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2014

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Differential Protein Expression Of Caco-2 Cells Treated With Selenium Nanoparticles Compared With Sodium Selenite And Selenomethionine, Linglin Fu, Xuxia Yan, Xinming Ruan, Junda Lin, Yanbo Wang Dec 2014

Differential Protein Expression Of Caco-2 Cells Treated With Selenium Nanoparticles Compared With Sodium Selenite And Selenomethionine, Linglin Fu, Xuxia Yan, Xinming Ruan, Junda Lin, Yanbo Wang

Biomedical Engineering and Sciences Faculty Publications

The study was designed to determine the differential protein expression of Caco-2 cells treated with different forms of selenium including sodium selenite, selenomethionine (Se-Met), and selenium nanoparticles (nano-Se). Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and mass spectrometry (MS) were used to identify the differentially expressed proteins. The results indicated that seven protein spots, ubiquitin-conjugating enzyme E2 (E2), glutathione synthetases (GS), triosephosphate isomerase (TSP), T-complex protein 1 subunit zeta (TCPZ), lamin-B1, heterogeneous nuclear ribonucleoprotein F (hnRNP F), and superoxide dismutase [Cu-Zn] (Cu, Zn-SOD) were significantly different among all the groups. According to the order of control, sodium selenite, Se-Met, and Nano-Se, the …

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Study Abroad And Moral Development, Andrew B. Johnson, Danielle R. Hathcock Dec 2014

Study Abroad And Moral Development, Andrew B. Johnson, Danielle R. Hathcock

eJournal of Public Affairs

Why should students study abroad? The standard answer universities give cites three types of benefit: academic, cultural, and professional. We argue that this answer sells the value of study abroad short. Just as important as any of these benefits is the value study abroad has in promoting moral development. Drawing on key ideas of the seminal developmental psychologists Jean Piaget and Lawrence Kohlberg, we make the case that study abroad can facilitate moral development, whether one understands morality in utilitarian, Kantian, or sentimentalist terms. It does so by helping students take the perspective of those who are culturally different, inducing …

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Quickbooks Self-Employed Ios Application, Braden Young Dec 2014

Quickbooks Self-Employed Ios Application, Braden Young

Computer Science and Software Engineering

No abstract provided.

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Identification Of The Infection Route Of A Fusarium Seed Pathogen Into Non-Dormant Bromus Tectorum Seeds, Janalynn Franke Dec 2014

Identification Of The Infection Route Of A Fusarium Seed Pathogen Into Non-Dormant Bromus Tectorum Seeds, Janalynn Franke

Theses and Dissertations

The genus Fusarium has a wide host range and causes many different forms of plant disease. These include seed rot and seedling blight diseases of cultivated plants. The Fusarium-caused diseases of wild plants are less well-known. In this study we examined Fusarium sp. n-caused disease development on non-dormant seeds of the important rangeland weed Bromus tectorum as part of broader studies of the phenomenon of stand failure or ‘die-off’ in this annual grass. We previously isolated an undescribed species in the Fusarium tricinctum species complex from die-off soils and showed that it is pathogenic on seeds. It can cause high …

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Modeling Of Parachute Dynamics With Gpu Enhanced Continuum Fabric Model And Front Tracking Method, Qiangqiang Shi Dec 2014

Modeling Of Parachute Dynamics With Gpu Enhanced Continuum Fabric Model And Front Tracking Method, Qiangqiang Shi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

An advanced mesoscale spring-mass model is used to mimic fabric surface motion. The fabric surface is represented by a high-quality triangular surface mesh. Both the tensile stiffness and the angular stiffness of each spring are determined by the material's Young's modulus and Poisson ratio, as well as the geometrical characteristics of the surface mesh. The spring-mass system is a nonlinear Ordinary Differential Equation (ODE) system solved by fourth order Runge-Kutta method. The model is shown to be numerically convergent under the constraint that the summation of points masses is constant. Through coupling with an incompressible fluid solver and the front …

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Roles Of Zinc And Iron On Bone Health In A Rat Model Of Osteoporosis, Danhua Yan Dec 2014

Roles Of Zinc And Iron On Bone Health In A Rat Model Of Osteoporosis, Danhua Yan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Bone is one of the most vital organs in animals, serving as both structural and protective functions. Remodeling of bone is an important indicator of bone health, and disorders in bone remodeling may lead to bone diseases such as osteoporosis. Osteoporosis increases risk of bone fracture and even death, and much more preferable to be happened in postmenopausal women due to great changes in hormones. Micronutrients, such as Zinc (Zn) and Iron (Fe), would as well influence bone health in different manners. That Zn would promote bone health is widely accepted, for the reasons Zn increases osteoblast cell proliferation and …

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A Cultural Trade? Canadian Magazine Illustrators At Home And In The United States, 1880-1960, Shannon Jaleen Grove Dec 2014

A Cultural Trade? Canadian Magazine Illustrators At Home And In The United States, 1880-1960, Shannon Jaleen Grove

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation analyzes nationalisms in the work of Canadian magazine illustrators in Toronto and New York, 1880 to 1960. Using a continentalist approach--rather than the nationalist lens often employed by historians of Canadian art--I show the existence of an integrated, joint North American visual culture. Drawing from primary sources and biography, I document the social, political, corporate, and communication networks that illustrators traded in. I focus on two common visual tropes of the day--that of the pretty girl and that of wilderness imagery. Through visual and verbal rhetoric, and through institutional controls to exclude particular kinds of illustration from counting …

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Cpi-613, A Non-Redox Active Lipoic Acid Analog, Causes Hyper-Phosphorylation Of Bckdc E1Α In H460 Lung Cancer Cells In Vitro, Michael Simon Dahan Dec 2014

Cpi-613, A Non-Redox Active Lipoic Acid Analog, Causes Hyper-Phosphorylation Of Bckdc E1Α In H460 Lung Cancer Cells In Vitro, Michael Simon Dahan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The production of lipids and proteins for growth, as well as nucleotides for the replication of the genome, are key requirements that loom as importantly as the need for the production of energy in the transformed metabolic state of cancer cells. The remodeling of the TCA cycle (extensive anaplerosis and cataplerosis) reflects this need for biosynthetic macromolecules. CPI-613, a non-redox active lipoic acid analog that has been shown to selectively increase phosphorylation of the pyruvate dehydrogenase (PDH) E1 α subunit, thereby inactivating the entire complex, was investigated for its role in causing phosphorylation of the branched-chain amino acid dehydrogenase complex …

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Expression, Purification, And Characterization Of The Short Isoform Of Adenylosuccinate Lyase, Benjamin Rajan Dec 2014

Expression, Purification, And Characterization Of The Short Isoform Of Adenylosuccinate Lyase, Benjamin Rajan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Cells require purines for critical biological processes that can be created by the de novo biosynthetic pathway or maintained by the salvage pathways. The de novo pathway in humans requires 6 enzymes, some of which are multifunctional. Adenylosuccinate lyase (ASL) catalyzes step 8 of the de novo pathway converting susuccinylaminoimidazolecarboxamide ribonucleotide (SAICAR) to aminoimidazolecarboxamide ribotide (AICAR). It also catalyzes the second step of the purine nucleotide cycle by converting SAMP to AMP. A short isoform of ASL (sASL) is ubiquitously expressed in all cell types at a lower concentration. This shortened splice variant does not perform catalysis on either of …

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Orbitofrontal Cortex And The Decision-Making Process, Youran Wu Dec 2014

Orbitofrontal Cortex And The Decision-Making Process, Youran Wu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Orbitofrontal cortex (OFC) is situated at the ventral floor of the prefrontal cortex region. OFC and some of its related structure (ventral striatum, ventral tegmental area, basolateral amygdala) are considered to be part of the valuation system that is essential to the decision-making process. In order to understand the exact role OFC plays in the decision-making process, we sought to find out how decision variables are represented in different OFC projections, and what will happen if OFC projections were disrupted. The first specific aim of this project is to find out whether projections to OFC related structures are originated from …

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Mechanism And Inhibition Of The Enoyl-Acp Reductases From Biodefense And Emerging Opportunistic Pathogens, Carla Maya Neckles Dec 2014

Mechanism And Inhibition Of The Enoyl-Acp Reductases From Biodefense And Emerging Opportunistic Pathogens, Carla Maya Neckles

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The enoyl-acyl-carrier-protein reductase (ENR) catalyzes the last reaction in the elongation cycle in the fatty acid biosynthesis type II (FAS-II) pathway. To date, there are four known ENR isoenzymes: FabI, FabK, FabL, and FabV. We have rigorously characterized the FabV ENR from Burkholderia mallei (BmFabV) and have shown that this enzyme catalyzes substrate reduction via an ordered bi-bi mechanism, in which NADH binds first to the enzyme followed by the enoyl substrate [Lu, H. (2010) Biochemistry 49, 1281-1289]. However, this pathogen contains both FabI and FabV ENRs, and mechanistic insights into ENR substrate recognition are lacking in pathogens that solely …

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Biophysical Insights Into The Initiation And Inhibition Of Amyloid Formation By Islet Amyloid Polypeptide, Hui Wang Dec 2014

Biophysical Insights Into The Initiation And Inhibition Of Amyloid Formation By Islet Amyloid Polypeptide, Hui Wang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Amyloid formation, the aggregation of normally soluble proteins or polypeptides into highly ordered beta-sheet structures, is a characteristic feature of many human diseases including Alzheimer's disease, Parkinson's disease and type 2 diabetes. I centered my research on islet amyloid polypeptide (IAPP), a neuroendocrine hormone that forms fibrillar amyloid deposits in the extracellular space of the pancreatic islets of Langerhans in type 2 diabetes. Although whether IAPP amyloid formation is a cause or consequence of the disease is controversial, the aggregation process has been shown to induce beta-cell apoptosis and reduce beta-cell mass, which is a hallmark feature of type 2 …

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Design, Synthesis, And Biological Evaluation Of Novel Taxoid-Based Drug Conjugates And Theranostic Imaging Agents Towards Tumor-Targeted Chemotherapy, Jacob G. Vineberg Dec 2014

Design, Synthesis, And Biological Evaluation Of Novel Taxoid-Based Drug Conjugates And Theranostic Imaging Agents Towards Tumor-Targeted Chemotherapy, Jacob G. Vineberg

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Cancer remains the second leading cause of death in the United States, accounting for nearly a quarter of all deaths, and is exceeded only by heart disease. Traditional chemotherapy uses highly potent cytotoxic agents to kill rapidly dividing cancer cells, relying on the premise that these fast-growing cancer cells are more likely to be killed by these drugs. Despite the profound impact of traditional chemotherapy, lack of tumor-specificity continues to be a serious issue for cancer treatment. Paclitaxel and docetaxel are among the most widely used chemotherapeutic agents, in particular against cancers such as ovarian, breast, lung, and Kaposi's sarcoma; …

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Evidence For Genetic Contributions To Neurobehavioral Traits: Trait Fear/Fearlessness, Behavioral Inhibition, And The Late Positive Potential, Anna Ef Weinberg Dec 2014

Evidence For Genetic Contributions To Neurobehavioral Traits: Trait Fear/Fearlessness, Behavioral Inhibition, And The Late Positive Potential, Anna Ef Weinberg

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Psychiatric disorders are the most common and costly forms of disease and injury worldwide. Despite this, our ability to accurately identify and treat these disorders is limited, due in part to deficient understanding of the underlying mechanisms of dysfunction. The current study aimed to identify genetically-influenced neurobehavioral traits--individual differences evident in both self-report and neural response--that might help improve classification and treatment of mental disorders. Results from event-related potential (ERP) components sensitive to emotional content demonstrated that a) neural processing of emotional content is heritable, b) the heritable traits of heightened trait fear and behavioral disinhibition are associated with unique …

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Job Displacement, Retirement And The Roles Of Government Programs Among Older American Workers, Jieruo Liu Dec 2014

Job Displacement, Retirement And The Roles Of Government Programs Among Older American Workers, Jieruo Liu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The world has been going through one of worst economic recessions in history with severe job market downturns. In October 2009, the U.S. civilian unemployment rate reached a historical 10% and nearly 50% of the unemployed exhausted their 26-week regular Unemployment Insurance (UI) benefits and consequently, UI has been extended to 99 weeks. This dissertation examines the empirical facts of job displacement among the older American workers during the recent economic crisis, and studies their subsequent labor market and retirement decisions, with focus on the roles of government programs including UI and Social Security Old-Age Benefits (OA). Job displacement is …

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Disability And The Young Adult Reader: How Has The Portrayal Of Disability Changed In The Last Fifty Years?, Sharon Munroe Hinkson Dec 2014

Disability And The Young Adult Reader: How Has The Portrayal Of Disability Changed In The Last Fifty Years?, Sharon Munroe Hinkson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Literature offers an opportunity to share in the lived experiences of others, experiences that as readers we may otherwise never personally encounter. Disability in our society is a reality, yet one that has not been fully embraced--not unlike issues with race, gender, age, or sexual orientation. Individuals begin to encounter many of these matters early in life, but as impressionable adolescents, a time when they begin to understand and navigate the world, often times they meet these experiences in books. Since books are an especially important part of how thoughts and attitudes are shaped, this paper seeks to analyze a …

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Representations Of Disability In Of Mice And Men And One Flew Over The Cuckoo's Nest: Avoiding Handicapism In The Classroom, Lyndsay L. Mccabe Dec 2014

Representations Of Disability In Of Mice And Men And One Flew Over The Cuckoo's Nest: Avoiding Handicapism In The Classroom, Lyndsay L. Mccabe

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In this thesis, I examine two novels that feature characters with disabilities and that are often taught in secondary English classes. These texts will be analyzed through a disability studies perspective - a form of analysis that is not often taught in schools. The disability studies perspective involves looking at disability in a critical light and examining the social, cultural, and political ramifications of assumptions that are made about those considered to be " disabled" by the able-bodied majority. Using this lens, I will explore the assumptions about disability that seem to be represented in these works through their use …

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American Masculinity And Home In Antebellum Literature, Derek Scott Mcgrath Dec 2014

American Masculinity And Home In Antebellum Literature, Derek Scott Mcgrath

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The conventional argument in literary and gender studies of nineteenth-century United States culture has been that the home was women's claimed sphere of influence, whereas men were excluded from the home because of their economic, cultural, and societal commitments to the public sphere. Even as Catharine Beecher, Lydia Maria Child, Sarah Josepha Hale, and other adherents to a conservative domestic ideology closely associated the private sphere with women, these same writers identified specific roles and spaces that they expected men to occupy in the home. Hardly only a woman's domain, the home was a powerful force in motivating constructions of …

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Pharmacological Targeting Of Mutant P53 - Hsf1 Feed Forward Circuit, Dun Li Dec 2014

Pharmacological Targeting Of Mutant P53 - Hsf1 Feed Forward Circuit, Dun Li

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tumor suppressor protein p53 responds to cellular stress by activating transcriptional and transcription-independent programs that induce apoptosis, growth arrest or senescence. Given its critical tumor suppressing role, p53 is often mutated in human cancers. Once altered by missense mutations in the DNA-binding domain, mutant p53 (mutp53) protein becomes highly stabilized in tumors, which is critical for mutp53′s oncogenic gain-of function. Current insight into the mechanism of tumor-specific stabilization of mutp53 is fragmentary and largely derived from ectopically constructed cell systems. We find that in human cancer cells endogenous mutp53, despite its ability to interact with MDM2, suffers from a profound …

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The Effects Of Cpg And Upa Dinucleotides On The Attenuation Of Poliovirus By Codon Pair Deoptimization, Malka Arabov Dec 2014

The Effects Of Cpg And Upa Dinucleotides On The Attenuation Of Poliovirus By Codon Pair Deoptimization, Malka Arabov

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Codon pair bias, the preferential pairing of certain codons over others, has been observed in all species analyzed ranging from bacteria to mammals. Previous research has shown that artificial coupling of underrepresented codon pairs (codon pair deoptimization) in viral genomes (such as poliovirus and influenza virus) reduces gene function and leads to virus death or attenuation. Although the reason for this phenomenon is unclear, increasing underrepresented codon pairs in an RNA viral coding region consequently increases the frequency of CpG and UpA dinucleotides. These dinucleotides are suppressed in a variety of species and may be responsible for attenuation by codon …

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The Adenovirus L4-22k Protein Serves As The Master Regulator To Coordinate Late Gene Expression And Viral Dna Packaging, Diana Guimet Dec 2014

The Adenovirus L4-22k Protein Serves As The Master Regulator To Coordinate Late Gene Expression And Viral Dna Packaging, Diana Guimet

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The adenovirus L4-22K protein is multifunctional and critical for different aspects of viral infection. Following DNA replication, increasing amounts of the L4-22K protein are observed prior to the appearance of other late viral proteins. We found that L4-22K controls viral gene expression at the post-transcriptional level and regulates the accumulation of the L4-33K protein, another critical viral regulator, at the level of alternative pre-mRNA splicing. This initiates an activation cascade of late viral proteins, while early genes are being turned off. To gain a better understanding of the mechanism of action of L4-22K, we sought to map the critical elements …

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Missing-In-Metastasis Regulates Cell Motility And Invasion Via Ptpδ Mediated Changes In Src Activity, Fauzia Chaudhary Dec 2014

Missing-In-Metastasis Regulates Cell Motility And Invasion Via Ptpδ Mediated Changes In Src Activity, Fauzia Chaudhary

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Missing in Metastasis (MIM), also known as MTSS1, is a scaffold protein that is down-regulated in multiple metastatic cancer cell lines compared to non-metastatic counterparts. MIM regulates cytoskeletal dynamics and actin polymerization, and has been implicated in the control of cell motility and invasion. MIM has also been shown to bind to a receptor PTP, PTP-delta, an interaction that may provide a link between tyrosine phosphorylation-dependent signaling and metastasis. We used shRNA-mediated gene silencing to investigate the consequences of loss of MIM on the migration and invasion of the MCF10A mammary epithelial cell model of breast cancer. We observed that …

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Studies Of Hydrodynamic Processes In Alternative Magneto-Inertial Fusion Devices, Lina Zhang Dec 2014

Studies Of Hydrodynamic Processes In Alternative Magneto-Inertial Fusion Devices, Lina Zhang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The main goal of the research is evaluation of the plasma jet driven magneto-inertial fusion (PJMIF) concept via simulations. To achieve this goal, the development of mathematical models and numerical algorithms for PJMIF has been performed, and large-scale simulation studies have been conducted. In the PJMIF concept, a plasma liner, formed by the merger of a large number of radial, highly supersonic plasma jets, implodes on a magnetized plasma target and compresses it to conditions of the fusion ignition. 1- (spherically symmetric), 2- and 3-dimensional simulations of the implosion of plasma liners and compression of plasma targets have been performed …

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The Role Of Tolc In Francisella Tularensis Virulence, Christopher Richard Doyle Dec 2014

The Role Of Tolc In Francisella Tularensis Virulence, Christopher Richard Doyle

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Francisella tularensis is a Gram-negative, facultative intracellular pathogen and the causative agent of tularemia. F. tularensis is a Tier 1 agent of bioterrorism that is highly lethal via the pulmonary route of infection. F. tularensis invades host cells, escapes the phagosome, and replicates in the cytosol prior to being released upon host cell death. The molecular mechanisms behind the virulence of F. tularensis are largely unknown. Among the described virulence factors of F. tularensis is a functional type I secretion system (T1SS). The T1SS is important for the secretion of virulence factors from the bacterial cytoplasm to the extracellular environment. …

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Thalamocortical Input To The Primary Visual Cortex, Michelle Kloc Dec 2014

Thalamocortical Input To The Primary Visual Cortex, Michelle Kloc

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The lateral geniculate nucleus (LGN) is the region of the thalamus that innervates and relays sensory information to the primary visual cortex (V1). Thalamocortical (TC) input from the LGN drives the activity of V1, and underlies the health and function of the visual system. However, little is known about the synaptic properties of this input. LGN inputs innervate two layers, layer 4 (L4) and layer 6 (L6). This input has been examined functionally and anatomically, but the synaptic mechanisms of this input are poorly understood. The anatomy of the projection from the LGN to V1 encumbers the preparation of an …

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Cholinergic Modulation And Integration Of Excitatory Inputs To Basolateral Amygdala, James David Lederman Dec 2014

Cholinergic Modulation And Integration Of Excitatory Inputs To Basolateral Amygdala, James David Lederman

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The amygdala, a subcortical structure in the anterior temporal lobe, plays important roles in integrating sensory information from different brain areas, assigning emotional valence and effecting adaptive behavioral, physiological, and cognitive responses. Sensory inputs from cortical and thalamic sources, carrying highly processed sensory information and low level, more direct sensory information, respectively, converge in the basolateral nucleus of the amygdala (BLA). Here, neuromodulation by acetylcholine (ACh), released from inputs arising from the nucleus basalis of Meynert (NBM) in the basal forebrain, plays a major role in synaptic integration during different emotional arousal states. Using patch-clamp electrophysiology in acute brain slices …

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Propaedeutic To Philosophy: Dialogue And Truth In Philosophical Practice, Lauren Nelson Hesse Dec 2014

Propaedeutic To Philosophy: Dialogue And Truth In Philosophical Practice, Lauren Nelson Hesse

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation advocates a model of dialogue as an approach to education and to philosophical discourse itself that is capable of acknowledging and accommodating the manifold possibilities for human thought. Contemporary philosophy is permeated by a loss of certainty and the increasingly problematic nature of the concept of truth, and the complication of these concepts exposes significant limitations in the ways we conceptualize thought itself. Working in this vein, Gilles Deleuze identifies what he calls an " image of thought," which characterizes the forms we have traditionally allowed thinking to take. His critique of this image, along with its subsequent …

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Conflict And Cooperation As Social Responses To Ecological Change, Nicholas A. Seltzer Dec 2014

Conflict And Cooperation As Social Responses To Ecological Change, Nicholas A. Seltzer

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation examines ways the environment conditions individual incentives to participate in collective action. I hypothesize that as resources become scarce, individuals are more willing to participate in individually-costly collective action, including intragroup cooperation and intergroup hostility. The first and second of three studies establish a unit-of-selection based, game-theoretic foundation for intergroup conflict. The final study explores macro-level implications for the relationship between climate change and violence in Africa. For human beings and other highly social creatures, cooperation is the key adaptation with which we respond to environmental challenges. Faced with resource scarcity, group living becomes increasingly vital for individual …

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Shape-Based Analysis, Krishna Chaitanya Gurijala Dec 2014

Shape-Based Analysis, Krishna Chaitanya Gurijala

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Shape analysis plays a critical role in many fields, especially in medical analysis. There has been substantial research performed for shape analysis in manifolds. On the contrary, shape-based analysis has not received much attention for volumetric data. It is not feasible to directly extend the successful manifold shape analysis methods, such as heat diffusion, to volumes due to the huge computational cost. The work presented herein seeks to address this problem by presenting two approaches for shape analysis in volumes that not only capture the shape information efficiently but also reduce the computational time drastically. The first approach is a …

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Visual Association Mining Of Multivariate Data, Zhiyuan Zhang Dec 2014

Visual Association Mining Of Multivariate Data, Zhiyuan Zhang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The rapid development of information technology produces vast amounts of data with numerous attributes. These multi-dimensional datasets offer tremendous opportunities for studying existing behavioral patterns and for predicting future developments. However, the high-dimensional space exceeds human comprehension. More sophisticated visualization techniques than the arsenal of standard plots are needed. First, we introduce an interactive navigation technique to help the analysts explore within the multi-dimensional data spaces. We employ a network-based interface and pair it with a parallel coordinates plot. In the network interface, the dimensions form nodes that are connected by edges representing the strength of association between dimensions. The …

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