Digital Commons Network^™

The Line Between Addiction And Medication: Alcohol, Anesthesia, And Analgesia, Priya Joshi, B.S., Emanual Rubin, Md

Department of Pathology Honors Program Student Research Symposium

Alcohol is a particularly dangerous addiction because its consumption is legal even in excess, despite its harmful effects. Because alcohol has a multitude of targets in the central nervous system that are modified during chronic exposure, medications with overlapping targets such as anesthetics and analgesics must be modified when given to alcoholics. Unfortunately, as relatively little is known about the mechanism of addiction, it is difficult to predict how medications will be affected by central adaptation to chronic alcohol exposure. This review summarizes the consequences of alcohol exposure with particular attention to the GABA_Areceptor, and discusses the reasons …

Nuclear Localization Of Cpi-17, A Protein Phosphatase-1 Inhibitor Protein, Affects Histone H3 Phosphorylation And Corresponds To Proliferation Of Cancer And Smooth Muscle Cells., Masumi Eto, Jason A Kirkbride, Rishika Chugh, Nana Kofi Karikari, Jee In Kim

Department of Molecular Physiology and Biophysics Faculty Papers

CPI-17 (C-kinase-activated protein phosphatase-1 (PP1) inhibitor, 17kDa) is a cytoplasmic protein predominantly expressed in mature smooth muscle (SM) that regulates the myosin-associated PP1 holoenzyme (MLCP). Here, we show CPI-17 expression in proliferating cells, such as pancreatic cancer and hyperplastic SM cells. Immunofluorescence showed that CPI-17 was concentrated in nuclei of human pancreatic cancer (Panc1) cells. Nuclear accumulation of CPI-17 was also detected in the proliferating vascular SM cell culture and cells at neointima of rat vascular injury model. The N-terminal 21-residue tail domain of CPI-17 was necessary for the nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuated the nuclear …

Is Advertising To Teenagers Ethical? Media’S Influence On Body Image And Behavior, Stephanie Lemire

Honors Projects in Marketing

An examination of the ethics involved in advertising to adolescents. Specifically, a content analysis and survey research was conducted dealing with how television commercials and magazine advertisements targeted towards males ultimately affect female body image and behavior. The content analysis consisted of Axe Body Spray advertisements, as well as Sports Illustrated: Swimsuit Edition. Findings of survey research include increased body monitoring as a result of exposure to advertisements. Implications and future opportunities are discussed.

The Echo: April 26, 2013, Taylor University

2012-2013 (Volume 100)

Heritage Weekend: The Servant Leader – Lighthouse features new destinations, recruiting techniques – Taylor saves first dance for last weekend – Cosgrove class changes scheduled for fall – Changes in growth – Discipline in the classroom – Weekend Forecast – Behind the Times – Factually fictional – Hunger strike spreads at Guantanamo Bay prison – Around The World – Hilarious Headlines – The Geek Briefs – Water, sanitation initiatives focus on 2014 Lighthouse trip – Bioterrorism: deadly, but difficult to see – Preparations for campus garden underway – Taylathon 2013 – Bikes, Trikes and Band-Aids – Staging reality – Patchwork …

2013 Uab Expo, University Of Alabama At Birmingham

Expo Programs

Catalog of undergrauate student research poster presentations with abstracts.

Understanding The Middle Miocene Climatic Optimum: Evaluation Of Deuterium Values (Δd) Related To Precipitation And Temperature, Colin Gannon

Honors Projects in Science and Technology

The Middle Miocene Climate Optimum was a unique warming period in the Earth’s geologic history, when a high global mean annual temperature was accompanied by a relatively low global CO2 concentration. Hydrogen isotopic signals (specifically molecular δD, the ratio of deuterium to hydrogen) from lipids of fossils and sediments offer intrinsic insights into precipitation of ancient climates. Using samples collected from known Middle Miocene deposits, we measured δD of n-alkanes extracted from well-preserved plant and sediment samples from varying latitudes across the Northern Hemisphere, and then analyzed the data through a zonally averaged precipitation and evaporation climate model. The reduced …

Enhancing Coastal Resilience: Perspectives On Valuing Ri Coastal Lands, Kyle Nyskohus

Honors Projects in Science and Technology

This paper discusses coastal resilience as an organizing framework for future policymaking, coastal planning, and insurance decisions, and explores the different perspectives of the value of ecosystems held by various stakeholders in Rhode Island’s coastal communities. A grounded theory approach was used in an effort to abstract general insights from the substantive but isolated areas of coastal management and economics. Special attention is given to the perspectives of municipal decision makers, the National Flood Insurance Program, natural economists, and real estate developers. We have (1) conducted a statistical analysis of environmental spending of RI towns, (2) identified key models for …

2013 Uab Expo (Schedule), University Of Alabama At Birmingham

Expo Programs

Catalog of undergrauate student research poster presentations with abstracts.

Effects Of Clostridium Difficile On The Human Immune Response, Mike Mcgovern

Honors Projects in Science and Technology

Clostridium difficile is a bacterium that is rapidly becoming a large issue in the medical community due to its tendency to infect hospital patients and its resistance to antibiotics. By studying the way in which the pathogen interacts with the human immune system, it is possible to better understand how the body naturally fights off the disease. This knowledge can allow medical professionals to develop treatments that can help curtail the infection before serious symptoms occur. Working under a grant program alongside Professors Kirsten Hokeness and Chris Reid, I was able to research the effects that exposure to the C. …

Ua12/2/1 College Heights Herald, Vol. 88, No. 51, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Boyd, Kayla. Y Is for Yuck – WKU Farm, Agriculture
• Matchen, Quiche. Earth Day Festival to Encourage Being Green – Sustainability, GreenToppers
• Holloway, Kaely. Chinese Tea Ceremony Brings Culture to Campus – Chinese Club
• Grogg, Mitchell. Students Give Blood During Greek Week – Blood Drives
• Pait, Ryan. Veep is Parks & Recreation Painted Black – Television
• Hunley, Tom. WKU Needs to Prioritize – Construction, Tuition
• Stukenborg, Sarah. Rejection Against Annual Increase Sets Precedent for Future Automatic Fees – Student Government Association
• Prochazka, Tyler. Students Build Structures Out of Canned …

Use Of Exposure History To Identify Patterns Of Immunity To Pneumonia In Bighorn Sheep (Ovis Canadensis), Raina K. Plowright, Kezia R. Manlove, E. Frances Cassirer, Paul C. Cross, Thomas E. Besser, Peter J. Hudson

Wildland Resources Faculty Publications

Individual host immune responses to infectious agents drive epidemic behavior and are therefore central to understanding and controlling infectious diseases. However, important features of individual immune responses, such as the strength and longevity of immunity, can be challenging to characterize, particularly if they cannot be replicated or controlled in captive environments. Our research on bighorn sheep pneumonia elucidates how individual bighorn sheep respond to infection with pneumonia pathogens by examining the relationship between exposure history and survival in situ. Pneumonia is a poorly understood disease that has impeded the recovery of bighorn sheep (Ovis canadensis) following their widespread extirpation in …

The Tiger Vol. 107 Issue 13 2013-04-26, Clemson University

Tiger Newspapers

No abstract provided.

Acid Ceramidase Maintains The Chondrogenic Phenotype Of Expanded Primary Chondrocytes And Improves The Chondrogenic Differentiation Of Bone Marrow-Derived Mesenchymal Stem Cells, Calogera M. Simonaro, Sylvain Sachot, Yi Ge, Xingxuan He, Victor A. Deangelis, Efrat Eliyahu, Daniel J. Leong, Hui B. Sun, Jeffrey B. Mason, Mark E. Haskins, Dean W. Richardson, Edward H. Schuchman

Animal, Dairy, and Veterinary Science Faculty Publications

Acid ceramidase is required to maintain the metabolic balance of several important bioactive lipids, including ceramide, sphingosine and sphingosine-1-phosphate. Here we show that addition of recombinant acid ceramidase (rAC) to primary chondrocyte culture media maintained low levels of ceramide and led to elevated sphingosine by 48 hours. Surprisingly, after three weeks of expansion the chondrogenic phenotype of these cells also was markedly improved, as assessed by a combination of histochemical staining (Alcian Blue and Safranin-O), western blotting (e.g., Sox9, aggrecan, collagen 2A1), and/or qPCR. The same effects were evident in rat, equine and human cells, and were observed in monolayer …

Transfusion Related Acute Lung Injury, Nadia Abidi, Jay Herman, Md, Julie Karp, Md

Department of Pathology Honors Program Student Research Symposium

A 74 year old woman presented with hematemesis. Her medical history was significant for pulmonary embolism treated with warfarin anticoagulation, fibromyalgia treated with NSAIDs/steroids, and a prior bleeding event from a gastric ulcer. On admission she was stable with a hemoglobin of 8.7 g/dL and a therapeutic INR of 3.19. A type and screen determined a blood type of AB positive. In anticipation of endoscopy, the patient received one unit of red blood cells and four units of type AB plasma. Following transfusion, her INR was 1.83. The patient received an additional four units of type AB plasma to further …

Morphologic And Endoscopic Evaluation Of Collagenous Gastritis, Annie Ashok, Ashlie L. Burkart, Md, Cm

Department of Pathology Honors Program Student Research Symposium

Collagenous gastritis (CG) is a rare gastrointestinal condition of unknown etiology and pathogenesis characterized by the presence of a gastric subepithelial collagen band of variable thickness. While little is known about the disease, children and young adults often present with anemia, abdominal pain, and nodular gastric mucosa on endoscopy. In contrast, adults often present with chronic watery diarrhea and normal gastric mucosa on endoscopy. Disease associations (usually in adult cases) include celiac disease, collagenous colitis, collagenous sprue, and lymphocytic colitis. This study aims to further characterize the clinical, endoscopic and morphologic spectrum of CG.

Lumbar Chordoma: A Primary Bone Tumor, Andrew N. Fleischman, Bs, Brian O'Hara, Md

Department of Pathology Honors Program Student Research Symposium

INTRODUCTION

• Primary malignant bone tumor of embryonic notochord remnants
• 1-4% of primary bone tumors, <0.1 per 100,000
• Location: Sacral (50%), Skull base (35%), Vertebral column (15%)
• Classic, chondroid (5-15%), and dedifferentiated (5%) variants
• Most commonly in late middle age (50s to 60s)
• Low-grade, slow growing tumor
• But locally aggressive, high rate of local recurrence (20% in 1^st year)
• Local recurrence is most important predictor of mortality
• Metastasis only occurs very late in disease
• Median survival of about 6 years, less than 12 months with mets
• 5 year survival of 70%, 10 year survival of 40%
• Primary therapy- aggressive surgical resection (if possible) …

An Unexpected Immunohistochemical Profile In An Ovarian Lesion, Kate Fritton, Joanna Chan, Md

Department of Pathology Honors Program Student Research Symposium

A 27 year old female presented with pelvic pain and a palpable pelvic mass. Upon histological examination, the cystic mass contained a multi-cellular lining with nuclear grooves. Negative inhibin staining ruled out a follicular cyst and granulosa cell tumor while pan-cytokeratin positivity suggested an epithelial lesion. The lesion stained positive for thrombomodulin, ultimately suggesting a diagnosis of a Brenner cell tumor, although CD56 positivity in the tumor questions the known immunohistochemical profile of Brenner cell tumors. This unusual result opens the door to future research into the role CD56 in the diagnosis of ovarian neoplasms.

Myeloid Sarcoma: Extramedullary Relapse After Allogeneic Bone Marrow Transplant For Chronic Myelogenous Leukemia, Maria Gubbiotti, Alina Dulau Florea, Md, Renu Bajaj, Phd

Department of Pathology Honors Program Student Research Symposium

Myeloid sarcoma (MS) is an extramedullary tumor of myeloid precursor cells, which can precede or occur concomitantly with acute myeloid leukemia, myelodysplastic syndrome, or myeloproliferative neoplasms. Although MS can involve any organ, it is more common in the central nervous system (CNS) and gonads, sites known as “pharmacologic sanctuaries” where leukemic cells can survive despite systemic chemotherapy. Less often, this tumor can be the manner of relapse after allogeneic bone marrow transplantation.

The diagnosis is based on morphology and immunophenotype by either flow cytometry or immunohistochemistry of paraffin-embedded tissue, and confirmed by FISH or molecular studies. Myeloid sarcomas usually express …

A Case Of Hemoglobinopathy-Thalassemia Syndrome, Michele C. Khurana, B.S., Gene Gulati, Ph.D

Department of Pathology Honors Program Student Research Symposium

Patient Presentation

• 43 year-old African American female presents with left lower extremity pain
• Physical exam: unremarkable
• Past medical history:

Anemic since childhood

Avascular necrosis of left hip

DVT

Chronic illnesses: asthma, depression

Surgical history: appendectomy, tubal ligation, splenectomy, cholecystectomy, L hip replacement

• Family history: mother has lupus

Thoracic Dissecting Aneurysm And The Importance Of Genetics, Dan Kramer, Ba, Anthony Prestipino, M.D.

Department of Pathology Honors Program Student Research Symposium

Patient Presentation

• 28 year old white male with a past medical history significant for untreated hypertension
• Presents with 3 day history of chest discomfort, lower extremity weakness, bowel and bladder dysfunction, near-syncopal episodes
• Absent pulse in right femoral artery, weak pulse in left femoral artery
• Echosonography showed acute Type A dissecting aortic aneurysm
• Treatment

Immediately taken to surgery for repair of aorta with a graft and replacement of the aortic valve

• Outcome

Unstable after surgery

Biventricular heart failure

Persistent bleeding into mediastinum due to DIC

Required massive transfusion of RBCs, FFP, Cryoprecipitate, and Platelets

Became anuric and acidotic

Became fluid …

Adenoid Cystic Carcinoma In Unusual Locations – Differential Diagnosis Difficulties, Heather A. Mcmahon, B.S., Madalina Tuluc, Md

Department of Pathology Honors Program Student Research Symposium

Adenoid Cystic Carcinoma (ACC) is an uncommon malignant salivary gland tumor, representing 1% of all malignant tumors of the oral and maxillofacial region and 22% of all salivary gland malignancies. Although in the majority of cases ACC manifests in the major salivary glands, in rare instances it can be found in locations such as the esophagus, larynx, trachea, lacrimal gland, breast, prostate, lungs, or auditory canal. These unusual locations of ACC often pose a diagnostic challenge to the clinician and are associated with poorer outcomes for patients as compared to those ACC of a more typical presentation. In this study …

Correlations Between Gene Amplification And Protein Expression Of Topoisomerase 2a (Top2a) In Squamous Cell Carcinoma Of The Lung, Anita Modi, Msii, Charalambos C. Solomides, Md

Department of Pathology Honors Program Student Research Symposium

Background: While DNA topoisomerase 2A (TOP2A) plays an essential role in maintaining the structural integrity of the double helix during replication and recombination, excessive expression of this enzyme may promote malignant cell transformations. In fact, increased levels of TOP2A have been observed in various cancer cell lines including squamous cell carcinoma of the lung. This study sought to identify correlations between genotypic and phenotypic evidence of TOP2A obtained via in situ hybridization (ISH) and immunohistochemistry (IHC) techniques.

Methods Tissue microarrays created from 29 samples of Stage I Squamous Cell Carcinoma of the lung were stained with VENTANA BenchMark ULTRA platform …

Temporal Lobe Ganglioglioma In An Epilepsy Patient With Worsening Seizures: Case Study And Future Directions, Adam M. Olszewski, Mark Curtis, Md Phd.

Department of Pathology Honors Program Student Research Symposium

Gangliogliomas are rare brain tumors that have both neuronal and glial components. They hold a better prognosis than other infiltrative glial tumors, but differentiating between them can be challenging. While molecular markers are being studied, it is currently a histologic diagnosis.

In this case, the patient presented with epilepsy and worsening seizures secondary to a medial temporal lobe mass. Radiology report was inconclusive. Surgical resection was achieved and based on histologic examination the lesion was diagnosed as ganglioglioma, WHO grade I.

In this patient, pathological diagnosis of ganglioglioma offers a favorable prognosis and low risk of recurrence. In the future, …

Diagnostic Yield Of Endobronchial Ultrasound-Guided Fine Needle Aspiration (Ebus-Fna) In Lung Cancer Staging, Subtyping And Diagnosis Of Unexplained Mediastinal Lymphadenopathy, Rino Sato, Rossitza Draganova-Tacheva, Md

Department of Pathology Honors Program Student Research Symposium

INTRODUCTION

• Lung cancer (LC) is the most commonly diagnosed cancer worldwide and the most frequent cause of cancer death in both men and women in the US (more deaths than the next three most common cancers combined)¹
• Clinical staging of LC is an integral part of patient care because it directs therapy and has prognostic value

Patients are routinely investigated with a conventional workup (medical history, PE, lab tests, bronchoscopy), CT and integrated whole-body PET-CT, followed by mediastinal tissue staging for enlarged or PET-positive intrathoracic nodes²

• Mediastinal tissue staging has been classically performed by mediastinoscopy, but they can …

Melanocytoma Of The Cerebellopontine Angle, Pranay Soni, M.D, Lawrence C. Kenyon, Md, Phd

Department of Pathology Honors Program Student Research Symposium

Ms. M.G. is a 46-year-old woman with a history of hypertension and prior bilateral laser eye surgery. In 2009, she presented with vertigo, tinnitus, and decreased hearing in the left ear. An MRI scan revealed an enhancing mass in the posterior fossa that was thought to be an acoustic neuroma. In May of 2009, she underwent gamma-knife radiotherapy for the 2.7 cm mass.

In September of 2012, M.G. noted progressive change in her voice quality as well as a swallowing disturbance and left facial spasms. A subsequent MRI showed significant enlargement of the tumor to a maximal size of 3.7 …

Species Abundance And Distribution Of Squid In The Eastern Gulf Of Mexico And Tampa Bay With A Focus On Biology, Christine Oliver

USF St. Petersburg campus Honors Program Theses (Undergraduate)

No abstract provided.

Consuming Places: A Bioregional Comparison Of Voluntary Simplicity Lifestyles, Lauren Drakopulos

USF St. Petersburg campus Master's Theses (Graduate)

Many have argued that in the developed world, consumption has reached unsustainable levels, precipitating social, economic, and environmental decline. Voluntary simplicity is an anti-consumption lifestyle in which practitioners are seeking out an authentic connection to the external world with fulfillment garnered from relationships rather than through the accumulation of material goods. Under the framework of political ecology, this research examined how bioregional characteristics impacted the way in which simplifiers think about and practice simplicity. Using focus groups, in-depth interviews and participant observation, the author did a bioregional comparison of voluntary simplifiers living in the Greater Everglades Bioregion and the Sonoran …

Harbor Notes, April 26, 2013, Tom Scherberger

Harbor Notes

The April 26, 2013, issue of Harbor Notes.

The Bg News April 26, 2013, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. April 26, 2013. Volume 92-Issue 94.

Gardner-Webb Students Receive National Recognition On Annual Who’S Who List, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner- Webb University is pleased to announce that 35 students have been named to the 2012-13 “Who’s Who Among Students in American Universities and Colleges.” Each year, more than 2,800 schools across the United States and the District of Columbia nominate students for selection of this prestigious award. For consideration into the Who’s Who Program students must have an outstanding grade point average (GPA), must participate in school organizations or leadership activities, must be involved in the community, must exhibit future leadership ability or potential, and any other requirements that the student’s member institution requires.