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Fact Book 2012-2013, Office Of Institutional Research, Seton Hall University

Fact Books

No abstract provided.

Strategies For Success, David L. Huffman

Academic Leadership Academy

The physical and biological sciences provide a unique platform to attract and retain students interested in medicine, drug development, and basic and applied sciences. At WMU, the development of rational thinking skills and objective analysis of our world and how it works, positions our students to succeed in a competitive environment.

Current WMU students have difficulty envisioning their career path after they graduate from college, yet they have spent years acquiring and developing the tools of success. In order to help our students ‘see the light at the end of the tunnel’, a program called “Strategies for Success” was developed. …

Center For Grassland Studies, Winter/Spring 2013, Volume 19, No. 1

Center for Grassland Studies: Newsletters

PGA Golf Management Honors and Other News

From the Director

Management of Crop Residues Is Key to Forage Supply Now and in the Future

Fire Research

Turfgrass Update

Many Good Speakers Lined Up for 2013 Nebraska Grazing Conference

Innovations on the Land Symposium

Nebraska Youth Range Camp in June

Nebraska Range Camp Turns 50 — Reunion in August

CGS Associates

Resources

Impact Of Stress-Coping Strategies On Perceived Stress, Intrinsic Motivation, And Self-Efficacy Levels Of Students, Tanya M. Hudson

Education Dissertations and Projects

Impact of Stress-Coping Strategies on Perceived Stress, Intrinsic Motivation, and Self-Efficacy Levels of Students. Hudson, Tanya M., 2013: Dissertation, Gardner-Webb University, Stress/Coping/Adolescents/ Motivation/ Self-Efficacy/Stress-Coping Strategies Stress-coping strategies are identified by researchers as conditions used suitable to a situation when adolescents have a change in their environment or a stressor that they cannot control. The purpose of this dissertation was to explore the impact of stress-coping strategies on perceived stress levels, levels of intrinsic motivation, and self-efficacy. According to the research, stress results from an imbalance between the requirements of the environment and one's ability to cope with it (Aldwin, 2007). …

The Effects Of Variable Viscosity On The Peristaltic Flow Of Non-Newtonian Fluid Through A Porous Medium In An Inclined Channel With Slip Boundary Conditions, Ambreen Afsar Khan, R. Ellahi, Muhammad Usman

Mathematics Faculty Publications

The present paper investigates the peristaltic motion of an incompressible non-Newtonian fluid with variable viscosity through a porous medium in an inclined symmetric channel under the effect of the slip condition. A long wavelength approximation is used in mathematical modeling. The system of the governing nonlinear partial differential equation has been solved by using the regular perturbation method and the analytical solutions for velocity and pressure rise have been obtained in the form of stream function. In the obtained solution expressions, the long wavelength and low Reynolds number assumptions are utilized. The salient features of pumping and trapping phenomena are …

A New Gamboge Derivative Compound 2 Inhibits Cancer Stem-Like Cells Via Suppressing Egfr Tyrosine Phosphorylation In Head And Neck Squamous Cell Carcinoma, Rongxin Deng, Xu Wang, Yang Liu, Ming Yan, Sayaka Hanada, Qin Xu, Jianjun Zhang, Zeguang Han, Wentao Chen, Ping Zhang

Nursing Faculty Publications

Cancer stem-like cells represent a population of tumour-initiating cells that lead to the relapse and metastasis of cancer. Conventional anti-cancer therapeutic drugs are usually ineffective in eliminating the cancer stem-like cells. Therefore, new drugs or therapeutic methods effectively targeting cancer stem-like cells are in urgent need to successfully cure cancer. Gamboge is a natural anti-cancer medicine whose pharmacological effects are different from those of conventional chemotherapeutical drugs and they can kill some kinds of cancer cells selectively. In this study, we identified a new gamboge derivative, Compound 2 (C2), which presents eminent suppression effects on cancer cells. Interestingly, when compared …

Htlv Tax: A Fascinating Multifunctional Co-Regulator Of Viral And Cellular Pathways, Robert Currer, Rachel Van Duyne, Elizabeth Jaworski, Irene Guendel, Gavin Sampey, Ravi Das, Aarthi Narayanan, Fatah Kashanchi

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Human T-cell lymphotropic virus type 1 (HTLV-1) has been identified as the causative agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The virus infects between 15 and 20 million people worldwide of which approximately 2–5% develop ATL. The past 35 years of research have yielded significant insight into the pathogenesis of HTLV-1, including the molecular characterization of Tax, the viral transactivator, and oncoprotein. In spite of these efforts, the mechanisms of oncogenesis of this pleiotropic protein remain to be fully elucidated. In this review, we illustrate the multiple oncogenic roles of Tax by summarizing a recent …

Transcriptional Responses Of In Vivo Praziquantel Exposure In Schistosomes Identifies A Functional Role For Calcium Signalling Pathway Member Camkii, Hong You, Donald P. Mcmanus, Wei Hu, Michael J. Smout, Paul J. Brindley, Geoffrey N. Gobert

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Treatment for clinical schistosomiasis has relied centrally on the broad spectrum anthelmintic praziquantel; however, there is limited information on its mode of action or the molecular response of the parasite. This paper presents a transcriptional and functional approach to defining the molecular responses of schistosomes to praziquantel. Differential gene expression in Schistosoma japonicum was investigated by transcriptome-wide microarray analysis of adult worms perfused from infected mice after 0.5 to 24 hours after oral administration of sub-lethal doses of praziquantel. Genes up-regulated initially in male parasites were associated with “Tegument/Muscle Repair” and “Lipid/Ion Regulation” functions and were followed by “Drug Resistance” …

Thrombospondin-1 Signaling Through Cd47 Inhibits Self-Renewal By Regulating C-Myc And Other Stem Cell Transcription Factors, Sukhbir Kaur, David R. Soto-Pantoja, Erica V. Stein, Chengyu Liu, Abdel G. Elkahloun, Michael L. Pendrak, Alina Nicolae, Satya P. Singh, Zuqin Nie, David Levens, Jeffrey S. Isenberg, David D. Roberts

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells, increases asymmetric division, and enables these cells to spontaneously reprogram to form multipotent embryoid body-like clusters. c-Myc, Klf4, Oct4, and Sox2 expression is elevated in CD47-null endothelial cells, in several tissues of CD47- and thrombospondin-1-null mice, and in a human T cell line lacking CD47. CD47 knockdown acutely increases mRNA levels of c-Myc and other stem cell transcription factors in cells and in vivo, …

Cd56negcd16+ Nk Cells Are Activated Mature Nk Cells With Impaired Effector Function During Hiv-1 Infection, Jeffrey M. Milush, Sandra López-Vergès, Vanessa A. York, Steven G. Deeks, Jeffrey N. Martin, Frederick M. Hecht, Lewis L. Lanier, Douglas F. Nixon

Microbiology, Immunology, and Tropical Medicine Faculty Publications

BACKGROUND: A subset of CD3(neg)CD56(neg)CD16⁺ Natural Killer (NK) cells is highly expanded during chronic HIV-1 infection. The role of this subset in HIV-1 pathogenesis remains unclear. The lack of NK cell lineage-specific markers has complicated the study of minor NK cell subpopulations.

RESULTS: Using CD7 as an additional NK cell marker, we found that CD3(neg)CD56(neg)CD16⁺ cells are a heterogeneous population comprised of CD7⁺ NK cells and CD7(neg) non-classical myeloid cells. CD7⁺CD56(neg)CD16⁺ NK cells are significantly expanded in HIV-1 infection. CD7⁺CD56(neg)CD16⁺ NK cells are mature and express KIRs, the C-type lectin-like receptors NKG2A and NKG2C, and natural cytotoxicity receptors similar to …

A Comprehensive, Multi-Scale Dynamical Model Of Erbb Receptor Signal Transduction In Human Mammary Epithelial Cells, Tomas Helikar, Naomi Kochi, Bryan Kowal, Manjari Dimri, Mayumy Naramura, Srikumar M. Raja, Vimla Band, Hamid Band, Jim A. Rogers

Biochemistry and Molecular Medicine Faculty Publications

The non-receptor tyrosine kinase Src and receptor tyrosine kinase epidermal growth factor receptor (EGFR/ErbB1) have been established as collaborators in cellular signaling and their combined dysregulation plays key roles in human cancers, including breast cancer. In part due to the complexity of the biochemical network associated with the regulation of these proteins as well as their cellular functions, the role of Src in EGFR regulation remains unclear. Herein we present a new comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells. This model, constructed manually from published biochemical literature, consists of 245 nodes representing proteins …

Novel Insights Into Breast Cancer Genetic Variance Through Rna Sequencing, Anelia Horvath, Suresh B. Pakala, Prakriti Mudvari, Sirigiri Divijendra Natha Reddy, Kazufumi Ohshiro, Sandra Casimiro, Ricardo Pires, Suzanne A.W. Fuqua, Masakazu Toi, Luis Costa, Sujit S. Nair, Saraswati Sukumar, Rakesh Kumar

Biochemistry and Molecular Medicine Faculty Publications

Using RNA sequencing of triple-negative breast cancer (TNBC), non-TBNC and HER2-positive breast cancer sub-types, here we report novel expressed variants, allelic prevalence and abundance, and coexpression with other variation, and splicing signatures. To reveal the most prevalent variant alleles, we overlaid our findings with cancer- and population-based datasets and validated a subset of novel variants of cancer-related genes: ESRP2, GBP1, TPP1, MAD2L1BP, GLUD2 and SLC30A8. As a proof-of-principle, we demonstrated that a rare substitution in the splicing coordinator ESRP2(R353Q) impairs its ability to bind to its substrate FGFR2 pre-mRNA. In addition, we describe novel SNPs and INDELs in …

The Dn2 Myeloid-T (Dn2mt) Progenitor Is A Target Cell For Leukemic Transformation By The Tlx1 Oncogene, Lynnsey A. Zweier-Renn, Irene Riz, Teresa S. Hawley, Robert G. Hawley

Anatomy and Regenerative Biology Faculty Publications

Introduction: Inappropriate activation of the TLX1 (T-cell leukemia homeobox 1) gene by chromosomal translocation is a recurrent event in human T-cell Acute Lymphoblastic Leukemia (T-ALL). Ectopic expression of TLX1 in murine bone marrow progenitor cells using a conventional retroviral vector efficiently yields immortalized cell lines and induces T-ALL-like tumors in mice after long latency.

Methods: To eliminate a potential contribution of retroviral insertional mutagenesis to TLX1 immortalizing and transforming function, we incorporated the TLX1 gene into an insulated self-inactivating retroviral vector.

Results: Retrovirally transduced TLX1-expressing murine bone marrow progenitor cells had a growth/survival advantage and readily gave rise to immortalized …

Nuclear Envelope Laminopathies: Evidence For Developmentally Inappropriate Chromatin-Nuclear Envelope Interactions, Jelena Perovanovic, Jyoti K. Jaiswal, Nikola Markovic, Eric P. Hoffman

Genomics and Precision Medicine Faculty Publications

Background

During terminal differentiation of cells, there is typically a transition of the nuclear envelope from the Lamin B protein to Lamin A/C proteins. This is commensurate with exit from the cell cycle, and maintenance of the transcriptional programs associated with the terminally differentiated cells. Dominant missense mutations in Lamin A/C cause a broad spectrum of human genetic disorders, where specific point mutations are associated with defects in specific organs or tissues. We have previously presented a model where Lamin A/C mutations disrupt developmentally appropriate interactions between chromatin and the nuclear envelope and lead to poor coordination of E2F cell …

Dysembryoplastic Neuroepithelial Tumor With Atypical Presentation: Mri And Diffusion Tensorcharacteristics, Kalyan Paudel, Samuel Borofsky, Robert V. Jones, Lucien M. Levy

Radiology Faculty Publications

We report the neuroimaging findings of a 26-year-old female patient with a biopsy-proven dysembryoplastic neuroepithelial tumor (DNET). DNETs are an uncommon, usually benign, glial-neural cortical neoplasm of children and young adults who typically present with intractable seizures. DNETs may occur in any region of the supratentorial cortex, but have a predilection for the temporal lobes. Accurate neuroimaging diagnosis is essential since patients with DNET benefit from complete resection. However, accurate differentiation from other cortical lesions may be challenging. Typical conventional Magnetic Resonance Imaging (MRI) features can help in the differentiation from other similar cortical tumors. Diffusion tensor imaging can also …

Wound Care Challenges In Children And Adults With Spina Bifida: An Open-Cohort Study, Katherine Ottolini, Amy B. Harris, June K. Amling, Ann M. Kennelly, Leslie A. Phillips, Laura L. Tosi

Pediatrics Faculty Publications

Skin breakdown is a frequent concern for individuals with spina bifida. We explored wound incidence in patients with spina bifida and how it varies across a person's life span and functional neurologic level. We examined the settings in which skin breakdown most commonly occurred, looking for evidence of chronic, non-healing wounds. We also sought to develop criteria to improve wound monitoring. We identified reported wound episodes in an open-cohort study over a 13-year period, examining the hospital and outpatient clinical records of spina bifida patients at Children's National Medical Center (CNMC). Current age, age at wound presentation, sex, weight, functional …

The Association Of Cd81 Polymorphisms With Alloimmunization In Sickle Cell Disease, Zohreh Tatari-Calderone, Ryad Tamouza, Gama P. Lebouder, Ramita Dewan, Naomi L. Luban, Jacqueline Lasserre, Jacqueline Maury, Francois Lionnet, Rajagopal Krishnamoorthy, Robert Girot, Stanislav Vukmanovic

Pediatrics Faculty Publications

The goal of the present work was to identify the candidate genetic markers predictive of alloimmunization in sickle cell disease (SCD). Red blood cell (RBC) transfusion is indicated for acute treatment, prevention, and abrogation of some complications of SCD. A well-known consequence of multiple RBC transfusions is alloimmunization. Given that a subset of SCD patients develop multiple RBC allo-/autoantibodies, while others do not in a similar multiple transfusional setting, we investigated a possible genetic basis for alloimmunization. Biomarker(s) which predicts (predict) susceptibility to alloimmunization could identify patients at risk before the onset of a transfusion program and thus may have …

Activation Of Human Herpesvirus Replication By Apoptosis, Alka Prasad, Jil Remick, Steven L. Zeichner

Pediatrics Faculty Publications

A central feature of herpesvirus biology is the ability of herpesviruses to remain latent within host cells. Classically, exposure to inducing agents, like activating cytokines or phorbol esters that stimulate host cell signal transduction events, and epigenetic agents (e.g., butyrate) was thought to end latency. We recently showed that Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus-8 [HHV-8]) has another, alternative emergency escape replication pathway that is triggered when KSHV's host cell undergoes apoptosis, characterized by the lack of a requirement for the replication and transcription activator (RTA) protein, accelerated late gene kinetics, and production of virus with decreased infectivity. Caspase-3 …

Oximetry Signal Processing Identifies Rem Sleep-Related Vulnerability Trait In Asthmatic Children, Geovanny F. Perez, Maria J. Gutierrez, Shehlanoor Huseni, Krishna Pancham, Carlos E. Rodriguez-Martinez, Cesar L. Nino, Gustavo Nino

Pediatrics Faculty Publications

Rationale. The sleep-related factors that modulate the nocturnal worsening of asthma in children are poorly understood. This study addressed the hypothesis that asthmatic children have a REM sleep-related vulnerability trait that is independent of OSA.

Methods. We conducted a retrospective cross-sectional analysis of pulse-oximetry signals obtained during REM and NREM sleep in control and asthmatic children (n=134). Asthma classification was based on preestablished clinical criteria. Multivariate linear regression model was built to control for potential confounders (significance level p ≤ 0.05).

Results. Our data demonstrated that (1) baseline nocturnal respiratory parameters were not significantly different in asthmatic versus control children, …

Looking For The Forest And The Trees: Exercises To Provoke Abstract Thinking, Boriana Marintcheva

Biological Sciences Faculty Publications

No abstract provided.

The Amino Acid Permeases Aap3 And Aap6 Are Involved In Root-Knot Nematode Parasitism Of Arabidopsis, Heather H. Marella, Erik Nielsen, Daniel P. Schachtman, Christopher G. Taylor

Biological Sciences Faculty Publications

The root-knot nematode, Meloidogyne incognita, is an obligate parasite which depends entirely on the host plant for its nutrition. Root-knot nematodes induce the formation of a highly specialized feeding site consisting of several giant cells surrounded by a network of vascular tissues. Nutrients, including amino acids and sugars, are transferred apoplastically from the vascular tissues to the feeding site. Using Arabidopsis thaliana lacking the vascular-expressed amino acid permeases (AAP) AAP3 or AAP6, we demonstrate that disruption of amino acid transport can affect nematode parasitism. Nematode infestation levels are significantly reduced on the aap3 and aap6 mutants. AAP3 and AAP6 …

The Pittsburg Micropolitan Area Economic Report, Quarter 4, 2013, Pittsburg State University. Gladys A. Kelce College Of Business

Pittsburg Micropolitan Reports

The Pittsburg Micropolitan Area Economic Report is created by the Business and Economic Research Center (BERC) at Pittsburg State University.

An Empirical Study On The Matrix-Based Protein Representations And Their Combination With Sequence-Based Approaches, Loris Nanni, Alessandra Lumini, S. Berlin Brahnam

College of Business

Many domains have a stake in the development of reliable systems for automatic protein classification. Of particular interest in recent studies of automatic protein classification is the exploration of new methods for extracting features from a protein that enhance classification for specific problems. These methods have proven very useful in one or two domains, but they have failed to generalize well across several domains (i.e. classification problems). In this paper, we evaluate several feature extraction approaches for representing proteins with the aim of sequence-based protein classification. Several protein representations are evaluated, those starting from: the position specific scoring matrix (PSSM) …

Slower Uncoating Is Associated With Impaired Replicative Capability Of Simian-Tropic Hiv-1, Kenn Kono, Eric Takeda, Hiromi Tsutsui, Ayumu Kuroishi, Amy E. Hulme, Thomas J. Hope, Emi E. Nakayama, Tatsuo Shioda

College of Health and Human Services

Human immunodeficiency virus type 1 (HIV-1) productively infects only humans and chimpanzees, but not Old World monkeys, such as rhesus and cynomolgus (CM) monkeys. To establish a monkey model of HIV-1/AIDS, several HIV-1 derivatives have been constructed. We previously generated a simian-tropic HIV-1 that replicates efficiently in CM cells. This virus encodes a capsid protein (CA) with SIVmac239-derived loops between α-helices 4 and 5 (L4/5) and between α-helices 6 and 7 (L6/7), along with the entire vif from SIVmac239 (NL-4/5S6/7SvifS). These SIVmac239-derived sequences were expected to protect the virus from HIV-1 restriction factors in monkey cells. However, the replicative capability …

Land Snails And Slugs Of Missouri, Ronald D. Oesch, Larry E. Watrous, M. Christopher Barnhart

Faculty Books

The Land Snails and Slugs of Missouri is an identification guide and natural history based on field collections from more than 800 sites as well as historical records. The terrestrial mollusks (land snails and slugs) are a diverse, fascinating and accessible fauna that provides many opportunities for education, research and conservation. No generally available guide to this fauna had been published since 1962, and no regional guide focused on Missouri has ever before been prepared. This book presents descriptions, synonymy lists, and ecological notes for 149 native and introduced species in the state. It is richly illustrated, with color photographs …

Feeding Behavior Of Captive-Reared Juvenile Alligator Snapping Turtles (Macrochelys Temminckii), M. B. East, B. M. Fillmore, Day B. Ligon

College of Natural and Applied Sciences

Feeding preference of Macrochelys temminckii (Alligator Snapping Turtle) is not well known. Juveniles reared with no prior exposure to natural prey were tested for innate prey (i.e., fish) preference and foraging ability for mussels in coarse and fine substrates. Alligator Snapping Turtles consumed fish non-selectively, except that they selected Lepomis macrochirus (Bluegill) over Gambusia affinis (Mosquitofish) in live-prey trials, and Lepomis cyanellus (Green Sunfish) over Notemigonus crysoleucas (Golden Shiners) in carrion trials. Juvenile Alligator Snapping Turtles were less active and less successful when foraging for a benthic prey species, Lampsilis siliquoidea (Fatmucket), in coarse substrate than they were when the …

'In Love With Either/Or': Religion And Oppositional Logic In Margaret Atwood's The Handmaid's Tale (Chapter 3 Of Irigaray, Incarnation And Contemporary Women's Fiction), Abigail Rine

Faculty Publications - Department of English

Excerpt: "Margaret Atwood is a prolific and award-winning Canadian writer whose work regularly exposes the destructive and oppressive forces at work in society, particularly as they affect women. Though Atwood refers to herself as a 'strict agnostic: she maintains an interest in religion, which is evident in her fictional work (Moyers 2006).1 Atwood's second novel, Surfacing (1973) , has received a fair amount of critical attention for its religious themes and is examined in both Carol Christ's Diving Deep and Surfacing and Barbara Rigney's work Lilith's Daughters.2 Atwood's Cat's Eye (1989), with its mystical Marian imagery, has also been explored …

University Of Central Florida Factbook 2012-2013, University Of Central Florida

Historical Fact Book and Enrollment

Historical fact book and enrollment data for the University of Central Florida.

The 2nd Annual Africa Conference September 13, 2013, Tennessee State University

The Annual Africa Conference Programs

No abstract provided.

Maine Women Pioneers Iii: Vanguard, Homage, Worldview, Dirigo, University Of New England Art Gallery, Center For Ethics In Action

Exhibition Catalogues

Maine Women Pioneers III is the catalogue from the University of New England Art Gallery’s October 12, 2012—July 21, 2013 four-part exhibition.

Vanguard (Oct. 12 - Dec. 16, 2012) featured avant-garde, experimental and innovative works by nine Maine artists who offer insights into the future using mixed media, conceptual installation, performance and video elements. Featured artists: Susan Bickford, Diana Cherbuliez, Amy Stacey Curtis, Alicia Eggert, Lauren Fensterstock, Lihua Lei, Julie Poitras Santos, Carrie Scanga, and Ling-Wen Tsai.

Homage (Jan. 2 - March 3, 2013) highlighted veteran artists who are powerful examples of career and lifelong original creative accomplishment, ahead of …