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Integrating The Arts And Sciences In The Museum Setting, Emily Clare Riggins

Seton Hall University Dissertations and Theses (ETDs)

The division between the arts and sciences appears to be deepening in America. As political leaders emphasize STEM (science, technology, engineering and math) education in schools, arts education is diminished to make room for STEM courses. Concerned about this phenomenon, many art educators are working to integrate the arts into STEM education through a variety of arts integration efforts. Arts integration not only helps to preserve a place for the arts in the curriculum, it also has been shown to enhance STEM learning.

Arts integration is of special interest to art museum educators who feel that they can provide resources …

Cyclooxygenase-2, Prostaglandin E2, And Prostanoid Receptor Ep2 In Fluid Flow Shear Stress-Mediated Injury In The Solitary Kidney., Tarak Srivastava, Uri S. Alon, Patricia A. Cudmore, Belal Tarakji, Alexander Kats, Robert E. Garola, R Scott Duncan, Ellen T. Mccarthy, Ram Sharma, Mark L. Johnson, Lynda F. Bonewald, Ashraf El-Meanawy, Virginia J. Savin, Mukut Sharma

Manuscripts, Articles, Book Chapters and Other Papers

Hyperfiltration subjects podocytes to increased tensile stress and fluid flow shear stress (FFSS). We showed a 1.5- to 2.0-fold increase in FFSS in uninephrectomized animals and altered podocyte actin cytoskeleton and increased synthesis of prostaglandin E2 (PGE2) following in vitro application of FFSS. We hypothesized that increased FFSS mediates cellular changes through specific receptors of PGE2. Presently, we studied the effect of FFSS on cultured podocytes and decapsulated isolated glomeruli in vitro, and on solitary kidney in uninephrectomized sv129 mice. In cultured podocytes, FFSS resulted in increased gene and protein expression of cyclooxygenase (COX)-2 but not COX-1, prostanoid receptor EP2 …

Global Climate Change And The Southern Ocean: How Antarctic Fishes Physiologically Respond To A Changing Environment From The Cellular To The Organismal Level, Laura A. Enzor

Theses and Dissertations

Studies have projected that future changes in sea surface temperature and pCO2 levels will impact higher latitudes to a greater extent than in temperate regions. For notothenioid fishes of the Southern Ocean, evolution in extremely stable, cold waters has resulted in several adaptations which have left these fishes poorly prepared for global climate change. I have analyzed the metabolic and cellular response of Trematomus bernacchii, Pagothenia borchgrevinki and Trematomus newnesi to a long-term, multi-stressor scenario relevant to the predicted changes in the Southern Ocean. By combining whole animal respirometry with cellular level analysis of energy allocation, osmoregulatory mechanisms and cellular …

Mcp-1 In Colorectal Cancer: Benefits Of Exercise, Jamie Lee Mcclellan

Theses and Dissertations

The etiology of colon cancer is a complex phenomenon that involves both genetic and environmental factors. However, only about 20% have a familial basis with the largest fraction being attributed to environmental causes that can lead to chronic inflammation. Tumors associated macrophages drive the pro-inflammatory response in the tumor micro-environment and are associated with poor prognosis in certain cancers. Monocyte chemoattractant protein 1 (MCP-1) is thought to be the most important chemokine for recruitment of macrophages to the tumor microenvironment. In chapter 1, we examined the timing and magnitude of the intestinal inflammatory cytokine response in relation to tumorigenesis in …

The Cardio-Protective Effects Of Substance P In Both Ischemia/Reperfusion And And Short-Term Hypoxia Rat Models, Shaiban Jubair

Theses and Dissertations

Substance P, a member of the tachykinin family, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers surround coronary vessels, making them ideally positioned to sense changes in coronary pressure and/or flow. Recent studies have identified substance P as being protective acutely following ischemia-reperfusion due to its ability to induce coronary blood vessel vasodilation. In addition, studies conducted on non-cardiac tissue have reported substance P to be protective against cell death through a mechanism involving activation of anti-apoptotic AKT pathway. However, the possibility of substance P being similarly cardioprotective has not been reported. Accordingly, the purpose …

The Effects Of Robot-Child Interactions On Interpersonal And Intrapersonal Coordination, Kinga Palatinus

Master's Theses

Coordination is crucial throughout development, from motor development and language acquisition to children’s play and other social interactions. Based on the links between motor and social behavior, proper coordination should help children connect socially with others. Being part of a larger study investigating the effects of a multisystem intervention tool for children with ASD, this work examined the effect of robot-child interaction on interpersonal and intrapersonal coordination in typically developing children. 5-year-olds and 7 year-olds participated in a four-week training protocol, where children had to copy the movements of a small humanoid robot. Measures of cross recurrence quantification analysis revealed …

Monnet, The General, And The Community Of Six: French Policy On European Integration In The 1950s And 1960s, Daniel A. Gagnon

History & Classics Undergraduate Theses

This thesis examines the roles of Jean Monnet and General Charles de Gaulle in crafting French policy towards a united Europe during the postwar decades. Monnet strongly supported supranational integration in which the nations of Europe cede power to common governing institutions. But, French policy changed dramatically when de Gaulle came to power in 1958. As a nationalist he refused to sacrifice France’s independence by ceding power to the common institutions. He risked the existence of a united Europe, but after his sudden departure in 1969 it became clear that French popular opinion opposed his limiting policy towards European integration.

The Bg News December 15, 2014, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. December 15, 2014. Volume 94-Issue 48.

Climate-Induced Changes In The Germination Phenology Of Boechera Stricta, Samuel Johnson

Theses and Dissertations

Climate change is having demonstrable, worldwide impacts on ecological systems in ways that have modified aspects of organism behavior. Plant phenologies have responded to warmer temperatures in a variety of ways that may have implications for long-term species survival. How germination phenology changes in response to warmer climate is a largely unexplored question yet the ability of a plant to advance or delay germination in unfavorable conditions is critical for survival. Knowing the relative success and timing of germination under different climate regimes is important in understanding whether species can keep pace with the rate of climate change via migration …

Synthetic Physical Models For Animating Unsteady Fish Motions, Shyh-Kuang Ueng, Hong-Kai Chen

Journal of Marine Science and Technology–Taiwan

This paper presents physical models for simulating unsteady fish motions, including bursting, gliding, braking, turning, ascending and descending. A new wave model, the controllable body wave model, is developed to undulate the fish body to produce bursting and gliding motions. A key frame approach is adopted to realize braking, turning, descending and ascending. In the key frame method, individual motions are decomposed into sequences of key steps. The gestures of the fish in these key steps are recorded and regarded as key frames. In the run time, these recorded key frames are sequentially reproduced to generate swimming patterns. In addition …

Status And Trends Of The Rocky Intertidal Community On The Farallon Islands, Jan Roletto, Scott Kimura, Natalie Cosentino-Manning, Ryan Berger, Russell Bradley

Monographs of the Western North American Naturalist

The Farallon Islands in the Gulf of the Farallones National Marine Sanctuary (GFNMS) is a 7-island chain located 48 km west of San Francisco, California. Since 1993, GFNMS biologists and associates have monitored algal and invertebrate species abundances on the intertidal shores of the 2 South Farallon Islands. The monitoring occurred 1–3 times yearly in 6 study areas. In each study area, 3–4 permanent, 0.15-m² quadrats located between the upper and midintertidal zones were sampled for algal and sessile invertebrate cover and invertebrate counts. Taxonomic surveys were also completed to document other species in the vicinity of the sampling …

How The Esa Can Swallow Alaskan Tribal Sovereignty: The Story Of The Iliamna Lake Seals, Charisse Arce

American Indian Law Journal

No abstract provided.

Habitat And Harvest: The Modern Scope Of Tribal Treaty Rights To Hunt And Fish, Whitney Angell Leonard

American Indian Law Journal

No abstract provided.

The Influence Of Confucianism On Identity Formation Of A Multi-Skilled Migrant: An Autoethnography, Annabella Fung

The Qualitative Report

In this autoethnographical study, I examine how my identities were influenced by Confucianism. Two main Confucian concepts were examined: “selfperfection,” and “filial piety and submissiveness.” As a migrant who left Macau for Australia at fifteen, I have been immersed in diverse cultural climates, experienced gender bias, identity crisis and racial discrimination. I consider all experiences as essential steps of my evolution with ethnographic, interpretative, phenomenological and narrative understandings. This paper introduces the term “seasonal fluctuations” as a way to describe the changing meanings of my lived experiences that were interrogated by my three distinctive personalities: The Writer, The Interpreter and …

Mitigating The Effects Of Climate Change With Wind Energy And Gis, Rachael Isphording, Richard Snow, Mary Snow

Publications

The climate is changing, and humans are heavily exacerbating these changes. As the effects of climate change are being felt across the planet, scientists and policy makers are uniting to increase mitigation efforts and are researching renewable, clean energy sources to reduce the amount of greenhouse gas emissions released into the atmosphere during energy production. Of the different renewable energy technologies, wind energy is one of the most researched and implemented. Over the past twenty years, researchers have been applying Geographic Information Systems (GIS) to their climate change studies. GIS allows the user to spatially view, manipulate, and analyze data …

The Influence Of Dx-52-1 And Phosphorylation On The Interactions Of Galectin-3 With Its Binding Partners, Matthew L. Rotondi

Doctoral Dissertations

The Influence of DX-52-1 and Phosphorylation on the Interactions of Galectin-3 with its Binding Partners

Matthew L. Rotondi, PhD

University of Connecticut, 2015

Galectin-3, a member of a large family of animal based β-galactoside-binding lectins has been shown to play a role in a number of cellular and pathogenic processes. This protein has been shown throughout the literature to interact with a diverse multiplicity of proteins, involved in a diverse array of cellular functions, including cell migration and cell proliferation, both of which are of particular in regards to cancer research. Covalent modifications to Galectin-3 that can undermine its binding …

Alterations To Taste Preference In Mc4r Haploinsufficiency Manifest Prior To Dietary Induced Obesity And Are Accompanied By Dendritic Spine Alterations To Medium Spiny Neurons Of The Nucleus Accumbens In Adulthood, Robert Francis Roscoe Jr.

Theses and Dissertations

Obesity has reached epidemic proportions in the United States and has become an increasing public health concern for developed nations. Haploinsufficiency of melanocortin receptor 4 has been identified as the single most common monogenetic cause of obesity in humans. Using the MC4R +/- haploinsufficient rat, we sought to determine potential alterations in body weight and morphology, locomotor activity, sucrose concentration preference, and progressive-ratio operant testing in a dietary-induced obesity environment. Rats were placed on four separate diets corresponding to 1.7% saturated fat with 12.2% total kcal/fat, 6% saturated fat with a 40% total kcal/fat, 12% saturated fat with a 40% …

Metformin Arrests Growth And Induces Apoptosis Of Neuroblastoma Cells, Nadia Al-Sammarraie

Theses and Dissertations

Neuroblastoma is one of the most common solid neoplasms in children, which affects sympathetic neurons with a wide range of genetic abnormalities, especially MYCN amplification, a molecular marker of poor prognosis. Despite advance therapy, still the mortality rate for advance disease is high with frequent relapse and resistance to cytotoxic therapy with evidence of p53 mutation. Metformin, an oral hypoglycemic medication, is a relatively safe and cost effective drug with wide clinical applications, mainly for treatment of Type 2 diabetes. Recent studies have showed promising anticancer effect of metformin on various cancer types, especially on p53 mutant cells. In our …

Single Nucleotide Polymorphisms In Dna Repair And Oxidative Stress Genes, And Their Interaction With Antioxidants On Prostate Cancer Aggressiveness, Samuel Antwi

Theses and Dissertations

Prostate cancer is the leading invasive malignancy and the second most common cause of cancer death among American men. Despite compelling evidence that oxidative stress, ineffective DNA damage repair, and habitually low antioxidants intake may act in tandem to influence prostate carcinogenesis, few studies have examined gene-diet interactions involving these risk factors. Even fewer studies have examined such interactions in relation to prostate cancer aggressiveness. This study investigated whether single nucleotide polymorphisms (SNPs) in DNA repair- and oxidative stress-related genes modulated associations between antioxidant intake and prostate cancer aggressiveness. We utilized data from the North Carolina-Louisiana Prostate Cancer Project (PCaP) …

A Three-Dimensional-Engineered Matrix To Study The Microenvironment Of Cancer Stem Cells, Samaneh Kamali Sarvestani

Theses and Dissertations

Maintenance of cancer stem cells (CSCs) is regulated by their microenvironment. As cancer cells are affected by many factors in their microenvironment, a major challenge is to isolate the effect of a specific factor on CSCs while keeping other factors unchanged. We developed a synthetic inert 3D Poly Ethylene Glycol Di-Acrylate (PEGDA) gel culture system as a unique tool to study the effect of microenvironmental factors on CSCs response. Synthetic hydrogels provide the flexibility to design three-dimensional (3D) matrices to isolate and study individual factors in the tumor microenvironment. The first objective of this work was to investigate the effect …

Perception Of Police In Public Housing Communities, Taylor Brickley

Theses and Dissertations

Research on the relationship between police and citizens consistently finds that attitudes toward police (ATP) are least positive among black citizens in areas of concentrated disadvantage. While much of the research in this area focuses specifically on ATP among young black males in low-income communities because they have the most contact with police, there has been relatively little research that has included older and/or female residents. Additionally, research has yet to examine ATP in racial and economic enclaves that may have different social and environmental characteristics than the surrounding community. This study utilizes in-depth interviews with 60 residents of two …

Contextualized Robot Navigation, David Vincent Lu

McKelvey School of Engineering Graduate Student Theses & Dissertations

In order to improve the interaction between humans and robots, robots need to be able to move about in a way that is appropriate to the complex environments around them. One way to investigate how the robots should move is through the lens of theatre, which provides us with ways to analyze the robot's movements and the motivations for moving in particular ways. In particular, this has proven useful for improving robot navigation. By altering the costmaps used for path planning, robots can navigate around their environment in ways that incorporate additional contexts. Experimental results with user studies have shown …

The Effects Of Gamifying Optional Lessons On Motivation, Aaron Zemach

McKelvey School of Engineering Graduate Student Theses & Dissertations

Adding video-game elements to non-video-game interfaces (“gamification”) has become a common engagement strategy over the past several years in the domain of education. While prior studies have found that adding game elements to mandatory educational materials can increase students’ motivation to complete the materials, there has yet to be a study to investigate if game elements can make users more likely to engage with optional educational materials. In this study, we investigate whether users of a gamified educational interface are more motivated than users of a non-gamified interface to voluntarily complete educational materials. We found users of a gamified interface …

A Four-Dimensional Image Reconstruction Framework For Pet Under Arbitrary Geometries, Aswin John Mathews

McKelvey School of Engineering Graduate Student Theses & Dissertations

Positron Emission Tomography (PET) is a functional imaging modality with applications ranging from the treatment of cancer, studying neurological diseases and disease models. Virtual-Pinhole PET technology improves the image quality in terms of resolution and contrast recovery. The technology calls for having a detector with smaller crystals placed near a region of interest in a conventional whole-body PET scanner. The improvement is from the higher spatial sampling of the imaging area near the detector. A prototype half-ring PET insert built to study head-and-neck cancer imaging was extended to breast cancer imaging. We have built a prototype half-ring PET insert for …

Origin Of Maternal Age Effect In Congenital Heart Disease Risk For Offspring, Claire Elaine Schulkey

Arts & Sciences Graduate Student Theses and Dissertations

Increasing maternal age is widely acknowledged to lead to greater likelihood of pregnancy complications and congenital abnormalities, but the basis of this effect has not been well studied. Often dismissed as the product of oocyte ageing, the mechanistic basis of this maternal age effect is likely more complex.Congenital heart disease is a classic complex disease with multiple genetic and environmental modifiers, including maternal age. Maternal ageing is a known risk-factor in humans, and has been shown to exist in an Nkx2-5 haploinsufficient mouse model for the disease. This mouse model's maternal age risk is dependent upon strain background, with C57BL/6N …

The Influence Of Metacommunity Size On Species Diversity Across Spatial Scales, Lauren Woods

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation explores the influence of metacommunity size and landscape level processes, such as dispersal, on species diversity. A metacommunity is a group of local communities, or patches, connected by dispersal, and metacommunity size can be defined as the number of discrete local patches within a metacommunity. In chapter 1, I developed a framework to predict the effects of habitat destruction, or a reduction in metacommunity size, on the species richness of local patches of different sizes by integrating metacommunity theory with the equilibrium theory of island biogeography. The effect of metacommunity size on species richness in small and large …

Modulation Of Nmda Receptor Activity During Physiological And Pathophysiological Events, Christine Marie Emnett

Arts & Sciences Graduate Student Theses and Dissertations

N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that serve crucial signaling and neurotrophic functions throughout the central nervous system. Both hyperfunction and hypofunction of NMDARs are associated with neurological and neuropsychiatric conditions. Thus, both positive and negative pharmacological NMDAR modulators are of clinical interest as treatments. Understanding drug mechanisms could lead to more rational drug design. Memantine and ketamine are NMDAR open channel blockers that exhibit similar pharmacodynamics at NMDARs but have different clinical uses. Memantine improves cognitive decline during Alzheimer's disease. Ketamine is an anesthetic and analgesic with psychotomimetic effects, but it is also a rapid acting and long-lived …

Isotope Harvesting At Heavy-Ion Fragmentation Facilities, Tara Elise Mastren

Arts & Sciences Graduate Student Theses and Dissertations

Isotope harvesting from heavy-ion fragmentation facilities is a potential source of isotopes of interest for applications research. With the upgrade of the National Superconducting Cyclotron Laboratory (NSCL) to the Facility for Rare Isotope Beams (FRIB) usable quantities of many isotopes of interest will be produced and available for harvest from an aqueous beam dump. If available, these isotopes would be of interest to a broad range of applications such as medicine, geology, and stockpile stewardship. Preliminary experiments were performed at the NSCL in order to determine the feasibility of isotope harvesting at (FRIB).A water target station that consisted of a …

The Late Ordovician Biogeochemical Carbon Cycle, John Garrecht Metzger

Arts & Sciences Graduate Student Theses and Dissertations

The isotopic composition of the carbonate carbon (δ13Ccarb) is one of the best tools for understanding the biogeochemical carbon cycle through Earth history. δ13Ccarb is also used to chemostratigraphically correlate coeval strata. This dissertation has three main foci that all utilize δ13Ccarb as the common data type. The geologic interval investigated was the Late Ordovician (458-444 Ma) with emphasis on the Guttenberg δ13C excursion, a globally correlated, positive ~3 / event that is ~400 kyr in duration. In the first topic we evaluate post-depositional alteration (i.e., diagenesis) of δ13Ccarb signals. In the second topic, we make reconstructions of sea level …

The Impacts Of Climate Change On The World’S Economic, Political, And Demographic Structures, Dino Kanlic

Arts & Sciences Graduate Student Theses and Dissertations

Climate change will have negative impacts on the political, economic, and demographic structures of society. These include a rise in ethnic tensions in the Indian Sub Continent, massive immigration to Europe, regional economic collapse and political destabilization in Africa, the inundation of island nations and economic losses in the Americas among many other changes which will combine to destabilize humanity for generations. International affairs has failed to come up with a solution because global warming is a universal prevention focused problem that trades short term gains for long term losses. Global warming will be solved by the onset of grid …