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Spinal Anesthesia: Should Everyone Receive A Urinary Catheter?: A Randomized, Prospective Study Of Patients Undergoing Total Hip Arthroplasty., Adam G Miller, Md, James Mckenzie, Bs, Max Greenky, Ba, Erica Shaw, Rnp, Kishor Gandhi, Md, William J Hozack, Md, Javad Parvizi, Md, Frcs

Rothman Institute Papers

BACKGROUND: The objective of this randomized prospective study was to determine whether a urinary catheter is necessary for all patients undergoing total hip arthroplasty under spinal anesthesia.

METHODS: Consecutive patients undergoing total hip arthroplasty under spinal anesthesia were randomized to treatment with or without insertion of an indwelling urinary catheter. All patients received spinal anesthesia with 15 to 30 mg of 0.5% bupivacaine. The catheter group was subjected to a standard postoperative protocol, with removal of the indwelling catheter within forty-eight hours postoperatively. The experimental group was monitored for urinary retention and, if necessary, had straight catheterization up to two …

August 21, 2013 Armstrong Graduate Curriculum Committee Minutes, Armstrong State University

Armstrong Faculty Senate: Graduate Curriculum Committee Minutes (Archived)

August 21, 2013 Armstrong Graduate Curriculum Committee Minutes

Schwebke Receives Award For Achievement In Std Research, Reporter Staff

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No abstract provided.

Schwebke Receives Award For Achievement In Std Research, Jim Bakken

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No abstract provided.

Low Seroprevalent Species D Adenovirus Vectors As Influenza Vaccines, Eric A. Weaver, Michael A. Barry

School of Biological Sciences: Faculty Publications

Seasonal and pandemic influenza remains a constant threat. While standard influenza vaccines have great utility, the need for improved vaccine technologies have been brought to light by the 2009 swine flu pandemic, highly pathogenic avian influenza infections, and the most recent early and widespread influenza activity. Species C adenoviruses based on serotype 5 (AD5) are potent vehicles for gene-based vaccination. While potent, most humans are already immune to this virus. In this study, low seroprevalent species D adenoviruses Ad26, 28, and 48 were cloned and modified to express the influenza virus A/PR/8/34 hemagglutinin gene for vaccine studies. When studied in …

Early Innate Immunity Determines Outcome Of Mycobacterium Tuberculosis Pulmonary Infection In Rabbits, Selvakumar Subbian, Nirmalya Bandyopadhyay, Liana Tsenova, Paul O'Brien, Viraj Khetani, Nicole L. Kushner, Blas Peixoto, Patricia Soteropoulos, Joel S. Bader, Petros C. Karakousis, Dorothy Fallows, Gilla Kaplan

Publications and Research

Background: Pulmonary infection of humans by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while asymptomatic latent Mtb infection (LTBI) is established in the remainder. The host immune responses that determine this differential outcome following Mtb infection are not fully understood. Using a rabbit model of pulmonary TB, we have shown that infection with the Mtb clinical isolate HN878 (a hyper-virulent W-Beijing lineage strain) leads to progressive cavitary disease similar to what is seen in humans with active TB. In contrast, infection with Mtb CDC1551 (a hyper-immunogenic clinical isolate) is efficiently …

An Optimization-Based Approach For Vaccine Prioritization, Timothy Schmoke

Theses

An effective vaccine prioritization process is essential to prevent the many issues that currently weaken global vaccination efforts. Identifying challenges associated with vaccine development is important when considering which initiatives will provide immunization that is effective, affordable, and easy to administer. The process of establishing priorities for vaccine development is complicated, though, by the conflicting interests of multiple stakeholders involved in the vaccine market. Additionally, uncertainties exist regarding: (1) the resources and time required for vaccine development, (2) the expected benefits of development, and (3) the anticipated demand for vaccination, further complicating the prioritization process. This study proposes a decision-support …

Becoming Adults In A Rural Yup'ik Community: A Longitudinal Qualitative Study Exploring Resilience, Tara J. Ford

Psychology

The aim of this study is to explore strategies for navigating challenges in a rural Alaskan Yup'ik community among youth and young adults. This qualitative study captures a longitudinal perspective as youth (N=25; 11 -18 years old) were originally interviewed in January 2010. For the current study, participants were re-interviewed in December 2012. Follow-up interviews addressed life challenges over the past three years and resources that helped them with their hard times. To reinforce the multifaceted nature of growing-up in a rural Yup'ik community, scholarly literature along with observations, conversations with local residents, and local wisdom captured in anthropological work …

Transcriptome Response Associated With Protective Immunity In T And B Cell Deficient Zebrafish, Aparna Krishnavajhala

Theses and Dissertations

RAG1-/- mutant zebrafish lack T and B lymphocytes. However, when re-exposed to homologous bacteria, these fish mount a response that provides specific protection. To further define this response, we utilized microarray analyses to determine the mechanisms underlying innate immune system memory in zebrafish. We also analyzed interferon (IFN) gamma by qRT-PCR. It is produced by activated NK cells and could indicate if this cell mediates the protective response seen in lymphocyte deficient zebrafish. Pathological studies and in situ hybridizations were performed to observe tissue changes and location of the cells that produced IFN gamma. Following bacterial re-exposure, zebrafish transcripts in …

Prescribed Reading: August 2013, Centracare Clinic

Prescribed Reading

• Health Care Matters: Get your immunizations to protect self and patients
• We want to hear from you!
• Welcome to our new CentraCare providers
• Welcome to our new employees
• Learn about area services for seniors
• More than a century of Leading with Care
• Recognition for Years of Service
• Loop the Plaza for your health
• Palliative care expands to Heart Center
• Two new features on Kronos
• Kudos to . .
• ZERO Prostate Cancer Run is Sept. 28
• Run Your ‘Sauks’ Off in Sauk Centre
• System leadership change update
• Recipes for a Healthy Lifestyle
• Share your story
• Employees encouraged to use MyChart
• 2nd …

Kandiyohi And Renville County Public Health - Health Data Compilation, Kelly Asche, Jordan Wente

Center for Small Towns

This project worked with Kandiyohi and Renville County Public Health to compile a comprehensive health narrative of the region. The narrative explored issues related to various health factors in the region, including demographic and economic factors. The final product was used to develop a list of priorities for health issues and initiatives.

An Evidence-Based Intervention To Improve Vaccination Rates For Seasonal Influenza Among Registered Nurses, Debra A. Maitre

Regis University Student Publications (comprehensive collection)

Executive Summary An Evidence-Based Intervention to Improve Vaccination Rates for Seasonal Influenza Among Registered Nurses Problem Seasonal influenza continues to cause the hospitalizations and deaths of tens of thousands every year in the U.S. (National Foundation for Infectious Diseases, 2008). Vaccination of healthcare workers for influenza has been recommended for more than 30 years (Willis & Wortley, 2007) and reports of transmission of influenza by registered nurses (RNs) to patients are well documented. In spite of these facts, RN vaccination rates remain below the recommended target of 90% (U.S. Department of Health and Human Services, 2012). The evidence suggests that …

Social Causes Of Diseases Receive Grant Support, Clinton Colmenares

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No abstract provided.

The Uropathogenic Escherichia Coli Effector Ybcl Modulates The Innate Immune Response In The Urinary Tract, Megan Elizabeth Lau

Arts & Sciences Graduate Student Theses and Dissertations

Uropathogenic Escherichia coli (UPEC) are the primary etiology of urinary tract infections (UTIs), one of the most common bacterial infections afflicting the human population. While UPEC cause disease throughout the urinary tract, bladder infection, or cystitis, is most prevalent. A key aspect of UPEC pathogenesis in the bladder is the modulation of the host inflammatory response. At acute time points, UPEC delay the arrival of immune cells, such as neutrophils, to the bladder. The lack of neutrophils in the bladder lumen enables UPEC to replicate freely in the urine and invade the bladder epithelium, a requirement for bacterial persistence, in …

Personality Pathology, Health-Related Stress, And General Functioning In Later Adulthood, Abigail D. Powers

All Theses and Dissertations (ETDs)

Personality disorders: PDs) are associated with many negative health outcomes, including overutilization of health care resources, increased risk for chronic health problems, and poor adherence to medical recommendations. It is unclear, however, how significantly personality pathology affects an individual's daily health and functioning when health problems have already occurred. The purpose of this dissertation was to determine whether the presence of PD features moderate individual change over time in physical, emotional, and social functioning among individuals with significant health problems. The sample included 1,630 community-dwelling participants, ages 55-64. PD features were measured at baseline; health problems and all outcome variables …

Oncogenes And Inflammation Rewire Host Energy Metabolism In The Tumor Microenvironment: Ras And Nfκb Target Stromal Mct4., Ubaldo E. Martinez-Outshoorn, Md, Joseph Curry, Md, Ying-Hui Ko, Md, Zhao Lin, Md, Madalina Tuluc, Md, David Cognetti, Md, Ruth Birbe, Md, Edmund A. Pribitkin, Md, Alessandro Bombonati, Richard Pestell, Md, Anthony Howell, Federica Sotgia, Michael P. Lisanti, Md

Kimmel Cancer Center Faculty Papers

Here, we developed a model system to evaluate the metabolic effects of oncogene(s) on the host microenvironment. A matched set of "normal" and oncogenically transformed epithelial cell lines were co-cultured with human fibroblasts, to determine the "bystander" effects of oncogenes on stromal cells. ROS production and glucose uptake were measured by FACS analysis. In addition, expression of a panel of metabolic protein biomarkers (Caveolin-1, MCT1, and MCT4) was analyzed in parallel. Interestingly, oncogene activation in cancer cells was sufficient to induce the metabolic reprogramming of cancer-associated fibroblasts toward glycolysis, via oxidative stress. Evidence for "metabolic symbiosis" between oxidative cancer cells …

Disseminating Evidence: Global Health And Nursing Column, Christina Bohn, Dr. Lynn Clark Callister

Journal of Undergraduate Research

The purpose of this project was to (1) disseminate evidence about global initiatives and individual nurses who are making a difference in the health of women and children worldwide, and (2) identify how nurses can become involved in global efforts. This evidence is published in MCN: The American Journal of Maternal Child Nursing and was presented at the Brigham Young University College of Nursing annual research conference on October 25, 2010.

Diffusion Of Innovation Across A National Local Health Department Network: A Simulation Approach To Policy Development Using Agent-Based Modeling, Mark Orr, Jacqueline Merrill

Frontiers in Public Health Services and Systems Research

The network that local health officials use to communicate about professional issues is sparsely connected, which may limit the spread of innovative practices. We used agent-based simulation modeling to find out if a policy to promote more connections improved the network’s capability to diffuse innovation. We found that unanticipated effects could result, depending on the requirements of the policy and the proportion of health officials involved. With carefully crafted assumptions and reliable data it is possible to untangle complex processes using simulation modeling. The results represent how the world might actually work which may provide useful decision support for policymakers …

Biofouling : A Means Of Aquatic Species Transfer, Anne Bouyssou, Josefin Madjidian

NSBWO

Ships carry seawater in their ballast tanks when they are not fully loaded with cargo, in order to maintain adequate trim, draught and stability, adjust list and limit stresses on the hull. It is now well documented that the water pumped into the ship contains aquatic organisms – which can also sink to the sediments at the bottom of tanks – and that these organisms are thereby transferred from the port of origin to the destination. But it is seldom mentioned that aquatic organisms are also found on the outside of ships, attached on their hulls and appendages, as a …

Candidatus Syngnamydia Venezia, A Novel Member Of The Phylum Chlamydiae From The Broad Nosed Pipefish, Syngnathustyphle Typhle, Alexander Fehr, Elisabeth Walther, Heike Schmidt-Posthaus, Lisbeth Nufer, Anthony B. Wilson, Miroslav Svercel, Denis Richter, Helmut Segner, Andreas Pospischil, Lloyd Vaughan

Publications and Research

Chlamydia are obligate intracellular bacteria and important pathogens of humans and animals. Chlamydia-related bacteria are also major fish pathogens, infecting epithelial cells of the gills and skin to cause the disease epitheliocystis. Given the wide distribution, ancient origins and spectacular diversity of bony fishes, this group offers a rich resource for the identification and isolation of novel Chlamydia. The broad-nosed pipefish (Syngnathus typhle) is a widely distributed and genetically diverse temperate fish species, susceptible to epitheliocystis across much of its range. We describe here a new bacterial species, Candidatus Syngnamydia venezia; epitheliocystis agent of S. typhle and close relative to …

Of Animalcula, Phthisis And Scrofula Historical Insights Into Tuberculosis In The Pre-Koch Era, Ritu Lakhtakia

Sultan Qaboos University Medical Journal

No abstract provided.

Non-Steroidal Anti-Inflammatory Drugs And Antibiotics Prescription Trends At A Central West Bank Hospital, Yasin I. Tayem, Marwan M. Qubaja, Riyad K. Taha, Omar B., Imadeddin A. Abu Shkheidem, Murad A. Ibrahim

Sultan Qaboos University Medical Journal

Objectives: We aimed to reliably describe the pattern of outpatient prescription of non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics (ATBs) at a central hospital in the West Bank, Palestine.Methods: This was a retrospective, cross-sectional study investigating a cohort of 2,208 prescriptions ordered by outpatient clinics and the emergency room over one year in Beit Jala Hospital in Bethlehem, West Bank. The orders were analysed for the rate and types of NSAIDs and ATBs utilised, and the appropriateness of these drugs to the diagnosis. Results: Of the total prescriptions, 410 contained NSAIDs (18.6%), including diclofenac (40.2%), low dose aspirin (23.9%), ibuprofen (17.8%) …

Management Of Infants And Children Who Are Contacts Of Contagious Tuberculous Patients, George Paul, Amal S. Al-Maani, Padmamohan J.

Sultan Qaboos University Medical Journal

Contact investigation and management form the key for tuberculosis (TB) control in countries with a low tuberculosis incidence. Oman, with a low TB incidence, has implemented contact investigation and management as one important strategy to control TB. However there is a lack of clear guidelines for the investigation and treatment of contacts, especially with regard to children who are contacts of TB cases. The failure to manage children in contact with infectious TB cases indicates a missed opportunity to prevent TB disease in a population which is prone to progress rapidly to severe and complicated illness. This article attempts to …

The Medical Case For A Positron Emission Tomography And X-Ray Computed Tomography Combined Service In Oman, Naima K. Al-Bulushi, Dale Bailey, Giuliano

Sultan Qaboos University Medical Journal

The value of a positron emission tomography and X-ray computed tomography (PET/CT) combined service in terms of diagnostic accuracy, cost-effectiveness and impact on clinical decision-making is welldocumented in the literature. Its role in the management of patients presenting with cancer is shifting from early staging and restaging to the early assessment of the treatment response. Currently, the application of PET/CT has extended to non-oncological specialties—mainly neurology, cardiology and rheumatology. A further emerging application for PET/CT is the imaging of infection/inflammation. This article illustrates some of the PET/CT applications in both oncological and non-oncological disorders. In view of the absence of …

Lifestyle Habits : Diet, Physical Activity And Sleep Duration Among Omani Adolescents, Hashem Kilani, Hazzaa Al-Hazzaa, Mostafa I. Musaiger, Abdulrahman

Sultan Qaboos University Medical Journal

Objectives: This study aimed to investigate the lifestyle habits—physical activity (PA), eating habits (EH), and sleep duration (SD)—of Omani adolescents, and to examine gender differences in such variables. Methods: 802 Omani adolescents (442 females and 360 males), aged 15‒18 years were randomly recruited. Anthropometric indices, PA level, and EH and SD were evaluated by the Arab Teenage Lifestyle questionnaire. A semi-quantitative food frequency questionnaire for dietary assessment was also administered. Results: The results showed that although the study subjects had a sedentary lifestyle (lack of PA, average of 6.7 hours sleep, and consumption of high calorie foods), they maintained a …

A Massive Tuberculosis Abscess At The Erector Spinae Muscles And Subcutaneous Tissues In A Young Man, Kawther T. Elshafie, Mustafa M. Al-Hinai, Hamdan A. Al-Hattali, Mohammed S., Osama Hassan, Rashid Al-Sukaiti

Sultan Qaboos University Medical Journal

Tuberculosis (TB) is a chronic granulomatous infection which can present in an atypical form. Isolated muscle involvement is very rare. We report a 25-year-old man who presented with a massive cystic swelling on the right side of his back, extending from the lower thoracic to the gluteal region. He had a history of contact with a friend who was suspected of having TB. Magnetic resonance imaging (MRI) showed that the origin of the cyst was from the erector spinae muscles. The result of a fluid aspirate showed acid fast bacilli. The swelling disappeared after treatment with anti-tuberculous medications. Muscular involvement …

Associations Between The Legal Context Of Hiv, Perceived Social Capital, And Hiv Antiretroviral Adherence In North America, J Craig Phillips, Allison Webel, Carol Dawson Rose, Inge B. Corless, Kathleen M. Sullivan, Joachim Voss, Dean Wantland, Kathleen Nokes, John Brion, Wei-Ti Chen, Scholastika Iipinge, Lucille Sanzero Eller, Lynda Tyer-Viola, Marta Rivero-Méndez, Patrice K. Nicholas, Mallory O. Johnson, Mary Maryland, Jeanne Kemppainen, Carmen J. Portillo, Puangtip Chaiphibalsarisdi

Publications and Research

Background Human rights approaches to manage HIV and efforts to decriminalize HIV exposure/transmission globally offer hope to persons living with HIV (PLWH). However, among vulnerable populations of PLWH, substantial human rights and structural challenges (disadvantage and injustice that results from everyday practices of a well-intentioned liberal society) must be addressed. These challenges span all ecosocial context levels and in North America (Canada and the United States) can include prosecution for HIV nondisclosure and HIV exposure/transmission. Our aims were to: 1) Determine if there were associations between the social structural factor of criminalization of HIV exposure/transmission, the individual factor of perceived …

Volume 50, Number 51: August 07, 2013, University Of North Dakota

University Letter Archive

No abstract provided.

Methods And Compositions For Inducing An Immune Response To Egfrviii, Peter M. Lauer, Keith Bahjat

Technology Transfer - Patents

The present invention relates to methods of inducing a T-cell response against a EGFRvIII in a subject. These method comprise administering to a subject a composition which expresses at least one immunogenic polypeptide, the amino acid sequence of which comprise a plurality of EGFRvIII polypeptide sequences, the sequence of which each comprise EEKKGNYV (SEQ ID NO: 3), and/or administering the polypeptide itself.

Antibacterial And Herbicidal Activity Of Ring-Substituted 2-Hydroxynaphthalene-1-Carboxanilides, Rodeney Govender, Et. Al.

Department of Biological Sciences Publications

In this study, a series of twenty-two ring-substituted 2-hydroxynaphthalene-1-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistant S. aureus strains, Mycobacterium marinum, M. kasasii, M. smegmatis. and M. avium paratuberculosis. The compounds were also tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. 2-Hydroxy-N-phenylnaphthalene-1-carboxanilide and 2-hydroxy-N-(3-trifluoromethylphenyl)naphthalene-1-carboxamide (IC50 = 29 µmol/L) were the most active PET inhibitors. Some of tested compounds showed the antibacterial and antimycobacterial activity against the tested strains comparable or higher than the standards ampicillin or isoniazid. Thus, …