Digital Commons Network^™

Modeling Mussel Mortality: Investigating The Importance Of Swash And The Potential Implications Of Changing Wave Environments, Shadow Leigh Gulledge

Theses and Dissertations

Rising sea level and increases in temperature are causing biogeographic shifts in intertidal zones and can also lead to shifts in the local vertical zonation of organisms due to changes in body temperature during aerial exposure during low tide. Swash is an important determinant of aerial body temperatures, and vulnerability of intertidal zones to changes in climate could potentially depend on how much and how often animals are cooled by waves. While wave heights (and thus swash) are generally expected to increase with climate change, anthropogenic physical structures, such as breakwaters and wave energy converters, can decrease wave height and …

'Precious Objects': Strange 'Things' In James And Wharton, John Kinard

Theses and Dissertations

In this work, I attempt to examine the importance of things, the strange agency of objects, which emerges in the literature of the late nineteenth century. To this end, I examine the economy of things in both Henry James and Edith Wharton. I attempt to connect this object agency with the emergent discourses and technologies of the time, and to link these both with media and queer theory.

Marine Population Connectivity: Range Boundaries And Climate Change, Rhiannon Leigh Rognstad

Theses and Dissertations

Population connectivity, particularly in open systems, is an important metric for understanding population-level processes on both ecological and evolutionary timescales. In coastal marine systems, adults are typically sedentary and dispersal occurs primarily during a larval stage when individuals are transported in ocean currents. Because coastal marine populations exist as networks of interconnected subpopulations, variation in the magnitude and extent of population connectivity can have profound effects on population dynamics and species distribution limits. Connectivity is a complex process, affected by a multitude of factors, including adult inputs and physical dispersal, which operate at multiple scales and may interact. This dissertation …

Periodontal Microorganisms, Obesity, Chronic Inflammation, And Type 1 Diabetes, Georges Joseph Nahhas

Theses and Dissertations

Periodontal disease is a low-grade chronic inflammation in the tissues surrounding the teeth caused by multiple, mostly gram-negative pathogens. It is associated with diabetes, obesity, and chronic inflammation. The specific roles that periodontal microorganism play in these conditions are not well-studied. Hereby, we explored how periodontal bacteria from sub gingival plaque clustered in youth with and without type 1 diabetes, and how such patterns related to body-mass-index percentile (BMI percentile), C-reactive protein (CRP) and adiponectin. Cross-sectional data were collected from 105 youth with type 1 diabetes and 71 without diabetes. Participants were between 12 and 19 years of age receiving …

Bibimbap: Identity Construction In Korean Third Culture Kids During Higher Education, Megan I. Beard

Theses and Dissertations

Amidst increasing interconnectedness and transmigration of the 21st century, a number of families are leaving South Korea for business, work, or education; their children are raised as Third Culture Kids (TCKs)—children who accompany their parents abroad. This study used the lens of cultural globalization to examine how Korean TCKs used their life experiences to inform their identity construction, especially during higher education. Participants were Korean students and recent alumni from universities in Korea, the United States, and abroad who had spent at least three childhood years living outside Korea with their families. Data were collected through a series of unstructured …

Climatic Controls On Organic Matter Decomposition In Boreal Peatlands, Michael J. Philben

Theses and Dissertations

Boreal peatlands currently contain 550 Pg C and are located at high latitudes where mean annual temperatures are expected to increase by as much as 7°C by the end of the century. There is growing concern that warming will stimulate decomposition, transforming peatlands from a sink to a source of atmospheric carbon dioxide and accelerating climate change. A primary goal of this dissertation was to evaluate the effect of climate change on organic matter decomposition in peatlands. This was achieved by developing and employing biochemical tracers to indicate the extent of peat decomposition across a range of naturally occurring climatic …

Application Of Various Adsorbents To Remove Micro-Pollutants In Aquatic System, Chanil Jung

Theses and Dissertations

Untreated or insufficiently treated pharmaceuticals and endocrine disrupting compounds (EDCs) as well as heavy metals have influenced the ecosystem and their exposures in the water system have threatened human health; causing cancers and adverse health effect to immune system. While various water treatment techniques have been applied to solve this problem, adsorption has been considered as one of the most efficient and manageable water purification techniques. Advanced analysis methods for aqueous contaminants have improved comprehension, allowing proficiency about the fate of trace leveled emerging contaminants, thus allowed to reveal the adsorption mechanisms of each pollutant. This dissertation focuses on the …

Ferric Reductases And Transporters That Contribute To Mitochondrial Iron Homeostasis, Anshika Jain

Theses and Dissertations

Iron (Fe) is the fourth most abundant element in the Earth’s crust, yet the availability of Fe to plants is often limited. This is because in most soil types, Fe precipitates as ferric-oxyhydroxy complexes, making it unavailable for uptake by plants. While the mechanisms involved in Fe uptake from the soil are relatively well understood, the mechanisms involved in its further distribution to the aerial portion of the plant and to subcellular compartments are not fully understood. During Fe deprivation, plants up-regulate root Fe acquisition machinery. How plants sense Fe deprivation and tie the Fe status of the plant to …

Toward The Combinatorial Development Of Hydrophobic-Tagged Antifolate-Directed Degradation Of Human Thymidylate Synthase, Daniel J. Menasco

Theses and Dissertations

Direct post-translational control over a protein of interest (POI) can be exploited by manipulating the cells protein quality-control systems responsible for either intracellular turnover through ubiquitination (POI half-life) or repairing and degrading misfolded proteins.1 In an effort to target and degrade a high value POI we selected the enzyme human thymidylate synthase (TS) for post-translational degradation through ligand-directed ubiquitination and hydrophobic tagging. Thymidylate synthase catalyzes the reductive methylation of 2’-deoxyuridine monophosphate (dUMP) to 2’-deoxythymidine monophosphate (dTMP). As the de novo source of dTMP the regulation of intracellular TS is strictly controlled by ubiquitinindependent proteasomal degradation mediated by an internal TS-degron …

Product And Consumer Characteristics As Moderators Of Consumer Response To Sustainable Products, Kealy Carter

Theses and Dissertations

This dissertation consists of two essays. In both, product sustainability is broadly focused on the environmental and social performance (Luchs et al. 2010) of a product. The first essay explores the role of firm sustainability reputation in behavioral intentions for sustainable products. Additionally, this essay applies construal level theory (Liberman and Trope 1998; Vallacher and Wegner 1985, 1987) and addresses the situation that exists wherein sales of sustainable products produced by firms founded under sustainability principles are more stable than those produced by traditional firms (Clifford and Martin 2011). The second essay introduces a measure of consumer perceived product sustainability …

The Role Of Lis1 In Adult Mammalian System, Xu Gao

Theses and Dissertations

Lis1 haploinsufficiency in humans results in a “smooth brain” phenotype called lissencephaly, and also causes severe cognitive and motor impairments and epilepsy. Seizure severity and frequency typically worsens with time; patients often die within the first decade due to seizure-induced aspiration and pneumonia. Various mouse models have been used to examine the role of Lis1 during brain development, and it is clear that Lis1 regulates a microtubule motor, cytoplasmic dynein. Intriguingly, Lis1 expression remains high in adult brains indicating that it plays a role in mature systems. Indeed, our group found that Lis1 and several related proteins regulate dynein-dependent axon …

Hope Chest: A Memoir Of Home, Marriage, And Objects, Emilie L. Duck

Theses and Dissertations

As a child, Emilie often imagined what her future home would look like. As she wandered through flea markets with her mother, she would envision the pieces she found there in a home of her own, building spacious libraries, comfortable bedrooms, and well-appointed kitchens in her imagination with the same passion that other children built models out of Legos. Although the houses always changed, there was an underlying certainty that she would eventually have one house—a certainty that could not be realized once she got married, and committed to living wherever the Army stationed her husband. In this memoir, Emilie …

Novel Biofabrication Technologies To Recapitulate In Vivo Geometries In Collagen Hydrogels, Veronica Rodriguez-Rivera

Theses and Dissertations

Tissue engineering and regenerative medicine aims to restore form and function to tissues that have been lost or damaged due to disease, congenital defect, or trauma. Biomaterials suitable to restore these complex tissues need to provide a balance between chemical and mechanical properties, providing accurate cell-matrix interaction and induce in vivo behaviors such as proliferation, differentiation and migration. It also requires that physical and chemical cues be presented to the body in the proper temporal and spatial pattern. The extracellular matrix exerts forces that are transmitted through focal adhesion causing changes in the cell behavior. The hypothesis for this dissertation …

Diversity, Genetics, And Health Benefits Of Sorghum Grain, Davina Rhodes

Theses and Dissertations

Staple cereal crops provide the majority of nutrients to the world's population, and thus, can significantly impact human nutrition and health. Phenotypic and genetic diversity within a crop can be useful for biofortification and crop improvement, but quantitative phenotyping is needed to identify varieties with high or low concentrations of a nutrient of interest, and to identify alleles responsible for quantitative trait variation of the nutrient. Sorghum [Sorghum bicolor (L.) Moench] is a diverse and widely adapted cereal crop that provides food for more than 500 million people in sub-Saharan Africa and Asia, and is becoming increasingly popular in specialty …

Thermal Ecology And Physiology Of An Intertidal Predator-Prey System: Pisaster Ochraceus And Mytilus Californianus, Cristian J. Monaco

Theses and Dissertations

Untangling natural systems’ complexity requires understanding the mechanisms responsible for organisms’ responses to environmental change. Recently, significant advances have been made by recognizing the relevance of direct and indirect effects, which take place when multiple biotic and abiotic factors influence each other. I examined potential direct effects of environmental variables on a predator-prey interaction, as well as potential indirect effects of these variables on the interaction itself. I placed emphasis on behavioral and physiological adaptations, which would potentially contribute/modify these effects. My study system was comprised of a rocky intertidal keystone predator, the sea star Pisaster ochraceus, and its main …

Revising For Genre: Mary Robinson's Poetry From Newspaper Verse To Lyrical Tales, Shelley Aj Jones

Theses and Dissertations

This dissertation focuses on Mary Robinson’s Lyrical Tales, not as the culminating point to which her writing inevitably led, as is frequently imagined in accounts of her life and work, but, instead, as the product of an intricate process of revision that highlights her investment in genre. Versions of many of the poems that Robinson included in Lyrical Tales originally were published in newspapers and periodicals. Rather than seeing the changes as a move toward a best or most mature or inspired version, I argue that Robinson revised to meet the requirements of her new genre, the lyrical tale. I …

Semiparametric Regression Analysis Of Bivariate Interval-Censored Data, Naichen Wang

Theses and Dissertations

Survival analysis is a long-lasting and popular research area and has numerous applications in all fields such as social science, engineering, economics, industry, and public health. Interval-censored data are a special type of survival data, in which the survival time of interest is never exactly observed but is known to fall within some observed interval. Interval-censored data arise commonly in real-life studies, in which subjects are examined at periodical or irregular follow-up visits. In this dissertation, we develop efficient statistical approaches for regression analysis of bivariate intervalcensored data, in which the two survival times of interest are correlated and both …

Experimental And Theoretical Studies Of Native And Engineered Vascular Tissue Mechanics, Boran Zhou

Theses and Dissertations

Background: Implantation of vascular grafts provides a means to restore blood flow in compromised regions of the circulatory system, and thus is used to treat a wide range of cardiovascular diseases. Despite significant advancements in autologous grafting strategies as well as the engineering of synthetic alternatives, mechanical, structural, and compositional incongruities between the graft and the host artery remain as contributing factors to graft failure. The typical failure modality manifests as proximal anastomotic intimal hyperplasia, which places restrictions on the host vessel size currently treated with grafting strategies (> 5 mm internal diameter). In order to improve long-term clinical outcomes, …

Theoretical Investigation Of The Catalytic, Liquid-Phase Hydrodeoxygenation Of Organic Acids And Esters, Sina Behtash

Theses and Dissertations

With worldwide fossil fuel resources dwindling and greenhouse gas emissions rising, it is urgent to find renewable liquid fuel alternatives from e.g. biomass to meet the world’s growing energy demand. Lipid feedstocks and pyrolysis oils from woody biomass can be utilized for the production of second-generation biofuels via a catalytic hydrodeoxygenation (HDO) process. The conversion of fatty acids and esters plays an important role in the activity and selectivity of these processes. Understanding the HDO reaction mechanism of organic acids and esters on metal surfaces is a prerequisite for the rational design of new HDO catalysts specifically designed for upgrading …

Understanding Geo-Social Network Patterns: Computation, Visualization, And Usability, Caglar Koylu

Theses and Dissertations

Geo-social networks are formed by flows of physical entities (e.g., humans, vehicles, sensors, animals), and communication (e.g., information, ideas, innovation) that connect places to places and individuals to individuals. Several major problems remain to be addressed for understanding the complex patterns in geo-social networks. This dissertation makes the following contributions to the theory and methodologies that aim at understanding complex geo-social data by integrating methods of computation, visualization and usability evaluation. Chapter 2 introduces a novel network-based smoothing approach that addresses the size-difference and small area problem in calculating and mapping locational (graph) measures in spatial interaction networks. The new …

Pattern Extraction From Spatial Data - Statistical And Modeling Approches, Hu Wang

Theses and Dissertations

Exploratory and statistical spatial data analyses are commonly used in a wide range of research fields, such as epidemiology, disease surveillance and crime analysis. Spatial epidemiology, for example, needs to detect significant spatial clusters of disease incidents to help epidemiologists identify environmental factors and spreading patterns associated with certain diseases. Existing spatial analysis approaches mostly focus on the analysis of spatial lattice data, i.e., observations organized by locations such as county or census tract. With the wide spread of location-aware technologies such as GPS and smart phones, spatial interaction data have become increasingly available, e.g., human daily mobility, traveling and …

Weight-Gain And Energy Balance, Benjamin Thomas Gordon

Theses and Dissertations

Energy balance is the result of a dynamic relationship between energy intake (EI), energy expenditure (EE) and energy storage (ES). These three components of energy balance have extremely complicated associations, and all three major components are consistently influenced by physiologic, psychological, and sociologic factors. Concerted changes between EE and EI result in alterations of the ES. Most often in clinical and research settings, bodyweight is used as marker of body composition (i.e., ES) changes. Traditional measurements of bodyweight do not give an accurate portrayal of ES change or the role it has in energy balance. This dissertation supplies new methods …

Dancing On Checkers' Grave By Eric Lane, Allison Kump

Honors Projects

My proposed honors project consists of directing my own, fully-actualized production of Eric Lane’s play Dancing on Checkers’ Grave within the BGSU’s Department of Theatre & Film Elsewhere season. As the director, I must hone in on the play’s relevance to today’s society and shape my storytelling tools to clearly communicate the narrative, establishing a relationship between the performers and the audience.

Dancing on Checkers’ Grave is a play about two very different teenage girls who come to bond over homework, “munchkining,” relationships, and nail polish. Rooted within the text are topics of sexual identity, what it means to be …

A Guide To Recruitment And Retention For A Band Program, Kara Kordella

Honors Projects

A Guide to Recruitment and Retention for a Band Program is a resource for teachers to establish a comprehensive recruitment and retention plan in their band program. This booklet outlines a recruitment program that can be implemented into a school band program in part or in whole. Also included in this booklet are lesson plans, student assessment worksheets, example recruitment documents, and ideas to be implemented as part of a retention program. All of the activities are backed by research into current recruitment practices, educational psychology, and instrument history and pedagogy. Interviews were also conducted with current and retired band …

An Essential Role For Self-Pmhc Throughout The Life Of A Cd4 T Cell: Contributions In The Thymus And Periphery, Stephanie Rodriguez

Arts & Sciences Graduate Student Theses and Dissertations

It is well established that self-peptide Major Histocompatibility Complexes (hereafter self-pMHC) are essential for the development of a broad repertoire of mature, self-tolerant CD4 and CD8 T cells. Despite clear knowledge that the pool of self-ligands is critical for positive and negative selection, the exact kinetics and dynamic nature of thymocyte interaction with self-pMHC class II (self-pMHCII) bearing antigen-presenting cells (APCs) during development is still largely a mystery. The enigmatic nature of selecting self-pMHC is not unique to the thymic environment; increasingly evident is the dependence of peripheral T cells on extra-thymic self-pMHC expression, specifically selecting self-pMHC, for their homeostatic …

Characterizing The Fitness Landscapes Of Gut Symbionts In Defined Community And Diet Contexts, Meng Wu

Arts & Sciences Graduate Student Theses and Dissertations

A species' niche is the description of all the environmental conditions required to permit a population of that species to persist, including the effects of the population on those conditions. This definition includes the species' resource requirements, as well as stress tolerances and interactions with other species acting as competitors, predators, parasites, and mutualists. The human gut microbiota serves as a microbial `metabolic organ' tasked in part with the biotransformation of many components of our diet. Relatively little is known about the factors that allow members of the human gut microbiota to persist in a habitat that experiences marked changes …

Gothic Literature And The Politics Of Indistinction, Nicholas Everett Miller

Arts & Sciences Graduate Student Theses and Dissertations

I recover the Gothic as a literature of political possibility. While scholars have long associated the Gothic tradition with political fear, I argue that Gothic novels challenge liberal ideas of the self to produce a sometimes radically egalitarian politics of freedom in the late-eighteenth and early-nineteenth centuries. Edmund Burke made much of the fearfulness of an egalitarian politics in the 1790s, and literary historians have relied on his influence to argue that Gothic fiction is primarily an expression of the fear that comes with the collapse of familial, social, and political distinctions. But fear is not all that accompanies such …

Bio-Enhanced Constructivism: Moral Facts For The Naturalistic But Morally Serious Philosopher, Jason Gardner

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACTBio-Enhanced Constructivism: Moral Facts for the Naturalistic but Morally Serious PhilosopherbyJason GardnerDoctor of Philosophy in PhilosophyWashington University in St. Louis, 2014Professor Eric Brown, ChairThere is a tension between being both morally and naturalistically serious because it is doubtful that features philosophers have ascribed to moral facts in order to explain why we should take them seriously can be given a naturalistic accounting. Yet even serious naturalists who think the tension is real and troubling persist in trying to be serious moralists. I do not think they can do so on their own terms. Thus the purpose of this dissertation: to …

Portland Spectrum, December 2014, Portland State University. Student Publications Board

Portland Spectrum

Editor: Corinne Hutfilz

Articles in this issue include: GMO: An Informed Right to Know; Aetna: Is it Worth it?; Torrenting on Campus; Food Insecurity Across College Campuses; Raise the Umbrella: Protests in Hong Kong Continued; A Point of View..... Arrival at Tangier (A Snapshot in Time; Meeting a Writer); and ISIS: A History of Terror;

Reduced Astrocyte Viability At Physiological Temperatures From Magnetically Activated Iron Oxide Nanoparticles, Nicholas J. Schaub, Deniz Rende, Yuan Yuan, Ryan J. Gilbert, Diana Andra Borca-Tasciuc

Chemical and Biochemical Engineering Faculty Research & Creative Works

Superparamagnetic iron oxide nanoparticles (SPIONs) can generate heat when subjected to an alternating magnetic field (AMF). In the European Union, SPIONs actuated by AMF are used in hyperthermia treatment of glioblastoma multiforme, an aggressive form of brain cancer. Current data from clinical trials suggest that this therapy improves patient life expectancy, but their effect on healthy brain cells is virtually unknown. Thus, a viability study involving SPIONs subjected to an AMF was carried out on healthy cortical rat astrocytes, the most abundant cell type in the mammalian brain. The cells were cultured with amino silane- or starch-coated SPIONs with or …