 22, 2014, University Of North Dakota
Volume 51, Number 23: January 22, 2014, University Of North Dakota
University Letter Archive
No abstract provided.
Comparison Of The White-Nose Syndrome Agent Pseudogymnoascus Destructans To Cave-Dwelling Relatives Suggests Reduced Saprotrophic Enzyme Activity, Hannah T. Reynolds, Hazel A. Barton
Comparison Of The White-Nose Syndrome Agent Pseudogymnoascus Destructans To Cave-Dwelling Relatives Suggests Reduced Saprotrophic Enzyme Activity, Hannah T. Reynolds, Hazel A. Barton
KIP Articles
White-nose Syndrome (WNS) is an emerging infectious mycosis that has impacted multiple species of North American bats since its initial discovery in 2006, yet the physiology of the causal agent, the psychrophilic fungus Pseudogymnoascus destructans ( = Geomyces destructans), is not well understood. We investigated the ability of P. destructans to secrete enzymes that could permit environmental growth or affect pathogenesis and compared enzyme activity across several Pseudogymnoascus species isolated from both hibernating bats and cave sediments. We found that P. destructans produced enzymes that could be beneficial in either a pathogenic or saprotrophic context, such as lipases, hemolysins, and …
Application Of Microarray And Functional-Based Screening Methods For The Detection Of Antimicrobial Resistance Genes In The Microbiomes Of Healthy Humans, Roderick M. Card, Philip J. Warburton, Nikki Maclaren, Peter Mullany, Elaine Allan, Muna F. Anjum
Application Of Microarray And Functional-Based Screening Methods For The Detection Of Antimicrobial Resistance Genes In The Microbiomes Of Healthy Humans, Roderick M. Card, Philip J. Warburton, Nikki Maclaren, Peter Mullany, Elaine Allan, Muna F. Anjum
School of Biomedical Sciences
No abstract provided.
January 21st 2014, Csusb
Superoxide Signaling In Perivascular Adipose Tissue Promotes Age-Related Artery Stiffness, Bradley S. Fleenor, Jason S. Eng, Amy L. Sindler, Bryant T. Pham, Jackson D. Kloor, Douglas R. Seals
Superoxide Signaling In Perivascular Adipose Tissue Promotes Age-Related Artery Stiffness, Bradley S. Fleenor, Jason S. Eng, Amy L. Sindler, Bryant T. Pham, Jackson D. Kloor, Douglas R. Seals
Graduate Center for Nutritional Sciences Faculty Publications
We tested the hypothesis that superoxide signaling within aortic perivascular adipose tissue (PVAT) contributes to large elastic artery stiffening in old mice. Young (4-6 months), old (26-28 months), and old treated with 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPOL), a superoxide scavenger (1 mm in drinking water for 3 weeks), male C57BL6/N mice were studied. Compared with young, old had greater large artery stiffness assessed by aortic pulse wave velocity (aPWV, 436 ± 9 vs. 344 ± 5 cm s(-1)) and intrinsic mechanical testing (3821 ± 427 vs. 1925 ± 271 kPa) (both P < 0.05). TEMPOL treatment in old reversed both measures of arterial stiffness. Aortic PVAT superoxide production was greater in old (P < 0.05 vs. Y), which was normalized with TEMPOL. Compared with young, old controls had greater pro-inflammatory proteins in PVAT-conditioned media (P < 0.05). Young recipient mice transplanted with PVAT from old compared with young donors for 8 weeks had greater aPWV (409 ± 7 vs. 342 ± 8 cm s(-1)) and intrinsic mechanical properties (3197 ± 647 vs. 1889 ± 520 kPa) (both P < 0.05), which was abolished with TEMPOL supplementation in old donors. Tissue-cultured aortic segments from old in the presence of PVAT had greater mechanical stiffening compared with old cultured in the absence of PVAT and old with PVAT and TEMPOL (both, P < 0.05). In addition, PVAT-derived superoxide was associated with arterial wall hypertrophy and greater adventitial collagen I expression with aging that was attenuated by TEMPOL. Aging or TEMPOL treatment did not affect blood pressure. Our findings provide evidence for greater age-related superoxide production and pro-inflammatory proteins in PVAT, and directly link superoxide signaling in PVAT to large elastic artery stiffness.
Emu Today, January 21, 2014, Eastern Michigan University
Emu Today, January 21, 2014, Eastern Michigan University
EMU Today
No abstract provided.
A Genome-Wide Association Study Identifies A Locus On Tert For Mean Telomere Length In Han Chinese., Yun Liu, Lan Cao, Zhiqiang Li, Daizhan Zhou, Wanqing Liu, Qin Shen, Yanting Wu, Dan Zhang, Xun Hu, Ting Wang, Junyi Ye, Xiaoling Weng, Hong Zhang, Di Zhang, Zhou Zhang, Fatao Liu, Lin He, Yongyong Shi
A Genome-Wide Association Study Identifies A Locus On Tert For Mean Telomere Length In Han Chinese., Yun Liu, Lan Cao, Zhiqiang Li, Daizhan Zhou, Wanqing Liu, Qin Shen, Yanting Wu, Dan Zhang, Xun Hu, Ting Wang, Junyi Ye, Xiaoling Weng, Hong Zhang, Di Zhang, Zhou Zhang, Fatao Liu, Lin He, Yongyong Shi
Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications
Leukocyte telomere length (LTL) is a predictor of aging and a number of age-related diseases. We performed genome-wide association studies of mean LTL in 2632 individuals,with a two-stage replication in 3917 individuals from Chinese populations. To further validate our findings, we get the results of 696 samples from a cohort of European ancestry. We identified two loci associated with LTL that map in telomerase reverse transcriptase (TERT; rs2736100, P = 1.93×10−5) on chromosome 5p15.33 and near keratin 80 (KRT80; rs17653722, P = 6.96×10−6) on 12q13.13. In Chinese population each C allele of rs2736100 and T allele …
Plasma Selenium Biomarkers In Low Income Black And White Americans From The Southeastern United States, Margaret K. Hargreaves, Jianguo Liu, Maciej S. Buchowski, Kushal A. Patel, Celia O. Larson, David G. Schlundt, Donna M. Kenerson, Kristina E. Hill, Raymond F. Burk, William J. Blot
Plasma Selenium Biomarkers In Low Income Black And White Americans From The Southeastern United States, Margaret K. Hargreaves, Jianguo Liu, Maciej S. Buchowski, Kushal A. Patel, Celia O. Larson, David G. Schlundt, Donna M. Kenerson, Kristina E. Hill, Raymond F. Burk, William J. Blot
Public Health, Health Administration, and Health Sciences Faculty Research
Biomarkers of selenium are necessary for assessing selenium status in humans, since soil variation hinders estimation of selenium intake from foods. In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interindividual differences in 383 low-income blacks and whites selected from a stratified random sample of adults aged 40–79 years, who were participating in a long-term cohort study in the southeastern United States (US). We assessed the utility of these biomarkers to determine differences in selenium status and their association with demographic, socio-economic, dietary, and other indicators. Dietary selenium intake …
The Collegian (2014-01-20), Cleiri Quezada
The Collegian (2014-01-20), Cleiri Quezada
UTB/TSC Archives - The Collegian [Newspaper]
Vol. 66, No. 16
Emu Today, January 20, 2014, Eastern Michigan University
Emu Today, January 20, 2014, Eastern Michigan University
EMU Today
No abstract provided.
Maternal Overweight And Obesity And Risk Of Congenital Heart Defects In Offspring, Jennifer Brite, Sarah Katherine Laughon, James Troendle, James Mills
Maternal Overweight And Obesity And Risk Of Congenital Heart Defects In Offspring, Jennifer Brite, Sarah Katherine Laughon, James Troendle, James Mills
Publications and Research
Objective Obesity is a risk factor for congenital heart defects (CHD), but whether risk is independent of abnormal glucose metabolism is unknown. Data on whether overweight status increases risk is also conflicting. Research Design and Methods We included 121815 deliveries from a cohort study, the Consortium on Safe Labor, after excluding women with pregestational diabetes as recorded in the electronic medical record. CHD were identified via medical record discharge summaries. Adjusted odds ratios (OR) for any CHD were calculated for prepregnancy body mass index (BMI) categories of overweight (25 to <30 kg/m2), obese (30 to <40 kg/m2), and morbidly obese (≥40 kg/m2) compared to normal weight (18.5 to <25 kg/m2) women, and for specific CHD with obese groups combined (≥30 kg/m2). A sub-analysis adjusting for oral glucose tolerance test (OGTT) results where available was performed as a proxy for potential abnormal glucose metabolism present at the time of organogenesis. Results There were 1388 (1%) infants with CHD. Overweight (OR=1.15 95% CI: 1.01–1.32), obese (OR=1.26 95% CI: 1.09, 1.44), and morbidly obese (OR=1.34 95% CI: 1.02–1.76) women had greater odds of having a neonate with CHD than normal weight women (P< 0.001 for trend). Obese women (BMI ≥30 kg/m2) had higher odds of having an infant with conotruncal defects (OR=1.34 95%CI: 1.04–1.72), atrial septal defects (OR =1.22 95% CI: 1.04–1.43), and ventricular septal defects (OR=1.38 95% CI: 1.06–1.79). Being obese remained a significant predictor of CHD risk after adjusting for OGTT. Conclusion Increasing maternal weight class was associated with increased risk for CHD. In obese women, abnormal glucose metabolism did not completely explain the increased risk for CHD; the possibility that other obesity-related factors are teratogenic requires further investigation.
Biochemical Analysis Of Blood Of Native Cattle In The Hilly Area Of Bangladesh, M. A. Mamun, M. M. Hassan, A. H. Shaikat, S.K.M.A. Islam, M. A. Hoque, M. Uddin, M. B. Hossain
Biochemical Analysis Of Blood Of Native Cattle In The Hilly Area Of Bangladesh, M. A. Mamun, M. M. Hassan, A. H. Shaikat, S.K.M.A. Islam, M. A. Hoque, M. Uddin, M. B. Hossain
Biochemistry Collection
A yearlong study was carried out in indigenous cattle of five upazila namely Khagrachari Sadar, Laxmichari, Matiranga, Mahalchari and Dighinala in Khagrachari Hill District, Bangladesh for determination of statuses of various biochemical parameters. Apparently healthy cattle (100) were selected and blood samples were collected aseptically. Biochemical analysis of carbohydrates, proteins, fats, minerals, electrolytes and enzymes were performed by using automated biochemical analyzer (Humalizer®-3000). The results showed that, the variations of parameters were not significant (P>0.05) between male and female. Although there was a slight increase of calcium 8.01±0.32mg/dl, glucose 69.21±2.31mg/dl, LDL 5.69±0.22mg/dl and uric acid 3.85±0.34mg/dl of female compared …