Digital Commons Network^™

Prediction Of Heptatic And Renal Clearance In Pediatric Populations: A "Bottom-Up" Approach Versus "Top-Down" Recognition Of Covariates, Hong Lu

Open Access Dissertations

Medications, including many that are widely used in children, are rarely tested in children. Their safety and effectiveness have not been established in children or have been established only for children of a certain ages. For example, 53 of 140 new medications were labeled for use in children when they were initially approved. Much of pediatric practice, particularly in hospitals and by specialists, has involved "off-label" use of medications. As a consequence, about one-third of the drugs prescribed in office-based pediatric practices and about two-thirds of those prescribed to children in hospital settings are unlicensed or off-label. This proportion reaches …

Trophic Ecology Of Oxygen Minimum Zone Zooplankton Revealed By Carbon And Nitrogen Stable Isotopes, Rebecca Williams

Open Access Dissertations

Oxygen minimum zones (OMZs) are areas in which midwater oxygen concentration can be significantly lower than in non OMZ areas at comparable depths. OMZs are of great interest because of the limits oxygen availability places on life. The potential for OMZ expansion with warming of the oceans has refocused attention on the importance of these areas and their potential impacts on the global carbon cycle. The large open ocean OMZs of the Eastern Tropical Pacific and Arabian Sea are notable for their size, thickness, and the intensity of oxygen depletion (

Here, I use measurements of natural abundance carbon and …

Academic Rigor For All: A Review Of Literature, Gabriel Reich, Volkan Sevim, Amanda Turner

MERC Publications

In this literature review, we will attempt to address the issue of academic rigor in several ways. First, we will review federal and Virginia policy documents that discuss academic rigor, and the research reports that influenced these documents. We will then attempt to articulate a clear definition of academic rigor that applies across academic contexts. This definition draws on the work of educational psychologists, sociologists, and scholars of teaching and learning. Finally we will review the research literature on rigorous classroom practice in two disciplines, history and mathematics.

Cultural Forum: Classical Societies And Western Dominance [10th Grade], Ellie Chernosky

Understanding by Design: Complete Collection

The goal of this unit is for students to understand what a “classical culture” is and why history remembers the West. Students will begin by learning about Greece and Rome, focusing on the modern legacies of these two classical civilizations. They will begin by distinguishing between early river valley civilizations and classical civilizations and analyzing the changes and continuities. Students will compare political systems, and then, they will analyze the influence of Greek democracy on America’s political system. Students will review the main legacies of Rome, and learn about the rise and fall of Rome by completing a model. After …

Understanding Geometry As An Axiomatic System, Danielle Kendrick

Understanding by Design: Complete Collection

After completing the Algebra I review and introducing several computational aspects of geometry including distance formula, midpoint formula, etc., we will introduce the idea of geometry as an axiomatic system. In this unit, we will decide what role rules play in governing behavior. Students will define and identify the four components of an axiomatic system; defined terms, undefined terms, axioms/postulates, and theorems. They will explore various axiomatic systems and decide how these systems dictate how appropriate behavior looks. We will explore Euclidean Geometry abstractly considering it at its most basic form, a set of rules that determine how geometric objects …

Modeling The World, Jeremy Martin

Understanding by Design: Complete Collection

Pre-Requisites for the Unit: Students should have studied exponential and polynomial functions and linear regression before starting this unit.

Context: This unit is envisioned as an end of course unit for Pre-Calculus. The unit is designed specifically to incorporate elements of Calculus and Statistics for students interested in taking either AP course.

Unit Goals: Students should come out of this unit with the ability to perform polynomial and exponential regression and interpret the residuals and coefficient of determination in context of the model’s goodness of fit. Students will gain proficiency in using computers and calculators to display data and create …

Pourquoi Stories, Dan Mallette

Understanding by Design: Complete Collection

This unit is based on Pourquoi Stories, which are stories of origin or stories that tell how or why something came to be. These stories are a form of the literary narrative. This unit is meant for students to explore the structure of stories and also what stories show the reader about different cultures. Specifically, this unit addresses the introductory hook, plot diagramming, the four basic conflicts in narrative and character development. This unit highlights these literary ideas by embracing the following multiple intelligences: spatial, linguistic, logical/mathematical, kinesthetic and naturalistic.

Energy Transformations In The Real World, Stephanie Sanders, Dayna Fogle

Understanding by Design: Complete Collection

This energy unit is intended as part three of a three part series where students use launchers to explore how scientists combine theory and measured data to build and use predictive models. The launchers will be used during projectiles, forces, and work/energy and students will measure and use data adjusted theoretical models to endeavor to complete two hands-on performance tasks. Historically, our students have struggled to understand why “physics breaks” in the lab, and we intend to use these launchers throughout our Newtonian mechanics units to open an ongoing dialogue about how modeling is used to bridge the gap between …

Where Everyone’S Place Is Valued: A Numeration Unit, Karen Morrison

Understanding by Design: Complete Collection

This is our first unit in 3rd grade math. It focuses specifically on Base Ten/Numeration, with a main emphasis on place value and money. Aligned with state standards, the students will be able to read, write in the three different forms (standard, expanded and written) and compare numbers up to the hundred-thousand place; additionally, students will be able to count collections of bills & coins and to solve real-world situations in which money is exchanged. The performance assessment is entitled: Ritzy Roadrunner Resort. Students will be invited to participate in an imaginative ritzy summer vacation, much like present day Atlantis …

Online Reading Informs Classroom Instruction And Promotes Collaborative Learning, Leslie Kate Wright, Sacha Zyto, David R. Karger, Dina L. Newman

Articles

Web-based collaborative annotation tools can facilitate communication among students and their instructors through online reading and communication. Collaborative reading fosters peer interaction and is an innovative way to facilitate discussion and participation in larger enrollment courses. It can be especially powerful as it creates an environment where all students are able to ask questions and contribute to a discussion about science. An online annotation tool, Nota Bene (NB), was tested in two biology courses: intermediate-level Molecular Biology (89 students) and upper level Cancer Biology (26 students). Student participation in these graded reading assignments ranged from 79% to 93%. A typical …

Preparation, Characterization And Applications Of Functionalized Carbon Nano-Onions, Mahendra K. Sreeramoju

Theses and Dissertations--Chemistry

Carbon nano-onions (CNOs) discovered by Ugarte in 1992 are multi-layered fullerenes that are spherical analogs of multi-walled carbon nanotubes with diameters varying from 6 nm to 30 nm. Among the various methods of synthesis, CNOs prepared by graphitization of nanodiamonds (N-CNOs) and underwater electric arc of graphite rods (A-CNOs) are the subject of our research. N-CNOs are considered as more reactive than A-CNOs due to their smaller size, high curvature and surface defects.

This dissertation focuses on structural analysis and surface functionalization of N- CNOs with diameters ranging from 6—10 nm. Synthetic approaches such as oleum- assisted oxidation, Freidel-Crafts acylation …

Oxidative Damage To Dna In Alzheimer's Disease, Sony Soman

Theses and Dissertations--Chemistry

Previous studies from our laboratory and others show a significant increase in levels of both nuclear and mitochondrial DNA and RNA oxidation in vulnerable brain regions in the progression of Alzheimer’s disease (AD). Although total DNA oxidation is increased in AD it remains unclear whether oxidative damage is widespread throughout the genome or is concentrated to specific genes. To test the hypothesis that specific genes are more highly oxidized in the progression of AD, we propose to quantify the percent oxidative damage in genes coding for proteins shown to be altered in the progression of AD using quantitative/real-time polymerase chain …

Hydrogenation And Hydrogenolysis Of Furan Derivatives Using Bipyridine-Based Electrophilic Ruthenium(Ii) Catalysts, Anitha Shankaralinge Gowda

Theses and Dissertations--Chemistry

The catalytic activity of ruthenium(II) bis(diimine) complexes cis-[Ru(6,6′-Cl₂bpy)₂(OH₂)₂](Z)₂ (2, Z = CF₃SO₃; 3, Z = (3,5-(CF₃)₂C₆H₃)₄B ,i.e. BArF), cis-[Ru(4,4′-Cl₂bpy)₂(OH₂)₂](Z)₂ (4, Z = CF₃SO₃; 5, Z = BArF) and cis-[Ru(bpy)₂(PR₃)(OH₂)](CF₃SO₃)₂ (7, bpy = 2,2’-bipyridine, PR₃ = P(C₆H₄F)_{3 …}

Structures And Reactions Of Biomolecules At Interfaces, Xiaoning Zhang

Theses and Dissertations--Chemistry

This dissertation serves to study a protein's conformation-function relationship since immobilized proteins often behave differently from their solution-state counterparts. Therefore, this study is important to the application of protein-based biodevices. Another aim of this dissertation is to explore a new approach to realize low voltage electrowetting without the help of oil bath. Utilizing this approach, a protein micro-separation was realized. Additionally, the interfacial properties of ionic liquid (IL) solid-like layer, which played a key role in electrowetting, was studied for further developments of IL-based applications.

Atomic Force Microscopy (AFM) was utilized in the study and played multiple roles in this …

Studies Of Organic Compounds Spreading Over High Energy Surfaces, Lingbo Lu

Theses and Dissertations--Chemistry

Spreading plays an important role in coating, lubrication, printing and etc. During the spreading process, a liquid thin film forms prior to the expansion of a liquid drop. This thin film is called a precursor film. It not only changes the spreading mechanism, but impacts the wettability of a liquid. Early studies on the precursor films showed the films were stacked in a terraced structure, and the radius of each layer of the films was proportional to the square root of time. Optical techniques such as ellipsometry, X-ray diffraction and X-ray reflectivity solved the conformations of liquid molecules at the …

Acenes And Acenequinones For Optics And Organic Electronics, Matthew Bruzek

Theses and Dissertations--Chemistry

Acenes have been explored by a number of research groups in the field of organic electronics with a particular emphasis on transistor materials. This group has been actively studying acene‐based organic semiconductors for more than a decade using a crystal engineering approach and has developed acene derivatives for applications in field‐effect transistors, light‐emitting diodes, and photovoltaics. In addition to organic electronics, crystal engineering has important applications in a number of other fields, quite notably in the design of metal‐organic frameworks. Chapters 2 and 3 of this dissertation focus on applying crystal engineering to the synthesis of acene derivatives for use …

Physicochemical Modifications And Applications Of Carbon Nano-Onions For Electrochemical Energy Storage, Rituraj Borgohain

Theses and Dissertations--Chemistry

Carbon nano-onions (CNOs), concentrically multilayered fullerenes, are prepared by several different methods. We are studying the properties of two specific CNOs: A-CNOs and N-CNOs. A-CNOs are synthesized by underwater arc discharge, and N-CNOs are synthesized by high-temperature graphitization of commercial nanodiamond. In this study the synthesis of A-CNOs are optimized by designing an arc discharge aparatus to control the arc plasma. Moreover other synthesis parameters such as arc power, duty cycles, temperature, graphitic and metal impurities are controlled for optimum production of A-CNOs. Also, a very efficient purification method is developed to screen out A-CNOs from carboneseous and metal impurities. …

N-Doped Multiwalled Carbon Nanotubes: Functionalization, Characterization And Application In Li Ion Batteries, Aman Preet Kaur

Theses and Dissertations--Chemistry

The focus of this dissertation is to utilize chemical functionalization as a probe to investigate the reactivity of N-doped multiwalled carbon nanotubes (N-MWCNTs). The surface of N-MWCNTs, being a set of potentially reactive graphene edges, provides a large number of reactive sites for chemical modification, so considerable changes in chemical and physical properties can be envisaged. We observed that both reduction (dissolving metal reduction/alkylation) and oxidation (H₂SO₄/HNO₃ and H₂SO₄/KMnO₄ mixtures) of N-MWCNTs lead to formation of interesting spiral channels and spiraled carbon nanoribbons. A variety of techniques, including TGA, SEM, …

The Role Of Bridging Therapy In Hepatocellular Carcinoma, Roberto Galuppo, Angie Mccall, Roberto Gedaly

Surgery Faculty Publications

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver accounting for 7% of all cancers worldwide. Most cases of HCC develop within an established background of chronic liver disease. For that reason, liver resection is only possible in selected patients. Liver transplantation has become the treatment of choice in patients with HCC, end-stage liver disease, and significant portal hypertension. Shortage of organ donors has resulted in overall increase of waiting list time with increased risk of dropout due to tumor progression. Neoadjuvant therapies have emerged as an alternative to control tumor growth in patients while waiting. The …

Evaluation Of Echo Ps Positioning System In A Porcine Model Of Simulated Laparoscopic Ventral Hernia Repair, Erin M. Hanna, Guy R. Voeller, J. Scott Roth, Jeffrey R. Scott, Darcy H. Gagne, David A. Iannitti

Surgery Faculty Publications

Purpose. Operative efficiency improvements for laparoscopic ventral hernia repair (LVHR) have focused on reducing operative time while maintaining overall repair efficacy. Our objective was to evaluate procedure time and positioning accuracy of an inflatable mesh positioning device (Echo PS Positioning System), as compared to a standard transfascial suture technique, using a porcine model of simulated LVHR. Methods. The study population consisted of seventeen general surgeons (n = 17) that performed simulated LVHR on seventeen (n = 17) female Yorkshire pigs using two implantation techniques: (1) Ventralight ST Mesh + Echo PS Positioning System (Echo PS) and …

A 22-Year-Old Female With Invasive Epithelioid Angiomyolipoma And Tumor Thrombus Into The Inferior Vena Cava: Case Report And Literature Review, Campbell Grant, John M. Lacy, Stephen E Strup

Surgery Faculty Publications

A 22-year-old female presented with back pain and was discovered to have a right-sided abdominal mass. Computed tomography (CT) scan revealed a 9 cm enhancing right upper pole renal mass with suspicion for tumor thrombus into the right renal vein and possibly the inferior vena cava (IVC). Magnetic resonance imaging (MRI) confirmed tumor thrombus into the inferior vena cava approximately 3 cm below the hepatic venous confluence. Open right radical nephrectomy with inferior vena cava thrombectomy was performed with removal of right kidney and tumor thrombus en bloc. Pathology revealed malignant epithelioid angiomyolipoma (EAML or PEComa). Epithelioid angiomyolipoma is a …

Chemical Transformations Of Arylsulfonamide Molecular Crystals, Rajan Giri

Masters Theses

The pursuit of chemical specificity and efficiency of chemical reaction in molecular crystals has attracted considerable attention over the last decade. The successful control of molecular alignment prior to such transformations continues to provide opportunities for near quantitative yields of new materials. This thesis reports the predictable self-assembly of aryl sulfonamide materials constructed from cinnamic acid and phenylpentadienoic acid fragments capable of forming supramolecular dimers that undergo unique photocyclization reactions. Use of racemic and enantiopure single-component building-blocks provides access to enantiocontrolled [2+2] photodimerized products.

Solid-state reaction precursors were prepared using conventional solution-based synthetic organic techniques. Component chirality (racemic or homochiral) …

Determination Of Structural Stabilities Of Metal-Free Porphyrin Cytochrome C, Zinc Cytochrome C, And Cobalt Cytochrome C, Usha K. Tottempudi

Masters Theses

No abstract provided.

Internet Accessible Remote Real-Time Laboratory For Computer Networking Curriculum, Oyindamola Idowu

Masters Theses

Despite the availability of equipment required to teach hands-on laboratory practices in a computer networking curriculum, educators are faced with the challenge of extending such practices to students in remote locations. Distance learning has become a substantial part of the current education system, requiring institutes of learning adjusting from traditional face-to-face courses to content that can be carried out over the internet so that students can complete part or all the requirements for certain courses in an online modality. Unfortunately, traditional networking laboratories were designed with the assumption students will be physically present. This research is aimed to provide at …

Using Field Studies To Meet The Next Generation Science Standards, Amy Brown

Masters Theses

New science standards, the Next Generation Science Standards (NGSS), recently have been released which require students to use modeling and other process skills and cross-cutting concepts to show understanding of core concepts. Understanding by design approach was used to develop an ecology curriculum in line with the NGSS framework, using field studies to involve students in real science. A schoolyard habitat area on Neoga School District property was used for the field studies. Students were assessed with pre- and post-tests, traditional classroom grades on labs and projects and the Modified ATSI and Children's Science Curiosity Scale. All students showed significant …

Crystal Structures Of Metal Sulfonates, Jon Lyle Obrecht

Masters Theses

Designing new materials with predictable chemical and physical properties has long been a goal of synthetic chemists. The functional properties of molecular compounds are intimately tied to the underlying chemical framework. In addition to atom selection and chemical connectivity, the spatial organization of the molecules often contributes to the function of materials. Because crystals are constructed of periodic arrays of components (i.e. atoms or molecules) with structures easily assessed via X-ray diffraction, crystalline materials offer ideal candidates to explore the relationship of component selection and crystal packing to material property.

One such property that has been extensively examined by …

Evaluating The Effectiveness Of The All Power Labs Power Pallet As A Training Tool For Biomass Gasification Education, Christopher Che Frederick

Masters Theses

The purpose of this study was to provide a better understanding of classroom training with regard to renewable energies. A lecture series and survey were developed by the principle researcher and presented to students in the Alternative and Renewable Energy Systems class and Machine Design class at Eastern Illinois University. The lecture series introduced students to biomass gasification and its application at Eastern Illinois University. The survey analyzed participant's level of knowledge of gasification technologies. The survey's pre and post test scores were used to validate the effectiveness of the training.

The All Power Labs Power Pallet was utilized as …

Systems Simulation Using Promodel: An Online Teaching Method, Gustavo Sioni Bosoli

Masters Theses

This study was designed with the purpose to create an online method to deploy the concepts and practical knowledge necessary for the course System Simulation {TEC 5523) offered by Eastern Illinois University. The course is currently offered on a hybrid format, with part of it being ministered in the classroom and the remaining on the online environment. This research focused on creating a set of multimedia and step-by-step lessons aimed to substitute the part of the course that demands the students to be present in the classroom. These lessons were developed based on exercises from the textbook currently used for …

Efficient Electrochemical Functionalization Of Carbon Nanotubes And Carbon Nanotube Membranes For Energy, Drug Delivery And Potential Catalysis Applications, Xin Zhan

Theses and Dissertations--Chemistry

Electrochemical diazonium grafting offers versatile functionalization of chemically inert graphite under mild condition, which is particularly suitable for CNT composite modification. Tetrafluorinated carboxylphenyl diazonium grafting provides the most controllable functionalization chemistry allowing near monolayer levels of functionality on carbon nanotubes. The functional density was successfully quantified by anion selective dye-assay and X-ray photoelectron spectroscopy (XPS) of thiol-Au self-assembled monolayers (SAM) as a calibration reference. This technique enables monolayer functionality at the tips of carbon nanotube membranes for biomimetic pumps and valves as well as thin conductive layers for CNT-based high area electrochemical support electrodes.

Double-walled carbon nanotube (DWCNT) membranes were …

Fluorinated Arene, Imide And Unsaturated Pyrrolidinone Based Donor Acceptor Conjugated Polymers: Synthesis, Structure-Property And Device Studies, Arawwawala Don T. Liyanage

Theses and Dissertations--Chemistry

FLUORINATED ARENE, IMIDE AND LACTAM-FUNCTIONALIZED DONOR ACCEPTOR CONJUGATED POLYMERS: SYNTHESIS, STRUCTURE-PROPERTY AND DEVICE STUDIES

After the discovery of doped polyacetylene, organic semiconductor materials are widely studied as high impending active components in consumer electronics. They have received substantial consideration due to their potential for structural tailoring, low cost, large area and mechanically flexible alternatives to common inorganic semiconductors. To acquire maximum use of these materials, it is essential to get a strong idea about their chemical and physical nature. Material chemist has an enormous role to play in this novel area, including development of efficient synthetic methodologies and control the …