Digital Commons Network^™

Analysis Of Plasminogen Binding To Treponema Denticola, A Key Periopathogen, Brittney Tegels

Theses and Dissertations

Periodontitis is a chronic inflammatory disease that affects over 116 million adults in the United States. A shift in the normal microflora occurs as periodontal disease develops resulting in a larger number of Gram-negative anaerobes and spirochetes. An increase in the oral spirochete, Treponema denticola, is highly correlated with periodontal disease progression and severity. The ability of this periopathogen to thrive in the subgingival crevice is dependent on complement evasion mechanisms. Earlier analyses demonstrated that the primary mechanism of T. denticola serum resistance is binding of the human complement regulatory protein, Factor H (FH), to the factor H-binding protein (FhbB). …

Design Of Engineered Biomaterial Architectures Through Natural Silk Proteins, Nicholas Kurland

Theses and Dissertations

Silk proteins have provided a source of unique and versatile building blocks in the fabrication of biomedical devices for addressing a range of applications. Critical to advancing this field is the ability to establish an understanding of these proteins in their native and engineered states as well as in developing scalable processing strategies, which can fully exploit or enhance the stability, structure, and functionality of the two constituent proteins, silk fibroin and sericin. The research outlined in this dissertation focuses on the evolution in architecture and capability of silks, to effectively position a functionally-diverse, renewable class of silk materials within …

Lanthorn, Vol. 48, No. 28, November 25, 2013, Grand Valley State University

Volume 48, July 1, 2013 - June 2, 2014

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

The Hero Legend In Colonial Southeast Asia, Thomas; University Gibson

Philippine Studies: Historical and Ethnographic Viewpoints

Four legends that originated in the different religious and colonial contexts of the Tagalog and Makassar peoples are shown to conform to Edward Tylor’s classical “hero pattern.” Using structural anthropology and cognitive linguistics, thisarticle argues that hero legends generated metaphors from concrete relationships in the domestic domain to conceptualize abstract relationships in a series of other domains. The hero pattern underwent transformations in tandem with changes in the political and economic institutions in which it was embedded. From its beginnings as a charter for rival city-states in the ancient Middle East, it became a charter for the universalistic world religions …

Ceratobasidium Root Rot: A New Disease Of Watermelon In Arizona, Claudia Nischwitz

All Current Publications

No abstract provided.

Rethinking Library Instruction: Using Learning Outcome Based Design To Teach Online Search Strategies, Meagan Lacy, Hsin-Liang Chen

University Libraries Faculty Research & Creative Works

Given the growing pressure on academic institutions and, by extension, academic libraries to establish student learning outcomes and demonstrate their impact on student learning, researchers at Indiana University – Purdue University Indianapolis (IUPUI) explored how outcome-based instructional design can be used to 1) collect student data, 2) assess student learning, and 3) improve instruction. Two surveys were distributed to 59 undergraduate students who were enrolled in an introductory composition course at IUPUI. Because previous studies (e.g. Ford, Miller and Moss 2005) have linked human individual differences with web search strategy, the first survey collected information about the students’ demographic features. …

Archives Annual Report, 2012-2013, Meg Miner

Administrative Reports

No abstract provided.

Knowledge Area Module V: Theories Of Organizational And Social Systems, Francis E. Howard

Faculty and Staff Publications

In this section the theories of Perry, Erikson, Kegan, Parks, as well as Belenky, Clinchy, Goldberger and Tarule are compared and contrasted. The significant ideas of each theorist on the stages of human development are analyzed and assessed in terms of their underlying assumptions about meaning making and the internal motivation to learn. The strategy that guided this examination focuses on the process of learning and its relation to the stages of development from infancy through adulthood.

Managing For Resilience: Early Detection Of Regime Shifts In Complex Systems, Tarsha Eason, Ahjond S. Garmestani, Heriberto Cabezas

United States Environmental Protection Agency: Publications

The broad implications of catastrophic regime shifts have prompted the need to find methods that are not only able to detect regime shifts but more importantly, identify them before they occur. Rising variance, skewness, kurtosis, and critical slowing down have all been proposed as indicators of impending regime shifts. However, these approaches typically do not signal a shift until it is well underway. Further, they have primarily been used to evaluate simple systems; hence, additional work is needed to adapt these methods, if possible, to real systems which typically are complex and multivariate. Fisher information is a key method in …

Vocal Jazz In Concert, Samantha Dominguez, Jesse Denny, Hannah Pachman, Jordan Lemay, Erin Theodorakis, Megan Sola-Guinto, Ben Finer, Kyla Mccarrel, Janet Orsi, Wyatt Miller, Donner Hanson, Preston Kennedy, Shana Munson

Printed Performance Programs (PDF Format)

No abstract provided.

The Impact Of Parental Psychological Control On College Students’ Relational Aggression And Friendship Quality, Megan F. Snider

Honors Theses

The present study investigated the relationships between parental psychological control and college students’ relational aggression and friendship quality. Based on previous research, it was expected that parents’ use of psychological control would be associated with students’ increased use of relational aggression with peers and lower friendship quality. Students completed a series of survey measures assessing their mothers’ and fathers’ use of psychological control, behavioral control, and warmth/acceptance. Students also completed a series of survey measures assessing their friendship quality, social skills, relational aggression, self-esteem, and social desirability. The study’s findings revealed that parental psychological control was associated with and predicted …

Creativity To The Core: How The Ky Core Academic Standards Can Enhance Creativity--Research, Dorie Combs

Journal of Excellence in College Teaching and Learning

The Common Core State Standards (CCSS) were developed by the Council of Chief State School Officers (CCSSO) and the National Governor’s Association in response to concerns about the poor performance of US students in comparison to students in other industrialized nations. A lack of understanding of the standards has led some to assume that any standards-based curriculum is going to focus on lower-level thinking skills and therefore impede critical and creative thinking. While Kentucky’s English language arts and mathematics standards are derived from the CCSS, Kentucky’s learning targets and standards are not limited to the CCSS standards. That is, there …

Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors As Cancer Therapeutics, Akintunde Akinleye, Parthu Avvaru, Muhammad Furqan, Yongping Song, Delong Liu

NYMC Faculty Publications

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate diverse cellular processes including proliferation, adhesion, survival, and motility. Dysregulated PI3K pathway signaling occurs in one-third of human tumors. Aberrantly activated PI3K signaling also confers sensitivity and resistance to conventional therapies. PI3K has been recognized as an attractive molecular target for novel anti-cancer molecules. In the last few years, several classes of potent and selective small molecule PI3K inhibitors have been developed, and at least fifteen compounds have progressed into clinical trials as new anticancer drugs. Among these, idelalisib has advanced to phase III trials in patients with advanced indolent non-Hodgkin's lymphoma …

Premed Club Program At All Children's Hospital Provides Comfort To Cystic Fibrosis Patients, November 22, 2013, Tom Scherberger

USF St. Petersburg Campus News and Press Releases

No abstract provided.

The Tiger Vol. 107 Issue 23 2013-11-22, Clemson University

Tiger Newspapers

No abstract provided.

The Spectral Properties Of (-)-Epigallocatechin 3-O-Gallate (Egcg) Fluorescence In Different Solvents: Dependence On Solvent Polarity, Vladislav Snitsarev, Michael N. Young, Ross M.S. Miller, David P. Rotella

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

(-)-Epigallocatechin 3-O-gallate (EGCG) a molecule found in green tea and known for a plethora of bioactive properties is an inhibitor of heat shock protein 90 (HSP90), a protein of interest as a target for cancer and neuroprotection. Determination of the spectral properties of EGCG fluorescence in environments similar to those of binding sites found in proteins provides an important tool to directly study protein-EGCG interactions. The goal of this study is to examine the spectral properties of EGCG fluorescence in an aqueous buffer (AB) at pH=7.0, acetonitrile (AN) (a polar aprotic solvent), dimethylsulfoxide (DMSO) (a polar aprotic solvent), and ethanol …

Ethics & Engineering, Adam Liska

Adam Liska Papers

1) How ethics works (4 slides)
2) 7 general ethical principles (13 slides)
3) Environmental ethics (2 slides)
4) Meta-ethics, theories about ethics (3 slides)
5) Laws & ethics (3 slides)
6) Professional codes of ethics (2 slides)
7) Conflict of Interest, etc. (4 slides)
8) Opportunity costs in research & design (1 slide)

New Nuclear Magnetic Imaging Will Propel Drug Development, Clinton Colmenares

Browse All News

No abstract provided.

2013 - Opera Workshop, Neiu Music Department

Music Department Performance Programs

Opera Workshop, Scene Recital, Sasha Gerritson, Director, Kay Kim, Jane Kenas-Heller, Accompanists, Little Women, Madama Butterfly, Miss Saigon,La Boheme, Rent, Falstaff

Harbor Notes, November 22, 2013, Tom Scherberger

Harbor Notes

The November 22, 2013, issue of Harbor Notes.

Analysis Of Western Lowland Gorilla (Gorilla Gorilla Gorilla) Specific Alu Repeats, Adam T. Mclain, Glenn W. Carman, Mitchell L. Fullerton, Thomas O. Beckstrom, William Gensler, Thomas J. Meyer, Christopher Faulk, Mark A. Batzer

Faculty Publications

Background: Research into great ape genomes has revealed widely divergent activity levels over time for Alu elements. However, the diversity of this mobile element family in the genome of the western lowland gorilla has previously been uncharacterized. Alu elements are primate-specific short interspersed elements that have been used as phylogenetic and population genetic markers for more than two decades. Alu elements are present at high copy number in the genomes of all primates surveyed thus far. The AluY subfamily and its derivatives have been recognized as the evolutionarily youngest Alu subfamily in the Old World primate lineage. Results: Here we …

The Pan American (2013-11-22), Norma Gonzalez, Lea Victoria Juarez

UTPA Archives - The Pan American Newspaper

Vol. 70, No. 13

November 22, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Comparative Genome Analysis Of Ciprofloxacin-Resistant Pseudomonas Aeruginosa Reveals Genes Within Newly Identified High Variability Regions Associated With Drug Resistance Development, Hsun-Cheng Su, Jainab Khatun, Dona M. Kanavy, Morgan C. Giddings

Biology Faculty Publications and Presentations

The alarming rise of ciprofloxacin-resistant Pseudomonas aeruginosa has been reported in several clinical studies. Though the mutation of resistance genes and their role in drug resistance has been researched, the process by which the bacterium acquires high-level resistance is still not well understood. How does the genomic evolution of P. aeruginosa affect resistance development? Could the exposure of antibiotics to the bacteria enrich genomic variants that lead to the development of resistance, and if so, how are these variants distributed through the genome? To answer these questions, we performed 454 pyrosequencing and a whole genome analysis both before and after …

Agenda And Minutes, University Of South Florida St. Petersburg General Education Committee Meeting, November 22, 2013, University Of South Florida St. Petersburg. Faculty Senate. General Education Committee

USF St. Petersburg General Education Committee Meetings

Agenda and minutes from the November 22, 2013, meeting of the General Education Committee of the University of South Florida St. Petersburg's Faculty Senate.

A Kennedy Memorial

News Releases

No abstract provided.

Soil Respiration In A Northeastern Us Temperate Forest: A 22‐Year Synthesis, M. A. Giasson, A. M. Ellison, R. D. Bowden, Patrick M. Crill, Erik A. Davidson, J. E. Drake, Serita D. Frey, J. L. Hadley, M. Lavine, J. M. Melillo, J. W. Munger, K. J. Nadelhoffer, L. Nicoll, Scott V. Ollinger, K. E. Savage, P. A. Steudler, J. Tang, Ruth K. Varner, S. C. Wofsy, D. R. Foster, A. C. Finzi

Faculty Publications

To better understand how forest management, phenology, vegetation type, and actual and simulated climatic change affect seasonal and inter‐annual variations in soil respiration (Rs), we analyzed more than 100,000 individual measurements of soil respiration from 23 studies conducted over 22 years at the Harvard Forest in Petersham, Massachusetts, USA. We also used 24 site‐years of eddy‐covariance measurements from two Harvard Forest sites to examine the relationship between soil and ecosystem respiration (Re).

Rs was highly variable at all spatial (respiration collar to forest stand) and temporal (minutes to years) scales of measurement. The response of Rs to experimental manipulations mimicking …

November 22, 2013, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Identification Of Human Pgc-1Α-B Isoforms Using A Novel Pgc-1Α-B Specific Antibody, Shannon Hedrick

Theses and Dissertations

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is known as the master regulator of mitochondrial biogenesis. PGC-1α holds this role by acting as a transcriptional coactivator for an array of transcription factors and nuclear hormone receptors, such as NRF-1/2 and ERRα/γ, whose downstream targets function in mitochondrial biogenesis and oxidative phosphorylation. PGC-1α is regulated both at the transcriptional and post-translational level in several signaling pathways, including p38 MAPK and AMPK. This regulation affects which transcription factor binding events can occur in a given tissue, and thus affects regulation of PGC-1α target genes. PGC-1α is downregulated in many neurodegenerative disorders as …

Elucidating The Complex Interplay Between Host And Virus, Linlin Gao

Open Access Dissertations

Upon virus infection, the innate immune response provides the first line of protection and rapidly induces type I interferons (IFN alpha/beta), which mediate potent antiviral effects. To maintain homeostasis and prevent autoimmunity, IFN production is tightly regulated; however, the mechanisms of negative regulation are poorly understood. Herein, we demonstrate that the A20 binding inhibitor of NF-kappaB 1 (ABIN1) is a novel negative regulator of antiviral signaling. Overexpression of ABIN1 inhibited IFN-beta promoter activation in response to virus infection or poly(I:C) transfection, whereas siRNA-mediated knockdown of ABIN1 enhanced IFN-beta production upon virus infection. ABIN1 interacted with the A20 regulatory molecule TAX1BP1 …