Digital Commons Network^™

Older Adult Perceptions Of The Assist Program, Joy Anthony

Graduate Research Projects

No abstract provided.

Derivation And Validation Of Cutoffs For Clinical Use Of Cell Cycle Arrest Biomarkers, Eric A.J. Hoste, Peter A. Mccullough, Kianoush Kashani, Lakhmir S. Chawla, Michael Joannidis, The Sapphire Investigators

Anesthesiology and Critical Care Medicine Faculty Publications

Background

Acute kidney injury (AKI) remains a deadly condition. Tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein (IGFBP)7 are two recently discovered urinary biomarkers for AKI. We now report on the development, and diagnostic accuracy of two clinical cutoffs for a test using these markers.

Methods

We derived cutoffs based on sensitivity and specificity for prediction of Kidney Disease: Improving Global Outcomes Stages 2–3 AKI within 12 h using data from a previously published multicenter cohort (Sapphire). Next, we verified these cutoffs in a new study (Opal) enrolling 154 critically ill adults from six sites in the …

Examining Success In Health Information Technology Implementation Research, Madison Ngafeeson

Conference Presentations

The implementation of health information systems (IS) is rapidly increasing. In the United States, $70 billion will be invested by the government to facilitate the adoption of the electronic health record over a ten-year period. However, IS acceptance is not success. We use content analysis to investigate the success component.

Ils Position Statement On Development Aid Effectiveness, International Life Saving Federation

International Journal of Aquatic Research and Education

No abstract provided.

What Is “The Good” Of Arts-Based Peacebuilding? Questions Of Value And Evaluation In Current Practice, Mary Ann Hunter, Linda Page

Peace and Conflict Studies

In a context of growing attention to the benefits of the arts in peacebuilding, this article reports on the findings of a small scoping study that aimed to identify how the arts are perceived and supported by international development agencies. Based on a 2012 analysis of five international aid agencies working in the South East Asia and Pacific region, the study found that arts and creative practices are not, as yet, afforded a significant role in current policy or strategy, although arts activity is recognised as a social development tool by agencies working in partnership with local organisations. Resulting from …

Research Digest - November 2014, Division Of Public Health Sciences, Department Of Surgery, Washington University School Of Medicine In St. Louis

Newsletters from the Division of Public Health Sciences

No abstract provided.

Postural Orthostatic Tachycardia Syndrome (Pots) Education, Awareness, And Support, Amy Knapp

Graduate Research Projects

No abstract provided.

Research & Strategic Partnerships: Quarterly Review, Volume 2, Issue 1, Portland State University. Research & Strategic Partnerships

Portland State Research Magazine

This Review describes connections among Portland State University, society's needs, and innovation: engineer Evan Thomas’s public health program in Rwanda, chemist Steve Reichow's protein research in the Collabo­rative Life Sciences Building, environmental historian Catherine McNeur's look back at urban agriculture in New York City, the "My Life" mentoring program for foster teens, and "Reclaiming Futures" interventions that help at-risk kids avoid incarceration.

It also focuses on EXITO. EXITO, Portland State University's largest-ever federal grant, awarded by the NIH to a team headed by Professors Carlos Crespo and Tom Keller. In the next decade, EXITO will help hundreds of underrepresented students …

Maternal Perception Of Child Body Weight And Physical Activity Behavior Patterns: Interactions With Gender And Ethnic Minority Status Of Preschool Children, Kayla F. Brooks

Electronic Theses and Dissertations

Childhood overweight and obesity is a complex disease that requires early identification and intervention. Little research has investigated the influence of maternal perception of child body weight on reported child physical activity behaviors and importance to change these behaviors. Using parent survey and child body mass index (BMI) data, the current study evaluated the difference between maternal perception of child weight status and reported physical activity and sedentary behavior levels amongst preschool-aged children. Reported child physical activity and sedentary behavior levels were not significantly different depending on maternal misperception. A significant interaction, however, between maternal perception of child body weight …

Rgs16, A Novel P53 And Prb Cross-Talk Candidate Inhibits Migration And Invasion Of Pancreatic Cancer Cells, Miranda B. Carper, James Denvir, Goran Boskovic, Donald A. Primerano, Pier Paolo Claudio

Biochemistry and Microbiology

Data collected since the discovery of p53 and pRb/RB1 suggests these tumor suppressors cooperate to inhibit tumor progression. Patients who have mutations in both p53 and RB1 genes have increased tumor reoccurrence and decreased survival compared to patients with only one tumor suppressor gene inactivated. It remains unclear how p53 and pRb cooperate toward inhibiting tumorigenesis. Using RNA expression profiling we identified 179 p53 and pRb cross-talk candidates in normal lung fibroblasts (WI38) cells exogenously coexpressing p53 and pRb. Regulator of G protein signaling 16 (RGS16) was among the p53 and pRb cross-talk candidates and has been implicated in inhibiting …

Anorexia/Bulimia, Transcendence, And The Potential Impact Of Romanticized/Sexualized Death Imagery, Heather D. Schild

Center for the Study of Ethics in Society Papers

Presented November 10, 2014. Papers presented for the Center for the Study of Ethics in Society Western Michigan University

Goomig Farmlands Development Baseline Water Quality In The Lower Keep River, D L. Bennett, Richard J. George Dr

Resource management technical reports

In 2008 the Ord Irrigation Expansion Project was approved by the Western Australian Government to develop irrigated agriculture on the Weaber Plain. By mid-2014 construction of almost all of the water supply, drainage, access, monitoring and other infrastructure for the 7400ha Goomig Farmlands development had substantially been completed. An important concern is the effect the Goomig Farmlands development may have on the water quality of the downstream lower Keep River aquatic environment, particularly as it relates to threatened species that inhabit or may inhabit the area. Possible increases in salinity, nutrients, suspended sediment, heavy metals and farm chemicals delivered in …

Stony Brook Press, V. 36, N. 03, Stony Brook University. Stony Brook Press.

Stony Brook Press

v. 36, n. 03, v.:ill. ; 38 cm (original analog pub.)

Atrx Is Required For Maintenance Of The Neuroprogenitor Cell Pool In The Embryonic Mouse Brain, Kieran Ritchie, L Ashley Watson, Benjamin Davidson, Yan Jiang, Nathalie G. Bérubé

Paediatrics Publications

Mutations in the alpha-thalassemia mental retardation X-linked (ATRX) gene cause a spectrum of abnormalities including intellectual disability, developmental delay, seizures, and microcephaly. The ATRX protein is highly enriched at heterochromatic repetitive sequences adjacent to the centromere, and ATRX depletion results in chromosome congression, segregation, and cohesion defects. Here, we show that Cre-mediated inactivation of Atrx in the embryonic mouse (Mus musculus) brain results in expansion of cerebral cortical layer VI, and a concurrent thinning of layers II-IV. We observed increased cell cycle exit during early-mid neurogenesis, and a depletion of apical progenitors by late neurogenesis in the Atrx-null neocortex, explaining …

T Helper Type 2-Polarized Invariant Natural Killer T Cells Reduce Disease Severity In Acute Intra-Abdominal Sepsis, R. V. Anantha, D. M. Mazzuca, S. X. Xu, S. A. Porcelli, D. D. Fraser, C. M. Martin, I. Welch, T. Mele, S. M.M. Haeryfar, J. K. Mccormick

Paediatrics Publications

Summary: Sepsis is characterized by a severe systemic inflammatory response to infection that is associated with high morbidity and mortality despite optimal care. Invariant natural killer T (iNKT) cells are potent regulatory lymphocytes that can produce pro- and/or anti-inflammatory cytokines, thus shaping the course and nature of immune responses; however, little is known about their role in sepsis. We demonstrate here that patients with sepsis/severe sepsis have significantly elevated proportions of iNKT cells in their peripheral blood (as a percentage of their circulating T cells) compared to non-septic patients. We therefore investigated the role of iNKT cells in a mouse …

The Author Responds, Michael Rieder

Paediatrics Publications

No abstract provided.

Exploiting High-Throughput Cell Line Drug Screening Studies To Identify Candidate Therapeutic Agents In Head And Neck Cancer, Anthony C Nichols, Morgan Black, John Yoo, Nicole Pinto, Andrew Fernandes, Benjamin Haibe-Kains, Paul C Boutros, John W Barrett

Oncology Publications

BACKGROUND: There is an urgent need for better therapeutics in head and neck squamous cell cancer (HNSCC) to improve survival and decrease treatment morbidity. Recent advances in high-throughput drug screening techniques and next-generation sequencing have identified new therapeutic targets in other cancer types, but an HNSCC-specific study has not yet been carried out. We have exploited data from two large-scale cell line projects to clearly describe the mutational and copy number status of HNSCC cell lines and identify candidate drugs with elevated efficacy in HNSCC.

METHODS: The genetic landscape of 42 HNSCC cell lines including mutational and copy number data …

Developmental Differences In The Influence Of Phonological Similarity On Spoken Word Processing In Mandarin Chinese., Jeffrey G Malins, Danqi Gao, Ran Tao, James R Booth, Hua Shu, Marc F Joanisse, Li Liu, Amy S Desroches

Brain and Mind Institute Researchers' Publications

The developmental trajectory of spoken word recognition has been well established in Indo-European languages, but to date remains poorly characterized in Mandarin Chinese. In this study, typically developing children (N=17; mean age 10; 5) and adults (N=17; mean age 24) performed a picture-word matching task in Mandarin while we recorded ERPs. Mismatches diverged from expectations in different components of the Mandarin syllable; namely, word-initial phonemes, word-final phonemes, and tone. By comparing responses to different mismatch types, we uncovered evidence suggesting that both children and adults process words incrementally. However, we also observed key developmental differences in how subjects treated onset …

Striatum In Stimulus-Response Learning Via Feedback And In Decision Making., Nole M Hiebert, Andrew Vo, Adam Hampshire, Adrian M Owen, Ken N Seergobin, Penny A Macdonald

Brain and Mind Institute Researchers' Publications

Cognitive deficits are recognized in Parkinson's disease. Understanding cognitive functions mediated by the striatum can clarify some of these impairments and inform treatment strategies. The dorsal striatum, a region impaired in Parkinson's disease, has been implicated in stimulus-response learning. However, most investigations combine acquisition of associations between stimuli, responses, or outcomes (i.e., learning) and expression of learning through response selection and decision enactment, confounding these separate processes. Using neuroimaging, we provide evidence that dorsal striatum does not mediate stimulus-response learning from feedback but rather underlies decision making once associations between stimuli and responses are learned. In the experiment, 11 males …

Localized, Non-Random Differences In Chromatin Accessibility Between Homologous Metaphase Chromosomes, Wahab A Khan, Peter K Rogan, Joan H.M. Knoll

Department of Medicine Publications

BACKGROUND: Condensation differences along the lengths of homologous, mitotic metaphase chromosomes are well known. This study reports molecular cytogenetic data showing quantifiable localized differences in condensation between homologs that are related to differences in accessibility (DA) of associated DNA probe targets. Reproducible DA was observed for ~10% of locus-specific, short (1.5-5 kb) single copy DNA probes used in fluorescence in situ hybridization.

RESULTS: Fourteen probes (from chromosomes 1, 5, 9, 11, 15, 17, 22) targeting genic and intergenic regions were developed and hybridized to cells from 10 individuals with cytogenetically-distinguishable homologs. Differences in hybridization between homologs were non-random for 8 …

Bmp4 And Lgl1 Are Down Regulated In An Ovine Model Of Congenital Diaphragmatic Hernia, Heather M A Emmerton-Coughlin, K Kathryn Martin, Jacky S S Chiu, Lin Zhao, Leslie A Scott, Timothy R H Regnault, Andreana Bütter

Surgery Publications

BACKGROUND/PURPOSE: The molecular pathophysiology of lung hypoplasia in congenital diaphragmatic hernia (CDH) remains poorly understood. The Wnt signaling pathway and downstream targets, such as bone morphogenetic proteins (BMP) 4 and other factors such as late gestation lung protein 1 (LGL1), are essential to normal lung development. Nitrofen-induced hypoplastic CDH rodent lungs demonstrate down regulation of the Wnt pathway including BMP4 and reduced LGL1 expression. The aim of the current study was to examine the molecular pathophysiology associated with a surgically induced CDH in an ovine model.

METHODS: Left thoracotomy was performed at 80 days in 14 fetal sheep; CDH was …

Using A Public Health Approach To Understand “Skipping” Snowmobiles In Pangnirtung, Nunavut, Canada, Audrey R. Giles, Meghan Lynch, Gwenyth S. Stadig, Michelle Doucette Issaluk, Francine Darroch, Shaelyn Strachan

International Journal of Aquatic Research and Education

No abstract provided.

Underwater Treadmill Training, Glycemic Control, And Health-Related Fitness In Adults With Type 2 Diabetes, Ryan T. Conners, Don W. Morgan, Dana K. Fuller, Jennifer L. Caputo

International Journal of Aquatic Research and Education

No abstract provided.

Factories, Phones And Faces In India: An Analysis Of Good World Solutions In Indian Factories, Holly Mckenna, Matt Stockamp

Miller Center Fellowship

Good World Solutions (GWS) is a social enterprise at the cutting edge of building transparency in global supply chains by connecting factory workers at the base of the pyramid with supply chain managers through affordable, scalable web and mobile technologies. GWS is supporting clothing brands that source from India through conducting mobile surveys in clothing factories through their innovative technology, Labor Link. By enabling workers to take a short mobile survey on banking, working conditions, and other subjects, GWS is able to gather a significant amount of quantitative data from workers that does not get skewed by factory management or …

Ilumexico Technology Research: Solar-Powered Cooler, Alexandria Cabral, Kiara Machuca, Kaci Mccartan

Miller Center Fellowship

When asked, customers showed interest in a variety of solar-powered products. These products were appliances and entertainment devices such as a blenders, washing machines, stoves, freezers, fans, televisions, stereos, and telephones. Many customers also asked for bigger solar systems in order to save more energy and attach more accessories, such as phone chargers. The most popular product requested was a solarpowered refrigerator (30% of population in Campeche). Led by a team of student engineers from Santa Clara University’s School of Engineering, Iluméxico has embarked on a journey to develop its next solar-powered product: a small-scale solar-powered cooler to be used …

Non-Structural Program To Limit E. Coli Within Antelope Creek Lincoln, Nebraska, Jeffrey Polkowski

Community and Regional Planning Program: Professional Projects

Beginning in 2008, The City of Lincoln, Nebraska set forth efforts to reduce pollutant loads within Antelope Creek below U.S. Environmental Protection Agency (EPA) criteria with the goal of eventually having segments of the stream removed from the Clean Water Act 303(d) list of impaired waters. Early efforts focus on channel improvements made as part of the Antelope Valley Project to increase the flood carrying capacity of the Creek. However, additional funding is being provided through an intergovernmental agreement between the Nebraska Department of Environmental Quality and the City of Lincoln (Grant Number: 56-1283) to allow the City of Lincoln’s …

Adobe Medicus 2014 6 November-December, Health Sciences Library And Informatics Center

adobe medicus

No abstract provided.

Leadership Lessons From Women University Presidents, Karen A. Longman, Susan R. Madsen, Mary E. Lyons, Constance M. Carroll, Carolyn J. Stefanco

Marketing and Strategy Faculty Publications

There is no question that more women are needed as leaders in all sectors worldwide. Yet, women are often faced with unique challenges and opportunities that drive the need for continued conversations. This engaging session will move forward a dialogue started at the June 2013 conference at Asilomar; it will that bring together three distinguished panelists—present female university presidents—who will discuss intriguing issues around their experiences in leading and the continued work needed to build, bridge, and blaze pathways for women and leadership.

Due Process Disaggregation, Jason Parkin

Notre Dame Law Review

One-size-fits-all procedural safeguards are becoming increasingly suspect under the Due Process Clause. Although the precise requirements of due process vary from context to context, the Supreme Court has held that, within any particular context, the Due Process Clause merely requires one-size-fits-all procedures that are designed according to the needs of the average or typical person using the procedures. As the Court explained when announcing the modern approach to procedural due process in Mathews v. Eldridge, the due process calculus must be focused on “the generality of cases, not the rare exceptions.” A more granular approach to due process rules, the …

Parting The Chevron Sea: An Argument For Chevron's Greater Applicability To Cabinet Than Independent Agencies, Andrew T. Bond

Notre Dame Law Review

This Note argues that cabinet agencies are better suited to receive Chevron deference than independent agencies because voters should desire such policy decisions to be made by those closest to electoral accountability, rather than unelected Article III judges with life-tenure. In other words, the judiciary should accept the countermajoritarian difficulty as fundamentally true and review cabinet agency decisions in light of Chevron deference. Part I examines the revolutionary decision of Chevron and its aftermath. Central to Part I is an inquiry into whether Chevron should be applied on a case-by-case or across-the-board basis, and whether Chevron has usurped the judiciary’s …