Digital Commons Network^™

The Role Of Mir-137 In Schizophrenia, Carrie Leigh Wright

Biomedical Sciences ETDs

The genetic basis of schizophrenia is still largely unknown. Recent evidence suggests that a microRNA (miRNA), miR-137 may be involved. The first large schizophrenia genome wide association (GWAS) study, published in 2011, identified a variant within the host gene of this miRNA (MIR-137) as the top association. Since then, further evidence for the potential influence of this miRNA within the disorder has accumulated. These studies used a variety of methods from GWAS to neuroimaging. However, few studies have evaluated the mechanism for the association of the MIR-137 variant, nor how alterations in the miRNA may have downstream effects on its …

Investigation Into The Early Events Of Epithelial Wound Healing And Hpv16 Infection, Michael P. Kivitz

Biomedical Sciences ETDs

HPV16 infection evidently occurs within wounded epithelial tissue, but the cellular and molecular events that culminate in infection establishment remain poorly understood. While HPV is exposed to a multitude of cells in the wound environment, only hyperproliferative keratinocytes are believed to support productive infection. Keratinocytes acquire mobility during wound repair by undergoing prominent phenotypic alterations through an epithelial-to-mesenchymal transition (EMT). In this study, cell- and tissue-based models were employed to characterize HPV infection during epithelial wound healing, using both physical injury and growth factor treatment to induce keratinocyte migration. In a tissue-based model of wounding and infection using NIKS-derived organotypic …

Novel Posttranslational Modification In Lkb1 Activation And Function, Szu-Wei Lee

Dissertations and Theses (Open Access)

Cancer cells display dramatic alterations in cellular metabolism to meet their needs of increased growth and proliferation. In the last decade, cancer research has brought these pathways into focus, and one emerging issue that has come to attention is that many oncogenes and tumor-suppressors are intimately linked to metabolic regulation (Jones and Thompson, 2009). One of the key tumor-suppressors involved in metabolism is Liver Kinase B1 (LKB1). LKB1 is the major upstream kinase of the evolutionarily conserved metabolic sensor—AMP-activated protein kinase (AMPK). Activation of the LKB1/AMPK pathway provides a survival advantage for cells under energy stress. LKB1 forms a heterotrimeric …

Religion, Conscience, And The Case For Accommodation, William A. Galston

San Diego Law Review

I do not believe that religion is an obsolete constitutional category. But I do believe that the holdings in United States v. Seeger and Welsh v. United States, the Vietnam-era draft cases that extended conscientious objector status to individuals invoking nonreligious claims, were correct. Can I consistently embrace both propositions? I think I can. My argument, in brief, is that religion is indeed special. But when we understand what it is about religion that warrants both distinctive privileges and distinctive burdens, we will see that some other systems of belief track these features of religion closely enough to warrant comparable …

Teacher Internship Report- Ceres High School, Michael L. Patterson

Agricultural Education: Graduate Internship Reports

This internship/project report includes validation documents required in meeting the quality criteria for secondary-level programs of instruction in agriculture. The documents are concurrently used for the Agriculture Incentive Grant review process at Ceres High School conducted by representatives of the California Department of Education. The internship included the development of a comprehensive program plan for Ceres High School. The plan includes information to receive state/local funding, outline the goals and objectives of the program, along with an overview of Ceres High School, the agriculture program and community.

Passive Takings: The State's Affirmative Duty To Protect Property, Christopher Serkin

Michigan Law Review

The purpose of the Fifth Amendment’s Takings Clause is to protect property owners from the most significant costs of legal transitions. Paradigmatically, a regulatory taking involves a government action that interferes with expectations about the content of property rights. Legal change has therefore always been central to regulatory takings claims. This Article argues that it does not need to be and that governments can violate the Takings Clause by failing to act in the face of a changing world. This argument represents much more than a minor refinement of takings law because recognizing governmental liability for failing to act means …

Reconciliation Ecology: A New Paradigm For Advancing Creation Care, Dave P. Warners, Michael Ryskamp, Randall Van Dragt

University Faculty Publications and Creative Works

Current global environmental challenges—species loss, overconsumption, climate change, and others—have not been countered in the faith community with a response worthy of their signifi cance. While the prevailing faith-based creation-care paradigm, environmental stewardship, has been invaluable in moving us beyond the utilitarian notion of “dominion,” the stewardship concept does not suffi ciently emphasize our embedded, dependent relationship with the creation. To better represent our creationcare responsibilities, we propose a new paradigm based on a model of servanthood and informed by the concept of reconciliation ecology, which focuses on mending broken relationships between human beings and nonhuman creation. Drawing from the …

Strategic Planning Tool Development Using Portfolio Decision Analysis, Luis B. Vargas Rojas

Graduate Theses and Dissertations

A portfolio decision analysis strategic planning tool was developed for the Facilities Management Office at the University of Arkansas. The tool provides information to support budget allocation decisions based on their Strategic Planning Project List, project attributes (e.g, seat utilization, scheduling preferences, and sustainability rank), and budget constraints. The projects are evaluated using multiobjective decision analysis. We introduce dynamic value functions, which vary the range of the value measures based on the planning horizon, to evaluate the projects). We determine facilities portfolios based on the project values and constraints using Linear Programming. In addition, insightful reports are generated, which provide …

Competing Visions: Political Constructions Of Memory After World War I, 1919-1936, Scott R. St. Louis

Grand Valley Journal of History

This paper argues that officials at the Paris Peace Conference, in the White House, and in the U.S. Congress strove for the realization of competing visions for the international order following World War I, and thus were required to construct their own interpretations of how the conflict should be remembered and what must be learned from it. A pervasive sense of victors’ justice dominated the proceedings in Paris, leading to the creation of a settlement which would find lasting support from neither European nor American decision makers. The dubious postwar arrangements made at Versailles would contribute to the resurgence of …

The Broadsheet- Issue 10, Merrimack College

The Broadsheet

Merrimack College's English Department newsletter.

This issue features:

• Senior Seminar Reflection
• Alison Leonard Profile
• Maleficent Film Review
• Dracula Untold Film Review
• Guest Book Review of Let’s Take the Long Way Home
• English Fall Excursion 2014

Diffusion Of The Lnternet And Its Effect On Gender Attitudes: A Cross-National Approach, Robert Roznowski

Masters Theses

The rapid diffusion of the Internet worldwide generates discussion about the social implications of the Internet. To explore the effect of Internet diffusion worldwide, this study examines changes in reported gender attitudes since the introduction of the Internet. I propose that the diffusion of the Internet fosters egalitarian changes in gender attitudes. Using cross-national data from forty countries over a time span of nearly twenty years, I successfully implement an alternative analysis technique, the slope-slope model, to examine the relationship between rates of Internet diffusion and changes in gender attitudes in the economic, political, and education domains. Internet diffusion affects …

Beyond Gothic : Ye Si's Spectral Hong Kong And The Global Culture Crisis = 哥特之外 : 也斯的鬼怪香港與全球化危機, Andrea Riemenschnitter

Journal of Modern Literature in Chinese 現代中文文學學報

No abstract provided.

A Ghost Tour In Rouge = 遊魂《胭脂扣》, Ho Yin Fong

Journal of Modern Literature in Chinese 現代中文文學學報

This paper discusses how Fleur's association to some of the worldwide ghost tours insinuates the haunting quality of the past, time, and the cityscape; in other words, it discusses how the tragic love story between Fleur and Twelfth Master can also be allegorically read as a tragic cultural story of Hong Kong. This discussion allegorically reads Fleur, Twelfth Master and Yuen as figures hauled by modernity.

Functional Genomics And Microbiome Profiling Of The Asian Longhorned Beetle (Anoplophora Glabripennis) Reveal Insights Into The Digestive Physiology And Nutritional Ecology Of Wood Feeding Beetles, Erin D. Scully, Scott M. Geib, John E. Carlson, Ming Tien, Duane Mckenna, Kelli Hoover

Department of Agronomy and Horticulture: Faculty Publications

Background: Wood-feeding beetles harbor an ecologically rich and taxonomically diverse assemblage of gut microbes that appear to promote survival in woody tissue, which is devoid of nitrogen and essential nutrients. Nevertheless, the contributions of these apparent symbionts to digestive physiology and nutritional ecology remain uncharacterized in most beetle lineages.

Results: Through parallel transcriptome profiling of beetle- and microbial- derived mRNAs, we demonstrate that the midgut microbiome of the Asian longhorned beetle (Anoplophora glabripennis), a member of the beetle family Cerambycidae, is enriched in biosynthetic pathways for the synthesis of essential amino acids, vitamins, and sterols. Consequently, the midgut …

Effects Of Feeding Distillers Grains Throughout A Yearling Heifer Beef Production System On Meat Quality Attributes And Effects Of Omnigen-Af With Ractopamine Hydrochloride On Animal Performance And Beef Carcass Characteristics Of Feedlot Steers, Kelby M. Sudbeck

Department of Animal Science: Dissertations, Theses, and Student Research

Heifers (n = 229; 225 kg ± 2) were used in a 2 x 2 x 2 factorial to determine the effects of longterm exposure to corn distillers grains plus solubles (DGS) on meat quality characteristics. Factors included supplementing 0.91 kg (LW) or 2.3 kg (HW) modified DGS (MDGS) while grazing corn stalks; 0.6% BW dry DGS (SS) daily or none (NS) during summer grazing; and finishing diet containing 40% wet corn gluten feed (CGF) or 40% MDGS (DGF) on a DM basis. An interaction was observed within CGF for discoloration, with SS increasing discoloration 30%; but no differences between …

The Greenback, The Humpback, And The Silverback: How A Third Wave Of Federal Water Policy Could Benefit The West, Reed D. Benson

Faculty Scholarship

Proposing any major new federal initiative regarding water in the western United States might seem preposterous, given conventional wisdom and entrenched positions on state control of water resources. But there is a strong rationale, and a growing imperative, for a new federal water .policy for the West. Many river basins face serious problems as limited water supplies are over-allocated, demands continue to increase, and climate change promises to exacerbate the West's perennial problems of scarcity and variability. Solutions to such problems are likely to be expensive and will need to address national interests as well as state and local concerns. …

A Highly Adaptive And Cost Effective Second Generation Incubator (Sgi) Towards Educational, Research And Clinical Processes, Yassir H. Al-Sayagh

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Today´s rising demand for more reliable and affordable alternatives to organ transplant has led to a growing market for in vitro tissue culture systems. The main objective of tissue engineering as a whole is to employ human tissue equivalents for commercial use. The state-of-the-art processes for producing these so called tissue models are still very expensive, difficult to produce and time-consuming.

To engineer tissues, in vitro, a three-dimensional support structure commonly termed scaffold is needed. Stem cells are then added to the scaffold. In order for tissue to materialize, the scaffold and the cells must be incubated (cultured) at a …

Litter Decomposition And Root Production In Response To Grazing On Sandhills Subirrigated Meadow, Ben W. Beckman

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Stocking density can be manipulated by management factors including herd size, pasture size, and grazing period length. Ultrahigh stocking density (mob grazing) is commonly characterized at 200,000 kg animal live weight ha^-1 or higher with multiple movements of livestock per day. Practitioners claim increased plant production, soil development, and nutrient cycling rates because of high trampling percentages resulting from ultrahigh socking densities. This study was conducted on subirrigated meadow in the Nebraska Sandhills in 2012 and 2013 to determine grazing method effect on annual root production and litter decomposition. Stocking rates were held constant while stocking densities varied by …

Groundwater Trend Analysis And Salinity Risk Assessment For The South-West Agricultural Region Of Western Australia, 2007–12, G Paul Raper, Russell Speed, John Andrew Simons, A L. Killen, Andrew Blake, A T. Ryder, Rosemary H. Smith, Grantley Stainer, L Bourke

Resource management technical reports

Dryland salinity is a hydrologically driven land degradation hazard in the south-west agricultural region of Western Australia (WA). Shallow-rooted annual crops and pastures transpire significantly less water than the native vegetation they replaced, leading to an increase in recharge, rising groundwater levels and the development of shallow watertables in areas where often none existed previously. Rising groundwater levels mobilise soluble salts, naturally stored at high concentrations in the regolith. These salts can be concentrated in the root zone of vegetation by evapotranspiration.

Delgado's Darkroom: Critical Reflections On Land Titles And Latino Legal Education, Richard Delgado

New Mexico Law Review

Comments from the U.S. Senator Dennis Chavez Endowed Lecturesheip/Symposium on Civil Rights hsoted by The University of New Mexico School of Law April 22, 2014

A Study Of The American Black Bear (Ursus Americanus) In Utah: An Analysis Of The Post-Denning Activities And Bear-Human Conflict, Julie Ann Miller

Theses and Dissertations

This study examined two different aspects of black bear (Ursus americanus) ecology in Utah. First, we determined the post-denning behaviors of female black bears in order to help management agencies protect bears from human disturbances as well as set spring hunts that minimize the taking of females with dependent young. We looked at the timing of den emergence (X = 25 March), the number of days at the den site post emergence (X = 11 days), and departure (X = 8 April) for female black bears in Utah from 2011—2013. We also analyzed the effects of cohort (lone …

Bard Free Press, Vol. 16, No. 3 (December 2014), Bard College

Bard Free Press - All Issues (2000-2018)

No abstract provided.

Bibliography For Work In Ecocriticism, Zümre Gizem Yılmaz

CLCWeb: Comparative Literature and Culture

No abstract provided.

Inclusive Recreation: The Malleability Of Attitudes Toward Disability Through Peer Interaction, Megan Fort

Theses and Dissertations

This study explored the malleability of attitudes with the goal of improving social inclusion for a stigmatized group, specifically individuals with developmental disabilities. Contact Theory was used as an intentional structure for meaningful intergroup contact to assess, understand, and improve meanings applied to individuals with disabilities at an inclusive summer day camp. Adolescent volunteers were administered quantitative questionnaires utilizing the Contact with Disabled Persons Scale (CDP) and the Multi-Dimensional Attitude Scale (MAS). Collected data were used to determine the efficacy of involvement in an inclusive recreation program on adolescent participants' attitudes toward disability. After a covariate-adjusted regression analysis, contact with …

Generality Of The Terminal Investment Hypothesis: Effects Of Extrinsic Mortality And Resource Availability On Age-Related Reproductive Investment, Allystair Jones

Theses and Dissertations

A central question in life history theory is, what combination of traits and behaviors will lead to the highest reproductive success throughout a lifetime. The trade-off between current and future reproduction is central to the lifetime reproductive success of an organism. If there is a cost to reproduction, then allocation of energy to current reproduction will come at a cost to future reproduction. We expect young individuals to favor future reproduction over current reproduction and that balance shifts to current reproduction as they age (i.e. terminal investment hypothesis). However, how this transition from an emphasis on future reproduction to emphasis …

Understanding The Diversification Of Central American Freshwater Fishes Using Comparative Phylogeography And Species Delimitation, Justin C. Bagley

Theses and Dissertations

Phylogeography and molecular phylogenetics have proven remarkably useful for understanding the patterns and processes influencing historical diversification of biotic lineages at and below the species level, as well as delimiting morphologically cryptic species. In this dissertation, I used an integrative approach coupling comparative phylogeography and coalescent-based species delimitation to improve our understanding of the biogeography and species limits of Central American freshwater fishes. In Chapter 1, I conducted a literature review of the contributions of phylogeography to understanding the origins and maintenance of lower Central American biodiversity, in light of the geological and ecological setting. I highlighted emerging phylogeographic patterns, …

Comparative Analysis Of Ceramics From Three Great Houses And One Small House Site In Southeast Utah, Rachel Marie Harris

Theses and Dissertations

Ceramics from three Utah great houses, Bluff, Cottonwood Falls, and Edge of the Cedars, were analyzed and compared with ceramics from Three Kiva Pueblo, which is not a great house site but was occupied contemporarily. Data on jar and bowl rim diameters were considered to understand great house feasting dynamics. Cooking jars with large rim diameters were more common at Three Kiva than they were at the great houses. This suggests that Three Kiva residents prepared large batches of food more frequently than great house residents. Distributions of Mancos Black-on-white bowl diameters were very similar at great houses and Three …

The Roman Riders: Ethnicity And Iconography On Roman Cavalrymen Tombstones, Jessica Colleen Kramer

Theses and Dissertations

The funerary grave stelae of the Roman cavalrymen are large, impressive monuments set apart from their military counterparts by the ornate relief carvings which they exhibit. The two most common motifs featured on these tombstones are the rider relief motifs and the totenmahl motifs. Aspects of both the reliefs and the inscribed epitaphs are distinctly characteristic of the Roman military. Throughout the history of the Roman Empire, men in the auxiliary cavalry units were recruited from non-Roman allied tribes. These recruits brought with them foreign languages, customs, and beliefs. Through a comparative study of Roman cavalry tombstones found in Great …

A Molecular Phylogeny Of Lampyridae With Insight Into Visual And Bioluminescent Evolution, Gavin Jon Martin

Theses and Dissertations

Fireflies are some of the most captivating organisms on the planet. Because of this, they have a rich history of study, especially concerning their bioluminescent and visual behavior. Among insects, opsin copy number variation has been shown to be quite diverse. However, within the beetles, very little work on opsins has been conducted. Here we look at the visual system of fireflies (Coleoptera: Lampyridae), which offer an elegant system in which to study visual evolution as it relates to their behavior and broader ecology. They are the best-known case of a terrestrial organism that communicates through the use bioluminescence. The …

Editorial, Raj Manchanda

Indian Journal of Research in Homoeopathy

No abstract provided.