Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2014

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 1921 - 1950 of 30886

Full-Text Articles in Entire DC Network

Sign Me Up! Determining Motivation For High School Chemistry Students Enrolling In A Second Year Chemistry Course, Nilda N. Camarena Dec 2014

Sign Me Up! Determining Motivation For High School Chemistry Students Enrolling In A Second Year Chemistry Course, Nilda N. Camarena

Theses and Dissertations - UTB/UTPA

A sample of 108 Pre-AP Chemistry students in Texas participated in a study to determine motivational factors for enrolling in AP Chemistry and University Chemistry. The factors measured were academic attitude, perceptions of chemistry, confidence level in chemistry, and expectations/experiences in the chemistry class. Students completed two questionnaires, one at the beginning of the year and one at the end. Four high school campuses from two school districts in Texas participated. Two campuses were traditional high schools and two were smaller magnet schools. The results from this study are able to confirm that there are definite correlations between academic attitudes, …

Go to article

The Italian Press And The Church: Italian Newspaper Coverage Of Lds-Related News And The Media Strategies Of The Church Of Jesus Christ Of Latter-Day Saints In Italy 2010-2012, Giulia Vibilio Matthews Dec 2014

The Italian Press And The Church: Italian Newspaper Coverage Of Lds-Related News And The Media Strategies Of The Church Of Jesus Christ Of Latter-Day Saints In Italy 2010-2012, Giulia Vibilio Matthews

Theses and Dissertations

The relationship between media and religion has been influenced by many factors in history. The Church of Jesus Christ of Latter-day Saints has received a great deal of media attention throughout the world in the past five years. In Italy, the Church National Council of Public Relations worked to provide the media with the necessary information to report accurate news about the Church. This thesis collected the information provided to the Italian media by the Church National Council and analyzed the main topic and the level of accuracy reported by the Italian media on Church-related news. The results show that …

Go to article

The Interaction Of Aeolian And Fluvial Processes In Dry Washes On The Colorado Plateau, Usa, Beau Jensen Walker Dec 2014

The Interaction Of Aeolian And Fluvial Processes In Dry Washes On The Colorado Plateau, Usa, Beau Jensen Walker

Theses and Dissertations

In the past decade there has been a call for integrated studies that examine the interaction of fluvial and aeolian processes (Belnap et al., 2011; Bullard and Livingstone, 2002). In this study, we examined the role of land-use, weather, and soil type on the flux of aeolian material into dry washes on the Colorado Plateau in central Utah, USA, and western Colorado, USA. Our goal was to quantify the impact of individual deposition and erosion events by correlating weather and land-use data with a combination of measurement methods including dust collection via dust traps, GPS surveying, and close-range photogrammetry. Our …

Go to article

Influence Of Pile Shape On Resistance To Lateral Loading, Guillermo Bustamante Dec 2014

Influence Of Pile Shape On Resistance To Lateral Loading, Guillermo Bustamante

Theses and Dissertations

The lateral resistance of pile foundations has typically been based on the resistance of circular pipe piles. In addition, most instrumented lateral load tests and cases history have involved circular piles. However, piles used in engineering practice may also be non-circular cross-section piles such as square and H piles. Some researchers have theorized that the lateral resistance of square piles will be higher than that of circular piles (Reese and Van Impe, 2001; Briaud et al, 1983; Smith, 1987) for various reasons, but there is not test data to support this claims. To provide basic comparative performance data, lateral load …

Go to article

Fabrication, Characterization, Optimization And Application Development Of Novel Thin-Layer Chromatography Plates, Supriya Singh Kanyal Dec 2014

Fabrication, Characterization, Optimization And Application Development Of Novel Thin-Layer Chromatography Plates, Supriya Singh Kanyal

Theses and Dissertations

This dissertation describes advances in the microfabrication of thin layer chromatography (TLC) plates. These plates are prepared by the patterning of carbon nanotube (CNT) forests on substrates, followed by their infiltration with an inorganic material. This document is divided into ten sections or chapters. Chapter 1 reviews the basics of conventional TLC technology. This technology has not changed substantially in decades. This chapter also mentions some of the downsides of the conventional approach, which include unwanted interactions of the binder in the plates with the analytes, relatively slow development times, and only moderately high efficiencies. Chapter 2 focuses primarily on …

Go to article

Role Of Epistasis In Alzheimer's Disease Genetics, Mark T. Ebbert Dec 2014

Role Of Epistasis In Alzheimer's Disease Genetics, Mark T. Ebbert

Theses and Dissertations

Alzheimer's disease is a complex neurodegenerative disease whose basic etiology and genetic structure remains elusive, despite decades of intensive investigation. To date, the significant genetic markers identified have no obvious functional effects, and are unlikely to play a role in Alzheimer's disease etiology, themselves. These markers are likely linked to other genetic variations, rare or common. Regardless of what causal mutations are found, research has demonstrated that no single gene determines Alzheimer's disease development and progression. It is clear that Alzheimer's disease development and progression are based on a set of interactions between genes and environmental variables. This dissertation focuses …

Go to article

Intersection Of Art And Criminal Law: The Ethics Of True Crime, Melissa Rutman Dec 2014

Intersection Of Art And Criminal Law: The Ethics Of True Crime, Melissa Rutman

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

True crime reporting has long captivated audiences. By reporting details of an actual crime in a sensationalized way, the genre is often described as “infotainment” – the blending of information and entertainment. The modern genre was likely inaugurated by Truman Capote’s In Cold Blood, and gripping accounts of murders and serial killers continue to populate bookshelves. True crime also spills over to primetime television in shows like the Nancy Grace show, with reporting on the Casey Anthony and Amanda Knox cases. But in addition to journalistic and sensational impact, true crime reporting also overlaps with legal investigation of crimes in …

Go to article

A Model For Meeting And Event Venues To Implement Green Practices, Justine Clewer Dec 2014

A Model For Meeting And Event Venues To Implement Green Practices, Justine Clewer

UNLV Theses, Dissertations, Professional Papers, and Capstones

In 2007 green meetings were ranked as the third most anticipated trend by Event Solutions magazine’s survey of 1,350 event professionals, however by 2011 it was an emerging trend (Goldblatt, 2012). Today, meeting and event planners are increasingly including clauses in their contracts with venues pertaining to green practices, and are willing to look elsewhere if a venue does not agree to partake in the green initiatives. For venues the failure to “go green” can mean a substantial loss of revenue. Nonetheless, many businesses are hesitant to engage in green (sustainable) practices, because they are not properly educated on the …

Go to article

A Study Of Airbnb As A Potential Competitor Of The Hotel Industry, Quynh Nguyen Dec 2014

A Study Of Airbnb As A Potential Competitor Of The Hotel Industry, Quynh Nguyen

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of the study is to examine Airbnb as a possible competitor of the hotel industry using Peteraf and Bergen’s broad-based competitor identification tool. Unlike existing empirical research on the subject, the study takes a qualitative approach to answer the research question. The results of the study assist hotel operators in determining the competitiveness of Airbnb and the need for a business response to the service.

Go to article

Microglia In The Healthy And Diseased Central Nervous System, Luisa Torres Dec 2014

Microglia In The Healthy And Diseased Central Nervous System, Luisa Torres

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Spinal cord injury (SCI) results in the death of neurons, disruption of neuronal connections, demyelination, and inflammation. There are three phases of SCI: Acute (from the time of impact to the first few days post-injury), secondary (hours to weeks), and chronic (months to years). Currently, little can be done to modify the acute phase. Efforts to intervene have focused on the subsequent phases to both promote healing and prevent further damage. In this study I show that the small molecule inhibitor Pifithrin-μ (PFT-μ significantly reduced lesion volume and decreased the presence of inflammatory cells (microglia and macrophages) in the lesion …

Go to article

Identification Of Sporulation-Defective Genes And A Rab-Cascade Model For The Formation Of The Forespore Membrane In Schizosaccharomyces Pombe, Esma Ucisik-Akkaya Dec 2014

Identification Of Sporulation-Defective Genes And A Rab-Cascade Model For The Formation Of The Forespore Membrane In Schizosaccharomyces Pombe, Esma Ucisik-Akkaya

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In the fission yeast, Schizosaccharomyces pombe, environmental stress conditions such as nitrogen starvation induce mating of two haploid cells. The newly formed diploid cells immediately undergo meiosis and form spores, which are equivalent to gametes in higher organisms. The packaging of the haploid nuclei, which are formed after two rounds of meiosis, is achieved by the de novo formation of double membranes called forespore membranes, which form adjacent to the meiotic spindle pole bodies (SPBs). This work focuses on the initiation of the forespore membrane at the SPB and the genes that are required for the proper formation of the …

Go to article

The Mechanisms Of Nmda Receptor Activation, Rashek Kazi Dec 2014

The Mechanisms Of Nmda Receptor Activation, Rashek Kazi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Glutamate-gated ion channels embedded within the neuronal membrane are the primary mediators of fast excitatory synaptic transmission in the central nervous system. The ion channel of these glutamate receptors contains a pore-lining transmembrane M3 helix surrounded by peripheral M1 and M4 helices. In the NMDA receptor (NMDAR), opening of the ion channel pore requires rearrangements of these helical elements, but there is currently no functional model for how this occurs. To address how agonist binding is transduced into pore opening in NMDARs, we manipulated the coupling between the ligand binding domain (LBD) and the M3 helix of the ion channel …

Go to article

Retrograde Ngf Signaling In Pain, Tanvir Khan Dec 2014

Retrograde Ngf Signaling In Pain, Tanvir Khan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Nerve growth factor (NGF) is a member of the nerurotrophin family that plays a crucial role during development. Although NGF was discovered because of its actions during development, it is now known to function throughout the life of the animal. NGF plays a profound role in nociception because its high affinity receptor, TrkA, is expressed in nociceptors. In mammals, NGF causes thermal hyperalgesia that develops within minutes (acute hyperalgesia) and lasts for several days (chronic hyperalgesia). While NGF-induced acute peripheral sensitization/hyperalgesia occurs via TRPV1 receptor activation, chronic hyperalgesia is thought to take place with a delay, caused by upregulation of …

Go to article

How To Perform A Democracy: A Genealogy Of The Bare Voice, Travis Wade Holloway Dec 2014

How To Perform A Democracy: A Genealogy Of The Bare Voice, Travis Wade Holloway

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

My dissertation argues that participatory democracy is born out of a unique mode of aesthetic performance. This thesis is based on recent French and Italian philosophy concerning democracy, inequality, and political representation. My point of departure, however, is Plato's genealogy of democracy in Book 3 of the Laws, where Plato explains that participatory democracy in Athens was a result of a prior revolution in the city's theater. This work is an extension of Plato's genealogy into the kind of poetry and theater and philosophy that Plato says was responsible for a revolution that brought political and economic equality to Athens. …

Go to article

The Substance Of Health: Aristotle, Deleuze And Guattari On The Dynamic Materiality Of The Living Body And Its Influence On Medical Concepts And Practices, Rachel Elaine Tillman Dec 2014

The Substance Of Health: Aristotle, Deleuze And Guattari On The Dynamic Materiality Of The Living Body And Its Influence On Medical Concepts And Practices, Rachel Elaine Tillman

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Western medicine relies on a mechanistic conception of matter as passive and inert. Yet matter, and especially living matter, is actually dynamic and agential. This has transformative implications both for our quest to understand what health is and for determining what kinds of practices best promote health. I draw on a diverse set of philosophical thinkers to articulate a dynamic conception of living bodily matter that can enable us to define health more robustly and promote it more effectively. First I discuss the theoretical framework put forth by contemporary feminist accounts of materiality (" new feminist materialisms" or " material …

Go to article

The Authoritarian Party Identity And Its Impact On American Political Polarization, Julie Ann Wronski Dec 2014

The Authoritarian Party Identity And Its Impact On American Political Polarization, Julie Ann Wronski

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Political scientists and pundits alike have characterized the American electorate as being increasingly polarized in recent decades. This polarization has been framed in the context of the " culture war," where party elites and citizens have become more ideologically divided on salient social issues. Recent contributions by political scientists suggest that the sources of " culture war" polarization are more deeply rooted in individual traits, and that partisan polarization represents a " worldview evolution" that has split citizens into Democratic and Republican camps on the basis of their needs for order, certainty, and security - conceptualized as authoritarianism. This argument …

Go to article

Ready, Set, Change: An Exploratory Case Study Of Readiness For Change Within Five New York State Voluntary Child Welfare Agencies, Jennette Allen-Mccombs Dec 2014

Ready, Set, Change: An Exploratory Case Study Of Readiness For Change Within Five New York State Voluntary Child Welfare Agencies, Jennette Allen-Mccombs

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Each year, significant financial resources are expended to implement new policies and programs in an attempt to facilitate organizational change (Fleming, Culler, McCorkle, Becker, & Ballard, 2011). In 2007, the New York State Office of Children and Family Services (OCFS) collaborated with Andrus Center for Learning and Innovation (ACLI) to implement the Sanctuary Model of organizational change within selected voluntary residential child welfare programs that serve youth with behavioral, emotional and social challenges. Since these organizations typically have bureaucratic structures in which culture is maintained through a set of rules and regulations, change may be particularly difficult (Dickinson & Perry, …

Go to article

Acculturation Experiences Of Latina Immigrants In Suffolk County, New York: A Grounded Theory Study, Jennifer Wood Dec 2014

Acculturation Experiences Of Latina Immigrants In Suffolk County, New York: A Grounded Theory Study, Jennifer Wood

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This study examines the process of acculturation for female Latina immigrants in Suffolk County, New York. Thirty in-depth audiotaped interviews were conducted with adult women who were born in Mexico, El Salvador, or Ecuador and a theoretical model for acculturation was constructed using grounded theory methodology. The model reflects the lived experiences and perceptions of the participants. It also provides a number of factors involved in the acculturative process and attainment of acculturative goals for the participants. Social, psychological, cultural, and environmental supports and barriers are presented that impact the acculturative process. Findings suggest that the level of acculturation attained …

Go to article

Molecular Characterization Of Quahog Parasite Unknown (Qpx), A Thraustochytird Pathogen Of The Hard Clam, Mercenaria Mercenaria, Ewelina Rubin Dec 2014

Molecular Characterization Of Quahog Parasite Unknown (Qpx), A Thraustochytird Pathogen Of The Hard Clam, Mercenaria Mercenaria, Ewelina Rubin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The hard clam or northern quahog, Mercenaria mercenaria, is one of the most valuable seafood products in the United States. Severe episodes of hard clam mortality have been consistently associated with infections caused by a thraustochytrid parasite called Quahog Parasite Unknown (QPX). Studies in the present dissertation examined the molecular bases of QPX virulence towards clams. Investigation of QPX transcriptome libraries generated a database of QPX putative virulence factors and other molecules potentially involved in interactions with the clam host. Multiple differential gene expression profiles were generated using oligoarray technology for QPX strains isolated from different geographic locations and for …

Go to article

Molecular Characterization Of Quahog Parasite Unknown (Qpx), A Thraustochytird Pathogen Of The Hard Clam, Mercenaria Mercenaria, Ewelina Rubin Dec 2014

Molecular Characterization Of Quahog Parasite Unknown (Qpx), A Thraustochytird Pathogen Of The Hard Clam, Mercenaria Mercenaria, Ewelina Rubin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The hard clam or northern quahog, Mercenaria mercenaria, is one of the most valuable seafood products in the United States. Severe episodes of hard clam mortality have been consistently associated with infections caused by a thraustochytrid parasite called Quahog Parasite Unknown (QPX). Studies in the present dissertation examined the molecular bases of QPX virulence towards clams. Investigation of QPX transcriptome libraries generated a database of QPX putative virulence factors and other molecules potentially involved in interactions with the clam host. Multiple differential gene expression profiles were generated using oligoarray technology for QPX strains isolated from different geographic locations and for …

Go to article

The Arts In The Showcase: Santiago's Exposiciã³N Internacional Of 1875 | The Arts In The Showcase: Santiago's Exposición Internacional Of 1875, Marcela Alejandra Drien Dec 2014

The Arts In The Showcase: Santiago's Exposiciã³N Internacional Of 1875 | The Arts In The Showcase: Santiago's Exposición Internacional Of 1875, Marcela Alejandra Drien

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

During the 1870s, exhibition culture attained particular relevance among the Chilean elite, who saw exhibitions as a forum for portraying Chile as a modern nation. In this context, Santiago's Exposición Internacional of 1875, the first international exhibition carried out in the country, provided a unique opportunity for the display of Chile's material and cultural progress among national and international audiences. This dissertation examines the role the arts played in shaping the international image of Chile as a " civilized" nation, while simultaneously attempting to highlight the unique features of Chilean national identity during the mid-to-late nineteenth century. Thus, the use …

Go to article

Sexual Decision Making In The Context Of Hookup Culture; A Mixed-Method Examination, Rachel Kalish Dec 2014

Sexual Decision Making In The Context Of Hookup Culture; A Mixed-Method Examination, Rachel Kalish

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation is a multi-method study of college students' sexual decision-making. It relies on interviews and focus groups to examine how college students make decisions within the context of the " hook-up culture" (Heldman and Wade 2010) prominent on American campuses. Patterns in the qualitative data are examined quantitatively using the Online College Life Survey. To understand how students make decisions in hookup culture, I examine their views of relationships, how they enact relationships, and the effects of hooking up on relationships. I that students envision relationships in their future, and choose not to expend time on them during their …

Go to article

Re-Facing Societies Through Art Faith47: A Heroine For Hope, Stephen Louis Francis Dec 2014

Re-Facing Societies Through Art Faith47: A Heroine For Hope, Stephen Louis Francis

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Areas of the world that are facing hardships of all kinds bare the same signature that is visible to all: a dilapidated infrastructure. A first step in improving the areas that are struggling is to give the citizens something to be proud of when they look out of their windows. The work of South African street artist Faith47 is the kind of art that can provide such pride and also hope for a better future. Using Faith47's native country, I am proposing a socialist regime of art to both physically and emotionally improve the areas and citizens who suffer each …

Go to article

Allan Desouza And Yong Soon Min: Arts From Multiple Borders, Kyungso Min Dec 2014

Allan Desouza And Yong Soon Min: Arts From Multiple Borders, Kyungso Min

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This work seeks to examine how the experiences and memories of crossing national border lines are visually embodied in the art of two artists of Asian descent, Allan deSouza and Yong Soon Min. In both their individual and joint practices, which interpret the idea of boundaries in varied contexts, the " belonging to nowhere" idea is transformed into a powerful multisensory event. Framing deSouza and Min's works within the narrative of borders, therefore, can help one appreciate the significance of cooperation for diaspora artists, particularly in embracing their displacement and replacement experiences. The first two chapters attempt to scrutinize the …

Go to article

Os Gemeos And The Giant Of Boston, Phuong-Lan Rebekah Tonthat Dec 2014

Os Gemeos And The Giant Of Boston, Phuong-Lan Rebekah Tonthat

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

On August 1st 2012, the Institute of Contemporary Art introduced the work of the twins Otavio and Gusavo Pandolfo, otherwise known as Os Gêmeos. This was the first solo US museum exhibition of the artists, who are possibly the best-known street artists of Brazil, and who have shown their work at Miami Art Basel, the Armory Show, P.S. 1, and the Tate Modern. The display consisted of two murals within the city of Boston, the most notable of the two commonly referred to as The Giant of Boston. The 70 foot by 70 foot crouched figure with a hidden face …

Go to article

Artifice, Aesthetics, And The Liminal Grotesque In Stanley Kubrick's Barry Lyndon, David Zachary Turchin Dec 2014

Artifice, Aesthetics, And The Liminal Grotesque In Stanley Kubrick's Barry Lyndon, David Zachary Turchin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Stanley Kubrick's oeuvre is characterized throughout by a distinct and unique interest in violence, sexuality, the uncomfortable, the eerie, the unknown, the beyond, and the grotesque. His aesthetic and conceptual approach achieves a special quality of calling attention to the liminal - those unspoken, unseen, uncertain, ungrounded, fleeting, and perhaps ineffable, moments and spaces in the visual and narrative presentation that occur between scenes, between characters, between images, and between the viewer and the film itself. In doing so Kubrick destabilizes the viewing experience and suspends the viewer in moments of uncertainty, discomfort, and ambiguity, achieving this effect even in …

Go to article

Between Here And There: The Ambiguous Ecologies Of Charles Simonds, Scott Volz Dec 2014

Between Here And There: The Ambiguous Ecologies Of Charles Simonds, Scott Volz

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

At the start of the 1970s, Charles Simonds began constructing miniature architectural ruins, what he calls dwellings, on the streets of New York City. They were fragile, temporary, and site specific. Occupying windowsills, wall crevices, and street gutters, the dwellings transformed their spaces from liminal to distinct. Over the course of the decade, Simonds built hundreds of dwellings in the Lower East Side alone, and they consequently developed a strong connection to the neighborhood. This essay addresses the dwellings as sites of makeshift ecologies. Looking at the reflexive relation between Simonds' sculptures and deteriorated living conditions in the Lower East …

Go to article

Collective Memory And Performative Reconquista: Action And Inaction In The Performance Art Of Regina Jose Galindo, Jasnira Lizbeth Zuniga Dec 2014

Collective Memory And Performative Reconquista: Action And Inaction In The Performance Art Of Regina Jose Galindo, Jasnira Lizbeth Zuniga

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Using Coco Fusco's notion of the Reconquista to read ¿Quién puede borrar las huellas? of 2003 and Reconocimiento de un cuerpo of 2008, this paper investigates performance artist Regina José Galindo's conceptual approaches of action and inaction. Grappling with very specific histories of violence and repression in attempts to deal with the unresolved, Regina José Galindo's performances here concern themselves with permanence and impermance, confronting and reactivating the bodies of her viewers by restaging collective memory and trauma. Focusing on pieces conceived and staged in the Latin American context, this paper contextualizes Galindo's performance in Guatemala and Argentina as attempts …

Go to article

Place Self: Identity At The Crossroads Of Place And Time In Catherine Opie's Los Angeles Landscape Seires, 1988-2004, Kim Woltmann Dec 2014

Place Self: Identity At The Crossroads Of Place And Time In Catherine Opie's Los Angeles Landscape Seires, 1988-2004, Kim Woltmann

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Catherine Opie achieved success and notoriety during the 1990s for several controversial photographic series of herself and members of her LGBT community that explored themes of sexuality, gender, and identity. She also, however, built a contemporaneous body of work throughout the 1990s comprised of landscape series. These images embraced a cool stoicism and deadpan aesthetic that contrasted the intimacy and dissidence of Opie's portraits, as well as the early branding of her as a contemporary provocateur. They therefore received little scholarly attention. More recent renewed interest in Opie's landscapes is largely inspired, retrospectively, because images of place have now overtaken …

Go to article

Characterization Of Trifunctional Glycinamide Ribonucleotide Synthetase And Its Role In Purinosome Complex, Iva Chitrakar Dec 2014

Characterization Of Trifunctional Glycinamide Ribonucleotide Synthetase And Its Role In Purinosome Complex, Iva Chitrakar

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The human de novo purine biosynthetic pathway consists of six proteins, which come together to form a protein complex called the purinosome. The tri-functional enzyme, TGART, which contains three domains, is one of the purinosome proteins. Protein-protein interaction studies have shown that TGART, along with two other de novo purine pathway proteins FGAMS and PPAT, is at the core of purinosome complex. Little is known, however about the interacting surface, stoichiometry or interaction mechanism. In order to understand this, we hope to solve the X-ray crystal structure of full-length human TGART, run quantitative protein interaction measurements on TGART, FGAMS and …

Go to article

First Prev Next Last