Digital Commons Network^™

References From Landslide Ecology, Lawrence R. Walker, Aaron B. Shiels

United States Department of Agriculture Wildlife Services: Staff Publications

No abstract provided.

Glutaredoxin-2 Is Required To Control Proton Leak Through Uncoupling Protein-3, Ryan J. Mailloux, Jian Ying Xuan, Brittany Beauchamp, Marjorie F. Lou, Mary-Ellen Harper

School of Veterinary and Biomedical Sciences: Faculty Publications

Glutathionylation has emerged as a key modification required for controlling protein function in response to changes in cell redox status. Recently, we showed that the glutathionylation state of uncoupling protein-3 (UCP3) modulates the leak of protons back into the mitochondrial matrix, thus controlling reactive oxygen species production. However, whether or not UCP3 glutathionylation is mediated enzymatically has remained unknown because previous work relied on the use of pharmacological agents, such as diamide, to alter the UCP3 glutathionylation state. Here, we demonstrate that glutaredoxin-2 (Grx2), a matrix oxidoreductase, is required to glutathionylate and inhibit UCP3. Analysis of bioenergetics in skeletal muscle …

Accessory Genes Confer A High Replication Rate To Virulent Feline Immunodeficiency Virus, Ryan M. Troyer, Jesse Thompson, John H. Elder, Sue Vandewoude

School of Veterinary and Biomedical Sciences: Faculty Publications

Feline immunodeficiency virus (FIV) is a lentivirus that causes AIDS in domestic cats, similar to human immunodeficiency virus (HIV)/AIDS in humans. The FIV accessory protein Vif abrogates the inhibition of infection by cat APOBEC3 restriction factors. FIV also encodes a multifunctional OrfA accessory protein that has characteristics similar to HIV Tat, Vpu, Vpr, and Nef. To examine the role of vif and orfA accessory genes in FIV replication and pathogenicity, we generated chimeras between two FIV molecular clones with divergent disease potentials: a highly pathogenic isolate that replicates rapidly in vitro and is associated with significant immunopathology in vivo, …

Who's Eating Law Firms' Lunch? The Legal Service Providers, Law Schools And New Grads At The Table, William D. Henderson, Rachel M. Zahorsky

Articles by Maurer Faculty

No abstract provided.

Smb Myosin Heavy Chain Knockout Enhances Tonic Contraction And Reduces The Rate Of Force Generation In Ileum And Stomach Antrum, Qian Huang, Gopal J. Babu, Muthu Periasamy, Thomas J. Eddinger

Biological Sciences Faculty Research and Publications

The role of SMA and SMB smooth muscle myosin heavy chain (MHC) isoforms in tonic and phasic contractions was studied in phasic (longitudinal ileum and stomach circular antrum) and tonic (stomach circular fundus) smooth muscle tissues of SMB knockout mice. Knocking out the SMB MHC gene eliminated SMB MHC protein expression and resulted in upregulation of the SMA MHC protein without altering the total MHC protein level. Switching from SMB to SMA MHC protein expression decreased the rate of the force transient and increased the sustained tonic force in SMB^(−/−) ileum and antrum with high potassium (KPSS) but not …

Dilettante, Venturesome, Tory And Crafts: Drivers Of Performance Among Taxonomic Groups, Stanley W. Mandel, Jane S. Craig, Alex Stewart

Management Faculty Research and Publications

Empirical research has failed to cumulate into a coherent taxonomy of small firms. This may be because the method adapted from biology by Bill McKelvey has almost never been adopted. His approach calls for extensive variables and a focused sample of organizations, contrary to most empirical studies, which are specialized. Comparing general and special purpose approaches, we find some of the latter have more explanatory power than others and that general purpose taxonomies have the greatest explanatory power. Examining performance, we find the types do not display significantly different levels of performance but they display highly varied drivers of performance.

Legal Thought In Enlightenment’S Wake, Jeffrey A. Pojanowski

Journal Articles

A review of Steven D Smith, The Disenchantment of Secular Discourse (Harvard University Press, 2010) 264 pp, Hbk £20.95, ISBN 978-0674050877.

This review essay considers Steven D. Smith’s most recent book, The Disenchantment of Secular Discourse. Rather than focusing on the book’s argument about the practices and pathologies of the public square, this essay uses Smith’s chapter on scientific thought as a platform for exploring connections between Disenchantment and Smith’s prior work in legal theory. The catalyst for these reflections is Scandinavian legal realism. Considering these elements together sheds light on both the limits and virtues of central ideas about …

Judges As Bad Reviewers: Fair Use And Epistemological Humility, Rebecca Tushnet

Georgetown Law Faculty Publications and Other Works

The future of fair use depends on whether judges act like bad reviewers, or whether they behave differently in interpreting challenged works than they do in almost every other aspect of judging. Ordinarily, judges are asked to produce definitive answers about the meanings of texts. But when it comes to literary judgments, the bad reviewer is the one who insists that a work has only one meaning, and announces the bottom line as if it were an absolute. A good reviewer explains the sources of her judgment, making room for other interpretations. This is also what is necessary to a …

Comparative Evaluation Of Operating Life For Phosphate-Specific Ion Exchange Resins, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

No abstract provided.

Blow-Up Phenomena For Nonlocal Inhomogeneous Diffusion Problems, Jianwen Sun, Feiying Yang

Turkish Journal of Mathematics

This paper is concerned with the blow-up of solutions to some nonlocal inhomogeneous dispersal equations subject to homogeneous Neumann boundary conditions. We establish conditions on nonlinearities sufficient to guarantee that solutions exist for all time as well as blow up at some finite time. Moreover, lower bounds for blow-up time of nonlocal problems are obtained.

Commencement Program (June 2013), Csusb

CSUSB Commencement Programs

No abstract provided.

Winter 2013

University of Richmond Magazine

No abstract provided.

Richmond Law Magazine: Winter 2013

Richmond Law Magazine

Features:

Outsourcing Childcare

The Long Wait for October

Click to Agree

Carbon Farming In Wa, Department Of Agriculture And Food, Western Australia, Department Of Regional Development And Lands, Western Australia

Natural resources published reports

Fact sheets:

1. Applying biochar to improve soil quality and crop productivity

2. Reducing methane emissions from cattle using feed additives

3. Cattle breeding for lower greenhouse gas emissions

4. Managing genetic codes to reduce methane emissions from cattle

5. Managing pastures and stocking rate to reduce methane emissions from cattle

6. Claying as a method of increasing soil carbon content

7. Green and brown manuring as part of carbon farming

8. Permanent environmental plantings to earn carbon credits

9. Nitrous oxide emissions from agricultural soils

10. Sheep genetics in methane reduction

11. Managing sheep pastures to reduce methane production …

Systematic Review Of Research Into The Psychological Aspects Of Prostate Cancer In Asia: What Do We Know?, Suzanne Kathleen Chambers, Melissa Karen Hyde, David Fu-Keung Ip, Jeffrey Charles Dunn, Robert Alexander Gardiner

Research outputs 2013

Background: To review the peer reviewed literature on the psychological aspects of the prostate cancer experience of men in Asia.

Materials and Methods: Medline and PsycINFO, CINAHL, ProQuest, and Web of Science (1999 – November Week 4, 2012) were searched. Inclusion criteria were: included men with prostate cancer and/or their partners or caregivers who identify as Asian recruited in an Asian country; and assessed health-related quality of life, psychological and social adjustment relating to prostate cancer and published in English after 1st January 1999 and prior to 30th November, 2012.

Study aims: design; quality; level of evidence, and key results …

How Affordances Associated With A Distractor Object Affect Compatibility Effects: A Study With The Computational Model Tropicals., Daniele Caligiore, Anna M. Borghi, Domenico Parisi, Rob Ellis, Angelo Cangelosi, Gianluca Baldassarre

School of Psychology

Seeing an object activates both visual and action codes in the brain. Crucial evidence supporting this view is the observation of object to response compatibility effects: perception of an object can facilitate or interfere with the execution of an action (e.g., grasping) even when the viewer has no intention of interacting with the object. TRoPICALS is a computational model that proposes some general principles about the brain mechanisms underlying compatibility effects, in particular the idea that top-down bias from prefrontal cortex, and whether it conflicts or not with the actions afforded by an object, plays a key role in such …

A Multimodal Perspective On The Composition Of Cortical Oscillations, K. C. Ronnqvist, C. J. Mcallister, G. L. Woodhall, I. M. Stanford, S. D. Hall

School of Psychology

No abstract provided.

Controlling The Execution Of A Security Council Mandate To Use Force: Does The Council Need A Lawyer?, Tamar Hostovsky-Brandes, Ariel Zemach

Fordham International Law Journal

No abstract provided.

Presenting Fake Figures: A Tool To Teach Effective Scientific Figure Design, Verónica A. Segarra, Stephanie Pulford, Susan Walsh

Faculty Publications

No abstract provided.

Competencies And Experiences Needed By Pre–Service Agricultural Educators To Teach Globalized Curricula: A Modified Delphi Study, Nathan W. Conner, T. Grady Roberts

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

The 21st century graduate must be able to interact with people from all over the world and must also be knowledgeable about the world (Longview Foundation, 2008). In order to produce graduates that are globally competent, The National Council for the Accreditation of Teachers (NCATE, 1982) has mandated that multi–cultural education be incorporated as part of the teacher–preparation curricula. The purpose of this study was to identify competencies and experiences needed by agricultural pre–service teachers in order to teach globalized curricula. A modified Delphi method was used and the panel consisted of 13 (n = 13) experts in the field …

Assisted Vaginal Deliveries In Mothers Admitted As Public Or Private Patients In Western Australia, Kristjana Einarsdottir, Fatima Haggar, Sarah Stock, Anthony Gunnell, Fiona Stanley

Research outputs 2013

Background: Mothers delivering as private patients in Australia have a high rate of assisted deliveries, which could lead to adverse infant outcomes in this group of patients. We investigated whether the risk of adverse infant outcomes after assisted deliveries was different for mothers admitted as public or private patients for delivery, when compared with unassisted deliveries.

Methods and findings: We included 158,241 vaginal, singleton, term birth admissions in our study where the infant was live born and without birth defects. The study population was identified from statutory birth and hospital data collections held by the Western Australian (WA) Department of …

Synthesis Of A New Scytovirin Protein Derivative, Sd1-Sd2-Sd2, To Decrease Hiv-1 Binding Affinity, Alexandra M. Wood

Honors Theses

Scytovirin is a novel anti-viral protein isolated from the cyanobacterium Scytonema varium. This protein has produced great scientific interest for its anti-human immunodeficiency virus (HIV) activity. Scytovirin disrupts the mechanism of HV infection by binding to HIV-1 proteins glycoprotein 120, glycoprotein 160, and glycoprotein 41. It does not bind to the CD4 receptor on human immune cells. The wild-type protein consists of a single 95 amino acid chain. When folded, Scytovirin's amino acid sequence is arranged into two distinct domains, each with a high degree of sequence conservation. This implicates the importance of both domains in anti-HIV activity. Primers were …

The Inhibition Of Splicing Of Glucose-6-Phosphate Dehydrogenase Mrna During Starvation By Heterogeneous Nuclear Ribonucleoprotein K, Travis Cyphert

Graduate Theses, Dissertations, and Problem Reports (ETD)

Splicing of nascent RNA transcripts is an essential step in gene expression and a target of nutrient regulation. Glucose-6-phosphate dehydrogenase (G6PD) is a lipogenic gene whose expression is regulated exclusively at this posttranscriptional stage. Expression of G6PD mRNA increases 15- to 17-fold during refeeding and is inhibited 80-90% by starvation and the addition of polyunsaturated fat to the diet. The large changes in the accumulation of G6PD mRNA are due to changes the rate of pre-mRNA splicing and not changes in its transcription. In this regard, dietary carbohydrate enhances intron removal, which increases the accumulation of G6PD mRNA. Starvation alters …

Characterizing Runoff Responses In A Mountaintop Mine Impacted And Forested Catchment In The Coalfields Of West Virginia, Andrew J. Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mountaintop mining (MTM) represents the largest land cover/landuse change in the Central Appalachian region. By 2012, the U.S. EPA estimates that MTR will have impacted approximately 6.8% of the predominately forested Appalachian Coalfield region of West Virginia (WV), Kentucky, Tennessee, and Virginia with nearly 4,000 miles of headwater streams buried under valley fills (VF). In spite of the scale and extent of MTM, its hydrologic impacts are poorly understood. Several devastating floods in the region have been attributed to MTM, but there is little evidence to either confirm or refute this belief. Existing research on the hydrologic impacts of MTM …

Patterns Of Lung Cancer Care And Associated Health Outcomes Among Elderly Medicare Fee For Service Beneficiaries In West Virginia And In The United States, Pramit Amrutlal Nadpara

Graduate Theses, Dissertations, and Problem Reports (ETD)

The elderly carry a disproportionate burden of lung cancer in the US. Although significant improvements have been made during the past decade in cancer treatment, substantial disparities still exist in guideline-based lung cancer care and outcomes. Such variation in lung cancer care is a cause for major concern in rural areas like West Virginia (WV). The purpose of this study was to do a comprehensive evaluation of variations in lung cancer care and associated health outcomes in the elderly. This retrospective study was conducted using SEER-Medicare and WVCR--Medicare linked data files for the years 2002-2007. As part of the project, …

Temporal Expression Of Key Angioregulatory Proteins In Response To Exercise And Detraining, Sara A. Olenich

Graduate Theses, Dissertations, and Problem Reports (ETD)

Angiogenesis is an important adaptation to exercise, occurring in response to a multitude of different stimuli including: shear stress, mechanical stretch, ischemia, electrical stimulation, and exercise. Current thinking suggests skeletal muscle angiogenesis is a temporal process controlled by a balance between positive and negative angiogenic proteins. But there is limited information on what molecular mediators control skeletal muscle angiogenesis in this time line, creating a critical need to clarify how individual protein responses regulate physiologic skeletal muscle angiogenesis in response to exercise training and/or physical deconditioning. Our objective is to characterize the temporal expression of several key positive (VEGF, MMP-2, …

Roles Of Speech-Language Pathologists In The Neonatal Intensive Care Unit, Katy Lane Greenlee

Honors Theses

This thesis examined the roles of speech-language pathologists (SLPs) within the Neonatal Intensive Care Unit (NICU). In 2004, the American Speech-Language-Hearing Association published a set of policy documents regarding speech-language pathology practice in the NICU. Research compiled in the literature review explained and supported each of the roles listed in the ASHA policy documents. The literature also revealed that very few sources specific to the speech-language pathology field addressed roles other than those related to feeding and swallowing evaluation and intervention. This research investigated ASHA-certified, masters-level SLPs' familiarity with each of their possible roles in the NICU, as well as …

Skeletal Cell Differentiation Is Enhanced By Atmospheric Dielectric Barrier Discharge Plasma Treatment., Marla J Steinbeck, Natalie Chernets, Jun Zhang, Deepa S Kurpad, Gregory Fridman, Alexander Fridman, Theresa A. Freeman

Department of Orthopaedic Surgery Faculty Papers

Enhancing chondrogenic and osteogenic differentiation is of paramount importance in providing effective regenerative therapies and improving the rate of fracture healing. This study investigated the potential of non-thermal atmospheric dielectric barrier discharge plasma (NT-plasma) to enhance chondrocyte and osteoblast proliferation and differentiation. Although the exact mechanism by which NT-plasma interacts with cells is undefined, it is known that during treatment the atmosphere is ionized generating extracellular reactive oxygen and nitrogen species (ROS and RNS) and an electric field. Appropriate NT-plasma conditions were determined using lactate-dehydrogenase release, flow cytometric live/dead assay, flow cytometric cell cycle analysis, and Western blots to evaluate …

Inhibitory Effect Of Il-17 On Neural Stem Cell Proliferation And Neural Cell Differentiation., Zichen Li, Ke Li, Lin Zhu, Quancheng Kan, Yaping Yan, Priyanka Kumar, Hui Xu, Abdolmohamad Rostami, Guang-Xian Zhang

Department of Neurology Faculty Papers

BACKGROUND: IL-17, a Th17 cell-derived proinflammatory molecule, has been found to play an important role in the pathogenesis of autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). While IL-17 receptor (IL-17R) is expressed in many immune-related cells, microglia, and astrocytes, it is not known whether IL-17 exerts a direct effect on neural stem cells (NSCs) and oligodendrocytes, thus inducing inflammatory demyelination in the central nervous system.

METHODS: We first detected IL-17 receptor expression in NSCs with immunostaining and real time PCR. We then cultured NSCs with IL-17 and determined NSC proliferation by neurosphere formation …

Inhibitory Effect Of Matrine On Blood-Brain Barrier Disruption For The Treatment Of Experimental Autoimmune Encephalomyelitis., Su Zhang, Quan-Cheng Kan, Yuming Xu, Guang-Xian Zhang, Lin Zhu

Department of Neurology Faculty Papers

Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clinical EAE and CNS inflammation. However, whether this effect of MAT is through protecting the integrity and function of the BBB is not known. In the present study, we show that MAT treatment had a therapeutic effect comparable to dexamethasone (DEX) in EAE rats, with reduced Evans Blue extravasation, increased expression of collagen IV, the major component of the basement …