Digital Commons Network^™

Land-Use Transitions And Carbon Emissions Of Aquaculture Expansion In The Brazilian Amazon, Felipe S. Pacheco, Sebastian A. Heilpern, Rafael M. Almeida, Suresh A. Sethi, Marcela Miranda, Nicholas Ray, Laura Greenstreet, Joshua Fan, Brendan H. Rappazzo, Marcelo Gomes Da Silva

School of Earth, Environmental, & Marine Sciences Faculty Publications

Accounting for land-use change underlying food sector expansion is critical for conserving ecosystem integrity. This challenge is particularly acute in the Amazon, where the conversion of forests for food production is pronounced and has broad implications for global biodiversity and the cycling of water and carbon. Here, we analyze land-use transitions associated with aquaculture development in the Brazilian Amazon. We found that a 450-fold increase in aquaculture pond area from 1985 to 2022 occurred primarily on pasturelands (87%) but also included wetland conversion (4%) and deforestation (5%). Notably, continued growth can be sustained within already altered landscapes: In Rondônia, the …

For Weight Loss: Why Do Glp-1 Agonists Work, And How Can We Make Them Work Better?, Charlise Giang, Jieyi Meng, Mahmoud Ali Mohammad, Zhenqi Liu, Xinle Wu, Yi Zhu

Children’s Nutrition Research Center Staff Publications

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have revolutionized the management of not only type 2 diabetes but also obesity. However, even with rapid therapeutic advances in GLP-1RAs, questions regarding the fundamental principles of GLP-1-mediated weight loss and the enhanced efficacy of next-generation therapies remain. In this comprehensive review article, we first examine the milestones of GLP-1, from its initial discovery and biological characterization to its successful translation into clinical therapy. Furthermore, this review highlights the latest clinical trial data, specifically HbA1c reduction, weight-loss efficacy, and safety profiles, while exploring current pipelines of major pharmaceutical companies. Additionally, we delineate the mechanistic …

Is Hanpp A Stressor Of Bird Species Richness?, Kaeli Mueller, Gustavo Ovando-Montejo, Christopher Lant

Environment and Society Student Research

One of the leading drivers of biodiversity loss is land use change due to the ever-increasing demand for food, livestock feed, biofiber, and biofuel. The concept of human appropriation of net primary production (HANPP) was developed to measure the impact that humans have on the environment by accounting for biomass removed from the environment in the form of crops, timber, and grazing. The species–energy hypothesis is an established ecological hypothesis postulating that greater species diversity is correlated with higher levels of energy from plant productivity; this can be measured as net primary production minus harvested HANPP or NPP_ecological. …

Enhancing Algae Biofilm Quantity And Value Through Controlled Light Intensity For Treatment Of Municipal Anaerobic Digestor Effluent, Joshua D. Wintch, Ronald C. Sims

Biological Engineering Student Research

Rotating algae biofilm reactors (RABRs) have been shown to remove nutrients from wastewater and to cultivate algae for bioproducts. Another key variable in RABR technology for cultivating microalgae biomass is light intensity. The goal of this study was to address a gap in the design and operation of algae biofilm reactors by analyzing the effects of light intensity on biomass quality and quantity, chemical precipitation of phosphorus, and phosphorus uptake into biomass. This study utilized a triplicate laboratory-scale experiment with PAR intensities from 10 to 2000 µmol m⁻²·s⁻¹. Municipal wastewater anaerobic digester effluent (ADE) was utilized …

Imsa Summer Symposium 2026, Student Inquiry And Reserach Reserach (Sir)

IMSAloquium Event Booklets

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program. For the first time, we are also excited to welcome IMSA Research, Inquiry Skills, and Experimentation (RISE) students to present at the Summer Symposium.

Cover Design

Luke Berryman

Performance Of Dual-Form Terminalia Catappa Organic Fertilizers On Sweet Corn Yield And Economic Viability In Tropical Highlands, Stefina Liana Sari, Eso Solihin, Rahmat Budiarto

Jurnal Kultivasi

Recycling underutilized plant biomass into organic fertilizers underpins low-input cropping strategies, but liquid and solid formulations derived from a common feedstock have seldom been evaluated side by side under field conditions. This study aimed to (i) characterize the physicochemical properties and safety profile of a liquid organic fertilizer (LOF) and a crumb-type organic fertilizer (COF) co-produced from Terminalia catappa leaf compost, (ii) compare their effects on sweet corn growth and yield, (iii) determine relative agronomic effectiveness (RAE), and (iv) evaluate economic feasibility of the most promising organic–inorganic combinations. We produced LOF and COF through aerobic composting of Terminalia catappa leaves …

Meta Fiction In Amir Taj Al-Sirr’S Novel Sayyid Al-Yaraqa¯T: Vision And Technique, Ali Bin Nasser Al-Sahli

UB Journal for Humanities

This study aims to address the dilemma facing the modern Arabic novel regarding how to break free from traditional narrative frameworks and venture into the realms of modernization and experimentation. In this context, the technique of “metafiction” emerges as a narrative mechanism that contributes to resolving this issue. Therefore, the study seeks to explore the manifestations of metafiction as “writing about writing” and to investigate how it is employed as a tool to involve the reader in the process of literary creation. To achieve this, the study adopts the structuralist/poetic approach, which is essential in literary studies due to its …

A New Species Of Liocheles Sundevall, 1833 (Scorpiones: Hormuridae) From The Western Himalayas, Virender К. Bhardwaj, Sunil Katal, H. T. Lalremsanga, Zeeshan A. Mirza

Euscorpius

Sampling in the Western Himalayas of India led to the discovery of a population of the genus Liocheles Sundevall, 1833, that differes from all Indian congeners. Molecular and morphological data confirmed the distinctiveness of the population, which is here described as a new species. The new species is morphologically similar to L. longimanus (Werner, 1939), from which it differs in the arrangement of trichobothria on external patella and structure of the hemispermatophore. A preliminary molecular phylogeny of the family Hormuridae based on the mitochondrial cytochrome oxidase I gene is presented.

Correlation And Redundancy Analysis Of Statistical Features For Permanent Magnet Synchronous Motor Fault Detection, Ibrahim Muhammad, Benjamin Olabisi Akinloye

Mansoura Engineering Journal

Feature selection plays a critical role in designing efficient and interpretable condition monitoring frameworks for electrical drives. In this paper, a correlation analysis of statistical and spectral features is performed for Permanent Magnet Synchronous Motor (PMSM) fault detection in naval windlass systems. Using both simulated data from a MATLAB/Simulink model and real shipboard current signals acquired from five Nigerian Navy vessels over one-month monitoring periods, higher-order statistical moments (Mean, Variance, Standard Deviation, Skewness, Kurtosis) and the Fault Severity Index (FSI) were computed alongside Total Harmonic Distortion (THD). Pearson correlation coefficients were employed to quantify feature relationships under healthy and faulty …

Numerical Parametric Assessment Of Lap-Spliced Reinforced Concrete Beams With Steel, Gfrp, And Hybrid Reinforcement, Salah Mohsen, Mohamed H. Makhlouf, Marwa I. Badawi, Gamal Ismail

Mansoura Engineering Journal

This study presents a numerical parametric investigation into the flexural performance of reinforced concrete beams incorporating different reinforcement types and lap splice configurations, based on finite element modeling using ABAQUS and benchmarked against ACI 440 design provisions. Sixteen beam models were developed and analyzed under four-point bending to evaluate the influence of reinforcement type (steel, GFRP, and hybrid), splice length, and number of spliced bars on the global structural response. The results indicate that splice detailing plays a governing role in controlling failure mode and ductility. Beams without lap splices exhibited enhanced ductile behavior, whereas shorter splice lengths and higher …

Investigation Of The Functional Dimensions Of Teats Up To Mid-Lactation In Bulgarian Murrah Buffaloes Established By Ultrasonography, Ivan Fasulkov, Pencho Penchev, Yordanka Ilieva, Manol Karadaev

The Thai Journal of Veterinary Medicine

The aim of this study was to monitor the changes in teat measurements from early to mid-lactation in the Bulgarian Murrah buffaloes. The experiment was carried out with twenty (10 primiparous and 10 pluriparous) lactating buffaloes. Five series of ultrasound measurements were performed, each consisting of two sessions for each animal corresponding to the phases of lactation: first lactation month (day 1 to day 30 postpartum) and mid- lactation (day 122 to day 152). The studied parameters were teat canal length (TCL), teat diameter (TD), teat wall thickness (TWT), and teat cistern diameter (TCD). The data were processed using the …

Greenovation As A Strategic Leverage For Sustainable Competitive Advantage, Amiya Kumar Mohapatra, Anil Kumar, Yiğit Kazançoğlu

Management Dynamics

Greenovation is the new currency of the global economy which focuses on ‘green and innovation’ that generates environmental benefits through reduced resource consumption, lower carbon emissions, and improved ecological performance aligned with Sustainable Development Goals (SDGs). Greenovation focuses on long-term value creation by integrating environmental externalities, resource circularity, and multi-stakeholder governance and accountability structures. Greenovation integrated with corporate strategies can provide greater strategic competitive advantages which is also termed as green competitive advantage. By systematically integrating product and process improvements through Greenovation, firms can attain competitive advantage for long-term value creation for both internal and external stakeholders. It is imperative …

Investigation Of Plasma-Induced Surface Modification Of Pmma Using Nd:Yag Laser-Induced Breakdown Spectroscopy, Shaimaa S. Mahdi, Asmaa J. Kadhim, Zainab Salam Khaleefah

Engineering and Technology Journal

Poly(methyl methacrylate) (PMMA) plays an important role in many applications, including biomedical, industrial, and optical applications. Due to its surface properties, which are essential to its performance. The PMMA samples were exposed to a dielectric barrier discharge (DBD) air plasma with a duration time of 300 s. In this investigation, laser-induced breakdown spectroscopy (LIBS) in combination with Fourier transform infrared spectroscopy (FTIR) was used to study the surface properties of exposed to plasma samples. The laser pulses were set to (60, 80, and 100) mJ. The resulted spectra were recorded over a wide spectral range from 200 to 1100 nm. …

Bim-Safety Integration In The Nigerian Construction Industry Using The Unified Theory Of Acceptance And Use Of Technology (Utaut) Model, Ranti T. Adebiyi, Ganiyu Amuda-Yusuf, Olubola Babalola, Nurudeen A. Bello, Aminat D. Amuda, Kaosarat A. Olowookere

Engineering and Technology Journal

Health and Safety (H&S) challenges are a significant concern in the Nigerian construction industry, largely due to the lack of a reliable national accident database and the persistence of a fatalistic safety culture. Building Information Modelling (BIM) is a transformative digital framework that enables visual hazard identification and proactive risk simulation; however, its use in site safety management remains limited and inconsistent. This study investigates the behavioural, social, and structural determinants influencing the adoption of BIM-based H&S practices among construction professionals, utilising the Unified Theory of Acceptance and Use of Technology (UTAUT). A hypothetical multi-level design was used to model …

An In-Depth Study Of Fruit Preservation: Effect Of Calcium Chloride And Methyl Jasmonate Applications On Quality And Biochemical Properties Of Cherry Fruits During Cold Storage, Muhammet Ali̇ Gündeşli̇

Turkish Journal of Agriculture and Forestry

Sweet cherry (Prunus avium L.) is a highly perishable fruit that undergoes rapid quality deterioration during postharvest storage. This study evaluated the effects of postharvest applications of Methyl Jasmonate (MeJA, 1 mM) and Calcium Chloride (CaCl₂, 2%), applied individually and in combination, on maintaining the quality and biochemical properties of cherries during 21 days of cold storage at 0 ± 1 °C. Key parameters including weight loss, decay rate, soluble solids content (SSC), pH, titratable acidity, respiration rate, phenolic profile, and organic acid composition were monitored. The combined MeJA + CaCl₂ treatment was consistently more effective than individual applications in …

Sewage Sludge Legislation In Central Europe: Contamination Concerns And Cross-Border Comparisons, Valerie Vranová, Aleš Kučera, Vlastimil Skoták, Erika Fialová, Rahul Datta

Turkish Journal of Agriculture and Forestry

Sewage sludge management represents a major challenge in Europe, carrying significant environmental and legal implications that require strong regulatory enforcement. Here, we explore the legislative measures, technological developments, and environmental impacts of sewage sludge management in Central Europe (Czechia, Slovakia, Germany, Austria, and Poland). Sludge management is regulated at the EU level through a series of directives (e.g., Council Directive 86/278/EEC, which forms the basis of national regulatory frameworks). However, national adaptations vary considerably: Croatia and Slovenia have invested in sludge phosphorus-recovery systems, while Poland and Slovakia have focused on the agricultural use of sludge as a fertilizer. Several countries, …

A Comparative Analysis Of Clinical Quality And Readability Of Neuropathic Pain Patient Information Leaflets: Türkiye Versus The United States, Gonul Sari, Argun Pire

Turkish Journal of Medical Sciences

Background/aim: Neuropathic pain management requires high patient adherence and complex dose-titration regimens, making the readability of patient information leaflets (PILs) a critical patient safety factor. This study aimed to compare the clinical content quality and linguistic readability of PILs for neuropathic pain medications between Türkiye (TİTCK) and the United States (DailyMed).

Materials and methods: A total of 11 pairs of innovator medications were analyzed. Clinical content was assessed using the 15-item Keystone Clinical Content Checklist (KCCC). Readability was assessed using the Ateşman index for Turkish texts and the Flesch Reading Ease Score (FRES) for English texts. Information quality and reliability …

Changes In T-Cell Subsets And Their Relationships With Disease Severity In Patients With Alopecia Areata, Hati̇ce Türk Daği, Hülya Özdemi̇r, Mehmet Akyürek, Fatma Tunçez Akyürek, Hasi̇be Artaç

Turkish Journal of Medical Sciences

Background/aim: Alopecia areata (AA) is a nonscarring hair loss disorder characterized by genetic susceptibility, environmental triggers, and T-cell–mediated autoimmunity. While various CD4+ and CD8+ T-cell subsets are implicated in its pathogenesis, the roles of follicular T-cell (Tfh), peripheral T-cell (Tph), and regulatory T-cell (Treg) subsets– particularly within the CD8+ population–remain incompletely defined. This study aimed to characterize circulating CD4+ and CD8+ T-cell subsets in Turkish patients with AA and to evaluate their associations with disease activity, duration, and severity.

Materials and methods: A total of 40 patients with AA and 40 healthy controls were enrolled. CD4+ and CD8+ T-cell subsets—including …

Histomorphological Changes In Human Septal Cartilage Stored In Different Preservation Solutions ​, Özlem Akkoca, Aki̇f Si̇nan Bi̇lgen, Harun Çoban, Fatma Aslan Yay, Zeynep Kaptan, Funda Balkiliç Akkaya, Rahmi̇ Kiliç, Sami̇ Engi̇n Muz

Turkish Journal of Medical Sciences

Background/aim: To assess the histopathological effects of three preservation solutions (70% ethanol, povidone-iodine, and ciprofloxacin) on human septal cartilage obtained during septoplasty and to compare their preservation characteristics for potential future graft applications. Optimal preservation of septal cartilage is clinically important because well-preserved grafts may reduce the need for secondary cartilage harvesting and the associated donor-site morbidity while facilitating reconstructive procedures during revision surgery.

Materials and methods: A total of 90 septal cartilage specimens obtained from 30 patients undergoing septoplasty were allocated to three preservation groups and stored in the designated preservation solutions at +4 °C. Samples were examined histologically …

Erratum To “Effects Of Colchicine On Sah-Induced Vascular Damage In An Experimental Subarachnoid Hemorrhage Model’’ [Turkish Journal Of Medical Sciences 56 (2) 2026 597-607] ​, Emi̇ne Demi̇r, Cumaali̇ Demi̇rtaş, Cansu Sönmez, Eray Meti̇n Güler, Sarper Kocaoğlu, Hakan Beyaztaş, Eyüp Çeti̇n

Turkish Journal of Medical Sciences

The original article can be accessed at https://doi.org/10.55730/1300-0144.6192.

Background/aim: Subarachnoid haemorrhage (SAH) is a severe cerebrovascular condition with high morbidity and mortality. Inflammation and oxidative stress are key factors in its pathophysiology, particularly in secondary vascular injury. This study aimed to evaluate the effects of colchicine on vascular integrity and biochemical markers following SAH in an experimental rat model.

Materials and methods: Eighteen female Sprague-Dawley rats were divided into three groups: Control (no SAH), SAH (induced without treatment), and SAH + Colchicine (1 mg/kg intraperitoneally at 1 h and 24 h). SAH was induced by autologous blood injection into …

L-Theanine Attenuates Alcl3-Induced Cognitive Dysfunction And Neurotoxicity In Rats: A Behavioral And Biochemical Study, Muhammet Oğuzhan Dönmez, Azi̇ze Şener, Şeyda Karaman Ersoy, Mahdi̇ Marzi̇, Göksel Şener

Turkish Journal of Medical Sciences

Background/aim: The effects of L-theanine (LTN), a natural compound found in tea leaves, on biochemical parameters and cognitive functions were investigated in an aluminum chloride (AlCl3)-induced Alzheimer’s disease-like experimental model.

Materials and methods: A total of 32 male Wistar rats were allocated into four groups: control, AlCl3-induced AD-like group, LTN-treated AD-like group, and donepezil-treated AD-like group. Donepezil was used as a reference drug. For the induction of AlCl3- induced neurotoxicity, AlCl3 was administered by gavage at a dose of 25 mg/kg/day during the 1st week and 150 mg/kg/day for the subsequent 3 weeks. LTN was administered orally at a dose …

Therapeutic Potential Of Nasal Kisspeptin-54 For Reducing Α-Synuclein Accumulation And Restoring Hippocampal Synaptic Plasticity In A 6-Hydroxydopamine-Induced Rat Model Of Parkinson’S Disease ​, Ayşegül Gemi̇ci̇ Si̇nen, Emre Savran, Okyanus Bora Güleç, Osman Si̇nen, Nari̇n Deri̇n

Turkish Journal of Medical Sciences

Background/aim: Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons and pathological aggregation of α-synuclein (α-syn), leading to significant motor and cognitive impairments. Kisspeptin-54 (KP-54), a neuropeptide primarily involved in reproductive regulation, has recently been implicated in neurorestorative processes, with emerging evidence suggesting beneficial effects on locomotor activity and cognitive function. However, its therapeutic potential in PD has not yet been fully investigated. This study aimed to evaluate the therapeutic efficacy of chronic nasal KP-54 administration in a 6-hydroxydopamine (6-OHDA) rat model of PD, focusing on motor and cognitive outcomes, hippocampal synaptic plasticity, and α-syn pathology.

Materials and …

Boric Acid Enhances The Antitumor Effects Of Paclitaxel By Modulating Apoptosis, Autophagy-Related Protein Expression, And Proinflammatory Cytokine Expression In Ovcar-3 Ovarian Cancer Cells ​, Nazmi̇ye Bi̇tgen, Gözde Özge Önder, Münevver Baran, Fatma Esen Karakuş, Meli̇ke Akbulut, Arzu Yay

Turkish Journal of Medical Sciences

Background/aim: Ovarian cancer is the eighth most prevalent malignancy among women globally and ranks third among gynecological cancers in terms of incidence. The limited efficacy of standard chemotherapy, primarily due to intrinsic drug resistance and high recurrence rates, highlights the urgent need for novel therapeutic strategies that are both effective and selectively cytotoxic.

Materials and methods: This study aimed to investigate the combined effects of boric acid (BA), a biologically active boron compound with emerging antitumor potential, and paclitaxel (PTX), a conventional chemotherapeutic agent, on cell viability, cell cycle progression, apoptosis, autophagy-related protein expression, and inflammatory signaling in the chemoresistant …

Robust Soil Moisture Content Detection Based On Data Augmentation Under Different Testing Conditions, Yang Li, Chenghao Liu, Jing Nie, Jingbin Li

Turkish Journal of Agriculture and Forestry

Accurate and cost-effective monitoring of soil moisture content is essential for the development of precision agriculture and the optimization of water resource management. While low-frequency acoustic signals are used to detect soil moisture content, models trained with controlled laboratory acoustic data often exhibit significant performance degradation with field data due to their sensitivity to environmental noise, soil heterogeneity, and structural variations. This study proposes a novel framework to enhance model robustness and generalization by integrating a WGAN-GP network data augmentation strategy into the soil moisture content workflow. This framework is designed to generate high-quality and diverse data on different soil …

Estimation Of Genetic Parameters In Lemon-Scented Basil (Ocimum Basilicum L.) Lines, Erdi̇nç Günay, İsa Telci̇

Turkish Journal of Agriculture and Forestry

Selective breeding of basil (Ocimum basilicum L.) is primarily aimed at improving plant architecture and essential oil quality, which are critical factors in increasing yield. In lemon-scented basil, the citral component responsible for the intense lemony aroma has significant commercial value in the cosmetics and perfumery industries. This study aimed to evaluate the genetic variability, heritability, and genetic advance of nine agronomic and quality related traits in lemon basil lines, and to explore the interrelationships among these traits. The phenotypic coefficient of variation (PCV) was higher than the genotypic coefficient of variation (GCV) for all traits, suggesting the influence of …

Landscape Character Analysis And Assesment At Local Scale, Eli̇f Önal, Serkan Özer

Turkish Journal of Agriculture and Forestry

​Landscape areas are one of the most important elements of human life all over the world. Varied landscape areas are a valuable natural resource and have high cultural value. The first step to ensure the effective landscape use is to identify these areas, analyze them in detail, and determine their characteristics. The northeastern Anatolia region in Türkiye has a rich diversity of landscapes because of varied geographic, climatic, and topographic features. The aim of this study was to identify the landscape character types in the Tortum district, located in the Tortum River basin in northeastern Türkiye, and to assess the …

Beyond Autophagic Dysregulation: Vma21 Deficiency Reveals Altered Vesicle Trafficking And Broadens The Pathogenic Framework Of X-Linked Myopathy With Excessive Autophagy, Christian Suarez

Arts & Sciences Graduate Student Theses and Dissertations

Maintenance of protein homeostasis is essential for cellular function and depends on the coordinated regulation of protein synthesis and degradation. The major intracellular pathways responsible for protein degradation are the ubiquitin-proteasome system (UPS) and autophagy. Disruption of these processes has been implicated in a broad range of diseases, including neuromuscular disorders. X-linked myopathy with excessive autophagy (XMEA) is a rare vacuolar myopathy caused by mutations in VMA21, which encodes an assembly chaperone required for proper assembly of the vacuolar H⁺-ATPase (V-ATPase), the primary proton pump responsible for acidifying intracellular compartments, including lysosomes. Although impaired lysosomal acidification and autophagic dysregulation have …

Readability Of Dermatology Patient Education Materials: A Comparative Analysis Of Turkish Dermatology Association Brochures And Texts Generated By Chatgpt And Gemini ​, Ahmet Kağan Özdemi̇r, Bengü Reyhan Botsali Özdemi̇r, Akin Aktaş

Turkish Journal of Medical Sciences

Background/aim: In modern healthcare, patient education materials (PEMs) are essential for bridging the gap between clinical knowledge and patient understanding. However, in Türkiye, where 64.6% of the adult population possesses inadequate or problematic health literacy, traditional medical brochures often exceed recommended reading levels. This study aimed to evaluate and compare the readability of Turkish dermatology PEMs prepared by the Turkish Dermatology Association (TDA) with those generated by artificial intelligence (AI) models.

Materials and methods: A total of 68 TDA PEMs were analyzed. Readability was assessed using the Ateşman Readability Index. Responses were generated by AI models to questions extracted from …

Can Hydrolyzed Silk Fibroin Derived From Bombyx Hatayensis And Ozonized Gel Modulate Inflammatory And Angiogenic Responses In A Corneal Alkali Burn Model? ​​, Şule Barman Kaki̇l, Hamdullah Suphi̇ Bayraktar, Okan Soylu, İshak Gökçek, Meryem İlkay Karagül, Zehra Demi̇ray Asoğlu

Turkish Journal of Medical Sciences

Background/aim: The therapeutic effects of hydrolyzed silk fibroin derived from Bombyx hatayensis and a commercially available ozonized gel, administered individually and in combination, were evaluated in a rat model of corneal alkali burn.

Materials and methods: A standardized corneal alkali burn was induced in the right eyes of Wistar albino rats using 1 N sodium hydroxide (NaOH). Animals were randomly assigned to six groups: negative control, positive control (PC), hydrolyzed silk fibroin (SF), ozonized gel (O), combined treatment (SF + O), and antibiotic treatment. Topical treatments were administered for 21 consecutive days. Clinical evaluation included assessments of corneal opacity, neovascularization, …

Antiobesity, Antidiabetic, And Antioxidant Activities Of Selected Rubia Species (Rubiaceae) And Lc–Ms/Ms-Based Chemical Profiling ​, Semi̇h Bulut, Ahmet Kahraman, Ayşenur Işik, Mustafa Abdullah Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Rubia species (Rubiaceae) are recognized as medicinal and industrial plants exhibiting diverse biological activities. This study was conducted to evaluate the antioxidant, antidiabetic, and antiobesity potential of extracts prepared from Rubia davisiana Ehrend. (an endemic species), R. peregrina L., and R. rotundifolia Banks & Sol., which grow naturally in Türkiye.

Materials and methods: The antioxidant activity of 80% ethanol extracts prepared from the aerial parts was evaluated using 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, ferric reducing power, metal chelating capacity, and total antioxidant capacity assays. Inhibition assays for α-glucosidase and α-amylase were performed to evaluate antidiabetic activity, …