Digital Commons Network^™

January 14, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Early Hypercytokinemia Is Associated With Interferoninduced Transmembrane Protein-3 Dysfunction And Predictive Of Fatal H7n9 Infection, Zhongfang Wang, Anli Zhang, Yanmin Wan, Xinian Liu, Chao Qiu, Xiuhong Xi, Yanqin Ren, Jing Wang, Yuan Dong, Meijuan Bao, Liangzhu Li, Mingzhe Zhou, Songhua Yuan, Jun Sun, Zhaoqin Zhu, Liang Chen, Qingsheng Li, Zhiyong Zhang, Xiaoyan Zhang, Shuihua Lu, Peter C. Doherty, Katherine Kedzierska, Jianqing Xu

Qingsheng Li Publications

A unique avian-origin A/H7N9 influenza virus has so far caused 134 cases with 44 deaths. Probing the host factors contributing to disease severity, we found that lower levels of plasma inflammatory cytokines on hospital admission correlated with faster recovery in 18 patients with A/H7N9 influenza virus, whereas high concentrations of (in particular) IL-6, IL-8, and macrophage inflammatory protein-1β were predictive of a less favorable or fatal outcome. Analysis of bronchoalveolar lavage samples showed up to 1,000-fold greater cytokine/chemokine levels relative to plasma. Furthermore, patients with the rs12252-C/C IFN-induced transmembrane protein-3 (IFITM3) genotype had more rapid disease progression and were less …

Tcd4+ Lymphocyte Are Related To Muscle Strength Parameters In Hiv-1 Positive Adolescents: A Preliminary Study, Erik D. Hanson, Fabio H. Ornellas, Claudio L. Battaglini, Reury F P Bacurau, Alan J P Moraes, Magnus Benetti, Marinella D. Negra, Carmen Lp Lancellotti

International Journal of Exercise Science: Conference Proceedings

Introduction: Catabolism of muscle and loss of function are complications that can occur during the course of HIV infection, and are commonly seen in a majority of adolescents with vertically transmitted Human Immunodeficiency Virus-type 1 (HIV-1). The levels of CD4+ and CD8+ lymphocytes, reference markers for the treatment of vertically transmitted HIV-1, also decline as the disease progresses. Alterations on these reference markers may be associated with neuromuscular force parameters in sedentary adolescents that have potential as prognostic indicators for treatment administration. Objective: To investigate the relationship between maximal isometric muscular contraction force and levels of CD4+ and CD8+ lymphocytes …

Infections And Immune Disturbances: Clinical-Based Outcomes, Stephane Bermon

International Journal of Exercise Science: Conference Proceedings

Whatever their level or type of sport practice, athletes are exposed to infectious diseases or immune-related problems. This susceptibility is partly explained by exercise-induced immuno-suppression. Moreover, many athletes are exposed to either pathogens or physico-chemical influences while practising their sports. Indeed, the respiratory tract, the digestive tract as well as the skin and mucosa can be seriously challenged in some aerobic outdoor or indoors sports as well as in some contact sports. At the upper respiratory tract level, and especially after exercise-associated hyperventilation, symptoms may develop, but it is sometimes difficult for the medical staff to confirm any infectious origin. …

Change Point Testing In Logistic Regression Models With Interaction Term, Youyi Fong, Chongzhi Di, Sallie Permar

UW Biostatistics Working Paper Series

The threshold effect takes place in situations where the relationship between an outcome variable and a predictor variable changes as the predictor value crosses a certain threshold/change point. Threshold effects are often plausible in a complex biological system, especially in defining immune responses that are protective against infections such as HIV-1, which motivates the current work. We study two hypothesis testing problems in change point models. We first compare three different approaches to obtaining a p-value for the maximum of scores test in a logistic regression model with change point variable as a main effect. Next, we study the testing …

Comparative Effectiveness Of Linezolid And Vancomycin Among A National Veterans Affairs Cohort With Methicillin-Resistant Staphylococcus Aureus Pneumonia, Aisling R. Caffrey, J. Morrill, Laura A. Puzniak, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Study Objective: As variability in vancomycin dosing, susceptibility, and tolerability has driven the need to compare newer agents with vancomycin in real-world clinical settings, we sought to quantify the effectiveness of linezolid compared with vancomycin on clinical outcomes for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia.

Design: Retrospective cohort study.

Data Source: Veterans Health Administration national databases.

Patients: Adults admitted to Veterans Affairs hospitals between January 2002 and September 2010 with diagnosis codes for MRSA and pneumonia, and who initiated and received at least 3 days of continuous intravenous vancomycin therapy (4943 patients) or intravenous or oral linezolid therapy …

Phages Of Non-Diary Lactococci: Isolation And Characterization Of Phi L47, A Phage Infecting The Grass Isolate Lactococcus Lactis Ssp Cremoris Dpc6860, Daniel Cavanagh, Caitríona M. Guinane, Horst Neve, Aidan Coffey, R. Paul Ross, Gerald F. Fitzgerald, Olivia Mcauliffe

Department of Biological Sciences Publications

Lactococci isolated from non-dairy sources have been found to possess enhanced metabolic activity when compared to dairy strains. These capabilities may be harnessed through the use of these strains as starter or adjunct cultures to produce more diverse flavor profiles in cheese and other dairy products. To understand the interactions between these organisms and the phages that infect them, a number of phages were isolated against lactococcal strains of non-dairy origin. One such phage, ΦL47, was isolated from a sewage sample using the grass isolate L. lactis ssp. cremoris DPC6860 as a host. Visualization of phage virions by transmission electron …

Cancer Vaccines: A Ray Of Hope, Lipika Chablani

Pharmacy Faculty/Staff Publications

In lieu of an abstract, here are the article's first two paragraphs:

Recent cancer statistics review by Surveillance, Epidemiology, and End Results (SEER) Program by National Cancer Institute (NCI) shows that cancer is the second most leading cause of death after heart diseases. Cancer incidence has grown from 19.2% to 23.3% from 1975 to 2010 (Figure 1)[1]. Lung cancer remains to be the most fatal form of cancer followed by colorectal, breast and prostate cancer in the country (Table 1)[1]. Regardless of several treatment options, cancer remains to be a unique challenge for both patients and the healthcare providers. Several …

Targeted Cytotoxic Therapy Kills Persisting Hiv Infected Cells During Art, Paul W. Denton, Julie M. Long, Stephen W. Wietgrefe, Craig Sykes, Rae Ann Spagnuolo, Olivia D. Snyder, Katherine Perkey, Nancie M. Archin, Shailesh K. Choudhary, Kuo Yang, Michael G. Hudgens, Ira Pastan, Ashley T. Haase, Angela D. Kashuba, Edward A. Berger, David M. Margolis, J. Victor Garcia

Biology Faculty Publications

Antiretroviral therapy (ART) can reduce HIV levels in plasma to undetectable levels, but rather little is known about the effects of ART outside of the peripheral blood regarding persistent virus production in tissue reservoirs. Understanding the dynamics of ART-induced reductions in viral RNA (vRNA) levels throughout the body is important for the development of strategies to eradicate infectious HIV from patients. Essential to a successful eradication therapy is a component capable of killing persisting HIV infected cells during ART. Therefore, we determined the in vivo efficacy of a targeted cytotoxic therapy to kill infected cells that persist despite long-term ART. …

2014-January-08-1/2 Welcome Dr. Means, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Ara H 6 Complements Ara H 2 As An Important Marker For Ige Reactivity To Peanut, Audrey E. Koid, Martin D. Chapman, Robert G. Hamilton, Ronald Van Ree, Serge A. Versteeg, Stephen C. Dreskin, Stef J. Koppelman, Sabina Wünschmann

Department of Food Science and Technology: Faculty Publications

The similarities of two major peanut allergens, Ara h 2 and Ara h 6, in molecular size, amino acid sequence, and structure have made it difficult to obtain natural Ara h 6 free of Ara h 2. The objectives of this study were to purify natural Ara h 6 that is essentially free of Ara h 2 and to compare its IgE reactivity and potency in histamine release assays to Ara h 2. SDS-PAGE of the highly purified allergen (<0.01% Ara h 2) revealed a single 14.5kD band and the identity of Ara h 6 was confirmed by LC-MS/MS. Ara h 6 showed a higher seroprevalence in chimeric-IgE ELISA (n=54), but a weaker biological activity in basophil histamine release assays than Ara h 2. Purified Ara h 6 will be useful for diagnostic IgE antibody assays, as well as molecular and cellular studies to investigate the immunological mechanisms of peanut allergy.

Assessing The Optimal Virulence Of Malaria‐Targeting Mosquito Pathogens: A Mathematical Study Of Engineered Metarhizium Anisopliae, Bernhard Konrad, Michael R. Lindstrom, Anja Gumpinger, Jielin Zhu, Daniel Coombs

School of Mathematical & Statistical Sciences Faculty Publications

Background

Metarhizium anisopliae is a naturally occurring fungal pathogen of mosquitoes. Recently, Metarhizium has been engineered to act against malaria by directly killing the disease agent within mosquito vectors and also effectively blocking onward transmission. It has been proposed that efforts should be made to minimize the virulence of the fungal pathogen, in order to slow the development of resistant mosquitoes following an actual deployment.

Results

Two mathematical models were developed and analysed to examine the efficacy of the fungal pathogen. It was found that, in many plausible scenarios, the best effects are achieved with a reduced or minimal pathogen …

Safety And Access: Is The Uk Regulatory Model Right For America?, Jocelyn Sweet

Health Law and Policy Brief

No abstract provided.

Control Of Ltr Transcription By Swi/Snf Baf And Pbaf Complexes, Irene Guendel, Rachel Van Duyne, Fatah Kashanchi

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

No abstract provided.

Fall 2013 Registration And Revenue Analysis - Excluding Law, University Of Southern Maine

Direction Package

No abstract provided.

Exosomes Derived From Htlv-1 Infected Cells Contain The Viral Protein Tax, Aarthi Narayanan, Elizabeth Jaworski, Rachel Van Duyne, Sergey N. Iordanskiy, Irene Guendel, Ravi Das, Robert Currer, Gavin C. Sampey, Myung Chung, Kylene Kehn-Hall, Charles Bailey, Anastas Popratiloff, Fatah Kashanchi

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

No abstract provided.

Compositions Including Triciribine And Trastuzumab And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti

USF Patents

This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

N-Substituted 5-Amino-6-Methylpyrazine-2,3-Dicarbonitriles: Microwave-Assisted Synthesis And Biological Properties, Aidan Coffey, Jiahui Guo, Et. Al.

Department of Biological Sciences Publications

In this work a series of 15 N-benzylamine substituted 5-amino-6-methyl-pyrazine-2,3-dicarbonitriles was prepared by the aminodehalogenation reactions using microwave assisted synthesis with experimentally set and proven conditions. This approach for the aminodehalogenation reaction was chosen due to its higher yields and shorter reaction times. The products of this reaction were characterized by IR, NMR and other analytical data. The compounds were evaluated for their antibacterial, antifungal and herbicidal activity. Compounds 3 (R = 3,4-Cl), 9 (R = 2-Cl) and 11 (R = 4-CF3) showed good antimycobacterial activity against Mycobacterium tuberculosis (MIC = 6.25 µg/mL). It was found that the lipophilicity is …

Redefining Quality In Developing World Education, Kristi Jane Yuthas, Marc J. Epstein

Business Faculty Publications and Presentations

In the outskirts of Medellin, Colombia, impoverished rural schoolchildren have cause for hope. The Colombian Coffee Growers’ Association wants to hire them. Why? Because these children have developed the independent thinking, communication, and work skills that will make them an asset to the industry. They developed these skills in their multigrade primary schools, where children do most of their learning in competence-based groups, while the teacher functions as guide and coach.

In Kenya, a teenage boy is also celebrating. A primary school dropout who once survived outside the law, he now runs his own small business, lives on his own, …

Comparison Of Antibodies That Mediate Hiv Type 1 Gp120 Antibody-Dependent Cell-Mediated Cytotoxicity In Asymptomatic Hiv Type 1-Positive Men And Women, Mariana M. Mata, Joyce R. Iwema, Shanna Dell, Leslie Neems, Beth D. Jamieson, John Phair, Mardge H. Cohen, Kathryn Anastos, Linda L. Baum

Open Access Publications

No abstract provided.

Transplantation Of Autologous Adipose Stem Cells Lacks Therapeutic Efficacy In The Experimental Autoimmune Encephalomyelitis Model, Xiujuan Zhang, Annie C. Bowles, Julie A. Semon, Brittni A. Scruggs, Shijia Zhang, Amy L. Strong, Jeffrey M. Gimble, Bruce A. Bunnell

Biological Sciences Faculty Research & Creative Works

Multiple sclerosis (MS), characterized by chronic inflammation, demyelination, and axonal damage, is a complicated neurological disease of the human central nervous system. Recent interest in adipose stromal/stem cell (ASCs) for the treatment of CNS diseases has promoted further investigation in order to identify the most suitable ASCs. To investigate whether MS affects the biologic properties of ASCs and whether autologous ASCs from MS-affected sources could serve as an effective source for stem cell therapy, cells were isolated from subcutaneous inguinal fat pads of mice with established experimental autoimmune encephalomyelitis (EAE), a murine model of MS. ASCs from EAE mice and …

Utility Of Surveillance Blood Cultures In Patients Undergoing Hematopoietic Stem Cell Transplantation, Sameeh S. Ghazal, Michael P. Stevens, Gonzalo M. L. Bearman, Michael B. Edmond

Internal Medicine Publications

Background Surveillance blood cultures are often obtained in hematopoietic stem cell transplant (HSCT) patients for detection of bloodstream infection. The major aims of this retrospective cohort study were to determine the utility of the practice of obtaining surveillance blood cultures from asymptomatic patients during the first 100 post-transplant days and to determine if obtaining more than one positive blood culture helps in the diagnosis of bloodstream infection.

Methods We conducted a 17-month retrospective analysis of all blood cultures obtained for patients admitted to the hospital for HSCT from January 2010 to June 2011. Each patient’s clinical course, vital signs, diagnostic …

Inhibition Of Methicillin-Resistant Staphylococcus Aureus-Induced Cytokines Mrna Production In Human Bone Marrow Derived Mesenchymal Stem Cells By 1,25-Dihydroxyvitamin D3, Aparna Maiti, William A. Jiranek

Orthopaedic Surgery Publications

Background Methicillin-resistant Staphylococcus aureus (MRSA) is the predominant cause of bone infection. Toll like receptors (TLRs) are an important segments of host response to infection and are expressed by a variety of cells including human mesenchymal stem cells (hMSCs). The active form of Vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has potent immunoregulatory properties, but the mechanism remains poorly understood. The genomic action of 1,25(OH)2D3 is mediated by vitamin D receptor (VDR), hormone-regulated transcription factor. VDR interacts with co-activators and co-repressors are associated with chromatin histone modifications and transcriptional regulation. The aim of our study is to explore MRSA-induced TLRs-mediated pro-inflammatory cytokines …

Town Of Derry Annual Report Fiscal Year Ending June 30, 2014., Derry Town Representatives

Derry, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Identification Of Low Molecular Weight Compounds Inhibiting Growth Of Corynebacteria: Potential Lead Compounds For Antibiotics, Jaime L. Patera, Jennifer C. Copeland, Alexander Eletsky, Greg A. Somerville, Thomas Szyperski, Robert Powers

Robert Powers Publications

The genus Corynebacterium consists of nearly seventy species and is closely related to the genera Mycobacterium, Nocardia, and Rhodococcus. The characteristic traits of Corynebacteria include cells that are shaped like straight rods with clubbed ends, as well as an extra cell wall layer consisting of mycolic acids covalently bound to the peptidoglycan layer which adds an additional layer of protection against antibiotics. Corynebacteria are very well studied and outstandingly important for the large scale biotechnological production of amino acids and nucleotides.^[1] Moreover, Corynebacteria produce several pathogens that affect humans and livestock. Toxins produced by C. diphtheriae …

Annual Reports Of The Town Officers Of The Town Of Madbury, New Hampshire For The Fiscal Year Ending December 31, 2013., Madbury Town Representatives

Madbury, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Strengthening Families And Communities To Prevent Youth Violence: A Public Health Approach, Deborah Gorman-Smith, Lauren Feig, Franklin Cosey-Gay, Molly Coeling

Children's Legal Rights Journal

No abstract provided.

Tuberculosis Of The Ankle: A Case Report, Drew Newhoff, Richard A. Miller

UNM Orthopaedic Research Journal

No abstract provided.

Expression And Characterization Of The Novel Oxidase Virh-Ox, John Dronzek

Chemistry Honors Papers

No abstract provided.

Is The Human Right To Water In Pennsylvania Fracked? An Analysis Of The Pennsylvanian Right To Water In The Hydraulic Fracturing Context And A Proposal For Reform Based On French And Ontario Environmental Rights Statutes, Steve Krejci

Student Works

No abstract provided.