Digital Commons Network^™

Hepatitis C Virus Infection And Prostate Cancer Risk: A Population-Based Case-Control Study Using The Seer-Medicare Dataset, Shan Jiang

Public Health Theses

Prostate cancer is the most common type of non-skin malignancy diagnosed among men, but the disease etiology and risk factors remain inconclusive. Hepatitis C virus (HCV) infection's prevalence is increasing in the US population. Studies have shown that the concentration of free serum testosterone, which may be directly associated with prostate cancer risk, was decreased among men with HCV infection. In order to evaluate the relationship between HCV infection and prostate cancer risk, we conducted a population-based case-control study using the SEER-Medicare dataset.

The study included 194,339 prostate cancer cases and 54,481 controls which were frequency-matched to the cases by …

Diaper Need And Maternal Mental Health: A Geographic Assessment In The City Of New Haven, Anna Kruse

Public Health Theses

Introduction: With the burden of poverty currently falling heavily on women and poverty as an established risk factor for poor mental health, it is important to understand the pathways by which poverty influences maternal mental health. Diaper need may represent a form of material hardship that has adverse consequences for the mental health of low income mothers. The aim of the present study was to examine the association between maternal mental health, diaper need, and neighborhood context. We hypothesized that mothers who reported diaper need would also report poor mental health and that neighborhood context would significantly impact this association. …

The Role Of Antibiotics In Microbial Interactions Of Copd, Kimberly Lay

Public Health Theses

Background: Chronic Obstructive Pulmonary Disease (COPD) exacerbations caused by bacterial infections account for more than 50% of all exacerbation episodes, with Haemophilus influenzae as the most frequently isolated pathogen. The role of antibiotics in treating COPD bacterial exacerbations remains unclear.

Objective: The current analysis evaluates the interaction of H. influenzaes with other pathogens while controlling for the use of antibiotics.

Methods: Data were from a longitudinal study of COPD patients conducted at a VA medical center from 1994-2010. Analysis was restricted to sputum samples collected over the course of one year in a total of 130 patients. Presence of Moraxella …

Potential Role Of Wildlife In Pathogenic Contamination Of Fresh Produce, Jeff A. Langholz, Michele T. Jay-Russell

Human–Wildlife Interactions

The safety of fresh produce is an important concern in the United States, especially in the wake of recent national foodborne illness outbreaks. The agricultural industry has implemented steps to enhance food safety along the entire farm-to-fork supply chain. This includes on-farm measures to exclude wildlife and to remove its habitat in and around fields. Farmers and others from across the United States have expressed concern about the ecological consequences and uncertain food safety benefits of such practices. This article reviews the scientific rationale behind management of wildlife and its habitat as part of good agriculture practices for enhancing food …

Green Harms Of Green Projects, John Copeland Nagle

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Arbovirus Persistence And Selection Of Persistent Variants Following Chronic Infection In Aedine Mosquitoes: A Comparative Study Between Ae. Aegypti And Ae. Albopictus 30 Days Post Infection With Sindbis Virus, Zoe Leah Lyski

UNF Graduate Theses and Dissertations

In the present investigation two container breeding mosquitoes, Aedes aegypti and Aedes albopictus were exposed to Sindbis virus (SINV). Mosquitoes were proffered a viremic bloodmeal using a vertical membrane feeder in an attempt to infect females while preserving virus-gut interactions that are speculated to be responsible for amplification and selective roles encountered in nature. Cohorts of 50 mosquitoes of each species were exposed to SINV strain TR339 or EMEM in a bloodmeal and incubated in insectary conditions for 30 days. Once infected, the mosquito remains persistently infected for life, accumulating mutations in the virus RNA genome. Plaque size variants may …

The Role Of Social Support And Emotional Representations In Health Outcomes For Individuals With Chronic Illness, Courtney Ann Lemons

UNF Graduate Theses and Dissertations

Health related outcomes for individuals with chronic symptoms of illness can be influenced by complex, socio-emotional processes. The primary interest of this study was to determine whether perceived social support lessens the negative emotional appraisals of illness experience (e.g. anger, fear, hostile interpretations of illness), and the role of these emotional appraisals in health outcomes for those diagnosed either with a conventional chronic illness (e.g. diabetes, arthritis, chronic obstructive pulmonary disease) or a functional somatic syndrome (e.g. fibromyalgia, chronic fatigue syndrome, irritable bowel). Data for this study were collected from a series of four surveys administered online, which included measures …

Dual Failures: The Role Of Race In Eighth Amendment Violations In Prisons, Jason Reed

Minnesota Journal of Law & Inequality

No abstract provided.

Untangling Cultural Differences In Behavioral, Physiological, And Psychological Symptoms Of Dementia And Alzheimer’S Disease, John S. Avant

Calvert Undergraduate Research Awards

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; 4^th ed. Revised; American Psychiatric Association) and (BPSD) there are many behavioral, physiological, and psychological issues that have been correlated with the progression of the Alzheimer’s disease and other dementias. Examples of these issues include; emotional regulation problems, variations in eating behavior, and an advancing decline in memory. Though certain symptoms of the disease seem to be widely universal, current literature shows that a number of disparities do exist. There are several differences between and within populations suffering from Alzheimer’s disease and dementia that are influenced by various …

Bloomberg’S Health Legacy: Urban Innovator Or Meddling Nanny?, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

Michael Bloomberg leaves the mayoralty of New York City, with his health legacy is bitterly contested. The public health community views him as an urban innovator—a rare political and business leader willing to fight for a built environment conducive to healthier, safer lifestyles. To his distractors, however, Bloomberg epitomizes a meddling nanny—an elitist dictating to largely poor and working class people about how they ought to lead their lives. His policies have sparked intense public, corporate, and political ire—critical of sweeping mayoral power to socially engineer the city and its inhabitants.

Here, I seek to show how Bloomberg has fundamentally …

A Cross-Sectional Study Of Jamaican Adolescents’ Risk For Type 2 Diabetes And Cardiovascular Diseases, Sheila Barrett, Fatma G. Huffman, Paulette Johnson, Adriana Campa, Marcia Magnus, Dalip Ragoobirsingh

Faculty Articles, Papers, and Other Scholarship

Objectives To compare obese versus non-obese Jamaican adolescents’ risk for type 2 diabetes (T2D) and cardiovascular diseases (CVDs); and to explore a suitable and economical method of screening for these risk factors in the school settings. Design A descriptive cross-sectional study of adolescents’ risk for T2D and CVD. All the participants were examined at their respective schools. Setting Jamaica, West Indies. Population 276 Jamaican adolescents aged 14–19 years, randomly selected from grades 9 to 12 from 10 high schools on the island and included both boys and girls. All ethnicities on the island were represented. Main outcome measures High fasting …

Identification Of Staphylococcus Aureus Sortase A Inhibitors As Potential Antibacterial Agents, Bala Chandra Chenna

All ETDs from UAB

Staphylococcus aureus (S. aureus) is the causative organism for a wide range of infectious diseases from superficial skin infections to dangerous bacteremias. Six pathogens named ESKAPE pathogens are responsible for majority of antibiotic resistant bacterial infections. MRSA is the single most prevalent ESKAPE pathogen. Many of the nosocomial MRSA strains are multi-drug resistant, and even methicillin-sensitive strains can be deadly. S. aureus has recently taken on a new role in causing an escalating number of community-acquired infections in non-hospitalized persons without predisposing risk factors. Due to the increase in the number of infections caused by multi-drug resistant S. aureus and …

Selection And Evolution Of Pneumococci In Response To Conjugate Vaccines, Christina M. Croney

All ETDs from UAB

Pneumococcal conjugate vaccines (PCVs) containing subsets of the >90 capsular polysaccharide antigens have been successful as a means of decreasing invasive and non-invasive pneumococcal disease worldwide. However, this success is limited to the specif-ic capsular serotypes against which PCVs are formulated and studies have reported the increase of nonvaccine serotypes. The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the United States in 2010 for the prevention of invasive pneumococcal disease (IPD) and otitis media and was released without efficacy data. In this study we set out to 1) determine potential efficacy for invasive and noninvasive pneumococcal disease and 2) …

Neutropenia And Progenitor Cell Mobilization In Ap3-B1 Mutant Pearl Mice, Matthew Vallejo

All ETDs from UAB

Mutations in the AP3-ß1 gene are known to cause Hermansky-Pudlak syndrome type 2 (HPS2) in humans and canine cyclic hematopoiesis (CH) in gray collie dogs. HPS2 patients have severe congenital neutropenia (SCN), and dogs have cyclic neutropenia (CN). The mechanism behind neutropenia is uncertain. Pearl mice have an AP3-ß1 mutation, but whether they actually have neutropenia has not yet been evaluated. This dissertation presents a discussion of the evaluation of neutropenia in pearl mice, hematopoietic progenitor cell mobilization defect in pearl mice and finally an evaluation of methods of dog-to-mouse xenotransplantation to establish a xenotransplant model of the dog hematopoietic …

Potential Roles Of The Immunostimulatory Signals Il-15 And Mica In Oncolytic Hsv-1 Therapy For Malignant Glioma, David Curtis Gaston

All ETDs from UAB

Malignant gliomas are the most frequently diagnosed and the most fatal primary brain tumors. Innovative therapeutic approaches are necessary to combat these devastating cancers, and oncolytic herpes simplex virus type-1 (oHSV) deleted of the γ134.5 neurovirulence gene is a promising adjunctive therapy. The primary mechanism of tumor clearance by oHSV is lytic replication specifically within malignant cells. oHSV also stimulates tumor infiltration of cytotoxic immune effector cells that can participate in tumor clearance. However, cytotoxic immune cells target oHSV as well as tumor, which may limit therapeutic efficacy. Further knowledge regarding the nature of these interactions and how the interactions …

The Flow Of The Social: Developing A Constructal Systemic Approach To The Study Of Health Inequalities, William A. Anderson

All ETDs from UAB

Society is a dynamic, living system. People, groups, institutions, and cultures are intricately interconnected. Changes in one area of society create changes in other areas. Causes and results may be closely linked or separated by time and space. Sociologists readily acknowledge this dynamic reality. However, our mainstream theories and methods often fail to account for it. Even after decades of research into social inequalities in health, medical sociology still seems far away from being able to offer any definitive ideas about why such inequalities exist and persist despite efforts to alleviate them. Medical sociology (and sociology in general) is centered …

Energy Performance Evaluation Of Aac, Hulya Aybek

All ETDs from UAB

The U.S. building industry constitutes the largest consumer of energy (i.e., electricity, natural gas, petroleum) in the world. The building sector uses almost 41percent of the primary energy and approximately 72percent of the available electricity in the United States. As global energy-generating resources are being depleted at exponential rates, the amount of energy consumed and wasted cannot be ignored. Professionals concerned about the environment have placed a high priority on finding solutions that reduce energy consumption while maintaining occupant comfort. Sustainable design and the judicious combination of building materials comprise one solution to this problem. A future including sustainable energy …

Adapter Based Strategies For Adenovirus Vector Retargeting To T Lymphocytes, Matthew S. Beatty

All ETDs from UAB

Adenoviruses are the most commonly used gene therapy vector for cancer therapy clinical trials. While adenovirus has shown a great track record in a variety of cancer therapeutics it has not progressed as a vector system for the modification of T lymphocytes. One of the major roadblocks towards utilizing adenovirus for T cell therapy is the lack of coxsackie virus and adenovirus receptor on the cell surface of T cell lineages. Exploitation of alternative receptors has allowed adenovirus vectors to be utilized in a variety of cell types that native adenovirus type 5 cannot infect. Thus, retargeting adenovirus to an …

Environmental Specific Effects On Life History And Energy Metabolism Traits In A Permethrin Resistant Strain Of Anopheles Gambiae, Dennis Otali

All ETDs from UAB

Widespread use of pyrethroids for control of malaria vectors together with use in agriculture for pest control has led to an increase in emergence of populations of pyrethroid resistant phenotypes. Insecticide resistance can likely alter vector development time, reproduction, behavior, and longevity, all of which can affect the potential for disease transmission. In this study we assessed whether the genetic modifications (kdr mutation, cytochrome P450 and esterase detoxification) in a permethrin resistant strain of An. gambiae influence traits related to fitness. The performances of these traits were compared between two strains of An. gambiae, one permethrin susceptible (ASEMBO1) and the …

Host Genetic Factors Associated With Cervical Human Papillomavirus Clearance, Staci Lynn Sudenga

All ETDs from UAB

This dissertation research focuses on how variants in various host genes are associated with clearance of HPV in three longitudinal cohorts from the United States. I first examined the definition of the intermediate phenotype to cervical cancer, HPV persistence and then I incorporated this phenotype in all my three aims by examining variations in xenobiotic metabolism genes in HIV-1 negative and immune-related genes in HIV-1 positive females and how these contribute to HPV infection outcomes. Several significant variants were associated with HPV clearance for the three aims. For the first aim, in ALTS assessing functional variants within xenobiotic metabolism genes …

Intracellular Quantitation And Pharmacokinetic Modeling Of Nucleoside Analogs In The Female Genital Tract, Amanda Marie James

All ETDs from UAB

Human Immunodeficiency Virus (HIV) is one of the leading infectious diseases in the world. In spite of substantial progress in the advancement of antiretroviral therapy for HIV treatment, new infections outpace the number of infected persons initiating ART. Therefore, the prevention of HIV remains a crucial health issue. Pre-Exposure Prophylaxis, (PrEP), which involves using one or more antiretroviral agents to reduce the risk of HIV infection prior to potential exposure, has shown effectiveness at reducing HIV transmission in study volunteers with different sexual orientation around the world. The clinical pharmacology of antiretroviral drugs, specifically tenofovir (TFV) and emtricitabine (FTC), in …

The First Hundred Years Of The Nebraska Public Health Laboratory: A Major Role Played In The Development Of Public Health, Kristin A. Watkins, Peter C. Iwen, Anthony R. Sambol

History of the College of Public Health: Papers and Posters

Public health laboratories are the invisible key to public health. These laboratories have played a significant role in the health of the community since their inception in the late 1800s. They provide confirmation of disease outbreaks and statistics on the health and welfare of the people, with more recent activities in the detection of biological and chemical agents of terrorism. However, the history of these laboratories is mostly unknown. For instance, a recent brief historical account of the Nebraska Department of Health and Human Services did not include information on the state public health laboratory in the timeline of historical …

The Environmental Cost Of Misinformation: Why The Recommendation To Use Warm Water For Handwashing Is Problematic, Amanda R. Carrico, Micajah Spoden, Kenneth A. Wallston, Michael P. Vandenbergh

Vanderbilt Law School Faculty Publications

Multiple government and health organizations recommend the use of warm or hot water in publications designed to educate the public on best practices for washing one’s hands. This is despite research suggesting that the use of an elevated water temperature does not improve handwashing efficacy, but can cause hand irritation. There is reason to believe that the perception that warm or hot water is more effective at cleaning one’s hands is pervasive, and may be one factor that is driving up unnecessary energy consumption and greenhouse gas emissions. We examine handwashing practices and beliefs about water temperature using a survey …

Imperial Japan's Human Experiments Before And During World War Two, Alan Vanderbrook

Electronic Theses and Dissertations

After Japan occupied Manchuria in 1931, Ishii Shiro created Unit 731 and began testing biological weapons on unwilling human test subjects. The history of Imperial Japan’s human experiments was one in which Ishii and Unit 731 was the principal actor, but Unit 731 operated in a much larger context. The network in which 731 operated consisted of Unit 731 and all its sub-units, nearly every major Japanese university, as well as many people in Japan’s scientific and medical community, military hospitals, military and civilian laboratories, and the Japanese military as a whole. Japan’s racist ultra-nationalist movement heavily influenced these institutions …

Immuno-Pcr Detection Of Lyme Borreliosis, Micah Halpern

Electronic Theses and Dissertations

Lyme borreliosis, more commonly referred to as Lyme disease, is the fastest growing zoonotic disease in North America with approximately 30,000 confirmed cases and 300,000 estimated infections per year. In nature, the causative agent of Lyme disease, the bacterium Borrelia burgdorferi, cycles between Ixodes sp. ticks and small mammals. Humans become infected with Lyme disease after being bitten by an infected tick. The primary indicator of a Borrelia burgdorferi infection is a bull’s eye rash typically followed by flu-like symptoms with treatment consisting of a 2-4 week course of antibiotics. If not treated, later stages of the disease can result …

Like A Hurricane: A Citation Analysis Of Emergency Management Scholarly Literature, Jennifer Noe, Julia M. Furay

Publications and Research

This bibliometric study used citation analysis to uncover citing characteristics in the burgeoning academic field of emergency management. Of the 281 degree programs listed by the Federal Emergency Management Agency nationwide, those at community colleges accounted for 17 percent of the total. Using the interdisciplinary database of Academic Search Complete, a sample of 5,099 citations was collected from 146 articles published between 2002 and 2012. The most strongly represented disciplines revealed by the analysis were Social Science, Science/Technology and Medicine. A majority of citations (45%) came from academic journals, with nearly half (44%) of those from Social Science. When citing …

Cancer Risk Analysis By Fuzzy Logic Approach And Performance Status Of The Model, Atinç Yilmaz, Kürşat Ayan

Turkish Journal of Electrical Engineering and Computer Sciences

Cancer is the leading life-threatening disease for people in today's world. Although cancer formation is different for each type of cancer, it has been determined by studies and research that stress also triggers cancer types. Early precaution is very important for people who have not fallen ill yet with a disease like cancer that has a high mortality rate and expensive treatment. With this study, we expound that the possibility of developing such disease may be decreased and people could take measures against it. For the 3 cancer types selected as pilot work by introducing a fuzzy logic model, the …

Examining The Impact Of Hepatitis C In Montana: A Descriptive Case Study, Blair Rice Snyder

Graduate Student Theses, Dissertations, & Professional Papers

The purpose of this study was to gather information about how Hepatitis C (HCV) affects Montanans. Montana specific information was collected about HCV transmission; factors influencing transmission; physical, social and psychological effects of having HCV and undergoing treatment; barriers to prevention and treatment; current available resources to those infected with HCV and ways to improve prevention and treatment. Secondary data consisted of a comprehensive literature review to describe the above factors and epidemiological information. Primary data was collected through key informant interviews and summary reports completed by people living with HCV. The findings suggest that HCV is primarily transmitted through …

Impact Of Climate Change On Occupational Health And Safety, Ariane Adam-Poupart, France Labrèche, Audrey Smargiassi, Patrice Duguay, Marc-Antoine Busque, Charles Gagné, Joseph Zayed

Rapports de recherche scientifique

Les effets des changements climatiques (CC) sont souvent discutés en fonction de leurs impacts sur l’environnement et sur la population générale. Toutefois, leurs conséquences sur la santé et la sécurité des travailleurs (SST) n'ont été que très peu abordées par la communauté scientifique. Pourtant, les travailleurs peuvent être directement ou indirectement affectés par les CC notamment par des contraintes thermiques auxquelles ils peuvent être exposés ou encore, par des modifications aux écosystèmes qui sont à la base de leurs activités économiques. L’objectif général de cette étude était d’explorer les avenues de recherche en regard de l’impact négatif des changements climatiques …

Sex And Statutory Uniformity: Harmonizing The Legal Treatment Of Semen, Myrisha S. Lewis

Faculty Publications

No abstract provided.