Digital Commons Network^™

From Legal Document To Monolog, Robert B. Pierce

Selected Papers of the Ohio Valley Shakespeare Conference

No abstract provided.

Computational Insights Into The Mechanisms And Structures Of Peptide Bond Cleaving Metalloenzymes And Their Synthetic Analogues, Tingting Zhang

Open Access Dissertations

The selective hydrolysis of peptide or amide bond is required in a wide range of biological, biotechnological and industrial applications. There are significant kinetic barriers to these reactions since peptide bonds are extremely stable and possess a half-life for hydrolysis of 350–600 years at room temperature and pH 4–8. Therefore, nature has devised enzymes to rapidly and selectively cleave these bonds under physiological conditions that are known as peptidases. Specifically, metallopeptidases, generate a scaffold capable of binding one or two metal ions to hydrolyze peptide bonds. The studies on metallopeptidases are important to understand the functions of these enzymes and …

Minutes Of The Faculty Senate Meeting, November 12, 2014, University Of Arkansas, Fayetteville. Faculty Senate

Faculty Senate Minutes

No abstract provided.

The Lumberjack, November 12, 2014, The Lumberjack Staff

2014

The student newspaper of Humboldt State University

The Path To And From The Discovery Of Transgenic Animals, Nov. 12, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Ceas E-News 11.12.2014, College Of Engineering And Applied Sciences

College of Engineering and Applied Sciences News

• New 2015 Medical Engineering Program and More Highlighted in Technology Century
• 2014 CEAS Alumni Excellence Academy Event
• 2014 Alumni Excellence Academy Recipients

Volume 52, Number 13: November 12, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

Marginal Coral Populations: The Densest Known Aggregation Of Pocillopora In The Galápagos Archipelago Is Of Asexual Origin, Iliana B. Baums, Meghann Devlin-Durante, Beatrice A. A. Laing, Joshua S. Feingold, Tyler B. Smith, Andrew Bruckner, Joao Monteiro

Marine & Environmental Sciences Faculty Articles

Coral populations at distributional margins frequently experience suboptimal and variable conditions. Recurrent El Niño-Southern Oscillation (ENSO) warming events have caused extensive mortality of reef-building corals in the Eastern Pacific, and particularly impacted branching pocilloporid corals in the Galápagos Islands. Pocillopora spp. were previously more common and formed incipient reefs at several locations in the archipelago but now occur as scattered colonies. Here, we report an unusually concentrated aggregation of colonies and evaluate their current genetic diversity. In particular we focus on a large population of 1614 live Pocillopora colonies found in a volcanic lagoon along the southern shore of Isabela …

Rotunda - Vol 93, No 11 - Nov 12, 2014, Longwood University

Rotunda

No abstract provided.

Alzheimer's Therapeutics Targeting Amyloid Beta 1-42 Oligomers I: Abeta 42 Oligomer Binding To Specific Neuronal Receptors Is Displaced By Drug Candidates That Improve Cognitive Deficits, Nicholas J. Izzo, Agnes Staniszewski, Lillian To, Mauro Fa, Andrew F. Teich, Faisal Saeed, Harrison Wostein, Thomas Walko Iii, Anisha Vaswani, Meghan Wardius, Zanobia Syed, Jessica Ravenscroft, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Patricia Finn, Gary Look, Gilbert Rishton, Hank Safferstein, Miles Miller, Conrad Johanson, Edward Stopa, Manfred Windisch, Birgit Hutter-Paier, Mehrdad Shamloo, Ottavio Arancio, Harry Levine Iii, Susan M. Catalano

Sanders-Brown Center on Aging Faculty Publications

Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression that is the basis for inhibition of electrophysiological measures of synaptic plasticity and thus learning and memory. We have utilized phenotypic screens in mature, in vitro cultures of rat brain cells to identify small molecules which block or prevent the binding and effects of Abeta oligomers. Synthetic Abeta oligomers bind saturably to a single site on neuronal synapses and induce …

Uab To Test Drug Shown To Completely Reverse Diabetes In Human Islets And Mice, Staff

Browse All News

No abstract provided.

Daily Eastern News: November 12, 2014, Eastern Illinois University

November

No abstract provided.

Easterner, Vol. 66, No. 8, November 12, 2014, Associated Students Of Eastern Washington University

Student Newspapers

This issue of the Easterner includes articles about a Black Student Union demonstration to promote awareness of racism, veteran support on campus, the women's soccer season, Eastern's President's Higher Education Community Service Honor Roll award, turnout for midterm elections, intramural paintball, study abroad, health apps, and the men's basketball, football, and rugby seasons.

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers Ii: Sigma-2/Pgrmc1 Receptors Mediate Abeta 42 Oligomer Binding And Synaptotoxicity, Nicholas J. Izzo, Jinbin Xu, Chenbo Zeng, Molly J. Kirk, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Gary Look, Gilbert Rishton, Hank Safferstein, Carlos Cruchaga, Alison Goate, Michael A. Cahill, Ottavio Arancio, Robert H. Mach, Rolf Craven, Elizabeth Head, Harry Levine Iii, Tara L. Spires-Jones, Susan M. Catalano

Sanders-Brown Center on Aging Faculty Publications

Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation, affect membrane trafficking and induce reversible spine loss in neurons, leading to impaired cognitive performance and ultimately to anterograde amnesia in the early stages of Alzheimer's disease (AD). We have identified a receptor not previously associated with AD that mediates the binding of Abeta oligomers to neurons, and describe novel therapeutic antagonists of this receptor capable of blocking Abeta toxic …

November 12, 2014, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Living Earth: A Nineteenth-Century Latter-Day Saint Perspective, J. Michael Hunter

Faculty Publications

By studying the worldview of Mormons living in the nineteenth century, we can better understand their interpretation of nature and their relationship to it. For Mormons of that era, the earth was alive and deeply affected by the attitudes and actions of the humans living upon it. Nineteenth-century Latter-day Saints spoke frequently of the earth, its nature, and its relationship to humanity. They referred to the earth in anthropomorphic terms. It was a living orb endowed with intelligence and feelings. The earth’s life paralleled that of the humans who lived on it. So entwined were the lives of the earth …

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.

Development Of A Reusable Nutrient Recovery System To Sustainably Integrate Small-Scale Sanitation And Agriculture, Jorge Luis Calabria

USF Tampa Graduate Theses and Dissertations

Emerging technologies in sanitation and food production foster the potential to advance progress towards key sustainable development goals of ensuring adequate sanitation and food security to all. Non-Sewered Sanitation Systems (NSSSs), as detailed by the recent International Organization for Standardization’s (ISO) 30500 standard, are being developed to overcome challenges of lacking sanitation infrastructure and resource scarcity by providing autonomous, off-grid wastewater treatment (WWT) service in a much smaller footprints than large centralized treatment facilities. A promising NSSS platform is the anaerobic membrane bioreactor (AnMBR) that can achieve high (WWT) throughput in a small footprint using ultrafiltration (UF) membrane filtration to …

A Functional Approach To Resolving The Biogeocomplexity Of Two Extreme Environments, Haydn Rubelmann Iii

USF Tampa Graduate Theses and Dissertations

The biodiversity of two distinct marine environments was observed to describe the biogeocomplexity of these extreme ecological systems. A shallow-water hydrothermal vent in Papua New Guinea served as a study of a thermophilic ecosystem influenced by arsenic rich vent fluids while a 60 m deep offshore primarily anoxic karst sink served as a study of an anaerobic sulfur-influenced habitat. Both environments support unique biological communities that are influenced by the physical and chemical pressures imposed on them by the harsh conditions of these systems. In Tutum Bay, Ambitle Isle, Papua New Guinea, a transect was created from a shallow hydrothermal …

Spectrum, Volume 33, Issue 8, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: On Aug. 22, rising junior Kaitlyn Doohry was struck by a motor vehicle while walking to campus. In honor of Doohry, the H.W. Wilson Foundation has given Sacred Heart $100,000 to establish an endowed scholarship in her memory (photos) --The career center is revamping its social media sites as a way to better inform students of the services they can offer --Pete Davidson, the newest featured player on “Saturday Night Live” (SNL) was at SHU on Nov. 3 for a stand-up comedy performance held in the University Commons --This year, through the Volunteer office around 90 students will …

The Utah Statesman, November 11, 2014, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

A Plausible Mechanism, Based Upon Short-Root Movement, For Regulating The Number Of Cortex Cell Layers In Roots., Shuang Wu, Chin-Mei Lee, Tomomi Hayashi, Simara Price, Fanchon Divol, Sophia Henry, Germain Pauluzzi, Christophe Perin, Kimberly L Gallagher

Department of Medical Laboratory Sciences & Biotechnology Faculty Papers

Formation of specialized cells and tissues at defined times and in specific positions is essential for the development of multicellular organisms. Often this developmental precision is achieved through intercellular signaling networks, which establish patterns of differential gene expression and ultimately the specification of distinct cell fates. Here we address the question of how the SHORT-ROOT (SHR) proteins from Arabidopsis thaliana (AtSHR), Brachypodium distachyon (BdSHR), and Oryza sativa (OsSHR1 and OsSHR2) function in patterning the root ground tissue. We find that all of the SHR proteins function as mobile signals in A. thaliana and all of the SHR homologs physically interact …

The Legacy, November 11, 2014, Lindenwood University

The Legacy (2007-2018)

Student Newspaper of Lindenwood University

Staff Senate Minutes, 2014 November 11, Clemson University

Staff Senate Minutes

No abstract provided.

Scanlan Presents ‘What Kind Of Scarcity And For Whom? Justice, Sustainability And The Global Dynamics Of Food Insecurity’, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Synergistic Effect Of Pro-Inflammatory Tnfα And Il-17 In Periostin Mediated Collagen Deposition: Potential Role In Liver Fibrosis, Suneetha Amara, Karina Lopez, Babak Banan, Sade-Kemi Brown, Margaret Whalen, Elbert L. Myles, Michael T. Ivy, Terrance Johnson, Kevin L. Schey, Venkataswarup Tiriveedhi

Biology Faculty Research

Background

The pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-17, have been implicated in the pathogenesis of liver fibrosis. In this study, we investigated the role of TNFα and IL-17 toward induction of profibrotic factor, periostin.

Methods

HepG2 cells were cultured and treated with inflammatory cytokines, TNFα and IL-17. Computational promoter sequence analysis of the periostin promoter was performed to define the putative binding sites for transcription factors. Transcription factors were analyzed by Western blot and Chromatin Immunoprecipitation. Periostin and transcription factor expression analysis was performed by RT-PCR, Western blot, and fluorescence microscopy. Type I collagen expression from fibroblast …

Method And Composition For Modulating Canonical Wnt Pathway Using Folate And Inositol, Kersti K. Linask

USF Patents

The canonical Wnt signaling pathway is implicated in many disorders including neural tube defects, limb malformations, and heart defects, developmental disorders associated with alcohol exposure (fetal alcohol syndrome) or exposure to bipolar medications (i.e. lithium), wound healing, and Alzheimer's disease. Elevated plasma homocysteine (HCy), which results from folate (folic acid, FA) deficiency, the mood-stabilizing drug lithium (Li), and alcohol (ethanol) are linked to the induction of human congenital heart and neural tube defects. FA supplementation ameliorates the observed developmental errors in the Li-HCy, or alcohol-exposed mouse embryos and normalized heart function. Li, HCy or Wnt3A suppress Wnt-modulated Hex and Islet-1 …

Detection Of Analytes Using Metal Nanoparticle Probes And Dynamic Light Scattering (Us), Qun Huo, Qiu Dai, Xiong Liu

UCF Patents

Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.

Medieval Women In Film: An Annotated Handlist And Reference Guide, With Essays On Teaching The Sorceress, Virginia Blanton, Martha M. Johnson-Olin, Charlene Miller Avrich

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Volume 112, Number 10 - Tuesday, November 11, 2014, Saint Mary's College Of California

The Collegian

No abstract provided.