Digital Commons Network^™

Plasma Membrane Compartmentalization Of D2 Dopamine Receptors, Meenakshi Sharma, Jeremy Celver, J. Christopher Octeau, Abraham Kovoor

Biomedical and Pharmaceutical Sciences Faculty Publications

Plasma membrane microcompartments could allow different signaling pathways to operate more efficiently and prevent cross-talk. We utilized a novel in-cell biotin transfer assay to demonstrate that the majority of plasma membrane-expressed D2 dopamine receptor (D2R) is microcompartmentalized within detergent-resistant structures. Conversely, a minority of D2R existed in a detergent-soluble form and interacted in a relatively unrestricted manner with other cellular proteins. The microcompartmentalization of D2R had functional consequences because dopamine-induced internalization of D2R was largely restricted to the compartmentalized receptor. The D2R-containing microcompartments did not correspond to putative detergent-resistant lipid raft structures. First, the detergent-insoluble D2R structures were significantly denser …

The Intersection Of Culture And Cognition: A Comparison Of Common Core State Standards Argumentative Writing Responses Of Elementary-Aged Hispanic/Latino And European-Origin White Students, Erin O'Hara-Rines

Doctor of Education (EdD)

This exploratory study employed statistical analysis and response excerpts to locate points of intersection between culture and cognition in a comparison of argumentative writing work samples of 74 Oregon fourth and fifth grade Hispanic/Latino and European-origin White students. Major findings indicated that Hispanic/Latino students more often 1) employed a diffuse, recursive organizational style that may be related to traditional features of Mexican discourse, 2) utilized elements of indirect language, a feature that has been associated with collectivist cultures, and 3) incorporated narrative elements, echoing a cultural mode for connection, while White students more often 1) evidenced use of a sequential, …

The Effects Of Exercise Participation On Cognition In Adults, Marisa L. Hastie

Doctor of Education (EdD)

Current research supports that regular participation in exercise not only benefits physical fitness parameters, but also that there are multiple beneficial effects on cognition and brain health. Few studies have been conducted on adults and many lack the specifics of the exercise prescription needed in order to elicit improvements in cognition. The purpose of this study was to examine the relationship between the different dimensions of physical fitness and cognitive improvements. Thirty-seven adults enrolled at a northwest community college were recruited for this study. Participants were divided amongst three exercise treatment groups: cardiovascular training (CVT), strength training (ST), and mixed …

A+, The Honors College, 2013, University Of Arkansas, Fayetteville. Honors College

A+ Magazine

No abstract provided.

Unrelated, Kathryn Muhlestein

AWE (A Woman’s Experience)

No abstract provided.

Prostate Cancer: Can Multiparametric Mr Imaging Help Identify Patients Who Are Candidates For Active Surveillance?, B. Turkbey, H. Mani, O. Aras, J. Ho, A. Hoang, A. R. Rastinehad, H. Agarwal, V. Shah, M. Bernardo, P. L. Choyke, +8 Additional Authors

Journal Articles

PURPOSE: To determine whether multiparametric magnetic resonance (MR) imaging can help identify patients with prostate cancer who would most appropriately be candidates for active surveillance (AS) according to current guidelines and to compare the results with those of conventional clinical assessment scoring systems, including the D'Amico, Epstein, and Cancer of the Prostate Risk Assessment (CAPRA) systems, on the basis of findings at prostatectomy. MATERIALS AND METHODS: This institutional review board-approved HIPAA-compliant retrospectively designed study included 133 patients (mean age, 59.3 years) with a mean prostate-specific antigen level of 6.73 ng/mL (median, 4.39 ng/mL) who underwent multiparametric MR imaging at 3.0 …

Comparison Of Endorectal Coil And Nonendorectal Coil T2w And Diffusion-Weighted Mri At 3 Tesla For Localizing Prostate Cancer: Correlation With Whole-Mount Histopathology, B. Turkbey, M. J. Merino, E. C. Gallardo, V. Shah, O. Aras, A. R. Rastinehad, W. M. Linehan, B. J. Wood, P. A. Pinto, P. L. Choyke, +3 Additional Authors

Journal Articles

PURPOSE: To compare utility of T2-weighted (T2W) MRI and diffusion-weighted MRI (DWI-MRI) obtained with and without an endorectal coil at 3 Tesla (T) for localizing prostate cancer. MATERIALS AND METHODS: This Institutional Review Board-approved study included 20 patients (median prostate-specific antigen, 8.4 ng/mL). Patients underwent consecutive prostate MRIs at 3T, first with a surface coil alone, then with combination of surface, endorectal coils (dual coil) followed by robotic assisted radical prostatectomy. Lesions were mapped at time of acquisition on dual-coil T2W, DWI-MRI. To avoid bias, 6 months later nonendorectal coil T2W, DWI-MRI were mapped. Both MRI evaluations were performed by …

Understanding The Anatomy Of Dystonia: Determinants Of Penetrance And Phenotype, R. P. Lerner, M. Niethammer, D. Eidelberg

Journal Articles

No abstract provided.

Adaptation To Climate Change And The Everglades Ecosystem, Frank Piccininni

Hofstra Law Student Works

The Florida Everglades is a vast and dynamic landscape characterized by pulsing flows of water, iconic wildlife, tree islands, and a complex mosaic of floral assemblages. The Everglades ecosystem was referred to as Payhay- okee, or grassy lake, by the Seminole Indians and has been designated as a World Heritage Site, a Ramsar Convention Wetland of International Importance, and a World Biosphere Reserve. Unfortunately, the “grassy lake” has been transformed into a highly managed network of canals and water management structures designed to reclaim the Everglades for agricultural use and settlement. Recognizing the deleterious impact of water management in the …

Disposition Of Mefloquine And Enpiroline Is Highly Influenced By A Chronic Schistosoma Mansoni Infection, Katrin Ingram, Urs Duthaler, Mireille Vargas, William Ellis, Jennifer Keiser

United States Army: Publications

Chronic Schistosoma mansoni infections lead to severe tissue destruction of the gut wall and liver and can influence drug disposition. This study aimed to investigate the impact of a chronic S. mansoni infection on the pharmacokinetic (PK) parameters of two promising antischistosomal lead candidates (mefloquine and enpiroline) in mice. Studies were conducted in two different mouse cohorts (S. mansoni-infected and uninfected mice) for both drugs. Plasma samples were collected at various time points after oral treatment (200 mg/kg of body weight) with study drugs. A high-performance liquid chromatography (HPLC) method was validated to analyze enpiroline and mefloquine in plasma. …

A Retrospective Study Of Anxiety Disorder Diagnoses In The Military From 2000 To 2009, Meghan E. Lovering, Susan P. Proctor, Kristin J. Heaton

United States Army: Publications

The objective of this study was to describe trends in the diagnostic rates for anxiety disorders (ADs) types in the U.S. military from 2000 to 2009. Data for the numbers of diagnosed cases for the first documented occurrence of ADs during ambulatory visits while serving in the military were obtained from the Defense Medical Epidemiology Database for all active duty service members and examined across branch of service and by gender. Results indicate that Anxiety Not Otherwise Specified (ANOS) was the most frequently diagnosed AD type in each of the 10 years between 2000 and 2009, with an average rate …

Evaluation Of The Implementation Of Professional Learning Communities And The Impact On Student Achievement, Cristi M. Bostic

Education Dissertations and Projects

This dissertation evaluated the implementation of professional learning communities in a large suburban school district in North Carolina. The presence of shared and supportive leadership, shared values and vision, collective learning and application, shared personal practice, supportive conditions for relationships, and supportive conditions for structures are all attributes that were assessed to determine the degree of implementation.

A quantitative and qualitative program evaluation was conducted using the CIPP evaluation model to determine the degree of implementation of professional learning communities and whether or not the implementation has had an impact on student achievement based on state end of course test …

Reception Centers In Response To Radiological Hazards: Correctly Triaging Survivors, Ameer Matariyeh

Master of Public Health Program Student Publications

A disastrous incident involving radiological materials has the potential to cause mass casualties exceeding several thousand. Early diagnostic screening and triage at community reception centers (CRC) are excellent tools to keep communities safe from unidentified radiological material. Community receptionists quickly screen survivors with portable radiation detectors before triaged first aid survivors are transported to a nearby hospital. Screening for radiation immediately upon arrival to a community reception center reduces internal and external radiation dose levels, as well as the chance of chronic radiation illness. This culminating experience sought to determine if different CRC flow charts affect survivor triage.

Abiotic Reduction Of Nitrite And Nitrate By Nanoscale Chemogenic Magnetite: Pathways For Significant Greenhouse Gas Production, Adam Charles Burdsall

Browse all Theses and Dissertations

The biogeochemical cycling of nitrogen in terrestrial systems is a major source of nitrous oxide (N₂O), which is among key greenhouse gases (GHG). While biotic processes are commonly accepted as the major drivers of N₂O production, the role of abiotic processes is less understood, and their importance may be underestimated. This study investigates abiotic reactions in the formation and breakdown of N trace gases, including nitric oxide (NO) and nitrous oxide (N₂O) by naturally occurring nanoscale magnetite in soil as denitrification (reduction of nitrite) intermediates. Nitrogen biogeochemical cycling has been studied extensively with respect …

Association Between The Luteinizing Hormone/Chorionic Gonadotropin Receptor (Lhcgr) Rs4073366 Polymorphism And Ovarian Hyperstimulation Syndrome During Controlled Ovarian Hyperstimulation, Travis J. O'Brien, Mariah M. Kalmin, Arthur F. Harralson, Adam M. Clark, Ian Gindoff, Samuel J. Simmens, David Frankfurter, Paul Gindoff

Pharmacology and Physiology Faculty Publications

Background

The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ovarian hyperstimulation (COH).

Methods

This was a prospective study of 172 patients undergoing COH at the Fertility and IVF Center at GWU. DNA was isolated from blood samples and a region encompassing the insLQ polymorphism was sequenced. We also investigated a polymorphism (rs4073366 G > C) that was 142 bp frominsLQ. The association of the insLQ and rs4073366 alleles and outcome to COH (number of mature follicles, …

The Expanding Genomic Landscape Of Autism: Discovering The 'Forest' Beyond The 'Trees', Valerie Wailin Hu

Biochemistry and Molecular Medicine Faculty Publications

Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by significant deficits in reciprocal social interactions, impaired communication, and restricted, repetitive behaviors. Because ASDs are among the most heritable of neuropsychiatric disorders, much of autism research has focused on the search for genetic variants in protein-coding genes (i.e., the "trees"). However, no single gene can account for more than 1% of the cases of ASD. Yet, genome-wide association studies have often identified statistically significant associations of genetic variations in regions of DNA that do not code for proteins (i.e., intergenic regions). There is increasing evidence that such noncoding regions are actively …

Community Annotation And The Evolution Of Cooperation: How Patience Matters, Atin Basuchoudhary, Vahan Simoyan, Raja Mazumder

Biochemistry and Molecular Medicine Faculty Publications

We investigate why biologists fail to contribute to biological databases although almost all of them use these databases for research. We find, using evolutionary game theory and computer simulations, that (a) the initial distribution of contributors who are patient determines whether a culture of contribution will prevail or not (b) institutions (where institution means “a significant practice, relationship, or organization in a society or culture”) that incentivize patience and therefore limit free riding make contribution more likely and, (c) a stable institution, whether it incentivizes patience or not, will increase contribution. As a result we suggest there is a trade-off …

Madison Forever Scholarships Change Lives

Madison Magazine

No abstract provided.

Assessing The "Goodness Of Fit" Between Scholarly Assertions And Audience Interpretations Of Media Images Of Black Male Athletes, Emily J. Houghton

Human Performance Department Publications

The purpose of this study was to examine the "goodness of fit" in sport media research, specifically how audiences interpret media images of Black male athletes and the ways in which their interpretations "fit" with scholarly assertions pertaining to racially marked media depictions. Participants in the study (n=36) were part of eight focus groups segmented by age, gender and race. They viewed and discussed mainstream media images of Black male athletes found on major American sport media websites (ESPN.com and SI.com). The images corresponded with five categories of representation found in the literature: highly competent/natural athlete, exotic savage, deviant, emotionally …

Cabbage Or Turnip?, Andrew Croft

USU Student Organic Farm Newsletter

No abstract provided.

Genetic And Physiological Responses Of Bifidobacterium Animalis Subsp. Lactis To Hydrogen Peroxide Stress, T. S. Oberg, Robert E. Ward, J. L. Steele, Jeff Broadbent

Nutrition, Dietetics, and Food Sciences Faculty Publications

Consumer interest in probiotic bifidobacteria is increasing, but industry efforts to secure high cell viability in foods is determined by these anaerobes’ sensitivity to oxidative stress. To address this limitation, we investigated genetic and physiological responses of two fully sequenced Bifidobacterium animalis subsp. lactis strains, BL-04 and DSM 10140, to hydrogen peroxide (H₂O₂) stress. Although the genome sequences for these strains are highly clonal, prior work showed they differ in both intrinsic and inducible H₂O₂ resistance. Transcriptome analysis of early stationary phase cells exposed to a sub-lethal H₂O₂ concentration detected …

Export Controls And Economic Sanctions, John W. Boscariol, Matthew A. Goldstein, David T. Hardin, Brett W. Johnson, Brooke M. Ringel, Nicholas M. Roegner

The International Lawyer

No abstract provided.

Transcript Abundance Responses Of Resistance Pathways Of Arabidopsis Thaliana To Deoxynivalenol, Jiazheng Yuan, Michelle M. Zhu, Khalid Meksem, Matt Geisler, Patrick Hart Dr, David A. Lightfoot

Articles

Mycotoxin deoxynivalenol (DON), produced by Gibberella zeae (Schwein.) Petch (teleomorph of Fusarium graminearum Schwabe) was known to be both a virulence factor in the pathogenesis of Triticum aestivum L. (wheat) and an inhibitor of Arabidopsis thaliana L. seed germination. Fusarium graminearum causes both Gibberella ear rot in maize (Zea mays L.) and Fusarium head blight (FHB) in wheat and barley. Arabidopsis thaliana was also a host for the related root rot pathogen F. virguliforme Aoki. A. thaliana seedling growth was reduced by the pathogen in a proportional response to increasing spore concentrations. Here, the changes in transcript abundances corresponding to …

Articulations 2013, Som School Of Osteopathic Medicine, Umdnj University Of Medicine And Dentistry Of Nj

Yearbooks

University of Medicine and Dentistry of New Jersey (UMDNJ) School of Osteopathic Medicine yearbook for the Class of 2013. This was the last graduating class of UMDNJ. 112 pages.

Contents: Osteopathic Oath 1, UMNDJ-SOM Campus 2, University Affiliated Medical Centers 3, Dean's Message 4, Administration/Faculty/Staff 5, Class of 2013 Candid Photos 16, Graduates 34, "The Next to Last Blast" Highlights 96, Convocation 98, Editor's Message 104.

Editor: Nancy Bastawros

Echo, Winter/Spring 2013, Columbia College Chicago

Echo

Student-produced magazine formerly published as Chicago Arts and Communication, changed to Echo magazine in 1997. Cover Articles: Up close and fursonal: inside the furry fandom; Back on the bike: from critical condition to Critical Mass; Talkin' trash: a day on the garbage circuit; Living canvases: tales of the tattoo trade; Preserving the page: Chicago's love affair with print. 80 pages.

Signaling Mechanisms Of Vav3, A Guanine Nucleotide Exchange Factor And Androgen Receptor Coactivator, In Physiology And Prostate Cancer Progression, Leah S. Lyons, Kerry L. Burnstein

Faculty Books and Book Chapters

The Rho GTPase guanine nucleotide exchange factor (GEF) Vav3 is the third member of the Vavfamily of GEFS and is activated by tyrosine phosphorylation. Through stimulation of Rho GTPaseactivity, Vav3 promotes cell migration, invasion, and other cellular processes. Work from our laboratory first established that Vav3 is upregulated in models of castration-resistant prostate cancer progression and enhances androgen receptor as well as androgen receptor splice variant activity. Recent analysis of clinical specimens supports Vav3 as a potential biomarker of aggressive prostate cancer. Consistent with a role in promoting castration-­resistant disease, Vav3 is a versatile enhancer of androgen receptor …

Hitting The Right Target: Taxonomic Challenges For, And Of, Plant Invasions, Peter Pyšek, Philip E. Hulme, Laura A. Meyerson, Gideon F. Smith, James S. Boatwright, Neil R. Crouch, Estrela Figueiredo, Llewellyn C. Foxcroft, Vojtěch Jarošik, David M. Richardson, Jan Suda, John R. U. Wilson

Natural Resources Science Faculty Publications

This paper explores how a lack of taxonomic expertise, and by implication a dearth of taxonomic products such as identification tools, has hindered progress in understanding and managing biological invasions. It also explores how the taxonomic endeavour could benefit from studies of invasive species. We review the literature on the current situation in taxonomy with a focus on the challenges of identifying alien plant species and explore how this has affected the study of biological invasions. Biosecurity strategies, legislation dealing with invasive species, quarantine, weed surveillance and monitoring all depend on accurate and rapid identification of non-native taxa. However, such …

Proposing New Barrens National Natural Landmarks, Todd R. Lookingbill, Mary C. Brickle, Katharina A.M. Engelhardt

Geography and the Environment Faculty Publications

The National Natural Landmarks (NNL) Program, administered and maintained through the National Park Service, was established in 1962 with the goal of highlighting sites that best demonstrate the outstanding geologic and biologic features of the United States. In a unique partnership between public and private landowners, the National Park Service accepts sites into the program that best illustrate the diversity of our country’s natural heritage regardless of ownership. The NNL program seeks solely to recognize these sites for their geologic and biologic significance and to strengthen the public’s appreciation for and conservation of America’s natural heritage. Potential NNLs are evaluated …

Dysmorphology And Dysfunction In The Brain And Calvarial Vault Of Nonsyndromic Craniosynostosis, Joel Stanley Beckett

Yale Medicine Thesis Digital Library

Craniosynostosis is a premature pathologic fusion of one or more sutures in the calvarial vault. The six calvarial sutures are growth sites between adjacent intramembranous bones, which allow for flexibility during passage through the birth canal and accommodation for the growing brain. Premature fusion results in obvious cranial morphologic abnormality and can be associated with elevated intracranial pressure, visual dysfunction, mental retardation and various forms of subtler learning disability.

A category of disease called isolated nonsyndromic craniosynostosis (NSC) represents nearly 85% of cases. It results in prototypical skull deformities and has newly-discovered correlations with poor neuropsychologic and visual functioning. Herein …

Breaking Scandal: Inside The Sexual Assault Coverage, The Jezebel Reporter's Defense, University Of Montana--Missoula. School Of Journalism

Montana Journalism Review

Year in Review -- The New Ball and Chain -- Two Nations, One Voice -- Running On Empty -- Lightweight Heroes -- Cover Story: The Blame Game -- You've Been Served -- How a Night Can Go Wrong -- Out of the Abyss -- Looking Down the Barrel -- Falling Far From Here -- Watchdog -- Made in Montana