Book Review - Brief Coaching With Children And Young People, Jeff Chang

Journal of Solution Focused Practices

No abstract provided.

Volume 1 Issue 2 - Complete

Journal of Solution Focused Practices

No abstract provided.

Mountain Monitor - 3rd Quarter 2014, Kenan Fikri, Mark Muro

Mountain Monitor Quarterly

As a group, the 10 major metro areas of the Mountain West outperformed the national economy during the third quarter of 2014 on all four indicators of economic vitality measured by the Mountain Monitor: employment growth, output growth, unemployment, and house prices. In the three months ending in September, the country’s large metropolitan areas were anticipating the rapid uptick in national economic growth that took hold at the end of 2014. Mountain region metro areas led the way.

All but two major metro areas in the region added jobs, and six did so at a faster rate than the …

Gambaran Sistem Penyelenggaraan Makanan Di Pondok Pesantren Hubulo Gorontalo, Sitti Aisyah Taqhi

Media Kesehatan Masyarakat Indonesia

Penyelenggaraan makanan adalah rangkaian kegiatan mulai dari perencanaan menu sampai dengan pendistribusian makanan kepada konsumen dalam rangka pencapaian status kesehatan yang optimal melalui pemberian makanan yang tepat dan termasuk kegiatan pencatatan, pelaporan, dan evaluasi. Penelitian ini bertujuan me-ngetahui gambaran sistem penyelenggaraan makanan di Pondok Pesantren Hubulo Gorontalo yang meliputi input, proses, dan output. Jenis penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif yang menggunakan data primer dan sekunder. Informan penelitian adalah pimpinan pondok pesantren, koordinator bagian keuangan, dan kepala dapur. Pengolahan dan analisis data menggunakan content analysis dan disajikan dalam bentuk teks naratif. Hasil penelitian diperoleh bahwa dari segi input …

Aeroponic/Hydroponic Growth Module, Sean Marrs, Joshua Moreno

Mechanical Engineering

No abstract provided.

Cal Poly India Project, Derek Babine, Austen Hibler, Alex Hernandez

Mechanical Engineering

This report documents the research, ideation, and development of a solution, implemented by the Cal Poly India Sanitation Team per the request of Mr. Harish Bhutani, to solve the problem of hazardous human waste management in poor villages in India. The sponsor envisioned a universal design that would give each household in those villages access to a private toilet system because the current solution is open defecation in water sources and farming fields. The initial constraints required the project be low cost, not use of electricity or water, have the ability to cater to an 8-10 person household, and be …

Fundraising Techniques Of San Luis Obispo Nonprofit Organizations, Samantha Suyemoto

Graphic Communication

The purpose of this study was to identify the strengths and weaknesses of using direct mail and electronic media in the fundraising techniques of local San Luis Obispo nonprofit organizations. The intended audience includes the nonprofits interviewed in each case study as well as the other organizations that fundraise within the San Luis Obispo area. Three case studies of nonprofit organizations within the area were conducted in conjunction with research on various types of funding. Results of this study are intended to benefit the nonprofits by providing more information on successful fundraising habits.

Fresh Bytes - Connected Hydroponics For Small-Scale Growing, Jack Bowen

Liberal Arts and Engineering Studies

Many users are now transitioning to small-scale hydroponics and aquaponics at home. There can be a barrier to entry with these systems as there is a delicate balance of chemicals, pH, etc. that must be maintained. There are sensors for these various components but they are either aimed at commercial production or are un-automated. Fresh Bytes is a microcomputer with sensors to detect all of these unseen components in a hydroponic system. A prototype of this microcomputer is produced along with CAD plans for more professional versions of it. The sensors are verified and future development is contemplated.

Aquaponics Art, Alexander Horton

Liberal Arts and Engineering Studies

Aquaponics has enormous potential to change the way we farm. I wanted to connect more people to Cal Poly's first aquaponics club by creating a functioning aquaponics art installation that allows people to plant their own plants. This paper is catalog of the design process as a reflection of what this project hopes to accomplish.

Developing A Tool For Site-Specific Gene Inactivation In Chlamydia, Cayla Marie Johnson

Theses

Chlamydia trachomatis is an obligate intracellular bacterial pathogen that infects both humans and domestically important animals. Research in the field has until more recently been hindered by a lack of genetic tools. We have modified Sigma's TargeTron^TM Gene Knockout System, which utilizes a mobile group II intron for site-specific insertion and gene inactivation, for use in C. trachomatis. As proof of principle, we used the system to inactivate incA, creating mutant strains DFCT3 and DFCT4 (independent clones both carrying incA::GII[bla]). IncA is a chlamydial inclusion membrane protein involved in homotypic fusion of inclusions when cells are infected with more …

Decomposing The Growth Of Us Wine Exports To China Into Scale, Competitive, And Second-Order Effects, Xiaorui Wang

Theses

The study aims at investigating the reason for the growth of US wine exports to China through utilizing CMS (Constant Market Share Analysis) model decomposed into three effects: scale, competitive and second-order effect. The result shows that the increasing demand of Chinese market is the key factor for the growth of US wine exports to China; at the same time, it also indicates that the product competitiveness of US wine is declining, while market distribution channels are lacking. The phenomenon of the increase of Chinese market for importing American wine can be attributed to the growing Chinese wine market, the …

Fate Control And Human Rights: The Policies And Practices Of Local Governance In America's Arctic, Mara Kimmel

ISER Articles

The loss of territoriality over lands conveyed under the Alaska Native Claims Settlement Act had adverse impacts for Alaskan tribal governance. Despite policy frameworks that emphasize the value of local governance at an international, regional, and statewide level, Alaskan tribes face unique obstacles to exercising their authority, with consequences for both human development and human rights. This Article examines how territoriality was lost and analyzes the four major effects of this loss on tribal governance. It then describes two distinct but complimentary strategies to rebuilding tribal governance authority that rely on both territorial and non-territorial authority.

Resource Revenues And Fiscal Sustainability: Lessons Of The Alaska Disconnect, Gunnar Knapp

ISER Articles

In 1968, the Prudhoe Bay oil field was discovered on Alaska’s North Slope – the largest oil field ever discovered in North America. That discovery led to an economic and fiscal transformation of the young state of Alaska. A 1969 sale of Prudhoe Bay leases brought the state $900 million in one day ($4.9 billion in 2014 dollars) – six times the state’s budget that year of $115 million (Ragsdale, 2008). After the completion of the Trans-Alaska pipeline, oil began flowing from the North Slope – bringing the state very large annual oil revenues. Cumulatively, between 1978 and 2014 the …

Conservation And Ecological Implications Of The Introgression Between Black Bass Subspecies, Rachel Tessier

Honors Capstones

No abstract provided.

Role Of Carbonaceous Materials In Polymer Matrix Composites For Friction Applications, Preston Lapping

Theses

The purpose of this research was to study the friction performance characteristics of a Copper, Antimony, and sulfide free environmentally automotive friction material using different allotropes of graphite as a replacement. Model brake friction materials were created and tested on a full scale brake dynamometer using the Society of Automotive Engineers J2430 test and Brake Effectiveness Evaluation Procedure. The dynamometer testing revealed the graphite replacement to have higher average effectiveness values when compared to the baseline friction material currently in production. The model samples generally had higher wear rates but some were comparable to the baseline and would be acceptable …

Mega: An Energy Aware Algorithm For Self-Powered Wireless Sensor Networks In Sustainable Smart Infrastructure, Dong Qi, Yu Chen, Shahrzad Towfighian

Mechanical Engineering Faculty Scholarship

Smart infrastructure is attractive for possessing many desirable features, such as uninterrupted monitoring of health conditions, timely response to damages, and human-infrastructure interactions. Embedded sensors that collectinformation are critical for decision making. However, the lifetime of electronic sensors is a constraint to infrastructure lifetime if sensors are physically embedded in the infrastructure at construction time. In this paper, we studied a self-powered wireless sensor network that harvests energy from mechan-ical vibration in the environment. A dynamic, hierarchical algorithm called MEGA is proposed that constructs clusters and elects the cluster head based on residue energy and energy harvest rate. Taking a …

Lkb1 Deficient Non-Small Cell Lung Cancer Cells Are Vulnerable To Energy Stress Induced By Atp Depletion, Chao Yang

Dissertations and Theses (Open Access)

Lung cancer is the second most frequent cancer in United States, which represents about 13.5% of new cancer cases every year. It accounts for about 27.2% of all cancer related deaths, which is more than the sum of deaths caused by prancretic, breast and colorectal. On average, only about 16% of lung cancer patients survive beyond 5 years. LKB1 is the third most mutated gene in lung cancer. It has been shown that LKB1 is mutated in at least 15% to 30% of NSCLC. Tumor with LKB1 mutation is associated with poor differentiation, high metastasis and worse response to chemotherapy. …

Swarna Ramaswamy_Thesis, Swarna S. Ramaswamy

Dissertations and Theses (Open Access)

STRUCTURAL INVESTIGATIONS OF LIGAND GATED ION CHANNELS

Swarna Ramaswamy, B.S

Advisor: Vasanthi Jayaraman, Ph.D.

Ion channels form an integral part of membrane proteins. In the nervous system including the central and the peripheral nervous system, ligand gated ion channels form a very important part of intercellular communications. They receive chemical signals and convert them to electrical signal, mainly by allowing ion passage across the cell membrane. Ion passage also translates into downstream signaling events. Faithful translation of these signals and transmittance is crucial for several physiological functions, implying that irregular ion channel function could lead to serious consequences.

This thesis …

A Novel Tablet Based System To Measure The Effect Of Subconcussive Blows On Sensorimotor And Cognitive Functioning, Stuart D. Red

Dissertations and Theses (Open Access)

Concussions have become a major societal concern with studies showing detrimental short and long-term effects on cognitive and sensory functioning. More recently, research has begun to focus on “subconcussive” blows to the head. Subconcussive blows, which are common in many sports (soccer, boxing, football, etc), do not result in the more obvious symptoms of a concussion but have the potential to cause severe brain injury. In our lab and others, eye movements have been used as a sensitive marker of cognitive and sensory changes related to specific diseases and treatments. We have developed a novel measure based on eye movement …

The Role Of Mir-34a In Inhibition Of Prostate Tumor Growth In The Bone And Induction Of Autophagy, Sanchaika Gaur

Dissertations and Theses (Open Access)

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in the United States, with most deaths occurring from bone metastasis. Several new therapies have been FDA approved for bone-metastatic PCa, but patient survival has only marginally improved due to therapy resistance, which often arises from constitutive activation of compensatory signaling pathways. This dissertation work focused on a mechanistic understanding of how cross talk between tyrosine kinase receptors contributes to therapy resistance, and how this may be overcome by downregulating expression of these receptors. In PCa cell lines and xenograft models, I demonstrated that activation of IGF-1R …

Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head And Neck Squamous Cell Carcinoma, Mayur Arvind Gadhikar

Dissertations and Theses (Open Access)

Cisplatin, despite being the cornerstone chemotherapy for the treatment of head and neck squamous cell carcinoma (HNSCC), provides clinical benefits in just a subset of patients. This together with the lack of biomarkers predicting therapeutic responses, have led to unacceptably high rate of treatment failures in HNSCC. TP53 is the most frequently mutated gene in HNSCC, and the effect of p53 loss or mutation on cisplatin responses in HNSCC is poorly understood. In the current study, we hypothesized that HNSCC cells respond to cisplatin in a p53 dependent manner and unambiguously show that presence of wild-type TP53 (wtp53) confers sensitivity …

P120-Catenin Regulates Rest And Corest, And Modulates Mouse Embryonic Stem Cell Differentiation, Moonsup Lee

Dissertations and Theses (Open Access)

The canonical-Wnt pathway and beta-catenin have been extensively studied to determine their contributions to stem cell biology, but less is known about p120-catenin in the nuclear compartment. P120 is developmentally required as a consequence of its biochemical and functional interactions with cadherins, small-GTPases and transcriptional regulators. We report here that p120-catenin binds to and negatively regulates REST and CoREST, that others have indicated form a repressive complex having diverse key roles in developmental and pathologic gene regulation. We thus provide the first evidence for a direct upstream modulator of REST/CoREST function. Using mouse embryonic stem cells (mESCs), mammalian cell lines, …

Hypoxia Mediated Downregulation Of Mirna Biogenesis Leads To Increased Tumor Progression, Rajesha Rupaimoole

Dissertations and Theses (Open Access)

In recent years, there has been a growing recognition of the importance of tumor associated microenvironment in the initiation and progression of tumors. However, a mechanistic understanding of the complicated biological interplay between the stromal framework and malignant regions of the tumor remains incompletely understood. In this study, we address mechanisms by which hypoxia in the tumor microenvironment leads to attenuation of miRNA biogenesis by downregulation of two key enzymes, Drosha and Dicer in cancer cells. Previous data from our laboratory had shown the clinical relevance of downregulated Dicer and Drosha in ovarian and other cancer types, but a clear …

Role Of Phosphorylation Of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis, Tanushree Chatterji

Dissertations and Theses (Open Access)

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that mediates interactions between the extracellular matrix and intracellular signaling pathways critical in promoting numerous cellular functions including adhesion, proliferation, survival and migration. Most FAK functions result from phosphorylation by Src family kinases, which trigger numerous signaling cascades. Overexpression of FAK is associated with metastasis in many solid tumors, including prostate cancer. Hence, understanding the mechanisms by which FAK is regulated in prostate cancer will better elucidate its role in prostate cancer metastasis. Work in this dissertation tested the hypothesis that altered phosphorylation of FAK is critical for cell migration and …

Sustained Adrenergic Signaling Promotes Cervical Cancer Progression, Nouara C. Sadaoui

Dissertations and Theses (Open Access)

Background: Chronic stress and sustained adrenergic signaling are known to promote tumor progression. The underlying mechanisms behind this process are not well understood. We examined the effects of sustained adrenergic signaling on cervical cancer progression through increased expression of HPV oncogenes, E6 and E7.

Materials and Methods: ADRβ expression levels were examined in patient-derived cervical cancer samples. We used an orthotopic model of cervical cancer to investigate the effects of restraint stress on tumor growth and metastasis. We evaluated the in vivo effects of a β-blocker, propranolol, and HPV E6/E7 siRNA. In vitro, ADRβ positive cervical cancer cells were …

Mdm2-Mediated Degradation Of Sirt6 Phosphorylated By Akt1 Promotes Tumorigenesis And Trastuzumab Resistance In Breast Cancer, Umadevi Thirumurthi

Dissertations and Theses (Open Access)

Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of potential regulators of SIRT6 would be an important and critical contribution towards cancer treatment. Here, we show that AKT1 phosphorylates SIRT6 at Ser³³⁸ and induces MDM2-SIRT6 interaction, priming SIRT6 for degradation via the MDM2-dependent ubiquitin-proteasome pathway. Blocking SIRT6 Ser³³⁸ phosphorylation …

Effects Of Oxytocin On Human Aggression, Joseph L. Alcorn Iii

Dissertations and Theses (Open Access)

EFFECTS OF OXYTOCIN ON HUMAN AGGRESSION

Joseph Louis Alcorn III, B.S.

Advisory Professor: Scott D. Lane, Ph.D.

Human interaction is comprised of common, yet complex, behaviors and the outcomes of these social behaviors can beneficially or detrimentally impact individual and public health. One social behavior that can have profound detrimental outcomes is aggression. Aggression is a class of social behavior that is particularly prevalent in individuals with antisocial personality disorder (ASPD) and comorbid substance use disorder (SUD). Aggression in these individuals can manifest at maladaptive levels that place considerable burdens on public health and communities. Therefore, understanding the neurobehavioral underpinnings …

Quantitative Analysis And Imaging-Based Insights Into The Characteristics And Mechanisms Of Yeast Pattern Formation, Lin Chen

Dissertations and Theses (Open Access)

Biofilm formation is a common lifestyle adapted by bacteria and fungi in response to various environmental stresses. Bacterial and fungal biofilms adhering to medical devices convey resistance to antibiotics or biocides, causing high rates of clinical infections. Microorganisms are protected from harsh environmental conditions by reduced stress penetration through the complex biofilm architecture with distinct patterns. Although the molecular regulations of surface patterning have been well characterized in bacteria, the mechanisms underlying the complex pattern formation in eukaryotic biofilms remain unclear.

This dissertation aims to investigate the salient features of robust colony expansion in yeast biofilms and the processes driving …

Functions Of The Homeobox Gene Dlx4 In Controlling Inflammatory Signaling And Metastasis Of Epithelial Ovarian Cancer, Dhwani Haria

Dissertations and Theses (Open Access)

Epithelial ovarian cancer (EOC) accounts for the most number of deaths among women with gynecological malignancies in the United States. Approximately 80% of EOC patients are diagnosed with disease that has disseminated beyond the confines of the ovaries. The five year survival rate for patients with advanced stage EOC is less than 30% and the recurrence of chemoresistant disease is high. Identifying the mechanisms that control peritoneal metastasis of EOC is therefore critical for improving treatment of advanced stage disease. The homeobox gene DLX4 encodes a transcription factor that is absent from most normal adult tissues. Previous studies from our …

Differential Pax5 Levels Promote Mcl Dispersal And Progression And Predict A Poor Prognosis In Advanced Mcl Patients, Albert Teo

Dissertations and Theses (Open Access)

Although PAX5 conditional silencing in mice models led to aggressive lymphoma formation, there has been a lack of understanding in the precise functions of PAX5 in human B cell cancers. PAX5 expression is used to diagnose different B cell lymphoma in the clinic including mantle cell lymphoma (MCL), which is one of the most aggressive B cell cancers. PAX5 levels in MCL patients were significantly repressed compared to normal B cells. Surprisingly, we found there were quantitative differences in PAX5 expression levels within MCL patient tissues, which prompted us to silence PAX5 in MCL cell lines to characterize PAX5 functions …