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Preventive Transparency In Third-Party Litigation Funding, Seth Katsuya Endo Nov 2025

Preventive Transparency In Third-Party Litigation Funding, Seth Katsuya Endo

Northwestern University Law Review

For years, efforts to comprehensively regulate third-party litigation funding have been unsuccessful. But bills requiring mandatory disclosure are being introduced in Congress, and the Advisory Committee for Civil Rules has finally agreed to take up the issue. By grounding the discussion of third-party litigation funding in both the broader civil procedure and professional responsibility scholarship, this Article identifies an easy, uncontroversial reform to preventively address the categorical concerns raised by the practice. The primary contribution is a doctrinal intervention, identifying how legal ethics are an integral part of federal civil procedure and then drawing out the implications for third-party litigation …

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Microplastic Variability In Wetland Sediments And Vegetation: A Case Study Of Spruce Bluff Preserve, Fl, Juana Maria Baudrix Nov 2025

Microplastic Variability In Wetland Sediments And Vegetation: A Case Study Of Spruce Bluff Preserve, Fl, Juana Maria Baudrix

Electronic Theses and Dissertations

Plastic pollution has become an imminent threat to the environment and human health. This study explores the occurrence, distribution, and retention mechanisms of microplastics (MPs) in Spruce Bluff Preserve, a 97-acre freshwater wetland ecosystem located along the eastern bank of the St. Lucie River in Port St. Lucie, FL. Understanding MP dynamics in transitional freshwater ecosystem is crucial for environmental management efforts given Florida’s heavily fragmented and managed landscape. This research specifically examined the relationship between wetland vegetation and MP retention in sediments across different ecological zones within the preserve. Surface sediment samples were collected along 8 transects of varying …

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Data For Fermentation Research Guide Analysis, Laura Guengerich Nov 2025

Data For Fermentation Research Guide Analysis, Laura Guengerich

Morris Library Data Sets

No abstract provided.

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Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3., Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner Nov 2025

Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3., Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner

Faculty Research 2025

Genomic studies of neurodevelopmental disorders (NDDs) have identified several relevant genomic variants. EBF3 is a gene with an excess of protein-coding de novo variants and underlies Hypotonia, Ataxia, and Delayed Development Syndrome. We previously identified noncoding de novo variants in an enhancer of EBF3 and further found enrichment of deletions of this enhancer in NDDs. In this study, we generated a novel mouse line that deletes the highly conserved, orthologous mouse region within the Rr169617 regulatory region, and characterized the molecular and phenotypic aspects of this mouse model. We found a deviation from Mendelian expectation (P=0.02) with significant depletion of …

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Exploring The Effectiveness Of Virtual Reality Learning Through Use Of Visual Eye-Tracking Analytics (Veta) And Biological Measurements, Mckinley Anne Sherman Nov 2025

Exploring The Effectiveness Of Virtual Reality Learning Through Use Of Visual Eye-Tracking Analytics (Veta) And Biological Measurements, Mckinley Anne Sherman

Master's Theses

Virtual Reality (VR) offers an immersive and interactive platform for experiential learning. The purpose of this thesis was to evaluate the relationship between physiological responses and cognitive workload within a VR learning environment and to explore VR as an effective instructional tool. This research compared participant engagement, stress, and learning performance within a 6th-grade science module developed in VR by incorporating biometric data collected via Polar H10 heart rate monitor and Varjo Areo VR headset eye-tracking. Thirty-three participants completed a pre-lesson demographic survey, post-lesson survey, VR sickness questionnaire, and the NASA Task Load Index (NASA-TLX). While completing the lesson, the …

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Antimicrobial Resistance And Transmission Risk Of Foodborne Escherichia Coli In Wet Markets, Sisi Li, Wei Zhou, Zhijin Zhou, Bin Wang, Chengjun Qiu, Zhangsheng Zhang, Qi Zhang, Yun Sun, Xu Xu, Tao Shen, Jianzhong Han, Daofeng Qu Nov 2025

Antimicrobial Resistance And Transmission Risk Of Foodborne Escherichia Coli In Wet Markets, Sisi Li, Wei Zhou, Zhijin Zhou, Bin Wang, Chengjun Qiu, Zhangsheng Zhang, Qi Zhang, Yun Sun, Xu Xu, Tao Shen, Jianzhong Han, Daofeng Qu

Journal of Food Science and Biotechnology

[Objective ] To evaluate the antimicrobial resistance and transmission risk of foodborne Escherichia coli in wet markets,this study isolated E.coli from pork,aquatic products,vegetables,and wastewater collected from three wet markets in Hangzhou,Zhejiang.[Method ] The isolates were identified by 16S rRNA sequencing,and their antimicrobial resistance phenotypes were determined via the disk diffusion method.PCR was employed to detect antimicrobial resistance genes and integrons in the isolates.The antimicrobial resistance characteristics of E.coli were analyzed,and conjugation experiments were performed to assess the potential for horizontal transfer of antimicrobial resistance genes.Co-occurrence network analysis was conducted to evaluate the transmission risk of antimicrobial resistance among the isolates.[Result …

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Establishment Of A Molecularly Imprinted Electrochemical Sensor Nh 2-Mwcnts@ 4-Fpba For The Detection Of Epidermal Growth Factor In Dairy Products, Ruyue Zhang, Yiwei Wang, Hongxiu Zeng, Bini Wang, Fuxin Zhang, Zhenquan Huo, Yufang Liu Nov 2025

Establishment Of A Molecularly Imprinted Electrochemical Sensor Nh 2-Mwcnts@ 4-Fpba For The Detection Of Epidermal Growth Factor In Dairy Products, Ruyue Zhang, Yiwei Wang, Hongxiu Zeng, Bini Wang, Fuxin Zhang, Zhenquan Huo, Yufang Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims to develop a rapid and accurate method for detecting epidermal growth factor (EGF ).[Method ] 4-Formylphenylboronic acid (4-FPBA ) was covalently anchored to the surface of aminocarbon nanotubes (NH 2-MWCNTs ) to synthesize nanocomposites (NH 2-MWCNTs@ 4-FPBA ),and NH 2-MWCNTs@ 4-FPBA was modified on a glassy carbon electrode.When EGF was present,4-FPBA captured the EGF template through benzaldehyde,and then the electrode was immersed in pyrrole solution to electropolymerize to form a pyrrole molecularly imprinted layer.Finally,after dissociation and removal of the EGF template in an acidic solution,a three-dimensional cavity complementary to the EGF template was formed.[Result ] …

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Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao Nov 2025

Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao

Journal of Food Science and Biotechnology

[Objective ] This study aims to increase the caproic acid yield of Aneurinibacillus JXN- 1.[Method ] First,a Plackett-Burman design was employed to screen the significant factors affecting caproic acid yield from eight medium components.Subsequently,the path of steepest ascent method was used to determine the optimal concentration ranges of these significant factors.Finally,a Box-Behnken design was utilized to establish a quadratic polynomial regression model,and the interactions among the significant factors were analyzed to predict the optimal medium composition.[Result ] The Plackett-Burman design identified the mass concentration s of sodium acetate and calcium folinate and the volume fraction of ethanol as significant influencing …

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A Stability-Indicating Validated Rp-Hplc Method For The Determination Of Etoricoxib And It’S Degradants: Investigation Of Greenness And Functionality Of The Developed Method, Lama Ghazal, Iyad Allous, Mhd Amer Almardini Nov 2025

A Stability-Indicating Validated Rp-Hplc Method For The Determination Of Etoricoxib And It’S Degradants: Investigation Of Greenness And Functionality Of The Developed Method, Lama Ghazal, Iyad Allous, Mhd Amer Almardini

Baghdad Science Journal

Etoricoxib is a novel NSAID that belongs to selective COX-2 inhibitors. The aim of this research is to develop a precise, selective, cost-effective, and validated HPLC analytical method for the quantitative determination of Etoricoxib and its degradants. The analysis was implemented on a C18 column (150 × 4.6 mm, 5 μm particle size) using a mobile phase containing methanol and ammonium acetate (60:40) at a flow rate of 0.9 mL/min, with the Photodiode Array detector wavelength set at 234 nm. The method was validated according to USP43-NF38 guidelines and the International Conference on Harmonization recommendations. Linearity was established with …

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The Rs1611770 Snp Polymorphism And Expression Of Mucin One Gene In Infertile Females In Baghdad, Iman Hamed Diab Al-Janabi, Asmaa M. Salih Almohaidi, Ibrahim Jasim Hammadi Al-Janabi Nov 2025

The Rs1611770 Snp Polymorphism And Expression Of Mucin One Gene In Infertile Females In Baghdad, Iman Hamed Diab Al-Janabi, Asmaa M. Salih Almohaidi, Ibrahim Jasim Hammadi Al-Janabi

Baghdad Science Journal

Infertility is the inability to become pregnant after six months or more of consistent, unprotected sexual activity. There are several causes of infertility, including hormonal, genetic, and environmental factors. The current investigation focuses on the polymorphism of SNP rs 1611770 in Mucin one gene and expression in infertility, considering a few demographic variables including age, body mass index and circumference of the abdomen. The current study included 30 infertile females and 30 fertile females. The mean BMI recorded Significant differences 28.76 ± 0.85 for infertile and 25.99 ± 0.65 for fertile, There are no significant differences in age and abdominal …

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Alirocumab In Dexamethasone-Induced Metabolic Syndrome: Therapeutic Benefits And Potential Hepatic Risks Through Rxr-Α / P-Akt Modulation, Miad A. Aljuhani, Mohamed S. Abdel-Bakky Nov 2025

Alirocumab In Dexamethasone-Induced Metabolic Syndrome: Therapeutic Benefits And Potential Hepatic Risks Through Rxr-Α / P-Akt Modulation, Miad A. Aljuhani, Mohamed S. Abdel-Bakky

Saudi Toxicology Journal

Background: Metabolic syndrome (MetS) elevates the risk of developing cardi-ovascular diseases and type 2 diabetes., driven by insulin resistance (IR), inflammation, and metabolic dysregulation. The PI3K/AKT pathway shows a key part in glucose and lipid metabolism. Alirocumab, a PCSK9 inhibitor, lowers LDL-C and improves IR but may cause hepatotoxicity. Aims: This study examines ali-rocumab’s effects on dexamethasone-induced MetS in rats, focusing on its metabolic benefits and potential liver toxicity. Methods: Over 30 days, 40 male Albino rats were distributed into control, Alirocumab, Dexamethasone, and Dexa-methasone+Alirocumab groups, with the latter receiving Dexamethasone to induce metabolic syndrome followed by Alirocumab administration. Results: …

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Real-World Evidence For Herbal Medicine Benefit In 9728 Type 2 Diabetes Patients-Peridonotitis Risk And Ambulatory Care Utilization., Wen-Wei Lin, Chieh-Tsung Yen, Hanoch Livneh, Hua-Lung Huang, Ming-Chi Lu, Wei-Jen Chen, Tzung-Yi Tsai Nov 2025

Real-World Evidence For Herbal Medicine Benefit In 9728 Type 2 Diabetes Patients-Peridonotitis Risk And Ambulatory Care Utilization., Wen-Wei Lin, Chieh-Tsung Yen, Hanoch Livneh, Hua-Lung Huang, Ming-Chi Lu, Wei-Jen Chen, Tzung-Yi Tsai

Leadership, Learning and Counseling Faculty Publications and Presentations

Recent evidence manifests that individuals with type 2 diabetes (T2D) are increasingly affected by oral disorders. Although medicinal herbs have shown promise in managing T2D, their benefit in managing periodontitis risk and subsequent healthcare utilization remains uncertain.

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Fetal Microchimerism Of The Eye Lens, Jamie Moubarak Nov 2025

Fetal Microchimerism Of The Eye Lens, Jamie Moubarak

Electronic Theses and Dissertations

Fetal microchimerism (FMc) is the presence of a small fetal cell population in the mother, sometimes exhibiting stem cell–like properties. FMc has been observed within many placental mammal organs, except the eye. We used Yspecific PCR on genomic mouse DNA to test the hypothesis that fetal microchimerism can also be found in the lens. Of the parous females tested, we detected an Ssty2-specific amplicon in 83% (5/6) of samples and an Sry-specific amplicon in 2/4 samples. 100% (5/5) of non-age-matched parous females were positive for both primers. These results provide evidence that cells of fetal or placental origin …

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Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner Nov 2025

Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner

2020-Current year OA Pubs

Genomic studies of neurodevelopmental disorders (NDDs) have identified several relevant genomic variants. EBF3 is a gene with an excess of protein-coding de novo variants and underlies Hypotonia, Ataxia, and Delayed Development Syndrome. We previously identified noncoding de novo variants in an enhancer of EBF3 and further found enrichment of deletions of this enhancer in NDDs. In this study, we generated a novel mouse line that deletes the highly conserved, orthologous mouse region within the Rr169617 regulatory region, and characterized the molecular and phenotypic aspects of this mouse model. We found a deviation from Mendelian expectation (P=0.02) with significant depletion of …

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The Impact Of Arginase1, Malondialdehyde Levels And The Activity Of Glutathione S-Transferase On The Development And Progression Of Diabetic Retinopathy In Some Iraqi Patients, Maha Faris Yaseen, Fayhaa M. Khaleel Nov 2025

The Impact Of Arginase1, Malondialdehyde Levels And The Activity Of Glutathione S-Transferase On The Development And Progression Of Diabetic Retinopathy In Some Iraqi Patients, Maha Faris Yaseen, Fayhaa M. Khaleel

Baghdad Science Journal

Diabetic retinopathy (DR) is the major cause of blindness due to microvascular damage from high blood glucose and lipid levels. Arginase1 is an enzyme that regulates β-cell activities, insulin resistance, and vascular complications, inflammatory responses, and oxidative stress. This study aimesto investigate the role of Arginase1 in Iraqi individuals with obesity, T2DM and DR and investigating the relationship with GST and MDA in the development of inflammation and oxidative stress that causes diabetic complication. This research included 120 participants: 40 obese controls, 40 diabetes Type 2 patients, and 40 diabetic retinopathy patients, aged 30–65, from both sexes. All groups …

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A Study Of Dipeptidyl Peptidase-4 In Iraqi Patients With Coronary Artery Disease, Saja Taha Yissen, Layla Othman Farhan Nov 2025

A Study Of Dipeptidyl Peptidase-4 In Iraqi Patients With Coronary Artery Disease, Saja Taha Yissen, Layla Othman Farhan

Baghdad Science Journal

Heart and blood vessel illnesses are collectively referred to as cardiovascular diseases (CVD). Although there is, till now, no known cure for the deadly disease known as CAD, it is extremely predictable, treatable, and preventative. Dipeptidyl peptidase 4 (DPP4) is a single-pass transmembrane protein that regulates glucose levels and has several roles in the immune system, cell migration and proliferation, and other areas. The purpose of the study is to measure the DPP 4 levels in the sera of Iraqi patients with CAD. The DPP4 was measured in Iraqi patients' serum in the current investigation to evaluate, which included forty …

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Synthesis, Characterization And Biological Activity Studies Of New Metal Ion Complexes With Schiff Base Derived From (Z)-3-Hydrazineylidene-1-Phenylpyrazolidine And Evaluating Them As Antioxidants, Zahra Mounir Ahmed, Naser Shaalan Nov 2025

Synthesis, Characterization And Biological Activity Studies Of New Metal Ion Complexes With Schiff Base Derived From (Z)-3-Hydrazineylidene-1-Phenylpyrazolidine And Evaluating Them As Antioxidants, Zahra Mounir Ahmed, Naser Shaalan

Baghdad Science Journal

The research includes the preparation of several complexes of the transition elements and zinc where M(II) = Co, Ni, Cu, and Zn, containing the 3d shell, with ligand (LH)was synthesized by treating the (Z)-3-hydrazineylidene-1-phenylpyrazolidine and Salicylaldehyde. Ligand (LH) was identified using FT-IR spectra,1H-13C-NMR, UV-Vis spectroscopy, elemental microanalysis CHN and mass spectrometry. The complexes were studied and identified with elemental microanalysis CHN, FT-IR spectroscopy, UV-Vis spectroscopy, conductivity measurement, and magnetic sensitivity. The result showed that, these complexes were classified as homogeneous tridentate complexes with the formula [M(LH) (H2O)2Cl] or [M(LH)2]. xH …

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Studying The Corrosion Inhibition Ability Of Metoclopramide Drug On The Copper Surface In Seawater And Theoretical Studies, Nafeesa J. Kadhim, Ahlam M. Farhan, Rasha A. Jassim, Muna S. Sando, Hawraa M. Abdulkareem, Taghried A. Salman Nov 2025

Studying The Corrosion Inhibition Ability Of Metoclopramide Drug On The Copper Surface In Seawater And Theoretical Studies, Nafeesa J. Kadhim, Ahlam M. Farhan, Rasha A. Jassim, Muna S. Sando, Hawraa M. Abdulkareem, Taghried A. Salman

Baghdad Science Journal

Protection study of the corrosion behavior of Copper surface was conducted with several concentrations of drug. Experimentally, voltammetric measurements were used to check the inhibition efficiency (% IE) in saline solution of 3.5% NaCl. The results showed an increase in the inhibition efficiency with increasing the concentration of the drug was 95.90%. Theoretical treatment of the drug in the gas phase was performed using the (hyperchem-8.07) program for molecular mechanics and semi-empirical computations. The (PM3) approach was used to determine the heat of formation (ΔH˚f), binding energy (ΔEb), and total energy (ET) for durq at 298 K. To explore the …

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Determination Of Ni (Ii) By Forming A New Complex N-(4-(Dimethyl Amino) Benzylidene)-3, 5-Dinitrobenzohydrazide Nickel (Ii) Chloride, Elham N. Mezaal, Kawther Ahmed Sadiq, Maha A. Mohammed Nov 2025

Determination Of Ni (Ii) By Forming A New Complex N-(4-(Dimethyl Amino) Benzylidene)-3, 5-Dinitrobenzohydrazide Nickel (Ii) Chloride, Elham N. Mezaal, Kawther Ahmed Sadiq, Maha A. Mohammed

Baghdad Science Journal

In this research, the theme for employing a simple and sensitive method is to employ a new Schiff base ligand (N'-(4-(dimethyl amino) benzylidene)-3, 5-dinitrobenzohydrazide) to estimate Ni (II) to form orange complex (N-(4-(dimethyl amino) benzylidene)-3, 5-dinitrobenzohydrazide nickel (II) chloride) in acid medium (hydrochloric acid), it gives an absorption peak at the wavelength 485 nm. The preferred conditions were studied to form the complex and obtain the highest absorbance including concentration of Schiff base ligand, the best medium for complex formation, effects of addition sequence on complex formation, the effect of temperature on the absorbance of the complex formed, and the …

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Preparation, Diagnosis, Theoretical Study, Biological Evaluation And Antioxidant Assay Of Zro2 Oxide Nanoparticles Using Environmentally Friendly Method, Wafaa Fayyad Tharp, Lekaa K. Abdul Karem Nov 2025

Preparation, Diagnosis, Theoretical Study, Biological Evaluation And Antioxidant Assay Of Zro2 Oxide Nanoparticles Using Environmentally Friendly Method, Wafaa Fayyad Tharp, Lekaa K. Abdul Karem

Baghdad Science Journal

This research included using an environmentally friendly method to synthesize nano particles of zirconium oxide using chamomile plant extract as a reducing agent in basic medium at pH 12, and then preparing the metal oxide using various techniques such as FTIR spectroscopy, scanning and transmission electron microscopy (SEM and TEM), energy-dispersive X-ray spectroscopy (EDX) to calculate the percentages of elements. The infrared spectrum showed the appearance of spectral bands at 559 and 441 cm–1 due to the formation of the bond between the oxygen and zirconium. Depending on AFM analysis, the average mean size of ZrO2 Nano partials …

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Spectrophotometric And Flow Injection System For Sensitive Determination Of Hesperidin And Naringenin Using Chromogenic Reagent, Ali M. Salman, Sadeem Subhi Abed Nov 2025

Spectrophotometric And Flow Injection System For Sensitive Determination Of Hesperidin And Naringenin Using Chromogenic Reagent, Ali M. Salman, Sadeem Subhi Abed

Baghdad Science Journal

Methods with high precision and sensitivity have been developed to estimate Hesperiden (HSP) and Naringenin (NAR) levels in various samples, including capsules for medicines and urine. These techniques utilize a flow injection device and an alkaline medium to perform a coupling reaction using diazotized metoclopramide (DMP) as chromogenic reagent. The utilization of the diazotized reagent of metoclopramide is regarded as an environmentally friendly chromogenic reagent. The peak absorption wavelengths for HSP and NAR are 442 nm and 416 nm, respectively, indicating that yellow dyes exhibit the most outstanding absorption at these specific wavelengths. Calibration curves were generated using a range …

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Preparation, Characterization, And Evaluation Of The Antioxidant Activity Of Chitosan Nano-Particles, Sura M. Abbood, Zahraa Raheem Murshidy, Aziz Y. H. Al-Ethari Nov 2025

Preparation, Characterization, And Evaluation Of The Antioxidant Activity Of Chitosan Nano-Particles, Sura M. Abbood, Zahraa Raheem Murshidy, Aziz Y. H. Al-Ethari

Baghdad Science Journal

Nanotechnology is considered as a modern technique which provides useful characteristics to the nanomaterial including small size with high biological activity and the possibility to obtain novel nano-biohybrids through combining efficient and safe transport carriers with biological molecules. The nanohybrid chitosan has important applications in the food industry, due to its biochemical properties, such as biocompatibility, biodegradability, non-toxicity. The goal of this research is to develop environmentally friendly, economically feasible and a simple prepared natural nanohybrid antioxidant instead of artificial one, which is a main characteristic on a food industrial scale. The sol-gel ion exchange method was used to prepare …

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Mechanism Of Immunotherapeutic And Anticancer Effects Of Moringa Peregrina Seed Extract On Non-Small-Lung Cancer, Nci-H460, Cell Line, Shaymaa Fadhel Abbas Albaayit, Maryam Kamel Mohammed, Ali Muhsin Ali, Rukesh Maharjan, Lubna M. Rasoul, Rasedee Abdullah, Mohd Hezmee Mohd Noor Nov 2025

Mechanism Of Immunotherapeutic And Anticancer Effects Of Moringa Peregrina Seed Extract On Non-Small-Lung Cancer, Nci-H460, Cell Line, Shaymaa Fadhel Abbas Albaayit, Maryam Kamel Mohammed, Ali Muhsin Ali, Rukesh Maharjan, Lubna M. Rasoul, Rasedee Abdullah, Mohd Hezmee Mohd Noor

Baghdad Science Journal

The Moringa peregrina plant possesses various therapeutic properties. This study determined the immunomodulatory and cytotoxic activities of M. peregrina seed ethanol extract (MPSE). Based on using gas chromatography-mass spectrometry analysis MPSE is rich in flavonoids, isothiocyanate, tocopherols, triterpenoids, and phenolics compounds. The immunomodulatory effect of MPSE was determined on whole blood and polymorphonuclear (PMNs) cells and macrophages. The in vitro antiproliferative effect was determined on the non-small-cell lung cancer, NCI-H460, cell line. Real-time quantitative PCR and flow cytometry were used to determine the expression of apoptotic genes in the MPSE-treated NCI-H460 cells. MPSE significantly (p < 0.001) suppressed whole blood, PMN cells and macrophage ROS production with IC50 values of 40.3 ± 0.3, 33.0 ± 0.6, and 26.1 ± 0.43 μg/mL, respectively. MPSE …

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Study The Effect Of Pseudomonas Trivialis, Isolated From Soils Subjected To High Anthropogenic Pressure, On Plant Resistance To Salt Stress, Lyudmila I. Zaynitdinova, Nikolay A. Lazutin, Rokhila N. Juraeva, Rustam B. Ergashev, Javlon J. Tashpulatov, Natal’Ya G. Akinshina, Shokhsanam A. Safarova Nov 2025

Study The Effect Of Pseudomonas Trivialis, Isolated From Soils Subjected To High Anthropogenic Pressure, On Plant Resistance To Salt Stress, Lyudmila I. Zaynitdinova, Nikolay A. Lazutin, Rokhila N. Juraeva, Rustam B. Ergashev, Javlon J. Tashpulatov, Natal’Ya G. Akinshina, Shokhsanam A. Safarova

Baghdad Science Journal

From soils exposed to anthropogenic load, a bacterial strain resistant to pollutants was isolated and characterized. The strain was identified as Pseudomonas trivialis 381 based on morphological, cultural, physiological and biochemical characteristics, as well as MALDI-TOF and 16S rRNA analysis. Its sequence was submitted to the NCBI GenBank (OR234684.1). Studies were conducted to evaluate the influence of the strain on seed germination and plant growth qualities. Laboratory studies have shown the stimulating effect of P. trvialis 381 on tomato seeds; seeds treated with the bacterial cultural liquid increased the energy of germination and seed germination to 100% (with the control …

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Isolation And Purification Of Phytosterols From Euphorbia Milii Plant Cultivated In Iraq By Phplc And Evaluation Of Anticancer Activity, Z. O. Salman, Bushra M.J. Alwash, E. J. Kadhim Nov 2025

Isolation And Purification Of Phytosterols From Euphorbia Milii Plant Cultivated In Iraq By Phplc And Evaluation Of Anticancer Activity, Z. O. Salman, Bushra M.J. Alwash, E. J. Kadhim

Baghdad Science Journal

Combined, plant sterols and stanols, substances structurally similar to cholesterol, are referred to as phytosterols. In plants, phytosterols serve the same purposes as cholesterol does in animals and people. This study’s primary goal was to compare two different cell line types to the extracted steroid and nano-steroid. PHPLC was used to isolate the novel steroid molecule from the Euphorbia milii plant in its pure form, and FT.IR was used to confirm its identity. The chemical had a retention time of 13.87. By using the chitosan-maleic complex process, nano-steroids were created. To evaluate produced nanoparticles, the Philips PW1730 XRD instrument was …

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In Vitro And In Vivo Evaluation Of Autochthonous Probiotics And Their Effects On The Mucosal Health Of Nile Tilapia (Oreochromis Niloticus), Sherilyn T. Abarra, Sahya Maulu, Sheu G. Odu-Onikosi, Taofik A. Momoh, Benjamin Eynon, Matthew Emery, Mark Rawling, Daniel L. Merrifield Nov 2025

In Vitro And In Vivo Evaluation Of Autochthonous Probiotics And Their Effects On The Mucosal Health Of Nile Tilapia (Oreochromis Niloticus), Sherilyn T. Abarra, Sahya Maulu, Sheu G. Odu-Onikosi, Taofik A. Momoh, Benjamin Eynon, Matthew Emery, Mark Rawling, Daniel L. Merrifield

School of Biological and Marine Sciences

The host microbiome is a promising source of probiotics for aquaculture species including Nile tilapia. In this study, the probiotic potential of autochthonous bacterial isolates from Nile tilapia and carp mid-intestines were screened in vitro. Two isolates (C61 and T70), closely related to Bacillus subtilis, exhibited antagonistic activity against multiple pathogen species and demonstrated multiple digestive enzyme activities. Their antagonistic activity in Aeromonas hydrophila assays remained even under simulated intestinal juice (SIJ) exposure. Subsequently, C61 (PT1) and T70 (PT2) were added to experimental diets at log 7 CFU/g of diet, and fed to Nile tilapia (5.32 ± 0.12 g) for …

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Artificial Light At Night Alters Seaweed Reproductive Phenology, Emma Moyse, Louise Firth, Tim Smyth, Thomas Davies Nov 2025

Artificial Light At Night Alters Seaweed Reproductive Phenology, Emma Moyse, Louise Firth, Tim Smyth, Thomas Davies

School of Biological and Marine Sciences

Artificial light at night (ALAN) is a growing, globally prevalent environmental stressor. It is known to disrupt biological processes across taxa and biomes, including reproductive phenology in terrestrial plants, but its potential to alter reproductive timings in marine macroalgae remains unexplored. We used reflectance spectrometry to quantitatively assess changes in receptacle ripeness of three fucoid macroalgae species at four field sites along an ALAN gradient in Plymouth Sound, UK over a six-month period. At sites with elevated ALAN (measured using Sky Quality Meters, range 16.15–18.76 mag arcsec −2, equivalent to 3.75 × 10 −2–3.38 × 10 −3 cd/m …

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Multisite Assembly Of Gateway Induced Clones (Magic): A Flexible Cloning Toolbox For Use In Vertebrate Model Systems, William B Gillespie, Yuwen Zhang, Oscar E Ruiz, Juan Cerda, Joshua Ortiz-Guzman, Michelle Sherman, Williamson D Turner, Gabrielle Largoza, Lili E Mosser, Esther Fujimoto, Chi-Bin Chien, Kristen M Kwan, Benjamin R Arenkiel, W Patrick Devine, Joshua D Wythe Nov 2025

Multisite Assembly Of Gateway Induced Clones (Magic): A Flexible Cloning Toolbox For Use In Vertebrate Model Systems, William B Gillespie, Yuwen Zhang, Oscar E Ruiz, Juan Cerda, Joshua Ortiz-Guzman, Michelle Sherman, Williamson D Turner, Gabrielle Largoza, Lili E Mosser, Esther Fujimoto, Chi-Bin Chien, Kristen M Kwan, Benjamin R Arenkiel, W Patrick Devine, Joshua D Wythe

Duncan NRI Faculty and Staff Publications

Here, we present MultiSite Assembly of Gateway Induced Clones (MAGIC), which leverages Gateway-based recombinatorial cloning technology for rapid, modular assembly of plasmids to facilitate transgenesis in cells and vertebrate animal models. The MAGIC collection of plasmids spans a range of in vitro and in vivo uses, from tools for optically and chemically tunable gene expression, to simultaneous expression of microRNAs and fluorescent reporters, to a suite of distinct subcellular compartmental fluorescent reporters, to Cre and Dre recombinase-dependent gene expression. MAGIC system components are compatible with existing MultiSite Gateway Tol2 systems currently used in zebrafish and mammalian lentiviral and adenoviral Destination …

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Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver, Xuan Qin, Si Chen, John M Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li Nov 2025

Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver, Xuan Qin, Si Chen, John M Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li

Faculty, Staff and Students Publications

Pexidartinib (PEX, TURALIO®), a tyrosine kinase inhibitor, is approved for treating tenosynovial giant cell tumor in adults. However, its potential to cause fatal liver injury has prompted the U.S. FDA to issue a black box warning, and the mechanisms underlying its hepatotoxicity remain largely unknown. As biotransformation may contribute to PEX-induced hepatotoxicity, understanding its metabolism is essential. Our previous research indicated that PEX forms reactive metabolites in human and mouse liver microsomes and in human hepatocytes. We investigated PEX metabolism and liver distribution in mice with a focus on metabolite characterization. Our data shows that PEX is mainly excreted into …

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Forecasting Pediatric Emergency Department Arrivals: Evaluating The Role Of Exogenous Variables Using Deep Learning Models, Egbe Etu Etu, Jordan Larot, Kindness Etu, Joshua Emakhu, Sara Masoud, Imokhai Tenebe, Gaojian Huang, Satheesh Gunaga, Joseph Miller Nov 2025

Forecasting Pediatric Emergency Department Arrivals: Evaluating The Role Of Exogenous Variables Using Deep Learning Models, Egbe Etu Etu, Jordan Larot, Kindness Etu, Joshua Emakhu, Sara Masoud, Imokhai Tenebe, Gaojian Huang, Satheesh Gunaga, Joseph Miller

Faculty Research, Scholarly, and Creative Activity

Background Forecasting pediatric emergency department (ED) demand remains a critical challenge in healthcare operations. This study aimed to identify exogenous variables influencing pediatric ED visits and evaluate the performance of different forecasting models. Method Using a retrospective observational design, we analyzed 192,347 pediatric ED visits across nine hospitals in Southeast Michigan between 2017 and 2019. Patient data were aggregated into daily arrival counts and enriched with exogenous variables such as weather, air quality, pollen, calendar, Google search trends, and chief complaints. Feature selection was performed using XGBoost and SHapley Additive exPlanations to identify the most influential predictors. Three forecasting models …

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