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2013

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Animal Skeletal Remains Of The Theodosius Harbor: General Overview, Vedat Onar, Gülsün Pazvant, Hasan Alpak, Nazan Gezer İnce, Altan Armutak, Zeynep Sevi̇m Kiziltan Jan 2013

Animal Skeletal Remains Of The Theodosius Harbor: General Overview, Vedat Onar, Gülsün Pazvant, Hasan Alpak, Nazan Gezer İnce, Altan Armutak, Zeynep Sevi̇m Kiziltan

Turkish Journal of Veterinary & Animal Sciences

Archaeological excavations at the site of Yenikapı, the most important main station for Metro and Marmaray projects on the European side of İstanbul, were started in 2004 with the discovery of numerous shipwrecks, amphorae, and skeletal remains belonging to animals. The findings from the excavations conducted by the İstanbul Archaeological Museums of the General Directorate of Cultural Heritage and Museums proved that this site, known in the Ottoman period as 'Langa Bostanları', was actually the ancient harbor of Theodosius. The archeological material and animal skeletal residues, mostly of horse origin, were found side by side in excavations initiated in 2004 …


Isolation Of Streptococcus Species From The Tonsils Of Slaughtered Pigs, Arzu Funda Bağcigi̇l, Serkan İki̇z, Kemal Meti̇ner, Naci̇ye Yakut Özgür, Seyyal Ak, Ahmet Ati̇la Ilgaz Jan 2013

Isolation Of Streptococcus Species From The Tonsils Of Slaughtered Pigs, Arzu Funda Bağcigi̇l, Serkan İki̇z, Kemal Meti̇ner, Naci̇ye Yakut Özgür, Seyyal Ak, Ahmet Ati̇la Ilgaz

Turkish Journal of Veterinary & Animal Sciences

The palatine tonsils of 220 pigs were examined for the occurrence of Streptococcus suis and other Streptococcus species. Samples were cultured onto Colombia agar plates with 5% defibrinated horse blood and selective antibiotic supplement and were incubated at 37 °C for 24-48 h aerobically. Presumptive colonies were identified using API20 Strep (bioMérieux). S. suis was not detected in any of the 220 palatine tonsils examined. S. porcinus was the most common streptococcus recovered and was isolated from 68 (31%) pigs. From the samples, S. agalactiae was isolated from 19 (8.6%), S. equi subsp. zooepidemicus from 10 (4.5%), S. uberis from …


Patellar Fracture And Patellar Tendon Rupture In A Dog, Murat Sarierler, İbrahi̇m Akin, Ali̇ Belge, Nuh Kiliç Jan 2013

Patellar Fracture And Patellar Tendon Rupture In A Dog, Murat Sarierler, İbrahi̇m Akin, Ali̇ Belge, Nuh Kiliç

Turkish Journal of Veterinary & Animal Sciences

The case of a patellar fracture in a 2-year-old male Chow Chow dog was reported. Clinical examination showed a few superficial wounds, erythema, a slight edema on the lateral aspect of the knee joint, and mild to moderate limping in the right hind leg. The patella was palpated more proximally than expected, while an acute ridge was felt at its distal pole. X-ray examination indicated that it had been fractured into 3 fragments. Following routine surgical preparation and inhalation anesthesia, the right knee joint was accessed through a lateral parapatellar incision. Spongious bone tissue was visible in the articular space …


Intrascrotal Testicular Torsion And Seminoma In A Dog With Chronic Renal Failure, Leandro Zuccolotto Crivellenti, Tathiana Ferguson Motheo, Ricardo Lima Salomão, Daniel Kan Honsho, Cladia Momo Jan 2013

Intrascrotal Testicular Torsion And Seminoma In A Dog With Chronic Renal Failure, Leandro Zuccolotto Crivellenti, Tathiana Ferguson Motheo, Ricardo Lima Salomão, Daniel Kan Honsho, Cladia Momo

Turkish Journal of Veterinary & Animal Sciences

A 10-year-old mongrel dog was presented with signs of vomiting, prostration, anorexia, abdominal pain, dyspnea, dysuria, and enhanced scrotal volume. Clinical, laboratory, and radiological examinations showed intrascrotal testicular pathology and chronic renal failure. Emergency treatment was carried out; however, the patient died. Necropsy diagnosed an intrascrotal testicular torsion and seminoma. The aim of the present report is to describe an intrascrotal testicular torsion associated with chronic renal failure in a dog.


Histological Changes In The Bone Structure Induced At 12 Weeks By Experimental Administration Of Bisphosphonates, Horea Artimoniu Almaşan, Mihaela Baciut, Oana Cristina Almaşan, Simion Bran, Grigore Baciut Jan 2013

Histological Changes In The Bone Structure Induced At 12 Weeks By Experimental Administration Of Bisphosphonates, Horea Artimoniu Almaşan, Mihaela Baciut, Oana Cristina Almaşan, Simion Bran, Grigore Baciut

Turkish Journal of Veterinary & Animal Sciences

Histological changes in bone structure were induced at 12 weeks by experimental administration of bisphosphonates, which have been associated with osteonecrosis of the jaws. The purpose of this study was to determine the effect of local administration of bisphosphonate on bone formation in rats. Surgically created bone defects were evaluated at 12 weeks by histological examination after bisphosphonate administration. Fifteen Wistar rats that underwent surgery to create a bone defect at the right femur were divided in 3 groups: 2 experimental groups and a control group. The 1st experimental group received bisphosphonate as a single 1-mL dose into the bone …


Economic Benefits Of Using Prebiotic And Probiotic Products As Supplements In Stimulation Feeds Administered To Bee Colonies, Silvia Patruica, Ioan Hutu Jan 2013

Economic Benefits Of Using Prebiotic And Probiotic Products As Supplements In Stimulation Feeds Administered To Bee Colonies, Silvia Patruica, Ioan Hutu

Turkish Journal of Veterinary & Animal Sciences

Spring stimulation feeding of honeybee colonies (Apis mellifera carpatica) is a very important technique for the encouragement of productive foraging. In addition to improving bee health by creating favorable conditions for the development of a beneficial intestinal bacterial flora, the use of prebiotic and probiotic supplements in the feed promotes good colony development, thus increasing the forager population. This paper presents the results for the economic benefit measured following use of supplements with acidifying substances (acetic and lactic acids) and probiotic products (Enterobiotics and Enterolactis Plus), as well as the synergism between them. A total of 110 bee colonies were …


Main Productive Performance Of Awassi Sheep In The Central Anatolian Region Of Turkey, Hakan Üstüner, Mehmet Mustafa Oğan Jan 2013

Main Productive Performance Of Awassi Sheep In The Central Anatolian Region Of Turkey, Hakan Üstüner, Mehmet Mustafa Oğan

Turkish Journal of Veterinary & Animal Sciences

This study aimed to determine milk yield, fertility, lamb growth, survival rate, and the effect of environmental factors on these parameters in the Awassi sheep of the Central Anatolian Region. The fertility parameters were determined to be as follows: heat rate, pregnancy rate, parturition rate, single-born rate, twinning rate, abortion rate, lamb rate, and number of lambs per parturition, based on the number of ewes assigned for mating, were 100%, 93.8%, 90.5%, 79.7%, 20.3%, 1.4%, 108.8%, and 1.20%, respectively. The survival rates of lambs at 60 and 120 days of age were 88.3% and 84.5%, respectively. The average lactation milk …


Occurrence Of Anti-Toxoplasma Gondii And Neospora Caninum Antibodies In Camels (Camelus Dromedarius) In The Center Of Iran, Hossein Hamidinejat, Masoud Ghorbanpour, Aria Rasooli, Mohammad Nouri, Seyedhossein Hekmatimoghaddam, Mohammad Mehdi Namavari, Mehdi Pourmehdi-Borojeni, Alireza Sazmand Jan 2013

Occurrence Of Anti-Toxoplasma Gondii And Neospora Caninum Antibodies In Camels (Camelus Dromedarius) In The Center Of Iran, Hossein Hamidinejat, Masoud Ghorbanpour, Aria Rasooli, Mohammad Nouri, Seyedhossein Hekmatimoghaddam, Mohammad Mehdi Namavari, Mehdi Pourmehdi-Borojeni, Alireza Sazmand

Turkish Journal of Veterinary & Animal Sciences

During the period from December 2008 to September 2009, we examined 254 serum samples (164 in hot-dry weather and 90 in cold-dry weather) from dromedary camels distributed all over Yazd Province, in the center of Iran. IgG antibodies were assayed by the modified agglutination test (MAT) and Neospora agglutination test (NAT) using whole tachyzoites of Toxoplasma gondii and Neospora caninum, incorporating 2-mercaptoethanol, for T. gondii and N. caninum, respectively. Anti-T. gondii antibodies were found in 37 (14.56%) of 254 camels with titers of 1:20 in 7, 1:40 in 6, 1:80 in 8, 1:160 in 1, 1:200 in 4, 1:400 in …


The Application Of A Phosphorus Mass Balance Model For Estimating The Carrying Capacity Of Lake Kariba, Lindah Mhlanga, Wilson Mhlanga, Paul Mwera Jan 2013

The Application Of A Phosphorus Mass Balance Model For Estimating The Carrying Capacity Of Lake Kariba, Lindah Mhlanga, Wilson Mhlanga, Paul Mwera

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to use an empirical mass balance equation to estimate the carrying capacity of Lake Kariba, where cage culture for Nile tilapia Oreochromis niloticus has been practiced since 1996. The carrying capacity for the lake was estimated at 33.2 × 103 t per year using the Dillon-Rigler phosphorus budget model.


Detection Of Fecal Coronavirus Antigen In Diarrheic Calves Of High- And Average-Producing Holstein Dairy Cows, Khalil Badiei, Mehrdad Pourjafar, Mohsen Ghane Jan 2013

Detection Of Fecal Coronavirus Antigen In Diarrheic Calves Of High- And Average-Producing Holstein Dairy Cows, Khalil Badiei, Mehrdad Pourjafar, Mohsen Ghane

Turkish Journal of Veterinary & Animal Sciences

From January to December 2009, 661 fecal samples from natural cases of diarrheic calves were taken by veterinary staff from the Department of Large Animal Internal Medicine of Shiraz Veterinary School and veterinary practitioners in Fars Province, Iran. The samples were taken from 267 diarrheic calves of high-producing dairy cows (HPDCs) and 394 diarrheic calves of average-producing Holstein dairy cows (APDCs). Fecal samples were collected and submitted for the laboratory diagnosis of coronavirus antigens. Herd selection was based on geographical location and density of cattle in the region. All herds had HPDC and APDC coronavirus-infected diarrheic calves in their population. …


Comparative Diagnostic Methods For Canine Ehrlichiosis, Chetan Parmar, Riddhi Pednekar, Anant Jayraw, Mukulesh Gatne Jan 2013

Comparative Diagnostic Methods For Canine Ehrlichiosis, Chetan Parmar, Riddhi Pednekar, Anant Jayraw, Mukulesh Gatne

Turkish Journal of Veterinary & Animal Sciences

The efficacy of blood and buffy coat smear examination, commercially available dot-enzyme-linked immunosorbent assay (ELISA) kit, and nested polymerase chain reaction (PCR) was evaluated in the diagnosis of canine ehrlichiosis in 40 dogs exhibiting symptoms suggestive of the disease. The intracytoplasmic rickettsial organisms were seen in the smears of only 1 dog (2.5%) with an extremely low level of parasitemia. Nested PCR with 16S rRNA revealed characteristic 378 bp bands indicating positive reaction in 8 (20.0%) dogs and sera samples of 21 (52.5%) dogs revealed anti-Ehrlichia antibodies. The dog that revealed organisms in the blood also showed positive results with …


Clinical Characteristics, Hematology, And Biochemical Analytes Of Primary Omasal Impaction In Bovines, Syed Aashiq Hussain, Sanjeev Kumar Uppal, Charanjit Randhawa, Naresh Kumar Sood, Shashi Kant Mahajan Jan 2013

Clinical Characteristics, Hematology, And Biochemical Analytes Of Primary Omasal Impaction In Bovines, Syed Aashiq Hussain, Sanjeev Kumar Uppal, Charanjit Randhawa, Naresh Kumar Sood, Shashi Kant Mahajan

Turkish Journal of Veterinary & Animal Sciences

This study was conducted on 11 animals (7 buffaloes and 4 cows) diagnosed with primary omasal impaction. In all the cases, laparorumenotomy was performed and omasal impaction was confirmed based on the consistency of the omasal contents along with an empty abomasum. Signalment, history, clinical signs, clinic-pathologic findings, and treatment were determined. Clinical examination was found to be helpful in subjective assessment of omasal impaction but could not aid in definitive diagnosis. Pain on palpation of the omasal area along with rectal findings could be a diagnostic feature. Neutrophilic leukocytosis was observed in a majority of animals. Total bilirubin, glucose, …


Morphological Similarities Between Spanish Pigeon Breeds., Pere Miquel Parés I Casanova Jan 2013

Morphological Similarities Between Spanish Pigeon Breeds., Pere Miquel Parés I Casanova

Turkish Journal of Veterinary & Animal Sciences

Relationships among 30 pigeon breeds were studied using data from 31 morphological characteristics. The relationships between breeds obtained from the study were rather congruent with the classification used by fanciers groups. The average Euclidean distance between pigeon breeds was 0.93 ± 0.16 STD. The results obtained were very compatible with those described in the literature for each classificatory group. Three large, perfectly definite clusters could be observed in this tree. A cluster was formed by Balearic nonpouter breeds and the Catalan Bare Pigeon. Another cluster occupied an intermediate position and was formed by thief pouters. They shared some remarkable peculiar …


High Clinical Disturbance And Mortality In Pigeon Flocks Caused By Hadjelia Truncata Infection In Sistan, Iran, Reza Nabavi, Javad Khedri, Mehdi Jahantigh Jan 2013

High Clinical Disturbance And Mortality In Pigeon Flocks Caused By Hadjelia Truncata Infection In Sistan, Iran, Reza Nabavi, Javad Khedri, Mehdi Jahantigh

Turkish Journal of Veterinary & Animal Sciences

A large number of birds in 3 pigeon flocks (containing 637 individuals) were severely affected by Hadjelia truncata. This was observed in April 2011 in Sistan District in Iran. In the affected birds, progressive weight loss, weakness, and death were observed. In the necropsy of 8 cases the gizzards were larger and softer than normal and in all of them distortion was detected. Stool examination by the Clayton Lane method revealed 72% infection among domestic pigeons. The hematological analysis of affected birds showed signs of decline in hematocrit and total protein volume. A levamisole treatment program could successfully remove the …


Presence Of Mycoplasmas In The Respiratory System Of Small Ruminants Managed Under An Extensive Production System, Zinka Maksimovic, Christian De La Fe, Maid Rifatbegovic Jan 2013

Presence Of Mycoplasmas In The Respiratory System Of Small Ruminants Managed Under An Extensive Production System, Zinka Maksimovic, Christian De La Fe, Maid Rifatbegovic

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to investigate the presence of mycoplasmas in the respiratory system of sheep and goat populations managed under extensive production systems. Specific culture and polymerase chain reaction techniques were performed on a total of 88 lung tissue samples and 142 nasal swabs obtained from multiple herds in Bosnia and Herzegovina. A total of 29 samples (12.6%) were found to be positive for mycoplasmas. Mycoplasma ovipneumoniae was detected in the nasal swabs and lungs of affected sheep (n = 19) and in the lungs of asymptomatic goat kids (n = 2), while M. arginini (n = …


The Aig Story (Chapter 18, Nationalization), Lawrence A. Cunningham, Maurice R. Greenberg Jan 2013

The Aig Story (Chapter 18, Nationalization), Lawrence A. Cunningham, Maurice R. Greenberg

GW Law Faculty Publications & Other Works

This is the final chapter of The AIG Story, a book about the growth of a large international insurance company that pioneered the opening of new markets and helped forge milestone international trade agreements, followed by an account of its near-destruction, first at the hands of an overzealous state attorney general and underwhelming board of directors, and then, as detailed in this chapter, at the hands of federal government officials overwhelmed by a financial crisis they could not understand. This chapter begins in mid-2008, when AIG’s losing financial products bets presented the company with a huge liquidity problem, though it …


The Expulsion Of Aliens And Other Topics: The Sixty-Fourth Session Of The International Law Commission, Sean D. Murphy Jan 2013

The Expulsion Of Aliens And Other Topics: The Sixty-Fourth Session Of The International Law Commission, Sean D. Murphy

GW Law Faculty Publications & Other Works

This essay analyzes the work of the International Law Commission during its sixty-fourth session in Geneva from May 7 to June 1, and from July 2 to August 3, 2012. The session marked the first year of a new quinquennium (2012-2016), with the Commission having completed its work during the prior quinquennium on four major topics: transboundary aquifers; reservations to treaties; responsibility of international organizations; and effects of armed conflict on treaties. The central topic under discussion during the sixty-fourth session concerned the expulsion of aliens, which led to the adoption on first reading of thirty-two articles, together with commentaries, …


The Congressional War On Contractors, Jessica Tillipman Jan 2013

The Congressional War On Contractors, Jessica Tillipman

GW Law Faculty Publications & Other Works

The U.S. Suspension & Debarment regime is designed to ensure that the federal government does business only with “responsible” partners. One of the most fundamentally (and frequently) misunderstood aspects of the FAR 9.4 suspension & debarment system is that these tools are only to be used for the purpose of protecting the Government, not to punish contractors for their past misconduct. Unfortunately, recent congressional initiatives demonstrate many legislators’ desire to transform debarment into a tool of punishment by banishing contractors from the procurement system “with little consideration of whether such action is needed or fair."

Instead of focusing on the …


Incentive Effects From Different Approaches To Holdup Mitigation Surrounding Patent Remedies And Standard-Setting Organizations, F. Scott Kieff, Anne Layne-Farrar Jan 2013

Incentive Effects From Different Approaches To Holdup Mitigation Surrounding Patent Remedies And Standard-Setting Organizations, F. Scott Kieff, Anne Layne-Farrar

GW Law Faculty Publications & Other Works

Debates about patent policy often focus on the potential for the threat of a court-imposed remedy for patent infringement to cause manufacturing entities and others to suffer patent holdup, especially when standardized industries are involved. This article uses lessons from the broader economics and political science literatures on holdup to explore various approaches to setting remedies for patent infringement—namely injunctions and money damages in the form of lost profits or reasonable royalties—with an eye towards the nature and extent of various forms of holdup they each might generate. In so doing, the article contrasts various narrower sub-categories of the broad …


Who's The Father?, Naomi R. Cahn, June Carbone Jan 2013

Who's The Father?, Naomi R. Cahn, June Carbone

GW Law Faculty Publications & Other Works

As this brief online essay observes, the litigation that produced the Supreme Court' 2013 decision in Adoptive Couple v. Baby Girl demonstrates why we are no closer to a definitive resolution of what to do when parents do not share assumptions about how to raise their child. The case illustrates the national lack of agreement on what makes someone a parent. At the core of these differences is the question of how to align parental behavior with the promotion of the child’s interest in stable and secure relationships.


Jurisgenerative Constitutionalism: Procedural Principles For Managing Global Legal Pluralism, Paul Schiff Berman Jan 2013

Jurisgenerative Constitutionalism: Procedural Principles For Managing Global Legal Pluralism, Paul Schiff Berman

GW Law Faculty Publications & Other Works

Global Legal Pluralism recognizes the inevitability (and sometimes even the desirability) of multiple legal and quasi-legal systems purporting to regulate the same act or actor. However, the resulting pluralism—just as inevitably—creates conflicts among norms that are potentially intractable. Thus, legal systems must address how best to respond to the realities of pluralism. This inquiry has constitutional dimensions because it goes to the constitutive character of communities and their relationships with other communities, be they international, transnational, national, subnational, or epistemic.

One response to pluralism is jurispathic: “kill off” all competing laws by declaring that one set of norms—and only one—shall …


Citigroup: A Case Study In Managerial And Regulatory Failures, Arthur E. Wilmarth Jr. Jan 2013

Citigroup: A Case Study In Managerial And Regulatory Failures, Arthur E. Wilmarth Jr.

GW Law Faculty Publications & Other Works

Citigroup has served as the poster child for the elusive promises and manifold pitfalls of universal banking. When Citicorp merged with Travelers to form Citigroup in 1998, Citigroup’s leaders and supporters asserted that the new financial conglomerate would offer unparalleled convenience to its customers through “one-stop shopping” for banking, securities and insurance services. They also claimed that Citigroup would have a superior ability to withstand financial shocks due to its broadly diversified activities.

During its early years, Citigroup was embroiled in a series of high-profile scandals, including tainted transactions with Enron and WorldCom, biased research advice, corrupt allocations of shares …


Grades Matter; Legal Writing Grades Matter Most, Jessica L. Clark Jan 2013

Grades Matter; Legal Writing Grades Matter Most, Jessica L. Clark

GW Law Faculty Publications & Other Works

In this study of 380 students in a law school’s 2011 graduating class, the data demonstrates a strong correlation between high performance in legal writing courses and high performance in non-legal writing courses. There is also a strong correlation at the opposite end: low performers in legal writing courses are low performers in non-legal writing courses. This article provides the hard data to support the significance of writing skills by demonstrating the correlation between performance in legal writing courses and performance in other law school courses by comparing grades and Grade Point Averages (GPAs). Of course grades and GPA data …


Legal Beagle Blog (January 2013), Roger Williams University School Of Law Library Jan 2013

Legal Beagle Blog (January 2013), Roger Williams University School Of Law Library

Law Library Newsletters/Blog

No abstract provided.


Newsroom: Goins '12: Common Cause Ri Board President, Roger Williams University School Of Law Jan 2013

Newsroom: Goins '12: Common Cause Ri Board President, Roger Williams University School Of Law

Life of the Law School (1993- )

No abstract provided.


20th Anniversary: Fulfilling The Promise: Calendar Of Events, Roger Williams University School Of Law Jan 2013

20th Anniversary: Fulfilling The Promise: Calendar Of Events, Roger Williams University School Of Law

Life of the Law School (1993- )

No abstract provided.


Emerging Policy And Practice Issues (2012), Steven L. Schooner, David J. Berteau Jan 2013

Emerging Policy And Practice Issues (2012), Steven L. Schooner, David J. Berteau

GW Law Faculty Publications & Other Works

This paper, presented at the West Government Contracts Year in Review Conference (covering 2012), attempts to identify the key trends and issues for 2013 in U.S. federal procurement. Budgetary and financial insecurity emerge as the most significant emerging issues in government contracting. Consistent with prior practice, this chapter offers extensive coverage of the federal procurement spending trend and attempts to predict what lies ahead. Among other things, it discusses the pending sequestration, procurement spending rates, agency purchasing data (particularly at the Defense Department, Department of Homeland Security, and the Department of State and the Agency for International Development), grants spending, …


Bid Protests: The Costs Are Real, But The Benefits Outweigh Them, Daniel I. Gordon Jan 2013

Bid Protests: The Costs Are Real, But The Benefits Outweigh Them, Daniel I. Gordon

GW Law Faculty Publications & Other Works

The author analyzes the costs and benefits of bid protests, with a focus on protests filed at the Government Accountability Office (GAO). The author explains that the costs are often overstated, in that GAO’s reporting methodology leads observers to overstate the number of protests and the frequency of successful protests. The author also reports on research regarding what happens after GAO sustains protests, and indicates that firms that successfully protest to GAO generally do not obtain the contract that was the subject of the protest. The article also explains that the “automatic stay” of procurements triggered by a protest to …


Ecotoxicological Assessment Of Silica And Polystyrene Nanoparticles Assessed By A Multitrophic Test Battery, Maria Casado-Gavalda, Ailbhe Macken, Hugh Byrne Jan 2013

Ecotoxicological Assessment Of Silica And Polystyrene Nanoparticles Assessed By A Multitrophic Test Battery, Maria Casado-Gavalda, Ailbhe Macken, Hugh Byrne

Articles

The acute ecotoxicity of different diameters of silica and polyethyleneimine polystyrene (PS-PEI)nanoparticles (NPs)was assessed on a test battery of aquatic organisms representing different trophic levels. Daphnia magna, Thamnocephalus platyurus, Pseudokirchneriella subcapitata and Vibrio fischeri, were employed in a series of standard acute ecotoxicity tests and work was complemented with two cytotoxicological end points on a rainbow trout gonadal cell line (RTG-2). Physico-chemical characterization of the NPs was performed in the different test media employed, using dynamic light scattering (DLS) and zeta potentiometry. In contrast to silica NPs exposure, for which no effect was observed for concentrations up …


Pulmonary Dwcnt Exposure Causes Sustained Local And Low-Level Systemic Inflammatory Changes In Mice, Furong Tian, Junja C. Habel-Ungewitter, Yin Renfu, Tobias Stoger Jan 2013

Pulmonary Dwcnt Exposure Causes Sustained Local And Low-Level Systemic Inflammatory Changes In Mice, Furong Tian, Junja C. Habel-Ungewitter, Yin Renfu, Tobias Stoger

Articles

Carbon nanotubes (CNTs) represent promising vectors to facilitate cellular drug delivery and to overcome biological barriers, but some types may also elicit persistent pulmonary inflammation based on their fibre characteristics. Here, we show the pulmonary response to aqueous suspensions of block copolymer dispersed, double-walled carbon nanotubes (DWCNT, length 1–10 lm) in mice by bronchoalveolar lavage (BAL) analysis, and BAL and blood cytokine and lung antioxidant profiling. The intratracheally instilled dose of 50 lg DWCNT caused significant pulmonary inflammation that was not resolved during a 7- day observation period. Light microscopy investigation of the uptake of DWCNT agglomerates revealed no particle …