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Pre-Training And Interpretability In Deep Learning Models, Weizhi An

Computer Science and Engineering Dissertations

In the evolving field of artificial intelligence, the efficacy of deep learning models is often gated by the quality of their training and the clarity of their decision-making processes. This dissertation addresses these crucial challenges by focusing on two key areas: enhancing pre-training strategies and improving model interpretability. Our approach is twofold, integrating novel pre-training methodologies that embed domain-specific knowledge early in the model training process, and developing advanced techniques for disentangling and clarifying the decision-making mechanisms within these models. The first direction of our research employs MoDNA, a motif-oriented pre-training framework specifically designed for DNA language models. By leveraging …

Influence Of Microbial Communities And Dilute Heavy Metals In Green Manure On Growth In Lactuca Sativa, Robert Lemay

Student Research Projects

This experiment investigated the effects of a green manure (Lemna minor, common duckweed) grown in varying levels of heavy metals and inoculated with local microbiomes on a crop (Lactuca sativa, volcana lettuce). The growth and health of the duckweeds were measured via root length and biomass, and the health of the lettuce crop was measured via head diameter and biomass.  Two levels of heavy metal concentrations were based on real-world stormwater runoff data to mimic an agricultural environment where accumulation of metals in local water bodies may be absorbed into green manure duckweeds. One microbial treatment and …

Limitations Of Reproductive Manipulation By Bacterial Endosymbionts In A Spider Host, Jordyn D. Proctor

Theses and Dissertations--Entomology

Maternally inherited bacterial endosymbionts are common in arthropods. Many of these bacteria manipulate host reproduction to favor the production of infected females, thereby increasing bacterial prevalence in the host population, even if cost is incurred to the host. However, there are also many factors that may inhibit symbionts’ ability to spread in host populations, including environmental constraints, symbiont-imposed costs on the host, interactions with co-infecting bacteria, or host biology. I explored two aspects of symbiont biology within a spider host, Mermessus fradeorum (Linyphiidae), which has varying combinations of up to five different bacterial endosymbionts in local populations: Rickettsiella, Tisiphia …

Impacts Of Livestock Dewormers On Dung Beetle Foraging Choices Across Spatial Scales, Madison L. Kluge

Theses and Dissertations--Entomology

Dung beetles provide ecosystem services in pasture systems but are vulnerable to chemical residues in livestock dung. Parasiticides containing macrocyclic lactones (MLs) are used to control parasites in livestock and are excreted unmetabolized in dung, exposing non-target organisms to these compounds. We used a multi-scale approach to examine whether ML residues alter dung beetle foraging ecology. At the field scale, we assessed dung beetle abundance and community composition using traps baited with dung from untreated cattle and cattle treated with ivermectin, moxidectin, or eprinomectin across eight farms and natural areas. At a smaller scale, we conducted behavioral assays to quantify …

Flow Injection Determination Of Fluoride For Total Organic Fluorine Analysis, Memona Zulafiqar

Chemistry & Biochemistry Theses

Poly- and perfluoroalkyl substances (PFAS) are anthropogenic chemicals that have gained increasing attention due to their association with a wide range of adverse health effects. These compounds are highly diverse, with approximately 15,000 PFAS reported. Their exceptional environmental stability and strong tendency to bioaccumulate result in environmentally relevant concentrations that typically occur at very low levels, often in the ng L⁻¹ range. This chemical diversity presents a major analytical challenge, as reference standards are available for only a limited number of PFAS. Consequently, conventional targeted analytical methods frequently quantify less than 1% of the total PFAS present, leading to a …

The Impact Of Parental Mental Health On Infant Outcomes In The Neonatal Intensive Care Unit: Length Of Stay, Feeding, Bonding, And Developmental Progress, Andee L. Plaskett

Nursing | Senior Theses

Background: The neonatal intensive care unit (NICU) can be a highly stressful environment for both infants and their parents. Poorer infant outcomes, including longer hospital stays, feeding difficulties, and delayed developmental progress can all be a reflection and outcome of elevated parental distress. Currently, mental health distress and infant screening tools are used in most NICUs but are not seen in all practices, it is also important to provide interventions based on the screening results. Screening tools are used to identify a problem but interventions should be implemented to try to alleviate the problem. Objective: By implementing a standardized screening …

Health Disparities In Cardiovascular Care: The Impact Of Diabetes Education And Post-Discharge Interventions For African American Adults At Risk For And After Myocardial Infarction, Trinity L. Billingsley

Nursing | Senior Theses

Background: Cardiovascular disease is the leading cause of death in the United States, affecting African American adults at higher rates compared to other racial and ethnic groups. Diabetes as a comorbidity is one of the risk factors of experiencing a myocardial infarction, remaining one of the leading causes of death among individuals with diabetes. Objective: To examine the effectiveness of structured diabetes education tailored to African American adults who are at risk for and after a myocardial infarction. Additionally assessing the complications of a myocardial infarction, the outcomes associated with structured education will be compared to the outcomes of …

Human Milk Feeding And Its Impact On The Incidence Of Necrotizing Enterocolitis, Maya C. Kern

Nursing | Senior Theses

One of the leading causes of morbidity and death for preterm and very low birth weight (VLBW) newborns is still necrotizing enterocolitis (NEC). Existing literature consistently shows that the bioactive, anti-inflammatory, and microbiome-supporting components of human breast milk, including donor human milk, significantly lower the incidence of NEC. However, a lot of infants are forced to rely on formula and nutrient fortifiers because they cannot obtain maternal or donor milk. A critical gap persists regarding whether human milk derived fortifiers offer greater NEC protection than bovine derived fortifiers in infants who must receive formula. This thesis examines three interconnected themes; …

Black Americans' Interactions With Law Enforcement: The Black Church's Response, Shalanda Ehiozee

Doctor of Ministry

This research interrogates the disproportionate frequency of lethal law enforcement encounters involving Black Americans, contextualizing these fatalities within the systemic racial hierarchies foundational to the United States. By tracing the historical evolution of policing from antebellum slave patrols to contemporary practice, this study contends that modern law enforcement serves as a sophisticated mechanism of racial and social control.

To examine this phenomenon, the research employs a qualitative, multidimensional methodology that synthesizes Comparative Caste Analysis, case study examination, and a Christological framework. This inquiry is further bolstered by a longitudinal analysis of African American ecclesiological activism, culminating in a theological reflection …

Turn On The Light Of Life(Tll) Pastoral Theology For Integrated Mental And Spiritual Health In The Ethiopian Orthodox Tewahedo Church Perspective, Leulekal Akalu Alemu

Doctor of Ministry

This study explores a unified framework for integrating mental health counseling with spiritual guidance within the Ethiopian Orthodox Tewahedo Church pastoral theology, emphasizing the essential role of clergy in promoting both spiritual and mental well-being. The initiative aims to establish a structured approach that aligns mental health strategies with theological principles, thereby enhancing the connection between mental wellness and spiritual vitality.

Current observations indicate that many clergy members lack adequate training in pastoral counseling, which significantly impedes their ability to effectively address the mental and social issues faced by their communities. This research seeks to empower church leaders by providing …

Re-Imagining Church As A Spiritual Family, Abraham Acosta-Newball

Doctor of Ministry

The contemporary Christian church faces a crisis of belonging; many members are opting out for non-theologically related reasons or differences. The claim for this exodus is a lack of genuine community that serves as an extended spiritual family. Modern churches function as event-centered gatherings, and less like a multigenerational community, reflecting instead a culture of individualism and spiritual consumerism. The purpose of this project is to explore strategies for churches to assume a more biblical role of a spiritual family. Particularly focusing on practical ways for building stronger community within multigenerational and multiethnic Worship settings. The project culminates in three …

Assessing Interdisciplinary Learning And Knowledge: A State-Of-The-Art Review And Heuristic, Kacey Beddoes, Kristi Bartlett

Product Design Faculty Publications

Background – The need for interdisciplinary training is increasingly important, but assessing the effects of interdisciplinary education initiatives remains challenging. One of the leading difficulties is identifying and selecting the best instrument or technique for a given purpose.

Purpose -- To help researchers and educators identify available options and determine the best options for their purposes, we conducted a literature review and created a heuristic table of available techniques. Our review addresses the questions: 1) What domain-general techniques and instruments exist for assessing interdisciplinary learning or knowledge? 2) What research scenarios, populations, and questions are each technique or instrument most …

Modeling Determinants Of Significant Noncompliance In The U.S. Mining Sector: A Fixed Effects Logistic Regression Approach, Eli Johnson

Dissertations, Master's Theses and Master's Reports

This study examines environmental compliance behavior among mining facilities regulated under the U.S. Clean Water Act (CWA). Using a national quarterly panel of National Pollutant Discharge Elimination System (NPDES)-permitted mining facilities, the analysis evaluates whether local socioeconomic and demographic indicators are associated with the likelihood that a facility enters significant noncompliance (SNC) status. Facility compliance histories are compiled from the U.S. Environmental Protection Agency’s Enforcement and Compliance History Online (ECHO) database and is merged with county- and state-level socioeconomic indicators and election data. A fixed-effects logistic regression model is used to account for time-invariant facility heterogeneity. The results suggest that …

Coming Out, Eliot T. Tracz

Minnesota Journal of Law & Inequality

No abstract provided.

Refunding The Community: What Defunding Mpd Means And Why It Is Urgent And Realistic, Jli Vol. 39 Editorial Board

Minnesota Journal of Law & Inequality

No abstract provided.

The Fiction Of Separation: Racial Gerrymandering Disguised As Partisan Redistricting, Crystal Barnes-Bullock

University of the District of Columbia Law Review

While constitutional doctrine formally distinguishes between racial and partisan gerrymandering, this distinction has become increasingly untenable in the modern electoral landscape. In many jurisdictions, particularly in the South, race and political affiliation are deeply intertwined. As a result, what courts treat as “partisan” redistricting often operates as de facto racial gerrymandering, shielding racially discriminatory practices from judicial review. The legal separation of race and party not only reflects a formalist fiction but also undermines the protections the Equal Protection Clause and the Voting Rights Act were designed to provide. The current legal framework that distinguishes racial gerrymandering from partisan gerrymandering …

Erased From The Permanent Record: Data Collection Practices And Non-Binary Student Experiences In School, Ashley Carey, Peter Piazza

Education Faculty Publications

State education data systems often undercount non-binary students, constraining schools’ ability to support them. This study examines the scope and implications of non-binary erasure in school data collection. Drawing on survey responses from nearly 13,000students across seven Massachusetts districts, we find that current practices substantially undercount non-binary students, who also report less positive experiences of school culture, including student–teacher relationships, belonging, and emotional safety. Although inclusive data could guide efforts to create more supportive environments, districts face growing political resistance from parent organizations aligned with the White Christian Nationalist movement. These groups frame inclusivity as a threat to parental rights. …

Intergenerational Resilience: Exploring Whether Positive Childhood Experiences Buffer The Transmission Of Harsh And Neglectful Parenting, Patricia J. Dixon

West Chester University Doctoral Projects

Childhood abuse and neglect are associated with lasting negative mental and physical health outcomes across the lifespan. In contrast, positive childhood experiences (PCEs) can promote long-term health and wellbeing and mitigate the harmful effects of childhood adversity. A primary risk factor for child maltreatment is parental experiences of maltreatment whereby history of childhood trauma increases the likelihood of utilizing harsh and/or neglectful parenting towards one’s children. This study employed secondary data analysis of the National Longitudinal Study of Adolescent to Adult Health to test whether cumulative PCEs confer protective effects against the generational transmission of harsh and neglectful parenting. Consistent …

Patenting Ai Discoveries In Life Sciences: Overcoming Eligibility, Disclosure, And Inventorship Challenges, Dhohyung Kim, Ryan P. Hiler

IP Theory

The pharmaceutical and biotechnology industries face transformative opportunities through artificial intelligence and machine learning integration. However, these technological advances create distinct patent law complications that traditional drug development does not encounter. This article analyzes three interconnected obstacles: establishing eligible subject matter under 35 U.S.C. § 101, meeting disclosure standards under § 112(a), and determining proper inventorship when AI systems contribute substantially to claimed inventions. Drawing from recent USPTO guidance and Federal Circuit precedent, this analysis offers evidence-based strategies for patent practitioners, research scientists, and business leaders seeking robust intellectual property protection for AI-integrated pharmaceutical innovations.

Silver Nanoparticle-Induced Disruption Of Astrocytic Morphology And Synaptic Microarchitecture In Rat Brain, Elli Williams

Theses, Dissertations and Capstones

Silver nanoparticles (AgNPs) are widely incorporated into consumer and medical products due to their antibacterial properties, increasing the potential for chronic exposure. AgNPs can be released into the environment, enter the body through ingestion or inhalation, cross the blood-brain barrier (BBB), and bioaccumulate in brain tissue. Previous in vitro studies demonstrate that AgNP exposure disrupts cytoskeletal organization and induces neurite collapse in neural cells, suggesting vulnerability of cytoskeleton-dependent structures in vivo. Astrocytes, through their perisynaptic astrocytic processes (PAPs) and perivascular endfeet, play critical roles in maintaining synaptic and neurovascular architecture, both of which rely heavily on cytoskeletal integrity. This …

Recentering Creativity In Copyright Law Discourse, Joshua Yuvaraj

IP Theory

Copyright discourse often centers around creativity; as a rationale for copyright, and as a threshold for copyright to subsist in songs, books, art and other creative works. Yet creativity remains an ethereal concept: if we do not know what it means, we cannot evaluate whether copyright law is promoting it, nor can we properly understand what it means for a work to be "creative" where that is required for copyright to subsist. An emerging strand of copyright discourse seeks to respond by examining scientific insights into the cognitive process of creativity to highlight how copyright law should be reshaped to …

Using Genetically Diverse Mice To Examine The Effects Of Environmental Enrichment Of The Transcriptome, Michael Richard Leonardo

Theses, Dissertations and Capstones

Environmental impoverishment is a model of early life stress with direct consequences across a wide range of neurological and physiological conditions. Neuron morphology and density as well as anxiety disorders and addiction have shown to have significant relationships with environmental impoverishment models. Conversely, environmental enrichment confers therapeutic benefits that are protective across these conditions. There is an observed spectrum of resistance or vulnerability to the effects of housing conditions across populations, indicating genetics as an influential factor. Understanding this interaction is critical for deepening our knowledge of how genes and environment interact in ways that confer resistance or vulnerability, and …

Eulogy For Daniel Subotnik דניאל עזרא בן אליעזר ואהובה Died–March 8 / 29 Adar 1, 57, Rabbi Wayne Franklin

Touro Law Review

No abstract provided.

If I Only Had The Words (To Tell You): Billy Joel Lyrics In Legal And Medical Scholarship, Seuli Bose Brill, Christian H. Brill

Touro Law Review

Law and medicine are often considered to be among the least accessible professions, partly because of the heavy use of non colloquial jargon. This article examines more than 150 instances in which Billy Joel’s lyrics have been used to improve the accessibility of legal and medical scholarship. Legal and medical professionals have used the words of the “Piano Man” to discuss a variety of topics—everything from civil procedure to property rights and the COVID-19 pandemic to colorectal surgery. Nontraditional communications techniques of this type do not just contribute to the body of legal and medical scholarship; they also help professionals …

53rd Annual Food Science And Technology Conference, Leonard Koolman, Elena-Alexandra Alexa, Jesus Maria Frias

Books/Book Chapters/ Proceedings

53rd IFSTI Annual Food Science and Technology Conference on 22nd and 23rd of January 2026. Theme is 'Global Food Resilience, its challenges and strategic approaches'.

A Conserved Ethylene-Triggered Cell Death Mechanism May Underlie Hollow Stem Formation Across Plant Species, Mengxiao Yan, Weijuan Fan, Yinghui Meng, Jiamin Zhao, Wei Yang, Ziyin Xu, Yusen Gao, Haiyan Zhuang, Wuyu Zhou, Yuqin Wang, Qingjun Huang, Ling Yuan, Hongxia Wang, Jun Yang

Plant and Soil Sciences Faculty Publications

Hollow stems have independently evolved multiple times across the plant kingdom and play crucial roles in plant development and various environmental adaptations. However, the mechanisms underlying stem hollowness remain poorly understood. Water spinach (Ipomoea aquatica) is one of the few hollow-stemmed plants in the Convolvulaceae family (eudicot: asterid), and its hollow stems are essential for thriving in aquatic environments. Using histochemical staining and transcriptome analysis, we found that programmed cell death (PCD) is involved in cavity formation at water spinach shoot tips. Single-cell and spatial transcriptome analyses further revealed that ethylene and reactive oxygen species (ROS) likely drive …

Safety And Efficacy Findings From A Phase Ib/Ii Study Of Asp-1929 Photoimmunotherapy With Pembrolizumab In Recurrent And/Or Metastatic Head And Neck Squamous Cell Carcinoma, David M. Cognetti, Joseph M. Curry, Jennifer Johnson, Michael Kwon, Shirley Y. Su, Francisco Civantos, Coral Olazagasti, Joseph Valentino, Susanne Arnold, R. Bryan Bell, Michael K. Gibson, Kyle Mannion, Kathryn M. Van Abel, Katharine A. Price, Haiying Dong, Amy H. Thorne, Toshiaki Suzuki, Ann M. Gillenwater

Otolaryngology--Head & Neck Surgery Faculty Publications

Background: ASP-1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing.

Methods: This phase Ib/II open-label study evaluated ASP-1929 photoimmunotherapy plus pembrolizumab in patients with recurrent/metastatic HNSCC (≥ 1 accessible lesion, PD-L1 combined positive score ≥ 1, ineligible for standard locoregional ther- apy). Primary objectives were safety/tolerability and objective response rate (ORR). Secondary objectives included overall sur- vival (OS) and progression-free survival (PFS).

Results: Eighteen patients (median age 63 years, 74% male) comprised the photoimmunotherapy-evaluable population. The confirmed ORR was 27.8% (95% CI 9.7–53.5); four of five responders had complete …

Supplemental Bibliographic Details. From 2001 Mars Odyssey To Earth’S Climate Crisis: Integrating Gamma Spectroscopy, Martian Soil Simulants, And Plant Genomes For Agroecology, Anchored In Sri Lanka’S Mars-Context Serpentinites, Suniti Karunatillake, Maheshi Dassanayake, Carlos Gary Bicas

Planetary Science Lab

Bibliographic details follow to supplement hyperlinked citations in the multinational GANGOTRI-supporting project conceived by Karunatillake, Dassanayake, and Gary-Bicas

Delaying Cancer Progression By Integrating Toxicity Constraints In A Model Of Adaptive Therapy, Jana L. Gevertz, Harsh Vardhan Jain, Irina Kareva, Kathleen P. Wilkie, Joel Brown, Yitong Pepper Huang, Eduardo Sontag, Vladimir Vinogradov, Mark Davies

Mathematics Sciences: Faculty Publications

Cancer therapies often fail when intolerable toxicity or drug-resistant cancer cells undermine otherwise effective treatment strategies. Over the past decade, adaptive therapy has emerged as a promising approach to postpone emergence of resistance by altering dose timing based on tumor burden thresholds. Despite encouraging results, these protocols often overlook the crucial role of toxicity-induced treatment breaks, which may permit tumor regrowth. Herein, we explore the following question: would incorporating toxicity feedback improve or hinder the efficacy of adaptive therapy? To address this question, we propose a mathematical framework for incorporating toxic feedback into treatment design. We and that the degree …

Evaluating Impact Of Occupational Exoskeletons On Physical Fatigue Using Wearable Sensors And Deep Learning, Hardik Vora, Fatemeh Davoudi Kakhki, Armin Moghadam

Mechanical Engineering

Musculoskeletal disorders remain a leading source of occupational injury in manufacturing and logistics industries, often resulting from repetitive lifting and load transfer tasks. While back-support exoskeletons have shown promise in alleviating physical strain, their biomechanical impact under realistic task conditions and their integration with intelligent monitoring systems require further exploration. This study investigates the efficacy of a passive lumbar-support exoskeleton in reducing muscle fatigue during manual material handling tasks by combining high-resolution surface electromyography (sEMG) data with a deep learning-based classification framework. Ten participants performed lifting and rotational (twisting) tasks with and without exoskeleton assistance, while EMG signals were collected …