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2013

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Preosteocytes/Osteocytes Have The Potential To Dedifferentiate Becoming A Source Of Osteoblasts, Elena Torreggiani, Brya G. Matthews, Slavica Pejda, Igor Matic, Danka Grcevic, Mark C. Horowitz, Ivo Kalajzic Sep 2013

Preosteocytes/Osteocytes Have The Potential To Dedifferentiate Becoming A Source Of Osteoblasts, Elena Torreggiani, Brya G. Matthews, Slavica Pejda, Igor Matic, Danka Grcevic, Mark C. Horowitz, Ivo Kalajzic

UCHC Articles - Research

Presently there is no clear evidence for the ability of mature osteogenic lineage cells to dedifferentiate. In order to identify and trace mature osteogenic lineage cells, we have utilized transgenic mouse models in which the dentin matrix protein 1 (Dmp1) promoter drives expression of GFP (active marker) or Cre recombinase (historic label) in preosteocytes/osteocytes. In long bone chip outgrowth cultures, in which cells on the bone surface were enzymatically removed, cells with previous activity of the Dmp1 promoter migrated onto plastic and down-regulated Dmp1-GFP expression. Dmp1Cre-labeled cells from these cultures had the potential to re-differentiate into the osteogenic lineage, while …

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Integration Of Sustainability In Higher Education: Three Case Studies Of Curricular Implementation, David Gosselin, Rod Parnell, Nicholas J. Smith-Sebasto, Shirley Vincent Sep 2013

Integration Of Sustainability In Higher Education: Three Case Studies Of Curricular Implementation, David Gosselin, Rod Parnell, Nicholas J. Smith-Sebasto, Shirley Vincent

School of Natural Resources: Faculty Publications

The integration of sustainability into higher education academic programs is occurring at an accelerated pace in response to international and national imperatives to rethink the way it serves the needs of society. Three case studies from the University of Nebraska- Lincoln, Northern Arizona University, and Kean University (NJ) outlines the academic structure, program, resources, the motivation and mechanisms for curricular change, key sustainability-learning outcomes and program goals, curricular changes, and assessment strategies these institutions used to integrate sustainability into their undergraduate curriculum. These three case studies exhibit several commonalities. They emphasize systems thinking and explicitly link human behavior and ecological …

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Faculty Fellows 2013-2014, Place Sep 2013

Faculty Fellows 2013-2014, Place

PLACE Historical Documents

This document provides biographies of PLACE faculty fellows at Linfield College for 2013-2014.

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Legacies Of War, Place Sep 2013

Legacies Of War, Place

PLACE Historical Documents

This document explains the PLACE theme at Linfield College for 2013-2014 (Legacies of War).

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Valuation Of The Ecosystem Services Provided By Coastal Ecosystems In Shandong, China: Developing A Non-Market Valuation System, Stephen Hynes, Rui Zhao, Jing Guo Sep 2013

Valuation Of The Ecosystem Services Provided By Coastal Ecosystems In Shandong, China: Developing A Non-Market Valuation System, Stephen Hynes, Rui Zhao, Jing Guo

Working Papers

Based on unique geographical, economic and ecological characteristics, the coastal regions have been serving as the most important supports for human benefits. From food provision, ecosystem regulation, wildlife habitat to various recreational and aesthetic activities, humans have been obtaining direct and indirect well-being from the coastal ecosystems. If properly managed and sustainably protected, these benefits should be translated to human welfare for current and future generations (Brenner, et al., 2010) . The lack of complete understanding of total values obtained from coastal ecosystems, especially the underestimating of ecosystem benefits has led to management failures. As a result, most coastal resources …

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A Funding Profile Of The Nih, Matthew Richardson Sep 2013

A Funding Profile Of The Nih, Matthew Richardson

Research Trends

No abstract provided.

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The Peculiar Persistence Of Medical Myths: How To Counter And Discourage Misinformation, Mike Taylor Sep 2013

The Peculiar Persistence Of Medical Myths: How To Counter And Discourage Misinformation, Mike Taylor

Research Trends

No abstract provided.

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Identification Of Proteins For Salt Tolerance Using A Comparative Proteomics Analysis Of Tomato Accessions With Contrasting Salt Tolerance, Peter Nveawiah-Yoho, Jing Zhou, Marsha Palmer, Roger Sauve, Suping Zhou, Kevin J. Howe, Tara Fish, Theodore W. Thannhauser Sep 2013

Identification Of Proteins For Salt Tolerance Using A Comparative Proteomics Analysis Of Tomato Accessions With Contrasting Salt Tolerance, Peter Nveawiah-Yoho, Jing Zhou, Marsha Palmer, Roger Sauve, Suping Zhou, Kevin J. Howe, Tara Fish, Theodore W. Thannhauser

Agricultural and Environmental Sciences Faculty Research

Tomato (Solanum lycopersicum) has a wide variety of genotypes differing in their responses to salinity. This study was performed to identify salt-induced changes in proteomes that are distinguishable among tomatoes with contrasting salt tolerance. Tomato accessions [LA4133 (a salt-tolerant cherry tomato accession) and ‘Walter’ LA3465 (a salt-susceptible accession)] were subjected to salt treatment (200 mm NaCl) in hydroponic culture. Salt-induced changes in the root proteomes of each tomato accession were identified using the isobaric tags for relative and absolute quantitation (iTRAQ) method. In LA4133, 178 proteins showed significant differences between salt-treated and non-treated control root tissues (P ≤ 0.05); 169 …

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Buoy Gear- A Potential For Bycatch Reduction In The Small-Scale Swordfish Fisheries: A Florida Experience And Indian Ocean Perspective., Evgeny V. Romanov, David W. Kerstetter, Travis Allan Moore, Pascal Bach Sep 2013

Buoy Gear- A Potential For Bycatch Reduction In The Small-Scale Swordfish Fisheries: A Florida Experience And Indian Ocean Perspective., Evgeny V. Romanov, David W. Kerstetter, Travis Allan Moore, Pascal Bach

Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures

A swordfish buoy gear, an innovative fishing practice developed in USA in early 2000s, provide a possibility of direct swordfish targeting yielding high CPUE of target species and very low bycatch levels. Here we present a summary of US experience and discuss potential application of this gear in the Indian Ocean region in the perspective of small-scale fisheries development and bycatch reduction.

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Curcumin-Free Turmeric Exhibits Anti-Inflammatory And Anticancer Activities: Identification Of Novel Components Of Turmeric (Abstract), Bharat Aggarwal, Wei Yuan, Shiyou Li, Subash C. Gupta Sep 2013

Curcumin-Free Turmeric Exhibits Anti-Inflammatory And Anticancer Activities: Identification Of Novel Components Of Turmeric (Abstract), Bharat Aggarwal, Wei Yuan, Shiyou Li, Subash C. Gupta

NCPC Publications and Patents

Abstract attached

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Multitargeting By Turmeric, The Golden Spice: From Kitchen To Clinic (Abstract), Subash C. Gupta, Bokyung Sung, Ji Hye Kim, Sahdeo Prasad, Shiyou Li, Bharat Aggarwal Sep 2013

Multitargeting By Turmeric, The Golden Spice: From Kitchen To Clinic (Abstract), Subash C. Gupta, Bokyung Sung, Ji Hye Kim, Sahdeo Prasad, Shiyou Li, Bharat Aggarwal

Faculty Publications

Abstract attached

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Review: Glycation Of Human Serum Albumin, Jeanethe Anguizola, Ryan Matsuda, Omar S. Barnaby, K. S. Hoy, Chunling Wa, Erin Debolt, Michelle Koke, David S. Hage Sep 2013

Review: Glycation Of Human Serum Albumin, Jeanethe Anguizola, Ryan Matsuda, Omar S. Barnaby, K. S. Hoy, Chunling Wa, Erin Debolt, Michelle Koke, David S. Hage

David Hage Publications

Glycation involves the non-enzymatic addition of reducing sugars and/or their reactive degradation products to amine groups on proteins. This process is promoted by the presence of elevated blood glucose concentrations in diabetes and occurs with various proteins that include human serum albumin (HSA). This review examines work that has been conducted in the study and analysis of glycated HSA. The general structure and properties of HSA are discussed, along with the reactions that can lead to modification of this protein during glycation. The use of glycated HSA as a short-to-intermediate term marker for glycemic control in diabetes is examined, and …

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Resistance Of Human Cytomegalovirus To Cyclopropavir Maps To A Base Pair Deletion In The Open Reading Frame Of Ul97, Brian G. Gentry, Laura E. Vollmer, Ellie D. Hall, Katherine Z. Borysko, Jiri Zemlicka, Jeremy P. Kamil, John C. Drach Sep 2013

Resistance Of Human Cytomegalovirus To Cyclopropavir Maps To A Base Pair Deletion In The Open Reading Frame Of Ul97, Brian G. Gentry, Laura E. Vollmer, Ellie D. Hall, Katherine Z. Borysko, Jiri Zemlicka, Jeremy P. Kamil, John C. Drach

Oncology Faculty Publications

Human cytomegalovirus (HCMV) is a widespread pathogen in the human population, affecting many immunologically immature and immunocompromised patients, and can result in severe complications, such as interstitial pneumonia and mental retardation. Current chemotherapies for the treatment of HCMV infections include ganciclovir (GCV), foscarnet, and cidofovir. However, the high incidences of adverse effects (neutropenia and nephrotoxicity) limit the use of these drugs. Cyclopropavir (CPV), a guanosine nucleoside analog, is 10-fold more active against HCMV than GCV (50% effective concentrations [EC50s] = 0.46 and 4.1 μM, respectively). We hypothesize that the mechanism of action of CPV is similar to that …

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The Era Of Incremental Change In The Technology Innovation Life Cycle: An Analysis Of The Automotive Emission Control Industry, Jaegul Lee, Nicholas Berente Sep 2013

The Era Of Incremental Change In The Technology Innovation Life Cycle: An Analysis Of The Automotive Emission Control Industry, Jaegul Lee, Nicholas Berente

Business Administration Faculty Research Publications

According to the life cycle model of technological evolution, after the emergence of a dominant design, technological product industries undergo an “era of incremental change.” This era of incremental change is not well understood in the existing literature. Although the period is typically characterized in terms of stability and minimal innovation, we find that the era of incremental change can be actually quite dynamic. Through our research into the period of time following the emergence of a dominant design in automotive emission control systems, we find that the overall product innovation in the industry did not decline immediately following the …

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Hypothesis Driven Single Nucleotide Polymorphism Search (Hydn-Snp-S), Rebecca J. Swett, Angela Elias, Jeffrey A. Miller, Gregory E. Dyson, G. AndréS Cisneros Sep 2013

Hypothesis Driven Single Nucleotide Polymorphism Search (Hydn-Snp-S), Rebecca J. Swett, Angela Elias, Jeffrey A. Miller, Gregory E. Dyson, G. AndréS Cisneros

Chemistry Faculty Research Publications

The advent of complete-genome genotyping across phenotype cohorts has provided a rich source of information for bioinformaticians. However the search for SNPs from this data is generally performed on a study-by-study case without any specific hypothesis of the location for SNPs that are predictive for the phenotype. We have designed a method whereby very large SNP lists (several gigabytes in size), combining several genotyping studies at once, can be sorted and traced back to their ultimate consequence in protein structure. Given a working hypothesis, researchers are able to easily search whole genome genotyping data for SNPs that link genetic locations …

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Scavenging, Cycling And Removal Fluxes Of 210Po And 210Pb At The Bermuda Time-Series Study Site, G. H. Hong, M. Baskaran, T. M. Church, M. Conte Sep 2013

Scavenging, Cycling And Removal Fluxes Of 210Po And 210Pb At The Bermuda Time-Series Study Site, G. H. Hong, M. Baskaran, T. M. Church, M. Conte

Environmental Science and Geology Faculty Research Publications

Quantifying relative affinities of Po and Pb in different populations of marine particulate matter is of great importance in utilizing 210Po as a tracer for carbon cycling. We collected and analyzed water samples for the concentrations of dissolved and total 210Po and 210Pb from the upper 600 m of the water column at Bermuda Time-series Study site (September 1999 to September 2000) to investigate their seasonality of concentrations and their ac-tivity ratio (210Po/210Pb activity ratio, AR). Sinking particles collected in sediment traps at depths of 500 m, 1500 m, and 3200 m from …

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Quantification Of Α-Ketoglutarate Cyanohydrin In Swine Plasma By Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry, Brendan L. Mitchell, Gary A. Rockwood, Brian A. Logue Sep 2013

Quantification Of Α-Ketoglutarate Cyanohydrin In Swine Plasma By Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry, Brendan L. Mitchell, Gary A. Rockwood, Brian A. Logue

Chemistry and Biochemistry Faculty Publications

Determination of exposure to cyanide can be accomplished by direct cyanide analysis or indirectly by analysis of cyanide detoxification products, such as thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid. A potentially important marker and detoxification product of cyanide exposure, α-ketoglutarate cyanohydrin (α-KgCN), is produced by the reaction of cyanide and α-ketoglutarate. Therefore, an ultra high-performance liquid chromatography tandem mass spectrometry method to determine α-KgCN in plasma was developed. Swine plasma was spiked with α-KgCN and α-KgCN-d4 (internal standard) and proteins were precipitated with 1% formic acid in acetonitrile. After centrifugation, the supernatant was dried, reconstituted, separated by reversed phase high performance liquid …

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Toxicokinetic Profiles Of Α-Ketoglutarate Cyanohydrin, A Cyanide Detoxification Product, Following Exposure To Potassium Cyanide, Brendan L. Mitchell, Raj K. Bhandari, Vikhyat S. Bebarta, Gary A. Rockwood, Gerry R. Boss, Brian A. Logue Sep 2013

Toxicokinetic Profiles Of Α-Ketoglutarate Cyanohydrin, A Cyanide Detoxification Product, Following Exposure To Potassium Cyanide, Brendan L. Mitchell, Raj K. Bhandari, Vikhyat S. Bebarta, Gary A. Rockwood, Gerry R. Boss, Brian A. Logue

Chemistry and Biochemistry Faculty Publications

Poisoning by cyanide can be verified by analysis of the cyanide detoxification product, α-ketoglutarate cyanohydrin (α-KgCN), which is produced from the reaction of cyanide and endogenous α-ketoglutarate. Although α-KgCN can potentially be used to verify cyanide exposure, limited toxicokinetic data in cyanide-poisoned animals are available. We, therefore, studied the toxicokinetics of α-KgCN and compared its behavior to other cyanide metabolites, thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid (ATCA), in the plasma of 31 Yorkshire pigs that received KCN (4 mg/mL) intravenously (IV) (0.17 mg/kg/min). α-KgCN concentrations rose rapidly during KCN administration until the onset of apnea, and then decreased over time in all …

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Sdwri Water News, South Dakota Water Resources Institute Sep 2013

Sdwri Water News, South Dakota Water Resources Institute

SDWRI Water News

No abstract provided.

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The Transmission Of Sustainable Harvesting Norms When Agents Are Conditionally Cooperative, Andries Richter, Johan Grasman Sep 2013

The Transmission Of Sustainable Harvesting Norms When Agents Are Conditionally Cooperative, Andries Richter, Johan Grasman

Fondazione Eni Enrico Mattei Working Papers

Experimental and observational studies have highlighted the importance of agents being conditionally cooperative when facing a social dilemma. We formalize this mechanism in a theoretical model that portrays a small community having joint access to a common pool resource. The diffusion of norms of cooperation takes place via interpersonal relations, while individual agents face the temptation of higher profits by overexploiting the resource. Agents remain conditionally cooperative, unless other individuals are misbehaving already. We can observe a bubble of conditional cooperators slowly building up followed by a sudden burst, which means that a transition from a cooperative social norm to …

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The Transmission Of Sustainable Harvesting Norms When Agents Are Conditionally Cooperative, Andries Richter, Johan Grasman Sep 2013

The Transmission Of Sustainable Harvesting Norms When Agents Are Conditionally Cooperative, Andries Richter, Johan Grasman

Fondazione Eni Enrico Mattei Working Papers

Experimental and observational studies have highlighted the importance of agents being conditionally cooperative when facing a social dilemma. We formalize this mechanism in a theoretical model that portrays a small community having joint access to a common pool resource. The diffusion of norms of cooperation takes place via interpersonal relations, while individual agents face the temptation of higher profits by overexploiting the resource. Agents remain conditionally cooperative, unless other individuals are misbehaving already. We can observe a bubble of conditional cooperators slowly building up followed by a sudden burst, which means that a transition from a cooperative social norm to …

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Scholarworks Statistics - September 2013, Scholarworks Sep 2013

Scholarworks Statistics - September 2013, Scholarworks

ScholarWorks Reports

For the month of September 2013, ScholarWorks recorded a total of 25,079 full-text downloads and 14,288 page views.

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The Issue Of Same-Sex Marriage: Defending The Tradition, Ennio Mastroianni Sep 2013

The Issue Of Same-Sex Marriage: Defending The Tradition, Ennio Mastroianni

Conversations on Jesuit Higher Education

No abstract provided.

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Silencing Subtelomeric Vsgs By Trypanosoma Brucei Rap1 At The Insect Stage Involves Chromatin Structure Changes, Unnati M. Pandya, Ranjodh Sandhu, Bibo Li Sep 2013

Silencing Subtelomeric Vsgs By Trypanosoma Brucei Rap1 At The Insect Stage Involves Chromatin Structure Changes, Unnati M. Pandya, Ranjodh Sandhu, Bibo Li

Biological, Geological, and Environmental Faculty Publications

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen variant surface glycoprotein (VSG) to evade mammalian host immune responses at the bloodstream form (BF) stage. Monoallelic expression of BF Expression Site (BES)-linked VSGs and silencing of metacyclic VSGs (mVSGs) in BF cells are essential for antigenic variation, whereas silencing of both BES-linked and mVSGs in the procyclic form (PF) cells is important for cell survival in the midgut of its insect vector. We have previously shown that silencing BES-linked VSGs in BF cells depends on TbRAP1. We now show that TbRAP1 silences both BES-linked and mVSGs …

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The Great Epoch: An Exploration Of The Psychology Of Desistance From Offending., Triona O'Sullivan Sep 2013

The Great Epoch: An Exploration Of The Psychology Of Desistance From Offending., Triona O'Sullivan

Dissertations

This research is an exploratory study aimed at examining the psychological processes underlying desistance from offending based on the lived experience of seven ex-offenders. A phenomenological approach was chosen and the research used qualitative semi-structured interviewing in order to collect rich data regarding the self-narratives of participants. Research findings confirmed several themes already prominent in the desistance literature including the importance of psychological maturation, the role of choice, the importance of the individuals’ self concept, the role of ‘making good’ and cognitive change in the area of thought processes and attitudes to offending. In addition several themes emerged which are …

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Getting To Evo-Devo: Concepts And Challenges For Students Learning Evolutionary Developmental Biology, Anna Hiatt, Gregory K. Davis, Caleb Trujillo, Mark Terry, Donald P. French, Rebecca M. Price, Kathryn E. Perez Sep 2013

Getting To Evo-Devo: Concepts And Challenges For Students Learning Evolutionary Developmental Biology, Anna Hiatt, Gregory K. Davis, Caleb Trujillo, Mark Terry, Donald P. French, Rebecca M. Price, Kathryn E. Perez

Biology Faculty Research and Scholarship

To examine how well biology majors have achieved the necessary foundation in evolution, numerous studies have examined how students learn natural selection. However, no studies to date have examined how students learn developmental aspects of evolution (evo-devo). Although evo-devo plays an increasing role in undergraduate biology curricula, we find that instruction often addresses development cursorily, with most of the treatment embedded within instruction on evolution. Based on results of surveys and interviews with students, we suggest that teaching core concepts (CCs) within a framework that integrates supporting concepts (SCs) from both evolutionary and developmental biology can improve evo-devo instruction. We …

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Draft Genome Sequence Of A Mucoid Isolate Of Pseudomonas Aeruginosa Strain C7447m From A Patient With Cystic Fibrosis, Yeshi Yin, T. Ryan Withers, Shannon L. Johnson, Hongwei D. Yu Sep 2013

Draft Genome Sequence Of A Mucoid Isolate Of Pseudomonas Aeruginosa Strain C7447m From A Patient With Cystic Fibrosis, Yeshi Yin, T. Ryan Withers, Shannon L. Johnson, Hongwei D. Yu

Biochemistry and Microbiology

Alginate overproduction by Pseudomonas aeruginosa, or mucoidy, plays an important role in the pathogenesis of chronic lung infections in cystic fibrosis (CF) patients. Here we report the draft genome sequence of a clinical isolate of mucoid P. aeruginosa strain C7447m from a CF patient with chronic lung infection.

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A Napoleonic Approach To Climate Change: The Geoengineering Branch, Anthony E. Chavez Sep 2013

A Napoleonic Approach To Climate Change: The Geoengineering Branch, Anthony E. Chavez

Washington and Lee Journal of Energy, Climate, and the Environment

Climate change is an inevitable consequence of human greenhouse gas emissions. Without substantial changes in anthropogenic causes of climate change, there will be severe negative impacts on our planet. Complete abolition of greenhouse gas emissions, however, is not possible, nor will it necessarily stop the negative impacts of climate change. Therefore, substantial research must be done in geoengineering to understand better how we can positively act to avert significant climate change. Given the practical difficulties and potential effects, there must be comprehensive oversight. Currently, differing national laws makes this difficult. Additionally the United States laws do not properly cover climate …

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Fall 2013, Marisela Cadena-Smith Sep 2013

Fall 2013, Marisela Cadena-Smith

Connection

The Official Community Newsletter for Collin College Connection is the college's award-winning community newsletter published three times a year to inform members of the Collin County community about college news, awards, events, and more.

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Snmipnuntn, September 2013, University Of Montana--Missoula. Mansfield Library Sep 2013

Snmipnuntn, September 2013, University Of Montana--Missoula. Mansfield Library

Snmipnuntn

No abstract provided.

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