Digital Commons Network^™

Extracellular Thimet Oligopeptidase Is Carried By Cell Membrane Microvesicles Of Human Prostate Cancer Cells, Yu Liu

Honors Thesis Collection

No abstract provided.

Molecular Matchmaking: A Computational Study Of The Electrostatic Interaction Between Chronic Myeloid Leukemia Drugs And Bcr-Abl Oncoprotein, Lucy Y. Liu

Honors Thesis Collection

In this project, we systematically use several computational techniques such as charge optimization and component analysis to study molecular recognition and binding in the chronic myeloid leukemia (CML) drug systems. Using CML drugs and their biological target, the Bcr-Abl oncoprotein, we systematically conduct a comparative analysis on five CML drugs bound to both the wild-type (WT) and T315I mutant Abl kinase. While early generation drugs (imatinib, nilotinib, and dasatinib) interact with Thr315 via a hydrogen bond, novel drugs ponatinib and PPY-A bypass interacting with Thr315 altogether. With the mutation to Ile at position 315, early generation drugs may experience a …

Regulation Of Levels And Localization Of Thimet Oligopeptidase In Prostate Cancer Cells By Β-Estradiol, Christa Defries

Honors Thesis Collection

The enzyme thimet oligopeptidease (TOP) catalyzes the hydrolysis of gonadotropin-releasing hormone (GnRH) in vitro, and evidence suggests that TOP is the primary enzyme responsible for GnRH hydrolysis in vivo, as well. If this is true, TOP could play an important role in regulating steroid hormone production via the hypothalamic-pituitary-gonadal (HPG) axis. In addition to its function at the level of the hypothalamus, TOP may also have a direct effect at the target tissue level. In order to determine if TOP has a direct modulating effect androgen and estrogen functions, prostate cancer cells were treated with estradiol, an end …

Determining The Role Of The Hedgehog Signaling Pathway During Limb Regeneration In The Red Flour Beetle, Tribolium Castaneum, Carla Mayela Villarreal

Honors Thesis Collection

Despite studies performed on many species, including amphibians and insects, the mechanisms regulating limb regeneration remain poorly understood. Hedgehog (Hh) is a major signaling pathway found in most, if not all, animal species, including humans. In vertebrates, Hh signaling has been shown to play key roles during limb regeneration. To determine whether Hedgehog might also play a role during limb regeneration in Tribolium castaneum, Hh signaling was silenced through RNA interference. In normal development, silencing of Hh signaling resulted in alteration of limb morphology. Disruption of Hh signaling during regeneration led to the impairment of blastema growth and subsequent …

The Hormonal And Genetic Regulation Of Melanization And Phenotypic Plasticity In The Milkweed Bug, Oncopeltus Fasciatus, Tiffany Chen

Honors Thesis Collection

No abstract provided.

From Military Exercises To Visions Of Wilderness: Constructed Environments In Vieques, Puerto Rico, Ada Smith

Honors Thesis Collection

I hope to tell the story of the contested landscape of a former military training base in Vieques, a small island municipality of Puerto Rico. Military occupation on the island from 1940 until 2003 led to serious environmental and economic devastation. In 2003, the Navy gave two-thirds of the island to U.S. Fish and Wildlife. In effect, toxic wasteland is now under “conservation” where clean-up is impossible given its status as a wildlife sanctuary. This paradox has been kept out of local dialogue and has provided popular media with a platform to dub Vieques as an untouched gem of the …

Expression Of Nuclear Receptor Coactivators In The Brain Of Progestin Receptor Isoform-Specific Knock-Out Mice, Young Hsu

Honors Thesis Collection

No abstract provided.

Launching A Novel Fmri Study Of Vocal Learning And Memory Acquisition In The Songbird Model, Rachel Parker

Honors Thesis Collection

No abstract provided.

The Scientific Method’S Missing Step: Using Marianne Moore And A.R. Ammons’S Poetry To See The Invisible, Sharon Tai

Honors Thesis Collection

No abstract provided.

A Feature-Based Approach To Estimate Protein-Protein Electrostatic Binding Energetics, Amelia Kreienkamp

Honors Thesis Collection

No abstract provided.

The Fiction Of The Fabricated Ruin: Memory And History In The Work Of Adrián Villar Rojas, Mina Juhn

Honors Thesis Collection

The sculptural practice of Adrián Villar Rojas (b. 1980, Argentina) threatens to fissure the continuous façade of our reality through its uncanny insinuation of parallel temporalities. His construction of monumental ruins amalgamates disparate forms ranging from the organic to the aggressively industrial, and his large-scale works are rendered more enigmatic due to their calculated destruction. His use of unfired clay produces a decaying aesthetic that alludes to the fragility of narratives traditionally imbued in monumental forms, thereby calling attention to the tenuous nature of memory and history. By producing works abroad that are intentionally oscillatory and endowing them with familial, …

Phenotypic And Genomic Differences Between Wildtype And Mutant Synechocystis Sp. Strain Pcc 6803 And Positive Phototaxis, Zihan Dong

Honors Thesis Collection

No abstract provided.

Community In Education: Lessons Learned From Around The World, Jiezhen Wu

Honors Thesis Collection

No abstract provided.

Exploration Of The Neurochemistry, Structural Morphology And Behavior In The Gcpii+/- Mouse Model With Magnetic Resonance, Palig Mouradian

Honors Thesis Collection

Schizophrenia plagues approximately 1% of the world’s population. This chronic brain disorder is marked by behavioral, cognitive and social abnormalities. Studies on the brain pathophysiology of schizophrenia have also found predominant structural and neurochemical aberrations. While no single cause of the disorder has been identified; environmental, genetic and epigenetic factors have been implicated. This thesis is both an investigation of the genetically modified GCPII^+/- mouse model as well as the groundwork for the implementation of diffusion tensor imaging and an updated epigenetic mouse model. Groundwork for the updated mouse model included rodent stereotactic surgery design to ultimately induce epigenetic …

A Modular Approach To The Characterization Of Histone H2a-Derived Antimicrobial Peptides, Maria E. Bustillo

Honors Thesis Collection

No abstract provided.

Annual Report For The Town Of Hebron, New Hampshire For The Fiscal Year Ending December 31, 2012., Hebron Town Representatives

Hebron, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

College Of Optometry Overview 2013, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physician Assistant Fort Lauderdale 2013, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

A Methodology For Coronary Stent Product Development: Design, Simulation And Optimization, Anweshana Vaizasatya

Dissertations

Coronary stents are slotted tubes made of metals, alloys, or polymers. They are deployed in human arteries, which are blocked by calcified plaque, to keep the arteries open and allow the blood to flow with ease. Coronary stents have been proven as an effective treatment device for heart diseases such as acute myocardial infarction. Design plays an important role for coronary stents to perform the clinical functions properly. Various parameters such as materials, structures, dimensions, and deployment methods etc., need to be considered in the design of coronary stents. There are numerous studies on design of coronary stents and many …

Report On The 2013 Rapid Assessment Survey Of Marine Species At New England Bays And Harbors, Christopher D. Wells, Adrienne L. Pappal, Yuangyu Cao, James T. Carlton

Publications

No abstract provided.

Medical Apps: Public And Academic Perspectives, William H. Krieger

Philosophy Faculty Publications

Medical apps have featured in popular websites and mainstream news media in recent months. However, there has been almost no mention of these tools in journals focusing on relevant ethical or social issues, including conflict of interest, the role of politics in science, and technological oversight.This essay examines the role that these philosophical issues might play in answering both public and academic questions about these pieces of emergent technology.

Cakes Without Sugar: Reasons Behind Foreign Investor Reluctance To Enter Mesopotamia, Nidham G. Al Abasey

Syracuse Journal of International Law and Commerce

No abstract provided.

Undergraduate Catalogue 2011-2013

Tennessee State University Undergraduate Catalogues

No abstract provided.

Late-Successional And Old-Growth Forests In The Northeastern United States: Structure, Dynamics, And Prospects For Restoration., Mark J. Ducey, John S. Gunn, Andrew A. Whitman

Natural Resources & the Environment

Abstract

Restoration of old-growth forest structure is an emerging silvicultural goal, especially in those regions where old-growth abundance falls below the historic range of variability. However, longitudinal studies of old-growth dynamics that can inform silvicultural and policy options are few. We analyzed the change in structure, including stand density, diameter distribution, and the abundance of large live, standing dead, and downed dead trees on 58 late-successional and old-growth plots in Maine, USA, and compared these to regional data from the U.S. Forest Inventory and Analysis program. Structural dynamics on the late-successional plots reflected orderly change associated with density-dependent growth and …

Guilty Or Not Guilty: Can Dna Help Prove Guilt Or Innocence?, Suzanne Eckstein

The Science Journal of the Lander College of Arts and Sciences

Throughout our history, science was always on the front lines for discovery and exploration. Science is used as an investigative tool by the human race to figure out all the mysteries of the universe. The discovery of DNA was tremendous, providing each human being with their own unique genetic identity - no longer would an individual be genetically confused with another. DNA fingerprinting, in particular, has changed the world. In the 1980's the legal system began using DNA fingerprinting to help establish the guilt of an indicted criminal. DNA (besides for fingerprints) is the only way to confirm scientifically if …

2012 Touro College & University System Faculty Publications, Touro College & University System

Faculty Publications Books

This is the 2012 edition of the Faculty Publications Book of the Touro College & University System. It includes all eligible 2012 publication citations of faculty within the Touro College & University System. It was produced by the Touro College Libraries.

A Promise Fulfilled - Syracuse University Graduates Its First Class Of Say Yes Scholars, Christine Yackel

Syracuse University Magazine

Highlights the role that Say Yes to Education has had on local Syracuse city high school students who have graduated through this program at Syracuse University by making the college dream affordable them.

The Cantor Years, Carol L. Boll

Syracuse University Magazine

Highlights the tenure of Chancellor Nancy Cantor and her distinctive and innovative thinking during her ten years at the helm of Syracuse University.

Equal Protection For Children Of Same-Sex Parents, Catherine E. Smith

Scholarly Articles

Gay rights litigation and advocacy traditionally have focused on the unequal treatment of gay and lesbian individuals and couples; less attention has been dedicated explicitly to the legal rights of the children of gay and lesbian parents. This Article asserts that a child of same-sex parents denied a government benefit has a cognizable equal protection challenge—a legal claim that is separate and distinct from that of the child’s gay or lesbian parents. It is well-settled equal protection law that the government may not treat nonmarital children differently than marital children because of moral disdain for their parents’ relationship, and laws …

2013-2014 Louisiana Tech University Catalog, Louisiana Tech University

Louisiana Tech University Catalogs

The Louisiana University Catalog includes announcements and course descriptions for courses offered at Louisiana Tech University for the academic year of 2013-2014.