Digital Commons Network^™

The Legacy, November 16, 2014, Lindenwood University

The Legacy (2007-2018)

Student Newspaper of Lindenwood University

Therapeutic Targeting Of The Inflammome, Kyle T. Wright, Charles Giardina, Anthony T. Vella

UCHC Articles - Research

Inflammatory responses can vary depending on a myriad of factors including: 1) the initiating stimulus or trigger, 2) the cell types, involved in the response, and 3) the specific effector cytokine-chemokine milieus produced. The compilation of these and other factors in a given mechanistic context is sometimes referred to as the “inflammome”. Humans and other higher order mammals have evolved (over time) several discrete inflammomes to counter the effects of pathogens. However, when these inflammomes are induced inappropriately, they drive the development of chronic inflammatory diseases. The vast majority of biological anti-inflammatory treatments currently being developed are focused on the …

Cal Poly Mustang Mascot Name Honors Past President Margaret Chase, Public Affairs Office

Press Releases

No abstract provided.

Camk2n1 Inhibits Prostate Cancer Progression Through Androgen Receptor-Dependent Signaling., Tao Wang, Shuiming Guo, Zhuo Liu, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen, Xiaming Liu, Hua Xu, Shaoxin Cai, Hui Chen, Weiyong Li, Shaohua Xu, Liang Wang, Zhiquan Hu, Qianyuan Zhuang, Liping Wang, Kongming Wu, Jihong Liu, Zhangqun Ye, Jun-Yuan Ji, Chenguang Wang, Ke Chen

Department of Cancer Biology Faculty Papers

Castration resistance is a major obstacle to hormonal therapy for prostate cancer patients. Although androgen independence of prostate cancer growth is a known contributing factor to endocrine resistance, the mechanism of androgen receptor deregulation in endocrine resistance is still poorly understood. Herein, the CAMK2N1 was shown to contribute to the human prostate cancer cell growth and survival through AR-dependent signaling. Reduced expression of CAMK2N1 was correlated to recurrence-free survival of prostate cancer patients with high levels of AR expression in their tumor. CAMK2N1 and AR signaling form an auto-regulatory negative feedback loop: CAMK2N1 expression was down-regulated by AR activation; while …

Sbe Notícias, Ano 9, No. 306, November 15, 2014, Gabrielle Mazzetti, Delci K. Ishida

SBE Notícias

Proposta de Criação da Gruta da Tarimba Mambaí (GO) - SEE fecha parceria solidárias em Minas; Curso de Resgate em caverna é tema de formação de bombeiros em Minas Gerais; Concurso Internacional de Fotografia Bioespeleológica; A alma do Osso; Circuito Cachoeiras; Parque Nacional Gunung Mulu; - Especialização de Feições Cársticas da Formação Furnas; Mudança de Preços Petar; Gruta do Mateus (MS); Análises de Relevância de Cavidades ; Espécie rara de morcego; Sagrado Xingu; Foto do Leitor Bart Cave

Proteomics Informed By Transcriptomics Reveals Hendra Virus Sensitizes Bat Cells To Trail-Mediated Apoptosis, James W. Wynne, Brian J. Shiell, Glenn A. Marsh, Victoria Boyd, Jennifer A. Harper, Kate Heesom, Paul Monaghan, Peng Zhou, Jean Payne, Reuben Klein, Shawn Todd, Lawrence Mok, Diane Green, John Bingham, Mary Tachedjian, Michelle L. Baker, David Matthews, Lin-Fa Wang

KIP Articles

Background Bats are a major reservoir of emerging infectious viruses. Many of these viruses are highly pathogenic to humans however bats remain asymptomatic. The mechanism by which bats control viral replication is unknown. Here we utilize an integrated approach of proteomics informed by transcriptomics to compare the response of immortalized bat and human cells following infection with the highly pathogenic bat-borne Hendra virus (HeV). Results The host response between the cell lines was significantly different at both the mRNA and protein levels. Human cells demonstrated minimal response eight hours post infection, followed by a global suppression of mRNA and protein …

Performance Of A Temperate-Zone Channel Catfish Biofloc Technology Production System During Winter, Bartholomew W. Green

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Channel catfish (Ictalurus punctatus) have been grown successfully in an outdoor biofloc technology production system. Outdoor biofloc production systems in the tropic sare operated year-round, whereas the channel catfish studies were conducted only during the growing season and biofloc production tanks were harvested and idled for the winter. If an outdoor biofloc production system is to be adopted by farmers at temperate latitudes, then data gaps related to system and fish performance over the winter must be addressed. The present study was conducted to address these data gaps for channel catfish culture. Waters from a recently completed biofloc …

The Effects Of Sleep Loss On Capacity And Effort, Mindy Engle-Friedman

Publications and Research

Sleep loss appears to affect the capacity for performance and access to energetic resources. This paper reviews research examining the physical substrates referred to as resource capacity, the role of sleep in protecting that capacity and the reaction of the system as it attempts to respond with effort to overcome the limitations on capacity caused by sleep loss. Effort is the extent to which an organism will exert itself beyond basic levels of functioning or attempt alternative strategies to maintain performance. The purpose of this review is to bring together research across sleep disciplines to clarify the substrates that constitute …

'They Gang In Stirks And Come Out Asses': Creative Writing And Scottish Studies, Liam Mcilvanney

Studies in Scottish Literature

Recounts the experience as a student of the New Zealand poet James K. Baxter and discusses the interrelation of creative writing and literary scholarship, in Scottish universities and in New Zealand.

The Popular Voice In Sir David Lyndsay's Satire Of The Thrie Estaitis, Greg Walker

Studies in Scottish Literature

Analyzes the representation of the Scottish people in the 16th century Scottish drama A Satire of the Thrie Estaitis by Sir David Lyndsay [or Lindsay] (1490-1555), through the figure of the Pauper or Poor Man in the first version (the 1540 interlude performed at Linlithgow), and the character of John of the Commonwealth in the two fuller versions (at Cupar in 1552 and Edinburgh in 1554). Distinguishes Lyndsay's Pauper from equivalent figures in plays by John Bale and Nicholas Udall, and argues (by contrast with Tyrone Guthrie's famous 1948 Edinburgh festival production) that John of the Commonwealth is less a …

“The Future Of The Planet”− Scottish Cosmopolitanism/ Cosmofeminism And Environmentalism In Theresa Breslin’S Saskia’S Journey, Fiona Mcculloch

Studies in Scottish Literature

Discusses major themes and concerns in the young adult novel Saskia's Journey, by Theresa Breslin, with special attention to the relation between Breslin's environmental themes (and Scottish setting) with her portrayal of the novel's central character and multigenerational family relationships.

"You Can't Be Creative Anymore": Students Reflect On The Lingering Effects Of The Five-Paragraph Essay, Jennifer P. Gray

Teaching/Writing: The Journal of Writing Teacher Education

The five-paragraph essay continues to make headlines in composition and pedagogy journals and on teacher listservs. This long-cherished genre has been touted for teaching the basics to writers in college, and teachers often claim that it is the best foundation for solid essay writing. In contrast, there are numerous five-paragraph essay critics who claim that the essay is a “school-created thing” that has no real-world value and persists due to an enshrinement in textbooks as preparation for objective standardized testing. Regardless of the debate, one thing remains: there is little research on the essay from the students’ perspective. This essay …

Writing At School: Test-Prep Writing And Digital Storytelling, Patricia A. Jacobs Phd, Danling Fu Phd

Teaching/Writing: The Journal of Writing Teacher Education

This article presents a study on two students’ from nonmainstream and working class backgrounds writing experiences in two different writing situations: writing for test preparation and writing for digital stories. The students’ writing behaviors, processes and products in these two settings are contrasted. The differences of the students’ writing experiences in this classroom during a four-month period suggest that it may be our teaching that trails behind the time rather than students from diverse backgrounds trailing behind in their school learning. The research findings point out that a test-driven teaching approach tends to limit students’ ability as learners and in …

2014 Northeastern Illinois University Fifth Annual Faculty Research Symposium - Abstracts, Symposium Steering Committee

Faculty Research and Creative Activities Symposium 2010-2017

No abstract provided.

The Bison, November 14, 2014

The Bison Newspapers

No abstract provided.

The New Hampshire, Vol. 104 [105], No. 18 (Nov. 14, 2014), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 104, but it is the 105th volume in the series. This was corrected in pencil.

Vernal Pool: A Participatory Art Project About Place + Precipitation, Karen Miranda Abel, Jessica Marion Barr

The Goose

Produced by Karen Miranda Abel with Jessica Marion Barr, Vernal Pool is an immersive, elemental water installation created as a participatory, contemplative inquiry into our transitory interrelationships with water and landscape. From November 2013 to April 2014, 114 individuals across Canada and abroad gathered snow samples as a form of extrinsic artistic practice about place and precipitation. With the arrival of spring, the reservoir of melted snow was convened for four days at Toronto’s historic Gladstone Hotel to create Vernal Pool.

10 Tips For Creating Awesome Powerpoint Presentations, Barbara Carder

Learning Showcase 2014

Introduction and Background: Franklin University faculty and staff create PowerPoint presentations to supplement information being presented. These presentations may be given in the classroom or the boardroom, but all too often are poorly constructed.

Response: This poster presentation provides 10 tips to keep in mind as a PowerPoint presentation is being created:

1. Know your audience
2. Use templates
3. Select two fonts
4. Font size matters!
5. Color counts
6. Follow the 6x6 rule
7. Highlights only please
8. Use quality images
9. Animate thoughtfully
10. Proofread!

Choroid Plexus In Developmental And Evolutionary Perspective, Brent Roy Bill, Vladimir Korzh

Biology Faculty Publications and Presentations

The blood-cerebrospinal fluid boundary is present at the level of epithelial cells of the choroid plexus. As one of the sources of the cerebrospinal fluid (CSF), the choroid plexus (CP) plays an important role during brain development and function. Its formation has been studied largely in mammalian species. Lately, progress in other model animals, in particular the zebrafish, has brought a deeper understanding of CP formation, due in part to the ability to observe CP development in vivo. At the same time, advances in comparative genomics began providing information, which opens a possibility to understand further the molecular mechanisms involved …

Seed Dormancy, Seedling Establishment And Dynamics Of The Soil Seed Bank Of Stipa Bungeana (Poaceae) On The Loess Plateau Of Northwestern China, Xiao Wen Hu, Yan Pei Wu, Xing Yu Ding, Rui Zhang, Yan Rong Wang, Jerry M. Baskin, Carol C. Baskin

Biology Faculty Publications

Studying seed dormancy and its consequent effect can provide important information for vegetation restoration and management. The present study investigated seed dormancy, seedling emergence and seed survival in the soil seed bank of Stipa bungeana, a grass species used in restoration of degraded land on the Loess Plateau in northwest China. Dormancy of fresh seeds was determined by incubation of seeds over a range of temperatures in both light and dark. Seed germination was evaluated after mechanical removal of palea and lemma (hulls), chemical scarification and dry storage. Fresh and one-year-stored seeds were sown in the field, and seedling …

Graduate Research Conference Program, 2014, Emu Graduate School

Graduate Research Conference

No abstract provided.

Do Wetland Characteristics, Specifically Plant Communities, Surface Water, And Soils Play A Significant Role In Whooping Crane (Grus Americana) Site Selection?, Kristin Marie Bahleda

Master's Theses and Doctoral Dissertations

To examine the relationship of environmental conditions and their effect on Whooping crane (Grus americana) nest site selection; wetland soils, plant community structure and surface water quality were analyzed throughout nineteen established nest sites and twenty non-nesting wetland sites. Due to past fire management throughout the refuge, the effects of fire history were also investigated by comparing burned (n=17) and un-burned (n=22) areas.

A multi-dimensional scaling analysis did not detect significant differences in plant community structure between nest and non-nesting sites, but did find a significant difference with respect to time since last burn. Soil parameters were not …

Modulation Of The Cardiac Calcium Release Channel By Homocysteine Thiolactone, Laura Jean Owen

Dissertations and Theses

Elevated levels in blood serum (≥10μmol/L) of the amino acid homocysteine is strongly correlated with the incidence of heart failure (HF). We present evidence that the cyclic thioester, homocysteine thiolactone (HTL), a metabolic product of homocysteine, irreversibly modifies proteins that regulate the contractile process in cardiac muscle. Two proteins found in the sarcoplasmic reticulum (SR), the Ca²⁺ pump (SERCA2), and the ryanodine receptor (RyR2), are responsible for controlling the cytosolic Ca²⁺ concentration and hence the contractile state of the heart. While both improper Ca²⁺ handling and elevated homocysteine levels have been considered bio-markers in HF, a direct …

November 14, 2014, The Dakota Student

The Dakota Student

No abstract provided.

The Bg News November 14, 2014, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 14, 2014. Volume 94-Issue 36.

Generation And Characterization Of Nanoaerosols Using A Portable Scanning Mobility Particle Sizer And Electron Microscopy, Adam J. Marty

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to demonstrate the ability to generate and characterize a nanometer sized aerosol using solutions, suspensions, and a bulk nanopowder, and to research the viability of using an acoustic dry aerosol generator/elutriator (ADAGE) to aerosolize a bulk nanopowder into a nanometer sized aerosol. The research compares the results from a portable scanning mobility particle sizer (SMPS) to the more traditional method of counting and sizing particles on a filter sample using scanning electron microscopy (SEM). Sodium chloride aerosol was used for the comparisons. The sputter coating thickness, a conductive coating necessary for SEM, was measured …

Responsibility And Responsiveness In The Novels Of Ann Radcliffe And Mary Shelley, Katherine Marie Mcgee

USF Tampa Graduate Theses and Dissertations

This dissertation looks at the ways in which humans interact with and respond to other humans and nonhumans in Ann Radcliffe's and Mary Shelley's novels. I argue that in light of the social and political turmoil surrounding the French Revolution, Radcliffe and Shelley call not so much for Revolution or drastic reform but for a change in the ways in which individuals respond to the needs of others, both human and nonhuman, and take responsibility for each other. The ways in which humans interact with the nonhuman inform the positive and negative practices that they should use to interact with …

Examination Of Possible Protective Effect Of Rhesus D Positive Blood Factor On Toxoplasma-Related Depressive Symptoms In Pregnancy, Lisa Lynn Parnell

USF Tampa Graduate Theses and Dissertations

Toxoplasma gondii infects approximately one third of the population worldwide. There is strong evidence that a relationship between T. gondii titer and depressive symptoms exists. There is also evidence suggesting a protective effect of RhD positive blood factor on toxoplasma-induced behavioral and personality changes. This protective effect may influence the relationship between T. gondii and prenatal depressive symptoms. The purpose of this secondary data analysis was to examine the possible protective effect of RhD positive blood factor on prenatal depressive symptoms in 56 pregnant women with T. gondii infection. The cross-sectional design was utilized to answer the question “Does positive …

The National Environmental Policy Act Of 1969 And Its Implications For Nafta: Public Citizen V. United States Trade Representative, 822 F. Supp. 21 (D.D.C.), Rev'd 5 F.3d 549 (D.C. Cir. 1993)., Kristin R. Loecke

Georgia Journal of International & Comparative Law

No abstract provided.

Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]Octanes As Selective α4β2-Nachr Ligands, Oluseye K. Onajole, J. Brek Eaton, Ronald J. Lukas, Dani Brunner, Lucinda Thiede, Barbara J. Caldarone, Alan P. Kozikowski

Translational Neuroscience

We report the synthesis and characterization of a series of enantiopure 5-cyclopropane-bearing pyridyldiazabicyclo[3.3.0]octanes that display low nanomolar binding affinities and act as functional agonists at α4β2-nicotinic acetylcholine receptor (nAChR) subtype. Structure-activity relationship studies revealed that incorporation of a cyclopropane-containing side chain at the 5-position of the pyridine ring provides ligands with improved subtype selectivity for nAChR β2 subunit-containing nAChR subtypes (β2∗-nAChRs) over α4∗-nAChRs compared to the parent compound 4. Compound 15 exhibited subnanomolar binding affinity for α4β2-and α4β2∗-nAChRs with negligible interaction. Functional assays confirm selectivity for α4β2-nAChRs. Furthermore, using the SmartCube assay system, this ligand showed antidepressant, anxiolytic, and antipsychotic …