Digital Commons Network^™

Student Learning Outcomes Poster Session For Csb/Sju Joint Board Of Trustees Meeting, December 5th, 2014, Pamela L. Bacon, Bret Benesh, Carie Braun, Brian Campbell, Theresa Johnson, Jeanne Cofell, Catherine Bohn-Gettler, Janean Kleist, Michelle Li-Kuehne, Barbara May, Janna Lafountaine, Megan Lampel, Zainab Oke, Emily Schroeder, Katherine Thao, Anya Winkler, Sanford L. Moskowitz, Lisa M. Lindgren, Charles W. Wright, Abraham Lauer, Joshua St. George, Bryan Van Der Heiden

Office of Academic Review and Curricular Advancement Staff Publications

A faculty and student poster session was held focusing on student learning outcomes at the December 5^th, 2014 joint Board of Trustee meeting. The posters focused on using assessment of student learning to improve teaching and learning and covered student learning outcomes at the course, departmental, and institutional levels.

Ms171: Interview With Margaret Kripke, Margaret Kripke Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history interview with Margaret Kripke. See more at Texas Medical Center-Women's History Project and its finding aid.

Tuberculosis Interferon-Gamma Responses In The Breast Milk Of Human Immunodeficiency Virus Infected Mothers, Lisa Cranmer, Mercy Kanyugo, Barbara Lohman-Payne, Ken Tapia, Grace John-Stewart

Institute for Immunology and Informatics Faculty Publications

Tuberculosis (TB) cellular immune responses were examined in breastmilk of HIV-infected mothers using the T-SPOT.TB interferon gamma release assay (IGRA). Positive TB IFN-γ responses were detected in 6 of 8 (75%) valid breast milk assays. Among 7 mothers with paired breastmilk and blood assays, TB IFN- γ responses were higher in breastmilk compared to blood (p=.02). The magnitude of TB IFN-γ responses in maternal breastmilk and blood were correlated. Elucidating the influence of breastmilk TB immune responses on infant TB susceptibility and immunity may inform future maternal TB vaccine strategies.

Comparing Disease Prevalence In Hard Corals At Four Different Reefs Near The Island Of Narganá In The Guna Yala Comarca Of Panamá, Connor Hinton

Independent Study Project (ISP) Collection

Coral reefs harbor much of the world’s known marine biodiversity. For a number of reasons, coral reefs are becoming increasingly threatened. Large portions of the world’s reefs have already been lost, and the number of degrading reefs is constantly on the rise. One cause for the destruction of coral reefs are coral diseases, ultimately causing coral mortality. With the death of corals, a key species is lost, endangering the entire reef ecosystem. Documenting the presence of such diseases could be useful in assessing current reef health and ameliorating the growing threat of coral diseases. In this project, 18 40m2 belt …

Discovering A Gold Mine Of U.S. Government Information: Exploring The Hathitrust Catalog And Its Rich Veins, Bert Chapman

Libraries Faculty and Staff Presentations

The Hathitrust Catalog provides researchers at member institutions with exponentially expanded access to historical U.S. Government information resources. This presentation describes how researchers can use this resource to conduct substantive research using government information resources on public policy issues such as Internal Revenue Service program problems, infectious diseases such as Ebola, and U.S. foreign relations with the former Soviet Union/Russian Federation.

We Are...Marshall, December 3, 2014, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Evaluating The Effectivesness Of Information Sources Regarding Hiv Among Gold Miners In Quảng Nam, Noah Landesberg

Independent Study Project (ISP) Collection

Young migrant males in strenuous manual labor environments represent a high-­‐risk population for the transmission of HIV/AIDS. In Vietnam, gold miners are representative of this high-­‐risk population. Phước Sơn district, Quảng Nam province is home to much of Vietnam’s mining activity and has a comparatively high rate of HIV. Previous studies have been done on HIV/AIDS prevalence in Quảng Nam as well as related knowledge and practices. This analysis of a 2014 questionnaire examines the effects of varying information sources on HIV/AIDS knowledge. The sample of workers was mostly male and between 25 and 49 years old. Migrants made up …

The Potentials And Challenges Of Big Data In Public Health, Rena N. Vithiatharan

Australian eHealth Informatics and Security Conference

The potential to use big data sources for public health increases with the broadening availability of data and improved methods of analysis. Whilst there are some well-known examples of the opportunistic use of big data, such as GoogleFlu, public health has not yet realised the full potential of such data sources. A literature review was undertaken to identify the potential of such data collections to impact public health, and to identify what challenges are currently limiting this potential. The potential include improved real-time analysis, research and development and genome studies. However, challenges listed are poor universal standardisation and classification, privacy …

Alternative Approaches To Lung Insults, Melpo Christofidou-Solomidou, Ph.D.

Division of Pulmonary, Allergy, and Critical Care Medicine Presentations and Grand Rounds

Objectives:

• Provide an understanding of current available botanical agents and their usefulness in lung disease;

• Provide an overview of current complementary approaches to lung disease and active areas of research in pre-clinical testing;

Overall Goals and Objectives:

Following this activity, a participant should be able to:

1. Recognize recent advances and developments in Pulmonary Medicine & Critical Care and translate into clinical practice

2. Integrate perspectives of multiple disciplines into decision-making on behalf of patients through structured plans for patient care.

3. Develop areas for future research and discuss appropriate methods to address these needs.

4. Summarize and continually …

Big Data In Healthcare: What Is It Used For?, Rebecca Hermon, Patricia A H Williams

Australian eHealth Informatics and Security Conference

Big data analytics is a growth area with the potential to provide useful insight in healthcare. Whilst many dimensions of big data still present issues in its use and adoption, such as managing the volume, variety, velocity, veracity, and value, the accuracy, integrity, and semantic interpretation are of greater concern in clinical application. However, such challenges have not deterred the use and exploration of big data as an evidence source in healthcare. This drives the need to investigate healthcare information to control and reduce the burgeoning cost of healthcare, as well as to seek evidence to improve patient outcomes. Whilst …

Geographic Distribution And Adaptive Significance Of Genomic Structural Variants: An Anthropological Genetics Perspective, Muthukrishnan Eaaswarkhanth, Pavlos Pavlidis, Omer Gokcumen

Human Biology Open Access Pre-Prints

Anthropological geneticists have successfully used single nucleotide and short tandem repeat variations across human genomes to reconstruct human history. These markers have also been used extensively to identify adaptive and phenotypic variation. The recent advent of high-throughput genomic technologies revealed an overlooked type of genomic variation, namely structural variants (SVs). In fact, some SVs may contribute to human adaptation in substantial and previously unexplored ways. SVs include deletions, insertions, duplications, inversions and translocations of genomic segments that vary among individuals from the same species. SVs are much less numerous than single nucleotide variants, but account for at least seven times …

Role Of Tissue Factor In Mycobacterium Tuberculosis-Induced Inflammation And Disease Pathogenesis, Hema Kothari, Shiva Keshava, Rit Vatsyayan, Nigel Mackman, L. Vijaya Mohan Rao, Usha R. Pendurthi

Cellular and Molecular Biology Faculty Publications and Presentations

Tuberculosis (TB) is a chronic lung infectious disease characterized by severe inflammation and lung granulomatous lesion formation. Clinical manifestations of TB include hypercoagulable states and thrombotic complications. We previously showed that Mycobacterium tuberculosis (M.tb) infection induces tissue factor (TF) expression in macrophages in vitro. TF plays a key role in coagulation and inflammation. In the present study, we investigated the role of TF in M.tb-induced inflammatory responses, mycobacterial growth in the lung and dissemination to other organs. Wild-type C57BL/6 and transgenic mice expressing human TF, either very low levels (low TF) or near to the level of wild-type (HTF), in …

The Case Of Reintegration Of Women Post Incarceration, Deana Raley Noble Phd

Dissertations

Women released from prison or jail face particular obstacles and challenges on reentry to the community, many of which are related to their childhood and to gender roles as women and mothers. This study relates the lived experience of one woman's successful transition to economic and mainstream societal reintegration and family reconnection after release from prison and the insights gained by the researcher. Case study methodology congruent with Miller's Relational-Cultural Theory philosophical framework was utilized in this in-depth, single case design and represents a unique case. The overall purpose of this descriptive and explanatory research was to explore precursors to …

Temperature-Responsive Injectable Hydrogels: Design, Characterization And Application As Localized Delivery Systems For Drug And Gene Therapy, Daniel Ghirmay Abebe

Electronic Theses and Dissertations Archive

In recent decades, block copolymers have found wide spread interest as drug delivery systems (DDS). Improvements in synthetic techniques, polymer engineering and nanotechnology have made it possible to design and construct a variety of DDS for emerging therapeutics, such as gene therapy. Block copolymer gene carriers have several advantages including improved biocompatibility, higher loading capacity and ease of large-scale production. However, the successful clinical application of these delivery systems has been plagued due to several shortcomings, such as poor stability in biological environment, low loading efficiency of therapeutic agents and relatively high cytotoxicity. The majority investigated block copolymer gene carriers …

The Trouble With Tourism, Steven J. Hollenhorst, Susan Houge Mackenzie, David M. Ostergren

Recreation, Parks and Tourism Administration

The hegemonic view of tourism is as a global panacea for struggling peoples, environments and economies (Smith and Brent 2001). This article begins by arguing that increasing worldwide risks from human-induced climate change fundamentally alter the veracity of this prediction claim. As one of the world’s largest industries, tourism is also one of the largest emitters of carbon, primarily from air transport. Far from standing apart from our carbon-dependent economy, tourism is quite profoundly a creation of that economy and cannot be an antidote to the very stuff of which it is made. Further, to the extent that tourism functions …

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Hedonic Architecture: Coexistance Of Hyper Stimulating And Hypo Stimulating Experiences, Rossitza Iovtcheva

Architecture Thesis Prep

This thesis proposes that rehabilitating effects can be achieved through natural stimulation facilitated by the architectural design. It argues that while hospital design requires stress reduction to improve healing, a polar experience of hyper stimulation is also necessary for a substance abuser in order to yield a decrease of relapse rates.

The Mirnaome Of Opisthorchis Viverrini Induced Intrahepatic Cholangiocarcinoma, Jin Peng, Yanjun Feng, Gabriel Rinaldi, Ponlapat Yonglitthipagon, Samantha Easley, Therawach Laha, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Banchob Sripa, Paul J. Brindley, Jason P. Mulvenna, Jeffrey M. Bethony, Jordan L. Plieskatt

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer, arising in the biliary ducts that extend into the liver. The highest incidence of ICC occurs in Southeast Asia, particularly in the Mekong River Basin countries of Thailand, Laos, Cambodia, and Vietnam, where it is strongly associated with chronic infection by the food-borne liver fluke Opisthorchis viverrini (OV), one of only three eukaryote pathogens considered Group one carcinogens. Intrahepatic cholangiocarcinoma is usually diagnosed at an advanced stage, with a poor prognosis and survival often less than 24 months. Hence, biomarkers that enable the early detection of ICC would be desirable and have a …

Profiling Mirnas In Nasopharyngeal Carcinoma Ffpe Tissue By Microarray And Next Generation Sequencing, Jin Peng, Yanjun Feng, Gabriel Rinaldi, Paul H. Levine, Samantha Easley, Elizabeth Martinez, Salman Hashmi, Nader Sadeghi, Paul J. Brindley, Jason P. Mulvenna, Jeffrey M. Bethony, Jordan L. Plieskatt

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Nasopharyngeal carcinoma (NPC) is a non-lymphomatous, squamous-cell carcinoma that occurs in the epithelial lining of the nasopharynx. Nasopharyngeal carcinoma has a geographically well-defined distribution worldwide, with the highest prevalence in China, Southeast Asia, and Northern Africa. Symptoms of nascent NPC may be unapparent or trivial, with diagnosis based on the histopathology of biopsied tissue following endoscopy of the nasopharynx. The tumor node metastasis (TNM) staging system is the benchmark for the prognosis of NPC and guides treatment strategy. However, there is a consensus that the TNM system is not sufficiently specific for the prognosis of NPC, as it does not …

Protein-Coated Nanoparticles Are Internalized By The Epithelial Cells Of The Female Reproductive Tract And Induce Systemic And Mucosal Immune Responses, Savannah E Howe, Vjollca Konjufca

Publications

The female reproductive tract (FRT) includes the oviducts (fallopian tubes), uterus, cervix and vagina. A layer of columnar epithelium separates the endocervix and uterus from the outside environment, while the vagina is lined with stratified squamous epithelium. The mucosa of the FRT is exposed to antigens originating from microflora, and occasionally from infectious microorganisms. Whether epithelial cells (ECs) of the FRT take up (sample) the lumen antigens is not known. To address this question, we examined the uptake of 20-40 nm nanoparticles (NPs) applied vaginally to mice which were not treated with hormones, epithelial disruptors, or adjuvants. We found that …

Long Wavelength Analysis Of A Model For The Geographic Spread Of A Disease, Layachi Hadji

Applications and Applied Mathematics: An International Journal (AAM)

We investigate the temporal and spatial evolution of the spread of an infectious disease by performing a long-wavelength analysis of a classical model for the geographic spread of a rabies epidemic in a population of foxes subject to idealized boundary conditions. We consider twodimensional and three-dimensional landscapes consisting of an infinite horizontal strip bounded by two walls a finite distance apart and a horizontal region bounded above and below by horizontal walls, respectively. A nonlinear partial differential evolution Equation for the leading order of infectives is derived. The Equation captures the space and time variations of the spread of the …

Solution Of The Sir Models Of Epidemics Using Msgdtm, Asad A. Freihat, Ali H. Handam

Applications and Applied Mathematics: An International Journal (AAM)

Stochastic compartmental (e.g., SIR) models have proven useful for studying the epidemics of childhood diseases while taking into account the variability of the epidemic dynamics. Here, we use the multi-step generalized differential transform method (MSGDTM) to approximate the numerical solution of the SIR model and numerical simulations are presented graphically.

Intramural Activity Report Fy 2014, Yolanda Carr

Intramural Activity Reports

The Sponsored Programs Annual Reports collection contains reports for the Extramural and Intramural Activities of the Southwestern Oklahoma State University faculty and students. The collection currently covers the years 2014 - 2017. More reports will be included as they are available.

Extramural activities mean they were funded by organizations independent of SWOSU.

Intramural activities mean they were funded by SWOSU.

Evaluating Current Management Of Drug-Resistanttuberculosis In Mumbai, India, Meryl Kus

Independent Study Project (ISP) Collection

This research was aimed at analyzing the current state of drug resistant tuberculosis in Mumbai and how effectively different actors in the realm of public health are managing DR-TB. The methods for this project involved a variety of semi-structured interviews as well as field observation. Key findings show a very present and largely negative private sector influence, effective NGO models for disease control, a burden of DR-TB/HIV comorbidity, and a rapid increase to transmission-based spread of DR-TB. Key implications of conclusions include the necessity of increasing the private sector’s compliance with WHO standards, adaptation of community and education based NGO …

L-Asparaginase Ii Produced By S. Typhimurium Inhibits T Cell Responses Through Hydrolysis Of L-Asparagine And Suppression Of Metabolic Reprogramming, Annmarie Torres

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Salmonella enterica serovar Typhimurium (S. Typhimurium) are pathogenic bacteria that suppress T cell responses to avoid clearance by the immune system, yet the mechanisms that mediate this immunosuppression remain largely unknown. Our laboratory previously showed that L-Asparaginase II produced by S. Typhimurium inhibits T cell responses and mediates virulence. The goal of my dissertation research was to determine the mechanism by which L-Asparaginase II produced by S. Typhimurium inhibits T cell responses. As described in my dissertation, I have found that L-Asparaginase II of S. Typhimurium exhibits L-asparagine hydrolysis activity and that this activity is required for the inhibition of …

Nutrition-Related Conditions Among Children Of Migrant And Seasonal Farmworkers In The United States: Causes And Solutions, Rebecca Halvorson

Food Science and Nutrition

The purpose of this literature review is to determine the prevalence of nutrition-related conditions among children of migrant and seasonal farmworkers (MSFW) compared to national averages, as well as effectiveness of strategies for minimizing any health discrepancies. MSFW live under harsh conditions, engage in long hours of physically demanding labor, and receive insufficient income. Compounding demographic characteristics create insurmountable barriers to quality health care and nutrition education resulting in disproportionately unhealthy children within the MSFW population as compared to the greater US population. The prevalence of overweight, obesity, diabetes mellitus, cardiovascular disease, and numerous infections is higher among MSFW children. …

Los Baños Times, Vol. 34, No. 9, College Of Development Communication, University Of The Philippines Los Baños

Los Baños Times

No abstract provided.

Hope Theory And Substance Abuse Treatment, Rhonda L. Alexander

Morehead State Theses and Dissertations

A Thesis Presented to the Faculty of the College of Arts, Humanities, and Social Sciences Morehead State University in Partial Fulfillment of the requirements for the Degree Master of Arts by Rhonda L. Alexander in December of 2014.

Structural And Computational Study On The Interaction Of Bacterial Cell Division Protein, Ftsz, With Its Inhibitors For New Antibacterial Drug Discovery, Edwin Ottoniel Lazo

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Filamenting temperature-sensitive mutant Z (FtsZ) from Mycobacterium tuberculosis (Mtb) is an essential bacterial cell division protein that polymerizes into a structure called the " Z-ring" . Here it has been targeted for drug discovery. Compounds that exhibit anti-tuberculosis activity have been synthesized and used in crystallization conditions. Four crystal structures of MtbFtsZ have been determined, of which two are similar to the published dimer (PDB 1RQ7) which exhibits lateral interactions; they belong to P65 space group and crystals diffracted to about 2.6Å. The other two structures had two trimers in the asymmetric unit. The crystals diffracted to approximately 3.5Å and …

Acculturation Experiences Of Latina Immigrants In Suffolk County, New York: A Grounded Theory Study, Jennifer Wood

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This study examines the process of acculturation for female Latina immigrants in Suffolk County, New York. Thirty in-depth audiotaped interviews were conducted with adult women who were born in Mexico, El Salvador, or Ecuador and a theoretical model for acculturation was constructed using grounded theory methodology. The model reflects the lived experiences and perceptions of the participants. It also provides a number of factors involved in the acculturative process and attainment of acculturative goals for the participants. Social, psychological, cultural, and environmental supports and barriers are presented that impact the acculturative process. Findings suggest that the level of acculturation attained …