Digital Commons Network^™

Wallace On Natural Selection: What Did He Really Have In Mind?, Charles H. Smith

DLPS Faculty Publications

No abstract provided.

Hypersaline Lake Environments Exhibit Reduced Microbial Dormancy, Joshua Christopher Vert

Theses and Dissertations

From acid seeps and deep-sea thermal vents to glacial ice and hypersaline lakes, extreme environments contain relatively simplified communities consisting of extremophiles that have evolved to survive and thrive under adverse abiotic conditions. In more neutral environments, microorganisms use dormancy as a common life history strategy to weather temporal fluctuations of resources or stresses until more 'optimal' conditions are present. It is unclear if dormancy is an essential survival mechanism for microorganisms in extreme environments; however, recent studies suggest that extreme environments may create stable conditions for extremophiles to the extent that dormancy is of less ecological importance. Using lake …

Identification And Differentiation Of Tier 1 Bacterial Agents Using Gas Chromatography-Mass Spectrometry, Dan Li

Theses and Dissertations

A simple method was developed for detection and differentiation of five Tier 1 bacterial agents, including Bacillus anthracis, Francisella tularensis, Yersinia pestis, Burkholderia pseudomallei and Burkholderia mallei as well as their closely related near neighbors by gas chromatography-mass spectrometry (GC-MS). Generally, different classes of compounds can be used as biomarkers for biowarfare agent detection, including nucleic acids (i.e., DNA or RNA), proteins (i.e., antibodies), carbohydrates (i.e., sugars), lipopolysaccharides, lipids (i.e., fatty acids) and small molecules. One-step thermochemolysis (TCM) was developed to provide GC-MS detectable biomarker signatures, including sugars, fatty acids and small molecules. Solid phase micro-extraction (SPME) was used for …

Overview Of The Recent Fda Process Validation Guidance For Medicinal Product Development And Manufacture, Nuala Calnan (Editor)

Conference Papers

This conference paper presents an overview of the recently published FDA Process Validation Guideline for the development and manufacture of medicinal drug products. It discusses the impacts of conducting life cycle based validation activities and highlights the future challenges in meeting the ongoing 'Continued Process Validation' (CPV) expectations of the regulator. It also presents the latest information on the EU draft Process Validation Guidance - due for publication in late 2013 / 2014.

Air-Quality And Climatic Consequences Of Bioenergy Crop Cultivation, William Christian Porter

Dissertations and Theses

Bioenergy is expected to play an increasingly significant role in the global energy budget. In addition to the use of liquid energy forms such as ethanol and biodiesel, electricity generation using processed energy crops as a partial or full coal alternative is expected to increase, requiring large-scale conversions of land for the cultivation of bioenergy feedstocks such as cane, grasses, or short rotation coppice. With land-use change identified as a major contributor to changes in the emission of biogenic volatile organic compounds (BVOCs), many of which are known contributors to the pollutants ozone (O₃) and fine particulate matter …

Kids Count The State Of The Child In Tennessee 2012, Tennessee. Commission On Children & Youth.

The State of the Child in Tennessee

No abstract provided.

June 7, 2013 Finance & Facilities (F&F) Committee Meeting, Evp For Administration

Finance and Facilities Committee

Documents related to the June 7, 2013 Board of Regents' Finance and Facilities Committee Meeting. (Agenda, Minutes, eBook, Notice)

Revegetation Guidelines For Stormwater Pollution Prevention Plan (Swppp) Closure In Central New Mexico, Jennifer Payne-Ross

Water Resources Professional Project Reports

A major challenge for construction stormwater permit holders in New Mexico is the closure of their Stormwater Pollution Prevention Plan (SWPPP) through successful revegetation of the post-construction sites. Successful revegetation of native plants is a difficult task to achieve. Without proper guidance, the SWPPP permit closure goal is exceptionally difficult to achieve in New Mexico. This paper examines comprehensive seeding guidance designed for contractors or other individuals without seeding experience that are responsible for permanent soil stabilization. When accurately followed and appropriately budgeted, the seeding guidance document developed in conjunction with this paper and presented in Appendix I should greatly …

The Microbial Link In Ecosystem Processing In The East Fork Of The Jemez River : Extracellular Enzyme Response To Habitat, Seasonal Fluctuations, And Wildfire Disturbance, Susan G. Kutvirt

Water Resources Professional Project Reports

Mounting evidence suggests that a warming climate in the southwestern United States threatens the quality and quantity of mountain source waters for New Mexicos largest surface water source, the Rio Grande. These waters, fed primarily by snowmelt, are critical to the ecological, agricultural, municipal, and cultural requirements of New Mexico. In an effort to construct a baseline of stream metabolism in the East Fork of the Jemez River (EFJR), a major tributary of the Rio Grande, our research team sampled macrophytes, algae, macroinvertebrates, and benthic microbial communities to assess changes pertaining to habitat and seasonal fluctuations and in response to …

Multi-Year Measurement Of Wholestream Metabolism In A Snowmelt-Dominated Montane Ecosystem, Betsy Shafer

Water Resources Professional Project Reports

Warming temperatures, reduced precipitation, and earlier snowmelt are predicted for the mountains of the southwestern U.S due to climate change. In addition, interannual variability in precipitation, partially linked to the El Niño-Southern Oscillation phenomenon (ENSO), also will impact stream-flow and ecosystem processes. Wholestream metabolism was modeled using continuous data for selected time periods ranging from 2005 to 2012. This eight-year study explores temporal trends in whole-stream metabolism parameters; as well, it links the potential impact of climate variability on these temporal trends. Gross primary production (GPP) and community respiration (CR) rates were comparable to other open-canopy lotic systems, and remained …

A Longitudinal Examination Of Risk And Protective Factors Associated With Drug Use And Unsafe Sex Among Young African American Females, Dexter R. Voisin

Faculty Scholarship

This study prospectively examined associations among multiple theoretically informed risk (e.g., depression, sexual sensation seeking, and risky peers norms) and protective factors (e.g., social support, STI knowledge, and refusal to have sex self efficacy) on unsafe sex among 715 African American adolescent females aged 15-21 who participated in an STI/HIV prevention intervention. Generalized estimating equation models were used to assess associations between baseline characteristics and sexual risk over a 12-month follow-up period. Overall risk in this population was high: at baseline, nearly a third of women reported sex under the influence of alcohol or substances; ≥ 2 partners for vaginal …

Thymidine Kinase 1: Diagnostic And Prognostic Significance In Malignancy, Melissa Marie Alegre

Theses and Dissertations

Thymidine kinase 1 (TK1) is a cancer biomarker which has diagnostic and prognostic potential in a variety of malignancies. TK1 is significantly elevated in the serum and tumor tissue of most malignancies. This increase in TK1 can be detected in the very early stages of malignancy, including in pre-malignant disease with an increased risk for progression. Several studies have demonstrated that elevated TK1 is found in serum months before any clinical symptoms of malignancy. It has also been demonstrated that TK1 is elevated months before clinical recurrence of malignancy. This work first sought to demonstrate the early nature of TK1 …

Expenditure, Confidence, And Uncertainty: Identifying Shocks To Consumer Confidence Using Daily Data, Marta Lachowska

Upjohn Institute Working Papers

The importance of consumer confidence in stimulating economic activity is a disputed issue in macroeconomics. Do changes in confidence represent autonomous fluctuations in optimism, independent of information on economic fundamentals, or are they a reflection of economic news? I study this question by using high-frequency microdata on spending and consumer confidence, and I find that consumer confidence contains information relevant to predicting spending, independent from other indicators. The exogenous movements in consumer confidence lead to very short fluctuations in consumer spending, consistent with the hypothesis that more consumer confidence reflects less uncertainty about the future.

Resource Legacies And Priming Regulate Microbial Communities In Antarctica's Dry Valleys, Sabrina Deni Saurey

Theses and Dissertations

Multiple mechanisms control bacterial community structure but two in particular, the "legacy" of past environmental conditions, and the "priming" of bacteria to respond to seasonal or reoccurring fluctuations in resources, have the potential to determine both bacterial communities, as well as, temporal shifts in active bacterial taxa. To begin to evaluate the legacy effects of resources on microbial communities, we added four limiting resources annually (i.e., water only; C-mannitol + water; N-NH4NO3 + water; and C, N + water) and measured shifts in bacterial community composition after seven years in a cold desert ecosystem in the McMurdo Dry Valleys, Antarctica. …

Materials Education And Research In Art And Design: A New Role For Libraries (Survey Stats), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.

Materials Education And Research In Art And Design: A New Role For Libraries (Program Sheet), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.

Materials Education And Research In Art And Design: A New Role For Libraries (Program Booklet), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.

Materials Education And Research In Art And Design: A New Role For Libraries (Website), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.

Service Learning And School Community Partnership, Sau Ting, Cynthia Wu, Yim Wah Mak, Man Kin Wong, Pak Ho Chan, Wing Ying, Winnie Lee, King Yu, Aron Kwok, Shuk Man, Sylvia Ting

Asia-Pacific Regional Conference on Service-Learning 亞太地區服務研習會議

Background

Service learning offered university students the opportunity to apply knowledge and skills in social care context while strengthening community health. This paper aimed at highlighting the essential features of the program in achieving sustainable outcomes.

Project design and methods

Students from different faculty, worked as a team to address the health issues of a less resourceful school. The students were required to plan and develop the related resources and products for matching the learning needs. Through the implementation, students shifted from following an instructive guide to acting on a more self-directed learning process at different stages of service. The …

Visual Sexuality: Integrating Art And Sex Therapies, Jillien Anne Kahn

LMU Theses and Dissertations

The goal of this research was to understand the potential challenges and benefits of an integration between art and sex therapies. Three interviews were performed: two with certified art therapists, one with a certified sex therapist, in order to understand how each of these professionals has chosen to approach issues of sexuality and creative expression within his or her practice. The data from the interviews was critically compared within and between each interviewee, producing three overarching themes that provide a framework for understanding the potential benefits and challenges of this integration. These three themes are defined as: 1) The importance …

Art In The Terror: An Analysis Of Nightmare Imagery In Art Therapy, Emily Christine Brozyna

LMU Theses and Dissertations

This paper examines the utilization of participants’ nightmares in art therapy to benefit treatment. The researcher utilized a self-study by means of making art about three of her own nightmares, followed by a comparative analysis in case studies. The researcher asked the participants to make art about a nightmare they reported they had while in a treatment session, and then provided them with the opportunity to alter the image for possible means of catharsis. The researcher then discussed the process with the participants in order to answer the research questions. The participants’ ages ranged from 6-15; with two males and …

Integrating Art Therapy And Eye Movement Desensitization And Reprocessing To Treat Post Traumatic Stress, Holland Elizabeth Breed

LMU Theses and Dissertations

This research study explored the integration of Art Therapy and Eye Movement Desensitization and Reprocessing (EMDR) to treat clients with Posttraumatic Stress Disorder (PTSD). The study explored how art therapy and EMDR can be combined effectively. First, a literature review investigated previous research connecting trauma and its neurological impact, as well as the subsequent causes, symptoms and criteria for PTSD, as well as the connection between neurobiology to art therapy and EMDR. Second, an in-depth interview with a licensed MFT and registered art therapist who is also a certified EMDR practitioner portrays the ways combining art therapy and EMDR to …

Community Partnership In Service-Learning : The St. Paul University Philippines’ Experience, Allan Peejay Lappay

Asia-Pacific Regional Conference on Service-Learning 亞太地區服務研習會議

Partnership is a key to an effective service-learning (SL). It develops competencies that promote the advancement of socially responsible citizens. As a prime Catholic University in Northeastern Philippines, St. Paul University Philippines (SPUP) has forged partnerships with communities to address their need of service and the students’ need of learning through active engagement. This allows Paulinian learners to connect with and benefit their surrounding communities through service while integrating their learning to their particular academic discipline. As SL fosters collaboration and partnership, it provides an avenue for learners to make valuable contributions to the community. To this end, St. Paul …

Omigapil Treatment Decreases Fibrosis And Improves Respiratory Rate In Dy2j Mouse Model Of Congenital Muscular Dystrophy, Qing Yu, Arpana Sali, Jack Van Der Meulen, Brittany K. Creeden, Heather Gordish-Dressman, Anne Rutkowski, Sree Rayavarapu, Kitipong Uaesoontrachoon, Tony Huynh, Kanneboyina Nagaraju, Christopher F. Spurney

Genomics and Precision Medicine Faculty Publications

No abstract provided.

Novel Regulatory Small Rnas In Streptococcus Pyogenes, Rafael A. Tesorero, Ning Yu, Jordan O. Wright, Juan P. Svencionis, Qiang Cheng, Jeong-Ho Kim, Kyu Hong Cho

Biochemistry and Molecular Medicine Faculty Publications

Streptococcus pyogenes (Group A Streptococcus or GAS) is a Gram-positive bacterial pathogen that has shown complex modes of regulation of its virulence factors to cause diverse diseases. Bacterial small RNAs are regarded as novel widespread regulators of gene expression in response to environmental signals. Recent studies have revealed that several small RNAs (sRNAs) have an important role in S. pyogenes physiology and pathogenesis by regulating gene expression at the translational level. To search for new sRNAs in S. pyogenes, we performed a genomewide analysis through computational prediction followed by experimental verification. To overcome the limitation of low accuracy in …

Western News, June 6, 2013, Western Michigan University

Western News (1972-2018)

Story highlights: Construction projects to cause few disruptions; Emergency communication system is changing; Broncoland video game released during student orientation; On Campus with Tracey Lawie.

Materials Collection Creation And Administration: A New Role For Libraries (White Paper), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

The Problem/Opportunity: To define, identify, and guide design-based materials collections in academic settings and foster community among those with existing collections and/or those considering creating and supporting one.

Contents and topics:

1. What is a materials collection?
2. Why have a materials collection?
3. Acquisition strategies
4. Organizational approaches
5. Programming possibilities
6. Symposium summary
7. Resources

Breast Cancer Antiestrogen Resistance 3 (Bcar3) Promotes Cell Motility By Regulating Actin Cytoskeletal And Adhesion Remodeling In Invasive Breast Cancer Cells., Ashley L Wilson, Randy S Schrecengost, Michael S Guerrero, Keena S Thomas, Amy H Bouton

Department of Cancer Biology Faculty Papers

Metastatic breast cancer is incurable. In order to improve patient survival, it is critical to develop a better understanding of the molecular mechanisms that regulate metastasis and the underlying process of cell motility. Here, we focus on the role of the adaptor molecule Breast Cancer Antiestrogen Resistance 3 (BCAR3) in cellular processes that contribute to cell motility, including protrusion, adhesion remodeling, and contractility. Previous work from our group showed that elevated BCAR3 protein levels enhance cell migration, while depletion of BCAR3 reduces the migratory and invasive capacities of breast cancer cells. In the current study, we show that BCAR3 is …

2013-June-06-2013 Staff Awards, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

The Weekly Challenger, June 6, 2013, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The June 6, 2013, issue of The Weekly Challenger.