Digital Commons Network^™

Evaluation Of Primary Stability In Bovine Ribs Following A Correction In Placement Depth, Matthew Bobbera

Graduate Theses, Dissertations, and Problem Reports (ETD)

For an implant to be successfully loaded at the time of placement it must have a certain degree of initial stability. While many factors have been shown to influence primary stability, this study aims to examine the effect of positional change on implant stability. 18 Straumann dental implants (16 Standard plus SLA active 3.3mm RN implants, 1 Standard plus SLA 3.3 mm RN implant, and 1 SLActive 4.1 mm RC bone level implant) were placed into two bovine ribs. Implants were divided into two groups with nine in each group and were either backed out or advanced. The primary stability …

Building Authentic Community Through Small Group Ministry Among Young Adults Of Select Churches Within The Greater New York Conference, Ricardo V. Bain

Doctor of Ministry Projects

Problem

The Greater New York Conference has several churches that have begun and sustained many programs for building interpersonal relationships between young adults within their membership. These programs have produced lukewarm results. In some cases these efforts failed. Many of the young adults have either left the church because they do not feel connected to others of their peer group, or they are present with little or no intentional ministry that relates to building their relational needs. In an interview with the immediate past and present youth directors of the conference, both admitted that there is tremendous need for a …

Seminario De Treinamento Para Lideres De Louvor De Capital Brazilian Temple, Edemilson Alves Cardoso

Doctor of Ministry Projects

Problem

The worship leader has a very important role at Capital Brazilian Temple in leading praise team and worship ministry. The difficulty lies in having church worship leaders prepared for this mission, as they have no Biblical training on worship theology. The worship leaders have has directed this ministry and congregational singing more based on ecclesiastical tradition and personal taste than according to Adventist theology of praise and worship.

Method

This research relates to the discipline of Applied Theology. It starts out by analyzing the Biblical and theological foundations of worship and praise in the Bible, the writings of Ellen …

A Mentoring Program For Equipping Youths As Leaders In The Rivers Conference, Nigeria, Ugochukwu Elems

Doctor of Ministry Projects

Problem

Young people feel neglected in the leadership process of Rivers Conference of the Seventh-day Adventists, Nigeria. On the other hand, the adults think that the young people lack the experience and skills needed to occupy positions of leadership. Unfortunately, while the young people are being marginalized in the leadership process, they constitute an overwhelming majority of the membership in Rivers Conference

Method

The mentoring approach adopted for equipping the young people of Rivers Conference as leaders in this project is a modification of Jesus' model of leadership proposed by Kreider (2008, p. 113). The process will be divided into …

Equipping Teenagers Of The Glendale Spanish Seventh-Day Adventist Church To Manage Their Finances Effectively, Jaime A. Heras

Doctor of Ministry Projects

Problem

America's teenagers do not understand the basic financial principles of earning, spending, saving, and investing. Adolescents who never learn to manage their budgets and adopt healthy financial habits grow up to be adults whose spending habits surpass their income. By carrying those habits into adulthood, they will make poor financial decisions that will impact every area of their lives. As a church, providing a financial training will not only increase the financial literacy of adolescents, but it can give them direction for godly priorities and practices as a lifestyle.

Method

A six-hour seminar on financial education and money management …

Trade Usage In The Courts: The Flawed Conceptual And Evidentiary Basis Of Article 2’S Incorporation Strategy, Lisa Bernstein

Coase-Sandor Institute for Law & Economics Research Paper Series

No abstract provided.

Mongolian Folklore Expressed Through Music Technology Original Multimedia Soundtrack On Horseback, Xinlei Chu

Electronic Theses and Dissertations

I returned to my hometown and recorded Mongolian folk music- Mongolian Long Song and Mongolian Throat Singing. I wanted to combine technology and traditional folk music and write an electronic piece based on Mongolian vocal materials. I used what I've sampled, manipulated the sounds, composed the music, gathered the videos together and created this multimedia piece - On Horseback. The names of the four movements - Sand, Cloud, Water, and Fire - are four elements that I chose to represent the lifestyle in Inner Mongolia.

This thesis covers the journey of how I created this piece. I've explored many variations …

Molecular Evolution Of Hominoid Primates: Phylogeny And Regulation, Ranajit Das

Electronic Theses and Dissertations

The complete mtDNA of one eastern gorilla was sequenced to provide the most accurate date for the mitochondrial divergence of gorillas. The most recent common ancestor of eastern lowland and western lowland gorillas existed about 1.9 million years ago, slightly more recent than that of chimpanzee and bonobo. This study also depicts that the eastern and western gorillas show species level genetic divergence.

Hominoid mating systems differ tremendously. The level of sperm competition varies according to the mating system, which presumably imposes unique selective pressures on the seminal proteins of each species. Cartilage acidic protein 1 (CRTAC1) was identified in …

Beneficial Effects Of The Nutritional Supplements On The Development Of Diabetic Retinopathy, Renu A. Kowluru, Qing Zhong, Julia M. Santos, Mangayarkarasi Thandampallayam, Doug Putt, Dennis L. Gierhart

Wayne State University Associated BioMed Central Scholarship

Abstract

Purpose

Increased oxidative stress and inflammatory mediators are implicated in the development of diabetic retinopathy, and in rats, its development can be prevented by antioxidants. Carotenoids are some of the powerful antioxidants, and diabetes decreases lutein and zeaxanthin levels in the serum and retina. The aim of this study is to investigate the effect of carotenoid containing nutritional supplements (Nutr), which is in clinical trials for ‘Diabetes Vision Function’, on diabetic retinopathy.

Methods

Streptozotocin-induced diabetic rats (Wistar, male) were fed Purina 5001 supplemented with nutritional supplements containing zeaxanthin, lutein, lipoic acid, omega-3 fatty acids and other nutrients, or without …

Targeting Cxcr4 With Ctce-9908 Inhibits Prostate Tumor Metastasis, Donald Wong, Pridvi Kandagatla, Walter Korz, Sreenivasa R. Chinni

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

CXCL12/CXCR4 transactivation of epidermal growth factor family receptors in lipid raft membrane microdomains on cell surface is thought to mediate tumor growth and subsequent development of metastatic disease. CTCE-9908 is a known inhibitor of CXCR4. Herein, we tested the efficacy of CTCE-9908 in inhibiting prostate cancer cell growth, invasion, and metastasis.

Methods

We used a panel of in vitro assays utilizing human prostate cancer cell lines and an in vivo orthotopic prostate cancer model to assess the anti-tumoral activity of CTCE-9908.

Results

We demonstrated that (a) CTCE-9908 treatment resulted in no significant change in the growth of PC-3 …

The Role Of Logistics Alliance Orientation On Forming The Alliance Structure: A Conceptual Framework, David M. Gligor, Mary C. Holcomb

Journal of Transportation Management

Little is known about how a firm decides what type of relationship to develop with a LSP and how the type of arrangement affects the service quality performance. This article proposes a conceptual framework to better understand how shippers decide what type of relationship to develop with a logistics service provider (LSP) within the strategy- structure-performance theoretical framework. A systematic literature review is used to develop a conceptual framework that considers the association between the firm’s strategic perspective on outsourcing and the resulting effect on the alliance structure. The concept of a logistics alliance orientation (LAO) is introduced to examine …

Compare Effects Of Diets Made With Different Saturated Fatty Acids On Body Weight Regulation And Metabolism In Wister Rats, Dilruba Fatema

Wayne State University Theses

Animal fats are known to cause elevated blood total and low-density- lipoprotein (LDL) cholesterol levels in humans and animals. This study was designed to investigate the effects of both the quality (coconut oil and a modified beef tallow with reduced saturated fatty acid content) and quantity (low and high) of dietary fat in body weight regulation and alteration of blood cholesterol levels in an animal model. Forty two male Wister rats were randomly divided into 4 groups: Control Low Fat (CLF, n=10), Control High Fat (CHF, n=10), Modified Low Fat (MLF, n=11), and Modified High Fat (MLF, n=11). They were …

Screening Of Natural Antimicrobial Agents And Antimicrobial-Resistant Bacteria Using A Soleris System, Mingyang Huang

Wayne State University Theses

ABSTRACT

SCREENING OF NATURAL ANTIMICROBIAL AGENTS AND ANTIMICROBIAL - RESISTANT BACTERIA USING A SOLERIS SYSTEM

by

MINGYANG HUANG

May 2014

Advisor: Dr. Yifan Zhang

Major: Food Science and Nutrition

Degree: Master of Science

Traditional broth micro-dilution method is a common assay of measuring Minimum Inhibitory Concentration (MIC) to determine the antimicrobial activity of an antimicrobial agent. However, this method is generally time-consuming and labor intensive. Alternatively, an automated optical method using the Soleris system was applied in this study. The system was compared to the traditional broth micro-dilution 96-well assay to test the antimicrobial activity of 11 essential oils and …

Antimicrobial Activity Of Essential Oil Emulsions And Possible Synergistic Effect On Food Borne Pathogens, Varun Tahlan

Wayne State University Theses

The objective of this study was to evaluate the antimicrobial activity of essential oil emulsions against food borne pathogenic bacteria and determine potential applications. The oils used for this study were cinnamon, oregano, clove, thyme, rosemary, sage, bergamot, nutmeg, lemon grass and bay. Oil in water emulsions were prepared using Tween 80 as an emulsifying agent, with a stock oil concentration in the emulsions of 20,000 ppm. Essential oil emulsions were individually screened against E. coli (ATCC 25922), E. coli (ATCC 700927), L. monocytogens (ATCC 19115), L. innocua (ATCC 33090) and S. Typhimurium (ATCC 19585) using the broth micro dilution …

Approaches To Improving Detection Of Invasive Fish Species In Western Lake Erie Through Analysis Of Monitoring Efficiencies And Metrics Of Community Distribution, Joshua Alan Southern

Wayne State University Theses

Efficient monitoring programs are essential for the early detection of invasive species. The Ohio Department of Natural Resources (ODNR) monitoring program encompassing 21 years of fish survey data from western Lake Erie was evaluated using Chao biodiversity analysis to determine the efficiency and precision of collection strategies of trawl and gillnet sampling, at detecting rare or non-native species. Overall, ODNR sampling annually accounted for ~80% of extant fish species, leaving gaps in coverage where rare and invasive species may be overlooked and proliferate.Obtaining 90% efficiency would require an estimated doubling of previous sampling effort. Computer simulations calculating different proportions of …

Bacteriophage Isolated From The Environment And E. Coli Of Meat Origin As A Reservoir Of Antibiotic Resistance, Manisha Polur

Wayne State University Theses

ABSTRACT

BACTERIOPHAGE ISOLATED FROM THE ENVIRONMENT AND E. COLI OF MEAT ORIGIN AS A RESERVOIR OF ANTIBIOTIC RESISTANCE

by

MANISHA POLUR

April 2014

Advisor: Dr. Yifan Zhang

Major: Nutrition and Food Science

Degree: Master of Science

This study was aimed to determine the extent of antibiotic resistance reservoir in bacteriophage. Bacteriophages were isolated and purified from waste water treatment plants, Detroit river, Belle Isle, Urban Garden soils and examined for the presence of beta-lactam antibiotic resistance genes. Thirty E. coli isolates from retail meat were analyzed for the presence of beta-lactam antibiotic resistance genes. 95% of E. coli them carried …

Contextualized Extraversion And Its Change In Cross-Cultural Adjustment, Mengqiao Liu

Wayne State University Theses

Bridging recent developments in personality changes and contextualized personality, the current research focuses on changes in contextualized personality and their impact on cross-cultural adjustment. Findings revealed that contextualized Extraversion provided incremental validity in predicting context-related outcomes (i.e., cross-cultural adjustment) above and beyond global Extraversion. Although no significant changes were revealed regarding contextualized Extraversion, individual characteristics (i.e., cultural flexibility and cross-cultural motivation) negatively predicted individual differences in the rate of contextualized Extraversion changes. Implications and limitations were discussed.

Development And Evaluation Of Plga-S-S-Peg Micelles Coencapsulating Curcumin Difluorinated And Paclitaxel For Synergistic Therapeutic Efficacy, Lakshmi Deepika Cheemalakonda

Wayne State University Theses

ABSTRACT

DEVELOPMENT AND EVALUATION OF PLGA-S-S-PEG MICELLES COENCAPSULATING CURCUMIN DIFLUORINATED AND PACLITAXEL FOR SYNERGISTIC THERAPEUTIC EFFICACY

by

LAKSHMI DEEPIKA CHEEMALAKONDA

August 2014

Advisor: Dr. Joshua Reineke Major: Pharmaceutical Sciences Degree: Master of Science

Solid tumors like pancreatic tumor has unique property of forming a dense desmoplastic layer around the tumor cells making it difficult for the drug to transport across this layer. Multi drug resistance is also one of the major limitation of chemotherapy. Therefore the aim of this project was to make PLGA-SS-PEG micelles encapsulating CDF and paclitaxel for synergistic cancer therapy. CDF was found to have 16-fold better …

The Rna Newton Polytope And Learnability Of Energy Parameters, Elmirasadat Forouzmand

Wayne State University Theses

Computational RNA secondary structure prediction has been a topic of much research interest for several decades now. Despite all the progress made in the field, even the state-of-the-art algorithms do not provide satisfying results, and the accuracy of output is limited for all the existent tools. Very complex energy models, different parameter estimation methods, and recent machine learning approaches had not been the answer for this problem. We believe that the first step to achieve results with high quality is to use the energy model with the potential for predicting accurate output. Hence, it is necessary to have a systematic …

A Decision Modeling For Phasor Measurement Unit Location Selection In Smart Grid Systems, Seung Yup Lee

Wayne State University Theses

As a key technology for enhancing the smart grid system, Phasor Measurement Unit (PMU) provides synchronized phasor measurements of voltages and currents of wide-area electric power grid. With various benefits from its application, one of the critical issues in utilizing PMUs is the optimal site selection of units.

The main aim of this research is to develop a decision support system, which can be used in resource allocation task for smart grid system analysis. As an effort to suggest a robust decision model and standardize the decision modeling process, a harmonized modeling framework, which considers operational circumstances of component, is …

In Vitro Characterization Of Serine 47 Phosphorylated Cytochrome C, Ashwathy Mary Varughese

Wayne State University Theses

Cytochrome c is a 12.4kDa ubiquitously expressed protein known to be involved in many physiological processes of the cell such as respiration and apoptosis. The goal of our lab is to increase our knowledge of the regulation of cytochrome c in these opposite activities, and our working model posits that cytochrome c is decisively regulated by phosphorylation. When phosphorylated, cytochrome c leads to an "optimal" functioning in the electron transport chain by lowering electron flux, preventing harmful high mitochondrial membrane potentials and thus ROS production under healthy conditions. However, under cellular stress cytochrome c might be dephosphorylated favoring high mitochondrial …

Functional Studies Of 5-Carboxyaminoimidazole Ribonucleotide Synthetase And Mutase From Thermotoga Maritima, Mingyang Zhao

Wayne State University Theses

De novo purine biosynthesis is divergent depending upon the organism. In bacteria, yeasts and plants, 5-aminoimidazole ribonucleotide (AIR) is converted to 4-carboxyaminoimidazole ribonucleotide (CAIR) by N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) synthetase (PurK) and N5-CAIR mutase (Class I PurE). In animals, AIR is converted into CAIR by AIR carboxylase (Class II PurE). The distinction makes PurK and Class I PurE good targets in design of antimicrobial drugs. N5-CAIR is chemically unstable with t1/2 of about 0.9 minutes at pH 7.8 and 37 °C. If the production of N5-CAIR is not regulated relative to its conversion to CAIR, ATP utilization can rapidly become non-stoichiometric. …

Effect Of Folate Deficiency On Mtor Signaling Network On The Liver Of Wild Type Mice, Essra Moussawi

Wayne State University Theses

Through various studies of dietary nutrients on the affects of the physiological and molecular pathways are a key study in understanding the interaction between dietary nutrients and the human genome that may severely impact the development of various cancers. A primary approach is observing the dietary nutrients, that we consume and how it plays a role in the cellular pathway of our bodies through experimental methods. Folate deficiency (FD) has shown, through studies, to play a role anti-cancer progression. Our goal was to observe the autophagy related proteins in the mTOR signaling pathway as it was suggested that mTOR may …

Proteomic Discovery Of Protein Phosphatase 1 Catalytic Subunit Protein Interaction Partners In Human Skeletal Muscle, Zhao Yang

Wayne State University Theses

Protein Phosphatase 1 (PP1), a member of Serine/ Threonine Phosphatase family, targets its dephosphorylation activity on serine and threonine residues. As the catalytic subunit of PP1, PP1c can achieve its substrate specificity only by binding with PP1 regulatory subunits. Previous researches have shown that PP1c can involve in multiple functional regulation by associating with various interaction partners. Since serine/ threonine phosphorylation on the Insulin receptor substrate-1 (IRS1) may direct inactivation and degradation of IRS1, this phosphorylation activity is believed to be a source of Insulin Resistance. PP1 is hypothesized to dephosphorylate serine/ threonine site on IRS1, which may rescue the …

Effect Of Long Term Rapamycin Treatment On Mtor Signalling Network In Colon And Liver Of C57bl/6 Mice, John Sorge

Wayne State University Theses

Many studies have investigated the effects of rapamycin on aging and cancer. However, the effects of long-term rapamycin supplementation on a cancer model have not been performed. This is the first study that investigates the effects of long-term supplementation of rapamycin in a cancer model. ACF analysis of colon tissues in mice showed no significant difference between controls and those supplemented with rapamycin. Factors such as energy balance, cellular environment, PI3K/Akt/mTOR pathway, and more have been assessed in this study. The duration of rapamycin supplementation seems to play an important role in the protection against cancer. Ultimately, this study suggests …

The Effect Of Gaba A Antagonism On Locomotor Activity And Dopamine Release In The Mouse Caudate Putamen Following Acute Toluene Inhalation: An In-Vivo Microdialysis Study, Sean Callan

Wayne State University Theses

Toluene is ubiquitous solvent commonly inhaled recreationally. Despite its frequency of misuse, there is little understanding of how toluene acts within the brain. To examine this, this master's thesis examined the impact of acutely inhaled toluene on dopamine (DA) release in the mouse CPu in vivo using microdialysis techniques. Toluene inhalation produced dose-dependent increases in DA levels as well as changes in locomotor activity. These effects were potentiated by pre-treatment with the GABAA antagonist bicuculline via reverse microdialysis delivery. These results suggest that the DA dynamics of toluene abuse are related to toluene's previously explored effects on the GABA system. …

Effect Of Construction Worker Demographic On E-Learning With Hazard Communication Standard, Serhan Kaya

Wayne State University Theses

Construction safety and health training can be delivered by different training methods, such as traditional, online and blended learning. E-learning is a newly introduced method whose effectiveness is still being investigated. This study focuses on the effect of construction worker demographics on the effectiveness of e-learning. The univariate analysis technique was used to find out the distribution and frequency of data collected by an internet based system. Further, multivariate analysis (cross tabulation) and analysis of variance (ANOVA) were performed to determine the association between the independent variables which are age, gender, ethnic background, union status, number of employees in the …

Synthesis And Characterization Of Brain Penetrant Prodrug Of Neuroprotective D264: Potential Disease Modifying Treatment Agent For Parkinson's Disease, Fahd Shamoon Dholkawala

Wayne State University Theses

Parkinson's disease (PD) is a complex neurodegenerative disorder with progressive loss of dopamanergic neurons in the substantia nigra region of the brain and accumulation of intracytoplasmic inclusions called `Lewy bodies'. PD is characterized by tremors, rigidity, slowness of movement, bradykinesia and postural imbalances. Although the etiology of PD is not well understood, it is well established that oxidative stress, mitochondrial dysfunction, alpha-synuclein aggregation play a central role in the pathogenesis of PD. Current treatment methods are based on symptomatic relief without addressing the underlying pathophysiological factors responsible for the disease. It is important to develop therapies which can address these …

Animal-Assisted Therapy For Incarcerated Youth: A Randomized-Controlled Trial, Nicholas P. Seivert

Wayne State University Theses

This study is a randomized-controlled trial of a specific animal-assisted therapy (AAT) called Teacher's Pet (TP) with incarcerated youth. The intervention was expected to result in increased empathy and reduced internalizing and externalizing behavior problems as compared to the control. Dog attachment was theorized to be the mechanism for the increased empathy and reduced behavior problems. In addition, due to the attachment-based nature of the intervention, it was hypothesized that those with a history maltreatment/foster care would benefit the most. Participants were138 youth at two Midwestern juvenile detention facilities. The TP intervention trained dogs for one hour, twice weekly for …

Effect Of Folate Deficiency On Expression Of Proteins On The Mtor Signaling Pathway In The Brain Of C57/Bl6 Mice, Nikita Patel

Wayne State University Theses

ABSTRACT

EFFECT OF FOLATE DEFICIENCY ON EXPRESSION OF PROTEINS ON THE mTOR SIGNALING PATHWAY IN THE BRAIN OF C57/BL6 MICE

by

NIKITA PATEL

December 2014

Advisor: Dr. Ahmad Heydari

Major: Nutrition and Food Science

Degree: Master of Science

Nutrient-gene interactions can significantly impact several cellular processes in the human body by altering important molecular pathways. Nutrition can affect brain structure, function and development throughout the life cycle; it can have a profound effect on cognition ad mental health leading to neurodegenerative diseases. It is important to elucidate the mechanisms by which diet can effect signaling pathways in the brain. The …