Digital Commons Network^™

Role Of Vimf In Gingipain Maturation In Porphyromonas Gingivalis, Arun S. Muthiah

Loma Linda University Electronic Theses, Dissertations & Projects

Gingipain activity in Porphyromonas gingivalis, the major etiological agent in adult periodontitis, is post-translationally regulated by unique Vim proteins including VimF, a putative glycosyltransferase. To ascertain the VimF mediated phenotype we first inactivated the vimF gene in P. gingivalis ATCC 33277 (FLL476), a less virulent fimbriated strain. We observed that the vimF-defective mutant (FLL476) showed a phenotype similar to that of the vimF-defective mutant (FLL95) in the P. gingivalis W83 background. While hemagglutination was not detected and autoaggregationn was reduced, biofilm formation was increased in FLL476. Also, invasive capacity decreased for this mutant. Furthermore, fimbrial structures were missing in FLL476, …

Motivational Interviewing Group To Address Cardiovascular Disease Risk Factors, Salma A. Salem

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this doctoral project was to create a group treatment manual for adults diagnosed with cardiovascular disease, who were displaying adverse health behaviors that were modifiable by lifestyle change. In order to create the manual, an extensive literature review was conducted in the areas of the prevalence of chronic illness in the United States, cardiovascular disease and associated health risk factors, motivational interviewing, health behavior change, and group therapy with adults. The result is a manual consisting of 10 detailed weekly sessions, including pre/post outcome measures, complete with handouts and facilitator guidelines for working with this population.

Study Of Brief Single Session Medical Family Therapy With Low-Income Patients, Mayuri Pandit

Loma Linda University Electronic Theses, Dissertations & Projects

Medical Family Therapy (MedFT) has been promoted as beneficial for vulnerable patient populations. However, there is a need for MedFT effectiveness studies with longitudinal randomized control trials. Thus, this pilot study investigated the results of a brief single session of MedFT over a one-week period with low-income primary care patients. Effectiveness in this study was defined as increasing a sense agency and communion and decreasing psychological distress. Results suggested that over time, MedFT may increase some sense of agency for lower-income patients, increase patient satisfaction with care, increase family support for patients with higher education, and decrease depression symptoms for …

Online Psychosocial Support For Oncology Patients: A Group Facilitation Manual, Kristen Mallory Richards

Loma Linda University Electronic Theses, Dissertations & Projects

A significant portion of the oncology population is seeking, yet not receiving, adequate psychological treatment. Therefore, the Internet has become an important resource for delivering services to those that may be limited by barriers that accompany traditional oncology support groups. While research has shown that online therapy is effective, the quality and efficacy of therapy is often unknown and/or sub-optimal and essential psychological care cancer patients deserve is compromised. The purpose of this project was to provide therapists and other mental health professionals with a structured, evidence-based guide to providing quality mental health care for cancer patients. First, a review …

Adverse Childhood Experiences And Acute Coronary Syndrome In Adulthood, Kanchana D. Wijesekera

Loma Linda University Electronic Theses, Dissertations & Projects

Research studies demonstrate that exposure to adverse childhood experiences (ACEs) lead to physical and mental health consequences in adulthood, including cardiovascular disease (Dong, Giles, Felitti et al, 2004; Felitti, Anda, Nordenberg, et al, 1998). One potential mechanism linking ACEs to cardiovascular disease is impaired social competence necessary for successful relationships and adequate social support. In the current study, the impact of ACEs on social support and subsequent incidence of acute coronary syndrome (ACS) was examined in a cohort of 6,596 older Seventh-day Adventists. After controlling for sociodemographic, lifestyle, and psychological factors, ACE exposure predicted increased risk of ACS by 31% …

Categorically Black, White, Or Wrong: 'Misperception Discrimination' And The State Of Title Vii Protection, D. Wendy Greene

University of Michigan Journal of Law Reform

This Article exposes an inconspicuous, categorically wrong movement within antidiscrimination law. A band of federal courts have denied Title VII protection to individuals who allege “categorical discrimination”: invidious, differential treatment on the basis of race, religion, color, national origin, or sex. Per these courts, a plaintiff who self-identifies as Christian but is misperceived as Muslim cannot assert an actionable claim under Title VII if she suffers an adverse employment action as a result of this misperception and related animus. Though Title VII expressly prohibits discrimination on the basis of religion, courts have held that such a plaintiff’s claim of “misperception …

Lost Branches On The Tree Of Life, Bryan T. Drew, Romina Gazis, Patricia Cabezas, Kristen S. Swithers, Jiabin Deng, Roseana Rodriguez, Laura A. Katz, Keith A. Crandall, David S. Hibbett, Douglas E. Soltis

Biology

Until recently, uploading sequences to GenBank (or EMBL) was generally considered sufficient to ensure reproducibility of phylogenetic studies using DNA sequence data. Increasingly, however, the systematics community is realizing that archiving raw DNA sequences is not adequate, and that the underlying alignments of DNA sequences as well as the resulting phylogenetic trees are pivotal for reproducibility, comparative purposes, meta-analyses, and ultimately synthesis. Indeed, there has been a growing clamor for journals to adopt and enforce more rigorous data archiving practices across diverse disciplines [4]–[8]. As a result, about 35 evolutionary journals [5],[9] have adopted policies …

Temporal And Spatial Requirements Of Drop-Dead Expression For Adult Survival In Drosophila Melanogaster, Christine Lynn Sansone

Dissertations (1934 -)

Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster including early lethality, neurodegeneration, fragile tracheae, gut dysfunction, reduced body mass, and female sterility. The cause of early lethality and the function of the drd protein remain unknown. To elucidate a molecular function of DRD, the temporal and spatial requirements of the drd gene for survival were determined. drd expression was manipulated with the Gal4-UAS system, using UAS-RNAi transgenes and a UAS-drd transgene on a drd mutant background to knock down and rescue expression of drd, respectively.

To investigate the temporal requirements of drd expression for adult …

Freesurfer Vs. Manual Tracing: Detecting Future Cognitive Decline In Healthy Older Adults At-Risk For Alzheimer's Disease, Alissa Butts

Dissertations (1934 -)

Alzheimer's disease (AD) is a neurodegenerative pathological process that is thought to begin years prior to observable symptom onset. The hippocampus appears to be particularly vulnerable to the underlying brain pathology of AD. Hippocampal volume is a sensitive measure in predicting conversion from mild cognitive impairment to AD, but less is known regarding the use of hippocampal volume in asymptomatic individuals at risk for AD who eventually decline. The inconsistent findings may, in part, be due to the chosen method of hippocampal segmentation. FreeSurfer (FS) and manual tracings (MT) are two common segmentation techniques that have unique costs and benefits. …

Synthesis Of Some Heterocyclic Compounds Derived From, Mohammed A. Abdul Razzaq Al-Iraqi, Maysa’A K. Shaker Al-Mala Kodair

Baghdad Science Journal

The 4-(α-bromo acetyl)-4'-toluene sulfonanilide (2) was used as key intermediate to synthesize new heterocyclic compounds. This bromo compound was synthesized via sulfonation of amino group of p-amino acetophenone using Hinsburg method with 4-toluene sulfonyl chloride to form 4-acetyl- 4'toluene sulfonanilide (1) which is used as a starting material in this work. This compound was brominated to yield compound (2) which is used as a precursor to synthesize new five and seven membered heterocyclic compounds such as substituted 1,3-oxazoles (3,4), 1,3-thiazole derivatives (5-7), thiourea compounds (8a,b), 1,3-Thiazoline-2-thione compounds (9a-f) and 1,2,5-triazepine compounds (11a-d). The synthesized compounds were identified depending upon physical, …

Aseptically Processed And Chemically Sterilized Btb Allografts For Anterior Cruciate Ligament Reconstruction: A Prospective Randomized Study., Peter A Indelicato, Michael G Ciccotti, Joel Boyd, Laurence D Higgins, Benjamin S Shaffer, C Thomas Vangsness

Department of Orthopaedic Surgery Faculty Papers

PURPOSE: To compare the clinical outcomes of bone-patellar tendon-bone (BTB) allografts processed via a novel sterilization system with the traditional aseptically processed BTB allografts for anterior cruciate ligament (ACL) reconstruction.

METHODS: A total of 67 patients undergoing ACL reconstruction at 6 independent investigation sites were randomized into one of two intervention groups, BioCleanse-sterilized or aseptic BTB allografts. Inclusion criteria included an acute, isolated, unilateral ACL tear, and exclusion criteria included prior ACL injury, multi-ligament reconstruction, and signs of degenerative joint disease. Post-op examiners and patients were blinded to graft type. Patients were evaluated at 6, 12, and 24 months. Clinical …

Adverse Health Effects Of Nighttime Lighting: Comments On American Medical Association Policy Statement., Richard G Stevens, George C Brainard, David E Blask, Steven W Lockley, Mario E Motta

Department of Neurology Faculty Papers

The American Medical Association House of Delegates in June of 2012 adopted a policy statement on nighttime lighting and human health. This major policy statement summarizes the scientific evidence that nighttime electric light can disrupt circadian rhythms in humans and documents the rapidly advancing understanding from basic science of how disruption of circadian rhythmicity affects aspects of physiology with direct links to human health, such as cell cycle regulation, DNA damage response, and metabolism. The human evidence is also accumulating, with the strongest epidemiologic support for a link of circadian disruption from light at night to breast cancer. There are …

The Variability Of Autophagy And Cell Death Susceptibility, Ben Loos, Anna-Mart Engelbrecht, Richard A. Lockshin, Daniel J. Klionsky, Zahra Zakeri

Publications and Research

Impaired autophagic machinery is implicated in a number of diseases such as heart disease, neurodegeneration and cancer. A common denominator in these pathologies is a dysregulation of autophagy that has been linked to a change in susceptibility to cell death. Although we have progressed in understanding the molecular machinery and regulation of the autophagic pathway, many unanswered questions remain. How does the metabolic contribution of autophagy connect with the cell’s history and how does its current autophagic flux affect metabolic status and susceptibility to undergo cell death? How does autophagic flux operate to switch metabolic direction and what are the …

...Of Cabbages And Kings, September 2013, Emeriti Society, University Of The Pacific

Emeriti Newsletter: "...Of Cabbages and Kings"

"...Of Cabbages and Kings" is the newsletter of the University of the Pacific Emeriti Society. Read more about the Emeriti Society of Pacific by clicking here.

University Of Massachusetts Boston: Campus Climate Project Final Report, September 2013, Rankin & Associates, Consulting

Office of Diversity and Inclusion Publications

The University of Massachusetts Boston is dedicated to fostering a caring university community that provides leadership for constructive participation in a diverse, multicultural world. The University has a long history of supporting initiatives that foster an inclusive living, learning, and working environment. The University’s mission statement offers the commitment of the institution to supporting an inclusive environment. The University also includes diversity and inclusion among its seven core values indicating its importance.

UMass Boston’s long term commitment to diversity and inclusion is evident in the curriculum, in research, and in the commitment to community engagement and participation. As an example, …

External Collaboration In Army Science And Technology: The Army’S Research Alliances, John W. Lyons, James A. Ratches

Defense and Technology Papers

In this study, the authors examine the decision for Army Research Laboratories to engage in external, formal collaborations such as collaborative alliances. They go on to assess ARL Collaborative Technology Alliances (CTAs), Collaborative Research Alliances (CRAs), and Information Technology Alliance (ITAs). The report concludes by examining the effectiveness of the examples given above, and a recommendation for formulating a set of assessment questions for Army managers considering collaboration in the future.

Linking Phenology And Biomass Productivity In South Dakota Mixed-Grass Prairie, Matthew Rigge, Alexander Smart, Bruce Wylie, Tagir Gilmanov, Patricia Johnson

Natural Resource Management Faculty Publications

Assessing the health of rangeland ecosystems based solely on annual biomass production does not fully describe the condition of the plant community; the phenology of production can provide inferences about species composition, successional stage, and grazing impacts. We evaluated the productivity and phenology of western South Dakota mixed-grass prairie in the period from 2000 to 2008 using the normalized difference vegetation index (NDVI). The NDVI is based on 250-m spatial resolution Moderate Resolution Imaging Spectroradiometer (MODIS) satellite imagery. Growing-season NDVI images were integrated weekly to produce time-integrated NDVI (TIN), a proxy of total annual biomass production, and integrated seasonally to …

Evidence For 20th Century Climate Warming And Wetland Drying In The North American Prairie Pothole Region, Brett A. Werner, W. Carter Johnson, Glenn R. Guntenspergen

Natural Resource Management Faculty Publications

The Prairie Pothole Region (PPR) of North America is a globally important resource that provides abundant and valuable ecosystem goods and services in the form of biodiversity, groundwater recharge, water purification, flood attenuation, and water and forage for agriculture. Numerous studies have found these wetlands, which number in the millions, to be highly sensitive to climate variability. Here, we compare wetland conditions between two 30-year periods (1946–1975; 1976–2005) using a hindcast simulation approach to determine if recent climate warming in the region has already resulted in changes in wetland condition. Simulations using the WETLANDSCAPE model show that 20th century climate …

Modeling The Effect Of Apc Truncation On Destruction Complex Function In Colorectal Cancer Cells, Dipak Barua, William S. Hlavacek

Chemical and Biochemical Engineering Faculty Research & Creative Works

In colorectal cancer cells, APC, a tumor suppressor protein, is commonly expressed in truncated form. Truncation of APC is believed to disrupt degradation of β-catenin, which is regulated by a multiprotein complex called the destruction complex. The destruction complex comprises APC, Axin, β-catenin, serine/threonine kinases, and other proteins. The kinases CK1α and GSK-3β, which are recruited by Axin, mediate phosphorylation of β-catenin, which initiates its ubiquitination and proteosomal degradation. The mechanism of regulation of β-catenin degradation by the destruction complex and the role of truncation of APC in colorectal cancer are not entirely understood. Through formulation and analysis of a …

“Seeing, Seeing, Seeing”: Deafness, Knowledge, And Subjectivity In Elizabeth Bowen, Maren Linett

Department of English Faculty Publications

In What is Posthumanism, Cary Wolfe enlists Temple Grandin’s account of her autism to critique reductive ideas of subjectivity. He quotes Oliver Sacks’s comment that Grandin’s first book was “unthinkable because it had been medical dogma for forty years or more that there was no ‘inside,’ no inner life, in the autistic, or that if there was it would be forever denied access or expression” (129). As Wolfe sees it, that dogma is founded in no small part on the too-rapid assimilation of the questions of subjectivity, consciousness, and cognition to the question of language ability—a dogma that is perhaps …

I Hear The Train A Comin'-An Interview With Peter Binfield, Co-Founder & Publisher, Peerj, Greg Tanenbaum

Against the Grain

No abstract provided.

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Against the Grain

No abstract provided.

Atg Interviews Peter Binfield, Greg Tananbaum

Against the Grain

No abstract provided.

Differences In Aquatic Microcrustacean Assemblages Between Temporary And Perennial Springs Of An Alpine Karstic Aquifer, Nataša Mori, Anton Brancelj

International Journal of Speleology

Microcrustacean (Copepoda, Ostracoda) assemblages were investigated at the interface of the vadose and phreatic zones in the alpine karstic aquifer from the Julian Alps in Slovenia (SE Europe). Two temporary and one perennial karstic outlets were sampled by filtering the water several times over 2 years. Concurrently, benthos from the mouth of a perennial spring and from an adjacent spring brook were collected. Altogether 24 microcrustacean species were recorded. The spatial and temporal variation in drift densities and species composition was high indicating complex groundwater hydrological pathways being dependent on precipitation regime. Non-metric Multidimensional Scaling (NMDS) clearly separated drift samples …

Epilithic And Aerophilic Diatoms In The Artificial Environment Of Kungsträdgården Metro Station, Stockholm, Sweden, Lena Norbäck Ivarsson, Magnus Ivarsson, Johannes Lundberg, Therese Sallstedt, Catarina Rydin

International Journal of Speleology

The Kungsträdgården metro station is an artificial and urban subsurface environment illuminated with artificial light. Its ecosystem is almost completely unknown and as a first step to better understand the biology and rock wall habitats the diatom flora was investigated. A total of 12 species were found growing on the rock walls of Kungsträdgården metro station. The results show the diatom flora in Kungsträdgården to be dominated by e.g. Diadesmis contenta, Diadesmis perpusilla, Pinnularia appendiculata, Nitzschia amphibia, Nitzschia sinuata and Diploneis ovalis. One species, Caloneis cf. aerophila, has never been reported from Sweden before. …

Table Of Contents

International Journal of Speleology

No abstract provided.

Fast And Robust Automatic Segmentation Methods For Mr Images Of Injured And Cancerous Tissues, Vanessa Karlen Tidwell

All Theses and Dissertations (ETDs)

Magnetic Resonance Imaging: MRI) is a key medical imaging technology. Through in vivo soft tissue imaging, MRI allows clinicians and researchers to make diagnoses and evaluations that were previously possible only through biopsy or autopsy. However, analysis of MR images by domain experts can be time-consuming, complex, and subject to bias. The development of automatic segmentation techniques that make use of robust statistical methods allows for fast and unbiased analysis of MR images.

In this dissertation, I propose segmentation methods that fall into two classes---(a) segmentation via optimization of a parametric boundary, and: b) segmentation via multistep, spatially constrained intensity …

West Coast Rock Lobster Fishery Ecological Risk Assessment 20 February 2013, Department Of Fisheries

Fisheries Occasional Publications

No abstract provided.

Patients’ Perception Of Patient–Provider Communication In Fertility Preservation Decision Making Among Young Women With Cancer, Aakrati Mathur, E. Roberto Orellana, Amy Frohnmayer, Pauline Jivanjee, Lillian Nail, Brandon Hayes-Lattin, Rebecca G. Block

School of Social Work Faculty Publications and Presentations

Fertility preservation (FP) for patients with cancer is an emerging field. With the advancement of technology, patients may face a complex decision-making process about whether to preserve fertility. The purpose of this article is to explore how young women with cancer perceive patient–provider communication in FP decision making. In this study, 25 women between the ages of 18 and 39 were interviewed retrospectively. They were interviewed one time to learn about their decision-making process related to FP. Results of this analysis indicate that patients seek support and involvement from providers throughout the process of decision making. They prefer providers to …

Prevalence And Distribution Of Metabolic Syndrome In A Southern Chinese Population. Relation To Exercise, Smoking, And Educational Level, Yong-Qiang Li, Li-Qin Zhao, Xin-Yu Liu, Hong-Lei Wang, Xiao-Hong Wang, Bin Li, Kang-Ping Deng, Ying Zhang, Qin Liu, Harry Holthofer, He-Qun Zou

Saudi Medical Journal

OBJECTIVE: To investigate the prevalence and distribution of metabolic syndrome (MetS) and the impact of exercise, smoking, and educational level on the risk of MetS in a southern Chinese population. METHODS: A cross-sectional study was conducted in Zhuhai City, China from June to August 2012. Data on exercise, smoking, and educational level, anthropometric parameters, blood pressure, lipid, and glucose levels were collected. The prevalence of MetS (as defined by the International Diabetes Federation) was determined. Data necessary to evaluate MetS, the socio-economic characteristics, and lifestyle were obtained for 4645 subjects aged 18-75 years old. RESULTS: A total of 19.8% of …