Digital Commons Network^™

Unlv Symphony Orchestra Concert Singers Chamber Chorale, Taras Krysa, David Weiller, Lillian Roberts, Stephanie Weiss, William Mccullough, Nathan Arsdale

Orchestra

Program listing performers and works performed.

Ideal Dating And Sexual Partners For Low-Income Heterosexual African American Adolescents, Darnell Nathaniel Motley

College of Science and Health Theses and Dissertations

Dating and sexual relationships among adolescents have been identified as both normative and beneficial. However, the research examining the dating and sexual relationships of African American adolescents has been narrow in scope, focusing primarily on risks of intimate partner violence, pregnancy, and STI/HIV transmission. This myopic focus has left a gap in the literature as it relates to the normative aspects of dating and sexual relationships for these youth.

The present study sought to better understand the dating and sexual partner preferences of 51 African American adolescents (male = 32, female = 19) recruited from Chicago and San Francisco. The …

Longitudinal Relations Between Dating Violence Victimization And Perpetration And Substance Use: The Moderating Role Of Gender And School Norms For Dating Violence, Katherine Taylor

Theses and Dissertations

Adolescent dating violence is commonly experienced by adolescents and is associated with a variety of negative outcomes. Stress and coping and social learning theories suggest that dating violence victimization may predict increased substance use and dating violence perpetration. However, few studies have assessed these relations over time, and existing studies have not assessed physical and psychological dating violence victimization separately nor focused on early adolescent populations. The current study addressed these gaps by examining longitudinal relations between physical and psychological dating violence victimization and substance use and physical and psychological dating violence perpetration among early adolescents. The extent to which …

Global Mortality Estimates For The 2009 Influenza Pandemic From The Glamor Project: A Modeling Study, Lone Simonsen, Peter Spreeuwenberg, Roger Lustig, Robert J. Taylor, Douglas M. Fleming, Madelon Kroneman, Maria D. Van Kerkhove, Anthony D. Mounts, W. John Paget

Global Health Faculty Publications

Background

Assessing the mortality impact of the 2009 influenza A H1N1 virus (H1N1pdm09) is essential for optimizing public health responses to future pandemics. The World Health Organization reported 18,631 laboratory-confirmed pandemic deaths, but the total pandemic mortality burden was substantially higher. We estimated the 2009 pandemic mortality burden through statistical modeling of mortality data from multiple countries.

Methods and Findings

We obtained weekly virology and underlying cause-of-death mortality time series for 2005–2009 for 20 countries covering ~35% of the world population. We applied a multivariate linear regression model to estimate pandemic respiratory mortality in each collaborating country. We then used …

How (And Why) Nclb Failed To Close The Achievement Gap:Evidence From North Carolina, 1998-2004, Roslyn Mickelson, Jason Giersch, Elizabeth Stearns, Stephanie Moller

The Bridge: Interdisciplinary Perspectives on Legal & Social Policy

Recent state and national policy changes for public education are premised upon the idea that high-stakes tests can improve student outcomes and close achievement gaps. Opponents maintain that such policies fail on both counts. Using a unique longitudinal dataset from North Carolina, we find that high-stakes tests have failed to close achievement gaps associated with social class and race, and that the persistence of these gaps is related, at least in part, to academic tracking. Such findings add to the questions being raised about such policies as No Child Left Behind.

Prescription Drug Importation And Reimportation, David M. Ermer

Health Law and Policy Brief

No abstract provided.

The Archaeology Of 19th-Century Health And Hygiene At The Sullivan Street Site, New York City, Jean E. Howson

Northeast Historical Archaeology

The households represented by archaeological remains at the Sullivan Street site in Greenwich Village are used to explore issues related to health care in 19th-century New York City. Backyard features and domestic artifact assemblages are discussed in the context of institutional development and specific changes in medical practice. Consumer choices are seen as responses to differential access to sanitation, medical care, and information. Social class had a significant effect on both the infrastructure and material culture of health and hygiene for these households.

Commonwealth Times 2013-11-25

Commonwealth Times, 1969-

No abstract provided.

November 25th 2013, Csusb

Coyote Chronicle (1984-)

No abstract provided.

Can Distress Tolerance Predict Chronic Worry? Investigating The Relationships Among Worry, Distress Tolerance, Cognitive Avoidance, Psychological Flexibility, Difficulties In Emotion Regulation, And Anxiety Sensitivity, Bethany Anne Sabourin

Master's Theses and Doctoral Dissertations

According to the avoidance theory of worry proposed by Borkovec, Alcaine, and Behar (2004), chronic worry functions as an avoidance mechanism, enabling an individual to diminish the physiological experience of anxiety by impeding emotional processing of the fear stimulus. Previous research has revealed significant correlations between chronic worry and difficulties in emotion regulation (Salters-Pedneault et al., 2006) as well as anxiety sensitivity (Floyd, Garfield, & LaSota, 2005). Distress tolerance which is significantly related to anxiety sensitivity (Bernstein, Zvolensky, Vujanovic, & Moos, 2009) is strongly associated with many maladaptive avoidance behaviors (Anestis et al., 2007; Linehan, 1993; Timpano et al., 2009; …

Capture Of Lipopolysaccharide (Endotoxin) By The Blood Clot: A Comparative Study, Margaret T. Armstrong, Frederick R. Rickles, Peter B. Armstrong

Medicine Faculty Publications

In vertebrates and arthropods, blood clotting involves the establishment of a plug of aggregated thrombocytes (the cellular clot) and an extracellular fibrillar clot formed by the polymerization of the structural protein of the clot, which is fibrin in mammals, plasma lipoprotein in crustaceans, and coagulin in the horseshoe crab, Limulus polyphemus. Both elements of the clot function to staunch bleeding. Additionally, the extracellular clot functions as an agent of the innate immune system by providing a passive anti-microbial barrier and microbial entrapment device, which functions directly at the site of wounds to the integument. Here we show that, in …

2013 November 25 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

Determining The Extent And Characterizing Coral Reef Habitats Of The Northern Latitudes Of The Florida Reef Tract (Martin County), Brian K. Walker, David S. Gilliam

Marine & Environmental Sciences Faculty Articles

Climate change has recently been implicated in poleward shifts of many tropical species including corals; thus attention focused on higher-latitude coral communities is warranted to investigate possible range expansions and ecosystem shifts due to global warming. As the northern extension of the Florida Reef Tract (FRT), the third-largest barrier reef ecosystem in the world, southeast Florida (25–27° N latitude) is a prime region to study such effects. Most of the shallow-water FRT benthic habitats have been mapped, however minimal data and limited knowledge exist about the coral reef communities of its northernmost reaches off Martin County. First benthic habitat mapping …

Iterative Feature Removal Yields Highly Discriminative Pathways, Stephen O’Hara, Kun Wang, Richard A. Slayden, Alan R. Schenkel, Greg Huber, Corey S. O’Hern, Mark D. Shattuck, Michael Kirby

Publications and Research

Background We introduce Iterative Feature Removal (IFR) as an unbiased approach for selecting features with diagnostic capacity from large data sets. The algorithm is based on recently developed tools in machine learning that are driven by sparse feature selection goals. When applied to genomic data, our method is designed to identify genes that can provide deeper insight into complex interactions while remaining directly connected to diagnostic utility. We contrast this approach with the search for a minimal best set of discriminative genes, which can provide only an incomplete picture of the biological complexity. Results Microarray data sets typically contain far …

Lapatinib And Sorafenib Kill Gbm Tumor Cells In A Greater Than Additive Manner, Seyedmehrad Tavallai

Theses and Dissertations

Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults, affecting thousands of people worldwide every year, with a life expectancy, post diagnosis of 12 months. Surgery, radiotherapy and chemotherapy together, result in an overall mean survival not exceeding 15 months. Targeted therapeutic agents sorafenib, an oral multi kinase inhibitor, and lapatinib, an epidermal growth factor receptor (EGFR) inhibitor, used in combination have been shown to kill GBM cells be through inhibition of major growth mediating signaling pathways that are frequently over expressed in gliomas, including mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase/ protein kinase B (PI3K/AKT). …

The Prioritization Of Student Mental Health In The School Setting: Secondary Administrators' And Educators' Knowledge Of Adolescent Suicidal Risk Factors And Warning Signs, Chiquita Elliott

Theses and Dissertations

This study investigated the knowledge level of secondary building-level administrators and secondary teachers regarding adolescent suicidal risk factors and warning signs. Additionally, this study contributed a social mediation component, to explore whether educators believe that they have the potential to be change agents for youth in their school communities. Three hundred forty-three participants (318 teachers, 18 assistant principals and 7 principals) from the middle and high schools in a local public school district in the Mid-Atlantic Region of the United States completed a survey pertaining to information on adolescent suicide. Data analyses were conducted through detailed cross-tabulations and analysis of …

Nonlinear Scoring Functions For Similarity-Based Ligand Docking And Binding Affinity Prediction, Michal Brylinski

Faculty Publications

A common strategy for virtual screening considers a systematic docking of a large library of organic compounds into the target sites in protein receptors with promising leads selected based on favorable intermolecular interactions. Despite a continuous progress in the modeling of protein-ligand interactions for pharmaceutical design, important challenges still remain, thus the development of novel techniques is required. In this communication, we describe eSimDock, a new approach to ligand docking and binding affinity prediction. eSimDock employs nonlinear machine learning-based scoring functions to improve the accuracy of ligand ranking and similarity-based binding pose prediction, and to increase the tolerance to structural …

Ranking Literature From The Network Of Drug-Disease Association Through Multi-Layered Semantic Model, Karththikka Ramani Muthukuri

Electronic Theses and Dissertations Archive

This thesis presents the design and impementation of a system to find the top ranked relevant Medline citations with hyperlinks. The iput to the systm is a network of semantically related drug-diseases associations obtained by the DDNet. A fully functional system can be used for generation/validation of hypothesis or to find most relevant literature based on user input in birdging gap between the generation and utilzation of biomedical literature. Such a system may also have an impact in identification of "drug targets" and may open new avenues for "drug repositioning" in clinical and translational research. Multi-Layered LSA model is implemented …

Varying Effects Of Agricultural Pesticides On Host-Pathogen Interactions And Aquatic Ecosystems In An Amphibian System, Shane Michael Hanlon

Electronic Theses and Dissertations Archive

Due to the displacement of natural habitats by anthropogenic landscapes (e.g. agricultural fields), the use of agrochemicals (e.g. pesticides) has increased exponentially and non-target organisms such as amphibians are often at risk of exposure through direct overspray, runoff, or spraydrift. Because agricultural landscapes are encroaching on amphibian habitats, interactions likely occur between environmental pressures such as disease and contamination. Accordingly, I assessed the effects of pesticides on the amphibian pathogen Batrachochytrium dendrobatidis (Bd) host-pathogen interactions. As Bd-infected individuals have been found in agricultural-adjacent landscapes, pesticides can potentially alter host-pathogen interactions. In chapter two I demonstrated that pesticides can kill Bd …

Extreme Evolutionary Conservation Of Functionally Important Regions In H1n1 Influenza Proteome, Samantha Warren, Xiu-Feng Wan, Gavin Conant, Dmitry Korkin

CVM Publications

No abstract provided.

Crow's Nest, November 25, 2013, Crow's Nest Staff

Crow's Nest

The November 25, 2013, issue of the Crow's Nest.

"Dae Scotsmen Dream O 'Lectric Leids?" Robert Crawford's Cyborg Scotland, Alexander Burke

Theses and Dissertations

This thesis applies a Cybernetic interpretation to a selection of poetry by the Scottish Informationist poet Robert Crawford, drawn mostly from two collections: A Scottish Assembly (1990) and Sharawaggi: Poems in Scots (1990). Crawford is contextualized by observing the poetic influences of Robert Burns, John Davidson, and Hugh MacDiarmid, as well as the philosophical influence of George Elder Davie’s The Democratic Intellect. This paper argues that, in response to the Two Cultures hypothesis put forth by C. P. Snow and the widely-held belief that Scotland is irrevocably fractured, the shifting boundaries of the many disparate Scottish cultures are mediated by …

Cytotoxicity In The Age Of Nano: The Role Of Fourth Period Transition Metal Oxide Nanoparticle Physicochemical Properties, Charles C. Chusuei, Chi-Heng Wu, Shravan Mallavarapu, Fang Yao Stephen Hou, Chen-Ming Hsu, Jeffrey G. Winiarz, Robert S. Aronstam, Yue-Wern Huang

Clinical Lab Sciences Faculty Research and Publications

A clear understanding of physicochemical factors governing nanoparticle toxicity is still in its infancy. We used a systematic approach to delineate physicochemical properties of nanoparticles that govern cytotoxicity. The cytotoxicity of fourth period metal oxide nanoparticles (NPs): TiO₂, Cr₂O₃, Mn₂O₃, Fe₂O₃, NiO, CuO, and ZnO increases with the atomic number of the transition metal oxide. This trend was not cell-type specific, as observed in non-transformed human lung cells (BEAS-2B) and human bronchoalveolar carcinoma-derived cells (A549). Addition of NPs to the cell culture medium did not significantly …

Knockdown Of Selenocysteine-Specific Elongation Factor In Amblyomma Maculatum Alters The Pathogen Burden Of Rickettsia Parkeri With Epigenetic Control By The Sin3 Histone Deacetylase Corepressor Complex, Steven W. Adamson, Rebecca E. Browning, Khemraj Budachetri, José M.C. Ribeiro, Shahid Karim

Faculty Publications

Selenocysteine is the 21st naturally-occurring amino acid. Selenoproteins have diverse functions and many remain uncharacterized, but they are typically associated with antioxidant activity. The incorporation of selenocysteine into the nascent polypeptide chain recodes the TGA stop codon and this process depends upon a number of essential factors including the selenocysteine elongation factor (SEF). The transcriptional expression of SEF did not change significantly in tick midguts throughout the blood meal, but decreased in salivary glands to 20% at the end of the fast feeding phase. Since selenoprotein translation requires this specialized elongation factor, we targeted this gene for knockdown by RNAi …

The Bg News November 25, 2013, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 25, 2013. Volume 93-Issue 40.

The Filipino As Libertarian Contemporary Implications Of Anarchism, Charles J-H; Macdonald

Philippine Studies: Historical and Ethnographic Viewpoints

Modern Philippine society presents a number of traits that have puzzled or fascinated social scientists: an apparent looseness of organization, institutional fuzziness, intense factionalism, moral values geared toward smooth interpersonal interaction, a weak sense of public good, and a bilateral kinship system. Thisarticle revisits these points and makes sense of them by using a model of society called “anarchic” or “open-aggregated.” This conceptual grid applies to other societies and cultures, but is particularly enlightening with respect to Filipino values, their institutional style, and preferred types of behavior. Particular attention is paid to kinship and politics, to pakikisama and utang na …

Regularization Methods For Predicting An Ordinal Response Using Longitudinal High-Dimensional Genomic Data, Jiayi Hou

Theses and Dissertations

Ordinal scales are commonly used to measure health status and disease related outcomes in hospital settings as well as in translational medical research. Notable examples include cancer staging, which is a five-category ordinal scale indicating tumor size, node involvement, and likelihood of metastasizing. Glasgow Coma Scale (GCS), which gives a reliable and objective assessment of conscious status of a patient, is an ordinal scaled measure. In addition, repeated measurements are common in clinical practice for tracking and monitoring the progression of complex diseases. Classical ordinal modeling methods based on the likelihood approach have contributed to the analysis of data in …

X-Linked Mtmr8 Diversity And Evolutionary History Of Sub-Saharan Populations, Damian Labuda, Vania Yotova, Jean-François Lefebvre, Claudia Moreau, Gerd Utermann, Scott M. Williams

Dartmouth Scholarship

The genetic diversity within an 11 kb segment of the MTMR8 gene in a sample of 111 sub-Saharan and 49 non-African X chromosomes was investigated to assess the early evolutionary history of sub-Saharan Africans and the out-of-Africa expansion. The analyses revealed a complex genetic structure of the Africans that contributed to the emergence of modern humans. We observed partitioning of two thirds of old lineages among southern, west/central and east African populations indicating ancient population stratification predating the out of Africa migration. Age estimates of these lineages, older than coalescence times of uniparentally inherited markers, raise the question whether contemporary …

Sirt6 And Premature Aging Of Hutchinson-Gilford Progeria Syndrome Fibroblasts., Helal Endisha

Theses and Dissertations

The genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS) arises from a de novo single nucleotide mutation (1824CàT) in the LMNA gene. As a result, the mutated lamin A protein (progerin) remains farnesylated and permanently attached to the nuclear membrane. Progerin accumulates and deforms the nuclear membrane leading to an array of cellular abnormalities driving the cells to enter a state of permanent cell-cycle arrest early on in replicative age i.e. premature cellular senescence. Cellular senescence has been extensively studied as one of the contributing factors to aging in HGPS patients and other age-related diseases. There has also been evidence to show …

Variation And Modulation Of Micrornas In Prostate Cancer And Biological Fluids, Sarah Seashols

Theses and Dissertations

Prostate cancer is the second-most diagnosed and fatal carcinoma for males in the United States, and better diagnostic markers and potential therapies are needed. microRNAs are small, single-stranded RNA molecules that affect protein expression at the translational level, and dysregulation can dramatically affect cell metabolism. Comparison of 736 microRNA expression levels between the poorly metastatic SV40T immortalized prostate epithelial cell line P69 to its highly tumorigenic and metastatic subline M12 identified 231 miRs that were overexpressed and 150 miRs that showed loss of expression in the M12 cell line. Further evaluation of fourteen identified miRs was accomplished using other prostate …