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International Health Emergencies In Failed And Failing States, Chiara Giorgetti

Law Faculty Publications

Global health emergencies, particularly those occurring in Jailed and Jailing States, can become threats to the stability of the international community. This Article assesses the international mechanisms available to respond to such emergencies. After defining global health emergencies, it discusses the implications of global outbreaks in Jailed and Jailing States. It then examines the role played by the World Health Organization in controlling global health emergencies, with particular reference to the newly amended 2005 International Health Regulations and the Global Outbreak Alert and Response Network. Finally, it explores the role of other international organizations, including the United Nations Children's Fund …

Pubh 510.50: Introduction To Epidemiology, Curtis W. Noonan

University of Montana Course Syllabi

No abstract provided.

Social Connectedness And The Quality Of Life In Chronically Ill Patients, Inna Kleynshteyn

UNF Graduate Theses and Dissertations

Social connectedness, feelings of belonging and closeness with the social world, has been identified as an important aspect for the physical, emotional, and collective well-being. People faced with chronic illness may feel like they no longer belong, and this lack of connectedness may have a negative impact on health, well-being, and psychological functioning. The present study investigated social connectedness and quality of life in 151 patients with ongoing symptoms of chronic illness. It was hypothesized that lower levels of social connectedness would be associated with poorer health-related quality of life and more depression. Participants (N =151, 85.4% women, Mage = …

Using Arcmap, Google Earth, And Global Positioning Systems To Select And Locate Random Households In Rural Haiti, Peter J. Wampler, Richard R. Rediske, Azizur R. Molla

Open Access Publishing Support Funded Articles

Background: A remote sensing technique was developed which combines a Geographic Information System (GIS); Google Earth, and Microsoft Excel to identify home locations for a random sample of households in rural Haiti. The method was used to select homes for ethnographic and water quality research in a region of rural Haiti located within 9 km of a local hospital and source of health education in Deschapelles, Haiti. The technique does not require access to governmental records or ground based surveys to collect household location data and can be performed in a rapid, cost-effective manner.

Methods: The random selection of households …

Outlook Magazine, Winter 2013

Outlook Magazine

No abstract provided.

Treatment Of Fast Breathing In Neonates And Young Infants With Oral Amoxicillin Compared With Penicillin-Gentamicin Combination: Study Protocol For A Randomized, Open-Label Equivalence Trial, Antoinette Tshefu, Adrien Lokangaka, Cyril Engmann, Fabian Esamai, Peter Gisore, Adejumoke Idowu Ayed, Adegoke Gbadegesin Falade, Ebunoluwa A. Adejuyigbe, Chineme Henry Anyabolu, Robinson D. Wammanda, William N. Ogala, Lu Gram, Simon Cousens, Rajiv Bahl, Nigel Rollins, Sachiyo Yoshida, Shamim Ahmed Qaz

Paediatrics and Child Health, East Africa

Background: The World Health Organization recommends hospitalization and injectable antibiotic treatment for young infants (0–59 days old), who present with signs of possible serious bacterial infection. Fast breathing alone is not associated with a high mortality risk for young infants and has been treated with oral antibiotics in some settings. This trial was designed to examine the safety and efficacy of oral amoxicillin for young infants with fast breathing compared with that of an injectable penicillin–gentamicin combination. The study is currently being conducted in the Democratic Republic of Congo, Kenya and Nigeria

Methods/Design: This is a randomized, open-label equivalence trial. …

Paid Organ Donations And The Constitutionality Of The National Organ Transplant Act, John A. Robertson

UC Law Constitutional Quarterly

Organ transplant is a well-established medical therapy that saves thousands of lives. Yet many people who could survive with transplants die on waiting lists. With ever expanding indications for transplant, the supply of organs will never meet demand. But many more organ transplants could occur than do.

Under the National Organ Transplant Act ("NOTA"), the United States government prohibits the use of money in any form of organ donation scheme. By making it a federal felony to provide valuable consideration for organ donations, many proposed organ brokerages and exchanges have not been allowed to come to fruition. Valuable consideration includes …

'You Are Hereby Sentenced To A Term Of . . . Enslavement?': Why Prisoners Cannot Be Exempt From Thirteenth Amendment Protection, Alvaro Hasani

Barry Law Review

No abstract provided.

Humanitarian Aid In Question: The Case Of Rice Imports To Haiti, Madeleine R. Potter

Scripps Senior Theses

The instance of rice aid in Haiti definitively demands a reevaluation of humanitarian aid in today's world. In this thesis, I will outline the effects of rice aid on Haitian society and theoretically analyze humanitarian aid’s presence in “developing” countries. In addition to ruining many Haitian farmers' livelihoods, rice imports have aggravated Haiti's economic situation and national stability, the consequences of which have fallen primarily on the poor woman. I focus on the effects on the peasant woman in this thesis. Food insecurity remains a crisis. Throughout my thesis, I draw from the texts of scholars Slavoj Zizek, Jacques Rancière, …

Hypoxia Inducible Factor 1 Alpha (Hif-1a): A Major Regulator Of Placental Development, Renee E. Albers

Browse all Theses and Dissertations

Hypoxia-inducible factor-1 alpha (HIF-1a) is a critical component of the cellular oxygen-sensing machinery and is essential for placental formation and embryonic survival. In this study, we promoted prolonged expression of HIF-1a, by using a form that is insensitive to oxygen, denoted as CA-HIF-1a. In order to have continual placental specific expression of the CA-HIF-1a, lentiviral infection was performed on embryos at the blastocyst stage of development and transferred into pseudo-pregnant mothers. Placental analysis was performed via in situ hybridization on embryonic day 14.5 (E14.5) to determine the effects of CA-HIF-1a prolonged expression. Data indicate that prolonged activity of CA-HIF-1a restricted …

Understanding The Behavior And Attitude Of Professional Athletes In Saudi Arabia Toward Dietary Supplements, Sulaiman O. Aljaloud

Dissertations

A dietary supplement is defined as a product taken orally that contains a "dietary ingredient" (vitamins, minerals, herbs, amino acids, enzymes, etc.), and is intended to supplement one's diet. Dietary supplements include plant extracts and concentrates from foods. Supplements help provide required nutrients to fulfill nutritional levels for daily training or competitive performance, and can help remedy nutritional deficiencies. Therefore, it is important that sports professionals have a thorough knowledge of these supplement products. However, athletes need to be informed about the use and possible benefits, side effects, and risks associated with the use of dietary supplements. Four objectives guided …

A Single Case Study Of Cognitive Remediation Therapy With An Adolescent With Disordered Eating, Carol Lynn Galiano

PCOM Psychology Dissertations

Picky eating is currently not included in the diagnostic classification system DSM-IV TR as a distinct category of eating disorders in childhood. It can reach clinical significance requiring intervention when it results in chronic nutritional inadequacies and/or harmful impact on social development or family functioning. Studies have shown that patients with eating disorders have difficulties with executive functioning. These findings have been used to develop an intervention based on cognitive remediation therapy (CRT) which targets thinking skills and their role in the development and maintenance of an eating disorder. To further investigate, this study assessed the efficacy of an 8-week, …

Detection Of Antibodies Against Parascaris Equorum Excretory-Secretory Antigens, Steffanie V. Burk

Theses and Dissertations--Animal and Food Sciences

Parascaris equorum is a nematode parasite that infects young horses, sometimes causing unthriftiness, respiratory signs, or intestinal impaction in severe cases. Infection can be diagnosed by detection of eggs in feces, but this is only possible after the worms are fully mature. The goal of this study was to develop an antibody-based test for prepatent diagnosis of P. equorum infection. To produce western blot (WB) antigen, P. equorum larvae were cultured for collection of excretory-secretory antigens (ESA). Sera from 18 pregnant broodmares, their subsequent foals, and a group of 12 older mares and geldings were analyzed. In order to check …

Spe 3100 : Learning Differences Of Individuals With Moderate To Severe Exceptional Learning Needs, Special Education

Approved Course Proposals

No abstract provided.

Proceedings Of The First International Conference On Smarandache Multispace & Multistructures, Florentin Smarandache, Linfan Mao

Branch Mathematics and Statistics Faculty and Staff Publications

In recent decades, Smarandache’s notions of multispace and multistructure were widely spread and have shown much importance in sciences around the world. Organizedby Prof.Linfan Mao, a professional conference on multispaces and multistructures, named the First International Conference on Smarandache Multispace and Multistructure was held in Beijing University of Civil Engineering and Architecture of P. R. China on June 28-30, 2013, which was announced by American Mathematical Society in advance.

Evaluation Of A New Method For Large-Scale And Gene-Targeted Next Generation Dna Sequencing In Nonmodel Species, Ted Cosart

Graduate Student Theses, Dissertations, & Professional Papers

The efficient method called exon capture provides for sequencing genes genome-wide, targeting candidate genes, and sampling specific exons within genes. Although developed for model species with available whole genome sequences, the method can capture exons in nonmodel species using the genomic resources of a related model species. How close the relatives must be for effective exon capture is not known. The work herein demonstrates cross-taxa capture in ungulates, using the domestic cow genome as a reference. It also describes a computer program designed for collecting exon sequences for exon capture, allowing users to set per-gene and overall base pair (bp) …

Is Circumcision Legal?, Peter W, Adler

Richmond Journal of Law and the Public Interest

An important, divisive, and unanswered question of American law - and indeed of international law - is whether it is legal to circumcise healthy boys. American medical association and experts assert that circumcision is a common, safe, and relatively painlesss procedure with many medical benefits that exceed the risks. They argue that insurance should pay for it. Some religious organizations argue that circumcision is a sacred religious ritual. In any event, proponents claim that parents have a general and religious right to make the circumcision decision. They can point to the fact that no physician has ever been held liable …

Expression Of An Epitope Tagged Tarp Effector In Chlamydia Trachomatis, Brenda Nguyen

HIM 1990-2015

Previous studies performed on Chlamydia trachomatis have demonstrated how these obligate intracellular microbes invade host cells through the utilization of secreted effector proteins. One secreted effector called Tarp (translocated actin recruiting protein) is implicated in cytoskeleton rearrangements that promote bacterial entry into the host cell. The focus of our study is to create a plasmid that carries the tarP gene that when transcribed and translated from within Chlamydia trachomatis will generate a c-Myc epitope tagged Tarp. The tag will be used in future studies to track the progression of the protein through the infectious process and will allow us to …

Understanding The Role Of Plasmodium Falciparum Vamp8 Snare Homologue, Katherine Ferreira

HIM 1990-2015

Malaria is one of the worlds most deadly infectious diseases and results in almost a million deaths each year, largely in children under the age of five in Sub-Saharan Africa. Outside Africa, malaria is responsible for a large number of cases in the Amazon rainforest of Brazil, Middle East, and in some areas of Asia [37]. According to the World Health Organization, there was an estimated 655, 000 deaths from malaria in 2012. Malaria is caused by a eukaryotic Apicomplexan parasite, Plasmodium, which has three distinct life cycles occurring in the midgut of the female Anopheles mosquito, the liver of …

Threatened And Endangered Subspecies With Vulnerable Ecological Traits Also Have High Susceptibility To Sea Level Rise And Habitat Fragmentation, Allison M. Benscoter, Joshua S. Reece, Reed F. Noss, Laura A. Brandt, Frank J. Mazzotti, Stephanie S. Romañach, James I. Watling

Faculty Bibliography 2010s

The presence of multiple interacting threats to biodiversity and the increasing rate of species extinction make it critical to prioritize management efforts on species and communities that maximize conservation success. We implemented a multi-step approach that coupled vulnerability assessments evaluating threats to Florida taxa such as climate change, sea-level rise, and habitat fragmentation with in-depth literature surveys of taxon-specific ecological traits. The vulnerability, adaptive capacity, and ecological traits of 12 threatened and endangered subspecies were compared to non-listed subspecies of the same parent species. Overall, the threatened and endangered subspecies showed high vulnerability and low adaptive capacity, in particular to …

Operating Cooperatively (Oc) Sensor For Highly Specific Recognition Of Nucleic Acids, Evan M. Cornett, Martin R. O'Steen, Dmitry M. Kolpashchikov

Faculty Bibliography 2010s

Molecular Beacon (MB) probes have been extensively used for nucleic acid analysis because of their ability to produce fluorescent signal in solution instantly after hybridization. The indirect binding of MB probe to a target analyte offers several advantages, including: improved genotyping accuracy and the possibility to analyse folded nucleic acids. Here we report on a new design for MB-based sensor, called 'Operating Cooperatively' (OC), which takes advantage of indirect binding of MB probe to a target analyte. The sensor consists of two unmodified DNA strands, which hybridize to a universal MB probe and a nucleic acid analyte to form a …

Heat-Stress And Light-Stress Induce Different Cellular Pathologies In The Symbiotic Dinoflagellate During Coral Bleaching, C. A. Downs, Kathleen E. Mcdougall, Cheryl M. Woodley, John E. Fauth, Robert H. Richmond, Ariel Kushmaro, Stuart W. Gibb, Yossi Loya, Gary K. Ostrander, Esti Kramarsky-Winter

Faculty Bibliography 2010s

Coral bleaching is a significant contributor to the worldwide degradation of coral reefs and is indicative of the termination of symbiosis between the coral host and its symbiotic algae (dinoflagellate; Symbiodinium sp. complex), usually by expulsion or xenophagy (symbiophagy) of its dinoflagellates. Herein, we provide evidence that during the earliest stages of environmentally induced bleaching, heat stress and light stress generate distinctly different pathomorphological changes in the chloroplasts, while a combined heat-and light-stress exposure induces both pathomorphologies; suggesting that these stressors act on the dinoflagellate by different mechanisms. Within the first 48 hours of a heat stress (32 degrees C) …

In Vivo Expression Technology Identifies A Novel Virulence Factor Critical For Borrelia Burgdorferi Persistence In Mice, Tisha Choudhury Ellis, Sunny Jain, Angelika K. Linowski, Kelli Rike, Aaron Bestor, Patricia A. Rosa, Micah Halpern, Stephanie Kurhanewicz, Mollie W. Jewett

Faculty Bibliography 2010s

Analysis of the transcriptome of Borrelia burgdorferi, the causative agent of Lyme disease, during infection has proven difficult due to the low spirochete loads in the mammalian tissues. To overcome this challenge, we have developed an In Vivo Expression Technology (IVET) system for identification of B. burgdorferi genes expressed during an active murine infection. Spirochetes lacking linear plasmid (lp) 25 are non-infectious yet highly transformable. Mouse infection can be restored to these spirochetes by expression of the essential lp25-encoded pncA gene alone. Therefore, this IVET-based approach selects for in vivo-expressed promoters that drive expression of pncA resulting in the recovery …

Seasonality Influences Cuticle Melanization And Immune Defense In A Cricket: Support For A Temperature-Dependent Immune Investment Hypothesis In Insects, Kenneth M. Fedorka, Emily K. Copeland, Wade E. Winterhalter

Faculty Bibliography 2010s

To improve thermoregulation in colder environments, insects are expected to darken their cuticles with melanin via the phenoloxidase cascade, a phenomenon predicted by the thermal melanin hypothesis. However, the phenoloxidase cascade also plays a significant role in insect immunity, leading to the additional hypothesis that the thermal environment indirectly shapes immune function via direct selection on cuticle color. Support for the latter hypothesis comes from the cricket Allonemobius socius, where cuticle darkness and immune-related phenoloxidase activity increase with latitude. However, thermal environments vary seasonally as well as geographically, suggesting that seasonal plasticity in immunity may also exist. Although seasonal fluctuations …

Helicobacter Pylori Infection And Light Chain Gammopathy, José A. Girón, Shawn L. Shah

Faculty Bibliography 2010s

Objective. Helicobacter pylori provokes a host of immune alterations upon colonizing the gastric mucosa. Design. We report 22 individuals with confirmed Helicobacter pylori infection who were also managed for the concurrent elevation of immunoglobulin free light chain (kappa and lambda) levels. Result. Of the 22 patients, 15 patients (68.2%) had elevated free light chain levels: 6 patients (40%) had only kappa chain elevation, 2 patients (13.3%) had only lambda chain elevation, and 7 patients (46.7%) had both kappa and lambda chain elevation. Twenty out of the 22 patients (90.9%) were microbiologically confirmed cured with 3 patients being lost to follow-up …

Low Cost Tuberculosis Vaccine Antigens In Capsules: Expression In Chloroplasts, Bio-Encapsulation, Stability And Functional Evaluation In Vitro, Priya Saikumar Lakshmi, Dheeraj Verma, Xiangdong Yang, Bethany Lloyd, Hnery Daniell

Faculty Bibliography 2010s

Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading fatal infectious diseases. The development of TB vaccines has been recognized as a major public health priority by the World Health Organization. In this study, three candidate antigens, ESAT-6 (6kDa early secretory antigenic target) and Mtb72F (a fusion polyprotein from two TB antigens, Mtb32 and Mtb39) fused with cholera toxin B-subunit (CTB) and LipY (a cell wall protein) were expressed in tobacco and/or lettuce chloroplasts to facilitate bioencapsulation/oral delivery. Site-specific transgene integration into the chloroplast genome was confirmed by Southern blot analysis. In transplastomic leaves, CTB fusion proteins existed …

Longitudinal Genetic Analyses Of Staphylococcus Aureus Nasal Carriage Dynamics In A Diverse Population, Gowrishankar Muthukrishnan, Ryan P. Lamers, Austin Ellis, Vanathy Paramanandam, Alana B. Persaud, Sergio Tafur, Christopher L. Parkinson, Alexander M. Cole

Faculty Bibliography 2010s

Background: Staphylococcus aureus (SA) nasal colonization plays a critical role in the pathogenesis of staphylococcal infections and SA eradication from the nares has proven to be effective in reducing endogenous infections. To understand SA nasal colonization and its relation with consequent disease, assessment of nasal carriage dynamics and genotypic diversity among a diverse population is a necessity. Results: We have performed extensive longitudinal monitoring of SA nasal carriage isolates in 109 healthy individuals over a period of up to three years. Longitudinal sampling revealed that 24% of the individuals were persistent SA nasal carriers while 32% were intermittent. To assess …

Grape Extracts Inhibit Multiple Events In The Cell Biology Of Cholera Intoxication, Srikar Reddy, Michael Taylor, Mojun Zhao, Patrick Cherubin, Sandra Geden, Supriyo Ray, David Francis, Ken Teter

Faculty Bibliography 2010s

Vibrio cholerae produces cholera toxin (CT), an AB(5) protein toxin that is primarily responsible for the profuse watery diarrhea of cholera. CT is secreted into the extracellular milieu, but the toxin attacks its Gs alpha target within the cytosol of a host cell. Thus, CT must cross a cellular membrane barrier in order to function. This event only occurs after the toxin travels by retrograde vesicular transport from the cell surface to the endoplasmic reticulum (ER). The catalytic A1 polypeptide then dissociates from the rest of the toxin and assumes an unfolded conformation that facilitates its transfer to the cytosol …

Mycobacterial Trehalose Dimycolate Reprograms Macrophage Global Gene Expression And Activates Matrix Metalloproteinases, Kaori Sakamoto, Mi Jeong Kim, Elizabeth R. Rhoades, Rachel E. Allavena, Sabine Ehrt, Helen C. Wainwright, David G. Russell, Kyle H. Rohde

Faculty Bibliography 2010s

Trehalose 6,6'-dimycolate (TDM) is a cell wall glycolipid and an important virulence factor of mycobacteria. In order to study the role of TDM in the innate immune response to Mycobacterium tuberculosis, microarray analysis was used to examine gene regulation in murine bone marrow-derived macrophages in response to 90-mu m-diameter polystyrene microspheres coated with TDM. A large number of genes, particularly those involved in the immune response and macrophage function, were up-or downregulated in response to these TDM-coated beads compared to control beads. Genes involved in the immune response were specifically upregulated in a myeloid differentiation primary response gene 88 (MyD88)-dependent …

Global Stability Of Infectious Disease Models Using Lyapunov Functions, Zhisheng Shuai, P. Van Den Driessche

Faculty Bibliography 2010s

Two systematic methods are presented to guide the construction of Lyapunov functions for general infectious disease models and are thus applicable to establish their global dynamics. Specifically, a matrix-theoretic method using the Perron eigenvector is applied to prove the global stability of the disease-free equilibrium, while a graph-theoretic method based on Kirchhoff's matrix tree theorem and two new combinatorial identities are used to prove the global stability of the endemic equilibrium. Several disease models in the literature and two new cholera models are used to demonstrate the applications of these methods.