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2014

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Articles 16741 - 16770 of 20604

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Tcr Triggering By Pmhc Ligands Tethered On Surfaces Via Poly(Ethylene Glycol) Depends On Polymer Length, Zhengyu Ma, David N. Lebard, Sharon M. Loverde, Kim A. Sharp, Michael L. Klein, Dennis E. Discher, Terri H. Finkel Jan 2014

Tcr Triggering By Pmhc Ligands Tethered On Surfaces Via Poly(Ethylene Glycol) Depends On Polymer Length, Zhengyu Ma, David N. Lebard, Sharon M. Loverde, Kim A. Sharp, Michael L. Klein, Dennis E. Discher, Terri H. Finkel

Faculty Bibliography 2010s

Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC). The pMHC-TCR interaction is two-dimensional (2D), in that both the ligand and receptor are membrane-anchored and their movement is limited to 2D diffusion. The 2D nature of the interaction is critical for the ability of pMHC ligands to trigger TCR. The exact properties of the 2D pMHC-TCR interaction that enable TCR triggering, however, are not fully understood. Here, we altered the 2D pMHC-TCR interaction by tethering pMHC ligands …

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The Contribution Of Visceral Fat To Improved Insulin Signaling In Ames Dwarf Mice, Vinal Menon, Xu Zhi, Tanvir Hossain, Andrzej Bartke, Adam Spong, Adam Gesing, Michal M. Masternak Jan 2014

The Contribution Of Visceral Fat To Improved Insulin Signaling In Ames Dwarf Mice, Vinal Menon, Xu Zhi, Tanvir Hossain, Andrzej Bartke, Adam Spong, Adam Gesing, Michal M. Masternak

Faculty Bibliography 2010s

Ames dwarf (Prop1df, df/df) mice are characterized by growth hormone (GH), prolactin, and thyrotropin deficiency, remarkable extension of longevity and increased insulin sensitivity with low levels of fasting insulin and glucose. Plasma levels of anti-inflammatory adiponectin are increased in df/df mice, while pro-inflammatory IL-6 is decreased in plasma and epididymal fat. This represents an important shift in the balance between pro- and anti-inflammatory adipokines in adipose tissue, which was not exposed to GH signals during development or adult life. To determine the role of adipose tissue in the control of insulin signaling in these long-living mutants, we examined the effects …

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Notch-1 Mediated Cardiac Protection Following Embryonic And Induced Pluripotent Stem Cell Transplantation In Doxorubicin-Induced Heart Failure, Hilda Merino, Dinender K. Singla Jan 2014

Notch-1 Mediated Cardiac Protection Following Embryonic And Induced Pluripotent Stem Cell Transplantation In Doxorubicin-Induced Heart Failure, Hilda Merino, Dinender K. Singla

Faculty Bibliography 2010s

Doxorubicin (DOX), an effective chemotherapeutic drug used in the treatment of various cancers, is limited in its clinical applications due to cardiotoxicity. Recent studies suggest that transplanted adult stem cells inhibit DOX-induced cardiotoxicity. However, the effects of transplanted embryonic stem (ES) and induced pluripotent stem (iPS) cells are completely unknown in DOX-induced left ventricular dysfunction following myocardial infarction (MI). In brief, C57BL/6 mice were divided into five groups: Sham, DOX-MI, DOX-MI+ cell culture (CC) media, DOX-MI+ ES cells, and DOX-MI+ iPS cells. Mice were injected with cumulative dose of 12 mg/kg of DOX and 2 weeks later, MI was induced …

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Mycobacterium Avium Subspecies Paratuberculosis Causes Crohn's Disease In Some Inflammatory Bowel Disease Patients, Saleh A. Naser, Sudesh R. Sagramsingh,, Abed S. Naser, Saisathya Thanigachalam Jan 2014

Mycobacterium Avium Subspecies Paratuberculosis Causes Crohn's Disease In Some Inflammatory Bowel Disease Patients, Saleh A. Naser, Sudesh R. Sagramsingh,, Abed S. Naser, Saisathya Thanigachalam

Faculty Bibliography 2010s

Crohn's disease (CD) is a chronic inflammatory condition that plagues millions all over the world. This debilitating bowel disease can start in early childhood and continue into late adulthood. Signs and symptoms are usually many and multiple tests are often required for the diagnosis and confirmation of this disease. However, little is still understood about the cause(s) of CD. As a result, several theories have been proposed over the years. One theory in particular is that Mycobacterium avium subspecies paratuberculosis (MAP) is intimately linked to the etiology of CD. This fastidious bacterium also known to cause Johne's disease in cattle …

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A Chemical Biology Approach Identified Pi3k As A Potential Therapeutic Target For Neurofibromatosis Type 2, Alejandra M. Petrilli, Marisa A. Fuse, Mathew S. Donnan, Marga Bott, Nicklaus A. Sparrow, Daniel Tondera, Julia Huffziger, Corina Frenzel, C. Siobhan Malany, Christophe J. Echeverri, Layton Smith, Cristina Fernández-Valle Jan 2014

A Chemical Biology Approach Identified Pi3k As A Potential Therapeutic Target For Neurofibromatosis Type 2, Alejandra M. Petrilli, Marisa A. Fuse, Mathew S. Donnan, Marga Bott, Nicklaus A. Sparrow, Daniel Tondera, Julia Huffziger, Corina Frenzel, C. Siobhan Malany, Christophe J. Echeverri, Layton Smith, Cristina Fernández-Valle

Faculty Bibliography 2010s

Mutations in the merlin tumor suppressor gene cause Neurofibromatosis type 2 (NF2), which is a disease characterized by development of multiple benign tumors in the nervous system. The current standard of care for NF2 calls for surgical resection of the characteristic tumors, often with devastating neurological consequences. There are currently no approved non-surgical therapies for NF2. In an attempt to identify much needed targets and therapeutically active compounds for NF2 treatment, we employed a chemical biology approach using ultra-highthroughput screening. To support this goal, we created a merlin-null mouse Schwann cell (MSC) line to screen for compounds that selectively decrease …

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Kruppel-Like Factor 15 Is A Critical Regulator Of Cardiac Lipid Metabolism, Domenick A. Prosdocimo, Priti Anand, Xudong Liao, Han Zhu, Shamanthika Shelkay, Pedro Artero-Caldero, Lilei Zhang, Jacob Kirsh, D'Vesharronne Moore, Mariana G. Rosca, Edwin Vazquez, Janos Kerner, Kemal M. Akat, Zev Williams, Jihe Zhao, Hisashi Fujioka, Thomas Tuschl, Xiaodong Bai, P. Christina Schulze, Charles L. Hoppel, Mukseh K. Jain, Saptarsi M. Halder Jan 2014

Kruppel-Like Factor 15 Is A Critical Regulator Of Cardiac Lipid Metabolism, Domenick A. Prosdocimo, Priti Anand, Xudong Liao, Han Zhu, Shamanthika Shelkay, Pedro Artero-Caldero, Lilei Zhang, Jacob Kirsh, D'Vesharronne Moore, Mariana G. Rosca, Edwin Vazquez, Janos Kerner, Kemal M. Akat, Zev Williams, Jihe Zhao, Hisashi Fujioka, Thomas Tuschl, Xiaodong Bai, P. Christina Schulze, Charles L. Hoppel, Mukseh K. Jain, Saptarsi M. Halder

Faculty Bibliography 2010s

Background: Metabolic homeostasis is central to normal cardiac function. The molecular mechanisms underlying metabolic plasticity in the heart remain poorly understood. Results: Kruppel-like factor 15 (KLF15) is a direct and independent regulator of myocardial lipid flux. Conclusion: KLF15 is a core component of the transcriptional circuitry that governs cardiac metabolism. Significance: This work is the first to implicate the KLF transcription factor family in cardiac metabolism. The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms to tightly couple fuel supply with energy demand across a wide range of physiologic and pathophysiologic states, yet, when compared with other …

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Pathophysiology Of Autism Spectrum Disorders: Revisiting Gastrointestinal Involvement And Immune Imbalance, Mohtashem Samsam, Raheleh Ahangari, Saleh A. Naser Jan 2014

Pathophysiology Of Autism Spectrum Disorders: Revisiting Gastrointestinal Involvement And Immune Imbalance, Mohtashem Samsam, Raheleh Ahangari, Saleh A. Naser

Faculty Bibliography 2010s

Autism spectrum disorders (ASD) comprise a group of neurodevelopmental abnormalities that begin in early childhood and are characterized by impairment of social communication and behavioral problems including restricted interests and repetitive behaviors. Several genes have been implicated in the pathogenesis of ASD, most of them are involved in neuronal synaptogenesis. A number of environmental factors and associated conditions such as gastrointestinal (GI) abnormalities and immune imbalance have been linked to the pathophysiology of ASD. According to the March 2012 report released by United States Centers for Disease Control and Prevention, the prevalence of ASD has sharply increased during the recent …

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Toward In Vitro Models Of Brain Structure And Function, Michael L. Shuler, James J. Hickman Jan 2014

Toward In Vitro Models Of Brain Structure And Function, Michael L. Shuler, James J. Hickman

Faculty Bibliography 2010s

No abstract provided.

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Utilization Of Microscale Silicon Cantilevers To Assess Cellular Contractile Function In Vitro, Alec S. T. Smith, Christopher J. Long, Christopher Mcaleer, Nathaniel Bobbitt, Balaji Srinivasan, James J. Hickman Jan 2014

Utilization Of Microscale Silicon Cantilevers To Assess Cellular Contractile Function In Vitro, Alec S. T. Smith, Christopher J. Long, Christopher Mcaleer, Nathaniel Bobbitt, Balaji Srinivasan, James J. Hickman

Faculty Bibliography 2010s

The development of more predictive and biologically relevant in vitro assays is predicated on the advancement of versatile cell culture systems which facilitate the functional assessment of the seeded cells. To that end, microscale cantilever technology offers a platform with which to measure the contractile functionality of a range of cell types, including skeletal, cardiac, and smooth muscle cells, through assessment of contraction induced substrate bending. Application of multiplexed cantilever arrays provides the means to develop moderate to high-throughput protocols for assessing drug efficacy and toxicity, disease phenotype and progression, as well as neuromuscular and other cell-cell interactions. This manuscript …

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Histone Deacetylase Inhibitors Selectively Target Homology Dependent Dna Repair Defective Cells And Elevate Non-Homologous Endjoining Activity, Stephanie Smith, Jennifer Fox, Marco Mejia, Wanvipa Ruangpradit, Alihossein Saberi, Sunmi Kim, Yongjum Choi, Sehyun Oh, Yucai Wang, Kyungho Choi, Lei Li, Eric A. Hendrickson, Shunichi Takeda, Mark Muller, Kyungjae Myung Jan 2014

Histone Deacetylase Inhibitors Selectively Target Homology Dependent Dna Repair Defective Cells And Elevate Non-Homologous Endjoining Activity, Stephanie Smith, Jennifer Fox, Marco Mejia, Wanvipa Ruangpradit, Alihossein Saberi, Sunmi Kim, Yongjum Choi, Sehyun Oh, Yucai Wang, Kyungho Choi, Lei Li, Eric A. Hendrickson, Shunichi Takeda, Mark Muller, Kyungjae Myung

Faculty Bibliography 2010s

Background: We have previously used the ATAD5-luciferase high-throughput screening assay to identify genotoxic compounds with potential chemotherapeutic capabilities. The successful identification of known genotoxic agents, including the histone deacetylase inhibitor (HDACi) trichostatin A (TSA), confirmed the specificity of the screen since TSA has been widely studied for its ability to cause apoptosis in cancer cells. Because many cancers have acquired mutations in DNA damage checkpoints or repair pathways, we hypothesized that these cancers may be susceptible to treatments that target compensatory pathways. Here, we used a panel of isogenic chicken DT40 B lymphocyte mutant and human cell lines to investigate …

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Death And Disability In A Younge Phase Community, Michael W. Spence, Lana J. Williams, Sandra M. Wheeler Jan 2014

Death And Disability In A Younge Phase Community, Michael W. Spence, Lana J. Williams, Sandra M. Wheeler

Faculty Bibliography 2010s

Roffelsen is an early Younge phase mortuary component in southwestern Ontario. The single burial feature is a pit containing the articulated skeletons of seven successively buried individuals, ranging in age from a few months to late middle age. All had been stripped of soft tissues, except for the connecting tissues that maintained their articulation. Most also had a disk cut from the cranium and a hole drilled near bregma. All but the Want display various forms of developmental failure of the outer and middle ear and the petrous portion of the temporal bone. The pit was apparently the burial facility …

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Growth Hormone Action Predicts Age-Related White Adipose Tissue Dysfunction And Senescent Cell Burden In Mice, Michael B. Stout, Tamara Tchkonia, Tamar Pirtskhalava, Allyson K. Palmer, Edward O. List, Darlene E. Berryman, Ellen R. Lubbers, Carlos Escande, Adam Spong, Michal M. Masternak, Ann L. Oberg, Nathan K. Lebrasseur, Richard A. Miller, John J. Kopchick, Andrzej Bartke, James L. Kirkland Jan 2014

Growth Hormone Action Predicts Age-Related White Adipose Tissue Dysfunction And Senescent Cell Burden In Mice, Michael B. Stout, Tamara Tchkonia, Tamar Pirtskhalava, Allyson K. Palmer, Edward O. List, Darlene E. Berryman, Ellen R. Lubbers, Carlos Escande, Adam Spong, Michal M. Masternak, Ann L. Oberg, Nathan K. Lebrasseur, Richard A. Miller, John J. Kopchick, Andrzej Bartke, James L. Kirkland

Faculty Bibliography 2010s

The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease onset and progression due to declines in adipogenesis with advancing age. Recent reports indicate that the accumulation of senescent progenitor cells may be involved in age-related WAT dysfunction. Growth hormone (GH) action has profound effects on adiposity and metabolism and is known to influence lifespan. In the present study we tested the hypothesis that GH activity would predict age-related WAT dysfunction and accumulation of senescent cells. We found that long-lived GH-deficient and -resistant mice have reduced …

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Targeting The Biophysical Properties Of The Myeloma Initiating Cell Niches: A Pharmaceutical Synergism Analysis Using Multi-Scale Agent-Based Modeling, Jing Su, Le Zhang, Wen Zhang, Dong Song Choi, Jianguo Wen, Beini Jiang, Chung-Che Chang, Xiaobo Zhou Jan 2014

Targeting The Biophysical Properties Of The Myeloma Initiating Cell Niches: A Pharmaceutical Synergism Analysis Using Multi-Scale Agent-Based Modeling, Jing Su, Le Zhang, Wen Zhang, Dong Song Choi, Jianguo Wen, Beini Jiang, Chung-Che Chang, Xiaobo Zhou

Faculty Bibliography 2010s

Multiple myeloma, the second most common hematological cancer, is currently incurable due to refractory disease relapse and development of multiple drug resistance. We and others recently established the biophysical model that myeloma initiating (stem) cells (MICs) trigger the stiffening of their niches via SDF-1/CXCR4 paracrine; The stiffened niches then promote the colonogenesis of MICs and protect them from drug treatment. In this work we examined in silico the pharmaceutical potential of targeting MIC niche stiffness to facilitate cytotoxic chemotherapies. We first established a multi-scale agent-based model using the Markov Chain Monte Carlo approach to recapitulate the niche stiffness centric, pro-oncogenetic …

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In Vitro Selection Of Dna Aptamers Against Prostate Cancer Peptide Biomarkers, Elif Kuguoglu Jan 2014

In Vitro Selection Of Dna Aptamers Against Prostate Cancer Peptide Biomarkers, Elif Kuguoglu

HIM 1990-2015

This project is aimed toward finding DNA aptamers against prostate cancer peptide antigens. DNA aptamers can function to find and indicate the presence of certain molecules in a specimen. These aptamers will be obtained through the process of evolutionary selection, a specific process called SELEX which stands for Systemic Evolution of Ligands by Experimental Enrichment. By conducting several rounds of SELEX, a DNA aptamer will be selected to bind to a known peptide antigen. A biotinylated column will be utilized to stabilize a random library of DNA aptamers, and those peptides that bind to certain aptamers will cause a conformational …

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The Effect Of Weight And Size On Mental Rotation, Luke Furtak Jan 2014

The Effect Of Weight And Size On Mental Rotation, Luke Furtak

HIM 1990-2015

Shepard and Metzler (1971) argued that mental rotation is analogous to the real world in that people imagine the rotation of an object as if it were being physically rotated. This study tested this assertion by exposing participants to physical shapes that increased in size and weight. Participants interacted with blocks designed after Shepard and Metzler mental rotation size that differed in size and weight then performed subsequent mental rotation. We found no difference in reaction time but found that increased size reduced accuracy. We discuss the implications of this study as they pertain to embodied cognition.

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The Search For Truth In The Digital Cinematic Space And Green Screen Performances, Kade Dalton Jan 2014

The Search For Truth In The Digital Cinematic Space And Green Screen Performances, Kade Dalton

HIM 1990-2015

With the advent of the blockbuster and its visual effects, film has grown to accept these effects and the technology behind them, namely green screen mattes, as cornerstones to the post-production process. The propensity of green screen in all types of productions, especially those involving actors and their performances, raises questions about the methodology and workflow behind its common practice. Using real-life environments and people to create narrative scenes, this project explores the utilization of matte backgrounds to inform the rehearsal and performance aspects of cinematic story-telling.

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Deconstructing Presence: Rethinking The Intentionality Of The Subject On The Basis Of The Existentiality Of Dasein, Edgar Diaz Jan 2014

Deconstructing Presence: Rethinking The Intentionality Of The Subject On The Basis Of The Existentiality Of Dasein, Edgar Diaz

HIM 1990-2015

Having begun from the assumption that our most fundamental way to relate to the world stems from an #I think# and that consciousness is at the center of this act, Edmund Husserl sets himself up for a very narrow and specialized view of human experience. In the end, such assumptions in the philosophical tradition and their terms often remain unquestioned and ingrained in a paradigm of discourse. My aim is to move beneath these assumptions-using Heidegger's and Merleau-Ponty's phenomenological work-so as to, first, explicitly undermine the scope of Husserlian intentionality at its foundation and, second, decenter the subject in contemporary …

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Understanding The Role Of A Hemerythrin-Like Protein In Mycobacterium Tumerculosis, Caitlyn Herndon Jan 2014

Understanding The Role Of A Hemerythrin-Like Protein In Mycobacterium Tumerculosis, Caitlyn Herndon

HIM 1990-2015

According to the Centers for Disease Control and Prevention (CDC), 8 million people each year are infected with Mycobacterium tuberculosis (Mtb) leading to 1.5 million deaths annually. This staggering number calls for advancements in understanding this bacterium so progress can be made in treating and preventing the disease. It is particularly important to understand mechanisms by which TB survives inside hostile host immune cells known as macrophages and within hypoxic granuloma lesions of the lung. Preliminary microarray data has shown that a TB gene known as Rv2633c is induced upon macrophage invasion. Bioinformatic analysis of Rv2633c coding sequence shows the …

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3-Amino-2-Piperidinequinoline A Novel Natural Product-Inspiried Synthetic Compound With Antimalarial Activity, Cristhian Valor Jan 2014

3-Amino-2-Piperidinequinoline A Novel Natural Product-Inspiried Synthetic Compound With Antimalarial Activity, Cristhian Valor

HIM 1990-2015

Malaria afflicts about 500 million people worldwide thus causing significant global economic toll. The drugs available to treat the disease are rapidly losing their efficacy because of widespread prevalence of drug resistant parasites. Thus there is an urgent need to discover novel malaria therapeutics. This research is focused on to study the properties of a novel naturallike synthetic scaffold and analyze its selectivity, and cellular mechanism of action in Plasmodium falciparum. We have identified a novel compound, 3-amino-2-piperidinequinoline (APQ), which we termed UCF401. APQ demonstrated IC[sub50] at submicromolar concentrations against Plasmodium falciparum using the SYBR Green-I fluorescence assay measuring cellular …

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The Role Of Intestinal Sweet Taste Receptors (Strs) In The Regulation Of Glucose Absorption: Effects Of Short Term High Sucrose Diet (Hsd), Tania Hussain Jan 2014

The Role Of Intestinal Sweet Taste Receptors (Strs) In The Regulation Of Glucose Absorption: Effects Of Short Term High Sucrose Diet (Hsd), Tania Hussain

HIM 1990-2015

Sweet taste receptors are primarily found in the oral cavity of the mammalian species. However, recent studies have shown that sweet taste receptors can be found in extraoral tissues such as the pancreas, intestines, and adipose tissue. Our lab has previously found that sweet taste receptors are down-regulated on the pancreas in the presence of high plasma glucose levels. In order to assess the possibility that sweet taste receptors respond to high levels of glucose by suppressing its expression, we wanted to see if they reacted similarly on the intestines. We found that intestinal sweet taste receptors are down regulated …

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Migrant Labor, Development, And Hiv In Botswana, William Kearns Jan 2014

Migrant Labor, Development, And Hiv In Botswana, William Kearns

HIM 1990-2015

At independence, Botswana was highly underdeveloped and reliant on external capital earned through migrant labor. This presented several challenges to development despite the discovery of diamonds shortly after independence. However, no challenge was greater than the HIV epidemic which came to infect one in four Batswana. This thesis discusses the historical factors which promoted the spread of the virus in the greater context of migrant labor and development within Botswana.

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University Of Central Florida Factbook 2013-2014, University Of Central Florida Jan 2014

University Of Central Florida Factbook 2013-2014, University Of Central Florida

Historical Fact Book and Enrollment

Historical fact book and enrollment data for the University of Central Florida.

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The Effect Of Calorie Restriction On Insulin Signaling In Skeletal Muscle And Adipose Tissue Of Ames Dwarf Mice, Denise S. Wiesenborn, Vinal Menon, Xu Zhi, Andrew Do, Adam Gesing, Zhihui Wang, Andrzek Bartke, Deborah A. Altomare, Michal M. Masternak Jan 2014

The Effect Of Calorie Restriction On Insulin Signaling In Skeletal Muscle And Adipose Tissue Of Ames Dwarf Mice, Denise S. Wiesenborn, Vinal Menon, Xu Zhi, Andrew Do, Adam Gesing, Zhihui Wang, Andrzek Bartke, Deborah A. Altomare, Michal M. Masternak

Faculty Bibliography 2010s

Long-living Ames dwarf (df/df) mice are homozygous for a mutation of the Prop1(df) gene. As a result, mice are deficient in growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). In spite of the hormonal deficiencies, df/df mice live significantly longer and healthier lives compared to their wild type siblings. We studied the effects of calorie restriction (CR) on the expression of insulin signaling genes in skeletal muscle and adipose tissue of normal and df/df mice. The analysis of genes expression showed that CR differentially affects the insulin signaling pathway in these insulin target organs. Moreover, results obtained in both normal …

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Contrast Agents For Photoacoustic And Thermoacoustic Imaging: A Review, Dan Wu, Lin Huang, Max S. Jiang, Huabei Jiang Jan 2014

Contrast Agents For Photoacoustic And Thermoacoustic Imaging: A Review, Dan Wu, Lin Huang, Max S. Jiang, Huabei Jiang

Faculty Bibliography 2010s

Photoacoustic imaging (PAI) and thermoacoustic imaging (TAI) are two emerging biomedical imaging techniques that both utilize ultrasonic signals as an information carrier. Unique advantages of PAI and TAI are their abilities to provide high resolution functional information such as hemoglobin and blood oxygenation and tissue dielectric properties relevant to physiology and pathology. These two methods, however, may have a limited detection depth and lack of endogenous contrast. An exogenous contrast agent is often needed to effectively resolve these problems. Such agents are able to greatly enhance the imaging contrast and potentially break through the imaging depth limit. Furthermore, a receptor-targeted …

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Transit Focused Utc - January 1, 2014–June 30, 2014, Nctr Jan 2014

Transit Focused Utc - January 1, 2014–June 30, 2014, Nctr

NCTR Transit Focused UTC

No abstract provided.

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Isotope Turnover Rates And Diet-Tissue Discrimination In Skin Of Ex Situ Bottlenose Dolphins (Tursiops Truncatus), Nicole E. Browning, Christopher Dold, Jack I-Fan, Graham A. J. Worthy Jan 2014

Isotope Turnover Rates And Diet-Tissue Discrimination In Skin Of Ex Situ Bottlenose Dolphins (Tursiops Truncatus), Nicole E. Browning, Christopher Dold, Jack I-Fan, Graham A. J. Worthy

Faculty Bibliography 2010s

Diet-tissue discrimination factors (Delta N-15 or Delta C-13) and turnover times are thought to be influenced by a wide range of variables including metabolic rate, age, dietary quality, tissue sampled and the taxon being investigated. In the present study, skin samples were collected from ex situ dolphins that had consumed diets of known isotopic composition for a minimum of 8 weeks. Adult dolphins consuming a diet of low fat (5-6%) and high delta N-15 value had significantly lower Delta N-15 values than animals consuming a diet with high fat (13.9%) and low delta N-15 value. Juvenile dolphins consuming a diet …

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Elimination Of Laparoscopic Lens Fogging Using Directional Flow Of Co2, John Teague Calhoun, Jay A, Redan Jan 2014

Elimination Of Laparoscopic Lens Fogging Using Directional Flow Of Co2, John Teague Calhoun, Jay A, Redan

Faculty Bibliography 2010s

Background and Objectives: Surgeons constantly struggle with the formation of condensation on the lens of a. laparoscope, which prolongs procedures and reduces visibility of the abdominal cavity. The goal of this project was to build a device, that would direct a flow of carbon dioxide (CO2) into an open chamber surrounding the lens of a laparoscope, acting to keep moisture away from the lens and eliminate condensation. Methods: The device isolates the lens of the laparoscope from the humid environment of the intraperitoneal cavity by creating a microenvironment of dry CO2. This was accomplished by building a communicating sleeve that …

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Modeling And Mapping Isotopic Patterns In The Northwest Atlantic Derived From Loggerhead Sea Turtles, Simona A. Ceriani, James D. Roth, Christopher R. Sasso, Catherine M. Mcclellan, Michael C. James, Heather L. Haas, Ronald J. Smolowitz, Daniel R. Evans, David S. Addison, Dean A. Bagley, Llewellyn M. Ehrhart, John F. Weishampel Jan 2014

Modeling And Mapping Isotopic Patterns In The Northwest Atlantic Derived From Loggerhead Sea Turtles, Simona A. Ceriani, James D. Roth, Christopher R. Sasso, Catherine M. Mcclellan, Michael C. James, Heather L. Haas, Ronald J. Smolowitz, Daniel R. Evans, David S. Addison, Dean A. Bagley, Llewellyn M. Ehrhart, John F. Weishampel

Faculty Bibliography 2010s

Stable isotope analysis can be used to infer geospatial linkages of highly migratory species. Identifying foraging grounds of marine organisms from their isotopic signatures is becoming de rigueur as it has been with terrestrial organisms. Sea turtles are being increasingly studied using a combination of satellite telemetry and stable isotope analysis; these studies along with those from other charismatic, highly vagile, and widely distributed species (e.g., tuna, billfish, sharks, dolphins, whales) have the potential to yield large datasets to develop methodologies to decipher migratory pathways in the marine realm. We collected tissue samples (epidermis and red blood cells) for carbon …

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Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death Through Nox1-Regenerated Oxidative Stress, Dong-Hee Choi, Ji-Hye Kim, Joo-Ha Seo, Jongmin Lee, Wahn Soo Choi, Yoon-Seong Kim Jan 2014

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death Through Nox1-Regenerated Oxidative Stress, Dong-Hee Choi, Ji-Hye Kim, Joo-Ha Seo, Jongmin Lee, Wahn Soo Choi, Yoon-Seong Kim

Faculty Bibliography 2010s

In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death. We found that MMP3 activation causes the induction of Nox1 via mitochondrial reactive oxygen species (ROS) production and subsequently Rac1 activation, eventually leading to Nox1-derived superoxide generation in a rat DA neuronal N27 cells exposed to 6-OHDA. While a MMP3 inhibitor, NNGH, largely attenuated mitochondrial ROS and subsequent Nox1 induction, both apocynin, a putative Nox inhibitor and GKT137831, a Nox1 selective inhibitor failed to reduce 6-OHDA-induced mitochondrial ROS. However, both inhibitors for MMP3 and …

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Intravesical Alt-803 And Bcg Treatment Reduces Tumor Burden In A Carcinogen Induced Bladder Cancer Rat Model; A Role For Cytokine Production And Nk Cell Expansion, Evan Gomes-Giacoia, Makito Miyake, Steve Goodison, Aravindhan Sriharan, Ge Zhang, Lijing You, Jack O. Egan, Peter R. Rhode, Alexander S. Parker, Karl X. Chai, Hing C. Wong, Charles J. Rosser Jan 2014

Intravesical Alt-803 And Bcg Treatment Reduces Tumor Burden In A Carcinogen Induced Bladder Cancer Rat Model; A Role For Cytokine Production And Nk Cell Expansion, Evan Gomes-Giacoia, Makito Miyake, Steve Goodison, Aravindhan Sriharan, Ge Zhang, Lijing You, Jack O. Egan, Peter R. Rhode, Alexander S. Parker, Karl X. Chai, Hing C. Wong, Charles J. Rosser

Faculty Bibliography 2010s

Intravesical Bacillus Calmette-Guerin (BCG) has been shown to induce a specific immunologic response (i.e., activation of IL-2 and effector T-cells), while preclinical studies using ALT-803 (mutated IL-15 analogue combined with IL-15R alpha-Fc fusion) have shown promising results by prolonging the agent's half-life and stimulating CD8+ T-cells. Based on these results, we hypothesized that the intravesical administration of ALT-803 along with BCG will generate an immunologic response leading to significant bladder tumor burden reduction. Using a well-established carcinogen induced rat non-muscle invasive bladder cancer (NMIBC) model, we studied the effects of intravesical ALT-803 with and without BCG. Rat tissues were evaluated …

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