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Facilitation Of Electroporative Drug Uptake And Cell Killing By Electrosensitization, Olga N. Pakhomova, Betsy W. Gregory, Andrei G. Pakhomov

Bioelectrics Publications

Cell permeabilization by electric pulses (EP), or electroporation, is widely used for intracellular delivery of drugs and plasmids, as well as for tumour and tissue ablation. We found that cells pre-treated with 100-mus EP develop delayed hypersensitivity to subsequent EP applications. Sensitizing B16 and CHO cells by splitting a single train of eight 100-mus EP into two trains of four EP each (with 5-min. interval) decreased the LD(50) 1.5-2 times. Sensitization profoundly enhanced the electroporation-assisted uptake of bleomycin, a cell-impermeable cytotoxic agent accepted for killing tumours by electrochemotherapy. EP exposures that were not lethal per se caused cell death in …

Ceeaa Congratulations Graduates, Danille Parker

Physical Therapy Faculty Research and Publications

No abstract provided.

Amélioration Des Services Et Des Soins De Fin De Vie : Mieux Comprendre Les Effets Sur La Satisfaction Et Le Bien-Être Des Infirmières, Lise Fillion, Manon Truchon, Michel L'Heureux, Céline Gélinas, Marie Bellemare, Lyse Langlois, Jean-François Desbiens, Clémence Dallaire, Réjeanne Dupuis, Geneviève Roch, Marie Anik Robitaille

Rapports de recherche scientifique

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Avec le vieillissement de la population, la demande de soins palliatifs (SP) de fin de vie est croissante et les services de santé s’organisent. Au Québec, les SP de fin de vie sont surtout intégrés aux soins curatifs et on retrouve peu d’unités de SP spécialisées. Ces soins s'incorporent alors aux soins à domicile ou à ceux dispensés dans les unités de soins spécialisés en centre hospitalier, comme l’oncologie et les soins critiques. Les infirmières y jouent un rôle majeur. Selon ce choix organisationnel, les infirmières vivent un contexte de travail …

Gants Résistant Aux Piqûres D’Aiguilles : Évaluation De La Dextérité Manuelle, De La Sensibilité Tactile Et Du Confort Pour Les Travailleurs : Étude Exploratoire, Chantal Gauvin, Jaime Lara

Rapports de recherche scientifique

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Les policiers, les agents de la paix en services correctionnels, les éboueurs et les cols bleus horticulteurs sont très préoccupés par les risques de piqûre avec des aiguilles hypodermiques. Ces piqûres les exposent à du sang potentiellement contaminé et au risque de contracter des maladies transmissibles par le sang telles que le VIH et les hépatites B et C. Ces travailleurs doivent porter des gants résistant aux piqûres d’aiguilles tout en conservant une dextérité manuelle et une sensibilité tactile adéquates. Le choix de gants de protection dont ils disposent est limité, …

Worker Evaluation Of Manual Dexterity, Tactile Sensitivity And Comfort When Wearing Needlestick-Resistant Gloves: Exploratory Study, Chantal Gauvin, Jaime Lara

Rapports de recherche scientifique

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Les policiers, les agents de la paix en services correctionnels, les éboueurs et les cols bleus horticulteurs sont très préoccupés par les risques de piqûre avec des aiguilles hypodermiques. Ces piqûres les exposent à du sang potentiellement contaminé et au risque de contracter des maladies transmissibles par le sang telles que le VIH et les hépatites B et C. Ces travailleurs doivent porter des gants résistant aux piqûres d’aiguilles tout en conservant une dextérité manuelle et une sensibilité tactile adéquates. Le choix de gants de protection dont ils disposent est limité, …

Ceinture De Sécurité Pour Chariots Élévateurs À Contrepoids : Étude Préliminaire De Critères Normatifs Et D'Utilisabilité, Denis Rancourt, Sylvie Beaugrand, Christian Larue, Geneviève Masson

Rapports de recherche scientifique

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Depuis l’entrée en vigueur d’un nouvel article du Règlement québécois sur la santé et la sécurité du travail (RSST), les chariots élévateurs en porte-à-faux à grande levée, à poste de conduite au centre non élevable et à conducteur assis doivent être munis d’un dispositif de retenue empêchant le cariste d’être écrasé par la structure du chariot lors d’un renversement. La ceinture de sécurité pelvienne est un des moyens les plus couramment utilisés actuellement pour satisfaire cette exigence. À partir de la consultation des écrits, de l’examen sommaire de quelques ceintures vendues …

Characterization And Control Of Occupational Exposure To Nanoparticles And Ultrafine Particles, Maximilien Debia, Charles Beaudry, Scott Weichenthal, Robert Tardif, André Dufresne

Rapports de recherche scientifique

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De nombreux travailleurs sont exposés à un ensemble de particules présentes à une échelle nanométrique. En hygiène du travail, il est commun de différencier les nanoparticules (NP) manufacturées, des particules ultrafines (PUF) qui proviennent de sources naturelles, humaine ou industrielle. Étant donné qu’il existe des lacunes importantes dans les démarches usuelles d'évaluation du risque à ces particules, l’objectif de cette recherche était d’évaluer les expositions professionnelles à des PUF et des NP. L’objectif secondaire était de tester globalement les capacités d’évaluation des expositions professionnelles aux NP et aux PUF dans un …

Validation Of A Mechanical Hazard Fault Tree For Interventions In Printing Press Danger Zones, Laurent Giraud, Sabrina Jocelyn, Barthélemy Aucourt, Serge Massé, Renaud Daigle

Rapports de recherche scientifique

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En 2006, un recensement des pratiques d'usage les plus sécuritaires, relatives à des interventions sur des presses à imprimer, a été effectué par l'Association paritaire de santé et de sécurité du travail secteur imprimerie et activités connexes (ASP imprimerie), dans le but d'établir une procédure de travail sécuritaire propre à ces machines qui comportent plusieurs zones dangereuses. À partir de cela, l'ASP a construit un arbre de défaillance retraçant les combinaisons de causes engendrant l'écrasement d'une partie du corps d'un travailleur dans un angle rentrant de presse à imprimer. …

Predictors Of Posttraumatic Stress Disorders In Police Officers: Prospective Study, André Marchand, Richard Boyer, Céline Nadeau, Mélissa Martin

Rapports de recherche scientifique

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Ce projet de recherche vise à mieux comprendre le développement de l'état de stress post-traumatique (ÉSPT), à la suite d'un accident de travail, par l'étude des facteurs de risque et de protection qui y sont associés. Il provient d'une demande du milieu policier où les travailleurs sont fréquemment exposés à des événements traumatiques (ÉT). Les chercheurs posent l'hypothèse que les facteurs péri et post-traumatiques pourront mieux expliquer le développement de l'ÉSPT et l'adaptation aux ÉT vécus par le personnel exposé que les facteurs pré-traumatiques. Cette étude est originale, car elle s'intéresse …

Development Of A Clinical Practice Guideline On Work Functioning Assessment Of The Physically Impaired Person, Sophie Roy, Marie-José Durand, Hélène Corriveau

Rapports de recherche scientifique

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L’évaluation des capacités reliées au travail (ÉCT) de personnes souffrant d’une déficience physique est courante en ergothérapie. Les résultats obtenus servent à déterminer l’admissibilité à des services de réadaptation, à aider à la décision lors d’un processus de réorientation professionnelle ou encore l’admissibilité à des indemnités de remplacement de revenus. Ils peuvent aussi être utilisés dans la planification des interventions de réadaptation visant le retour en emploi ou pour l’adaptation d’un poste de travail. Cependant, la pratique des cliniciens à l’égard de l’ÉCT présente une grande variabilité qui pose un questionnement …

Presence, Intensity, And Temporal Changes In Generalized Anxiety Disorder Maintenance Factors In Workers Undergoing Rehabilitation For Persistent Musculoskeletal Pain, Marie-France Coutu, Marie-José Durand, André Marchand, Marie-Élise Labrecque, Djamal Berbiche, Geneviève Cadieux

Rapports de recherche scientifique

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Problématique : La prévalence du trouble d’anxiété généralisée (TAG) est plus élevée chez les personnes ayant une lombalgie, comparativement à la population en générale. En présence d’un TAG, l’intolérance à l’incertitude sera élevée et des stratégies inefficaces entraîneront le maintien de l’anxiété. À long terme, une réduction de l’efficacité personnelle à résoudre des problèmes et l’apparition de symptômes dépressifs pourraient nuire au retour au travail. L’objectif général de cette étude exploratoire vise à mieux comprendre la nature des manifestations anxieuses de travailleurs ayant un TMS persistant. Pour ce faire l’objectif principal …

Participatory Training In Manual Handling: Theoretical Foundations And Proposed Approach, Denys Denis, Monique Lortie, Marie St-Vincent, Maud Gonella, André Plamondon, Alain Delisle, Jacques Tardif

Rapports de recherche scientifique

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Les activités de manutention sont source de blessures musculo-squelettiques – particulièrement au dos – et ont fait l’objet de plusieurs études et d’efforts de prévention au fil des ans. Former les manutentionnaires est une avenue de prévention répandue. Une approche de formation dominante consiste à enseigner des consignes de base qui se matérialisent à travers des techniques standards que les manutentionnaires doivent appliquer en tout temps. Certaines études récentes remettent en question les effets de ces formations tandis que d’autres apportent un regard nouveau sur la réalité du travail de manutention. …

Adolescents With Fetal Alcohol Spectrum Disorder: Program For Prevention Of Juveniles Entering The Criminal Justice System, Erin Sykora, René Warzecha

Occupational Therapy Capstones

Purpose: The purpose of the product is to provide adolescents with fetal alcohol spectrum disorder (FASD) who are in a youth juvenile detention center the opportunity to participate in group sessions that will increase their functional occupational performance and decrease behaviors associated with their disorder.

Methodology: An extensive literature review was completed in order to determine the need for services and the information to include within the product. The authors looked at websites related to programming already implemented in Juvenile Centers to gather an idea of how to organize the product. A review of Cole’s 7 Steps was done in …

Fine Tuning A Well-Oiled Machine: Influence Of Nk1.1 And Nkg2d On Nkt Cell Development And Function, Sunil K. Joshi, Mark L. Lang

Bioelectrics Publications

Natural killer T cells (NKT) represent a group of CD1d-restricted T-lineage cells that provide a functional interface between innate and adaptive immune responses in infectious disease, cancer, allergy and autoimmunity. There have been remarkable advances in understanding the molecular events that underpin NKT development in the thymus and in the complex array of functions in the periphery. Most functional studies have focused on activation of T cell antigen receptors expressed by NKT cells and their responses to CD1d presentation of glycolipid and related antigens. Receiving less attention has been several molecules that are hallmarks of Natural Killer (NK) cells, but …

A Polymer-Based Microfluidic Device With Electrolyte-Enabled Distributed Transducers (Eedt) For Distributed Load Detection, Peng Cheng

Mechanical & Aerospace Engineering Theses & Dissertations

The capability of detecting distributed static and dynamic loads is indispensable in a wide variety of applications, such as examining anatomical structures of biological tissues in tissue health analysis and minimally invasive surgery (MIS) and determining the texture of an object in robotics. This dissertation presents a comprehensive study of a polymer-based microfluidic device with electrolyte-enabled distributed transducers and demonstrates a new concept on using a single microfluidic device for distributed-load detection, which takes advantage of the low-cost microfluidic fabrication technology and the low modulus and biocompatibility of polymer. The core of the device is a single deformable polymer microstructure …

Shared Leadership In Six Sigma Teams From The North Shore-Lij Health System, Brian J. Galli

Engineering Management & Systems Engineering Theses & Dissertations

The main goal of the research was to identify the relationships that the internal research team environment and external coaching variables had with the degree of shared leadership in the context of Six Sigma teams from the North Shore LIJ Health System. Furthermore, the research ascertained the relationships that these variables had with two performance metrics: a team's ability to complete project deliverables and satisfy customer's requirements. This research also sought to understand additional factors that affected the five variables.

The research found that while shared leadership did not positively change as a team progressed through the phases of the …

Structural And Functional Study Of Multidrug Membrane Transporters, Feng Ding

Theses and Dissertations in Biomedical Sciences

Multidrug membrane transporters (efflux pumps) in both prokaryotes and eukaryotes are responsible for ineffective treatment of a wide variety of diseases, including infections and cancer, underscoring the importance of better understanding of their structures and functions for design of effective therapies. Despite extensive studies over decades, their underlying molecular mechanisms remain largely unknown. In this dissertation, we focus on the study of structures and functions of multidrug membrane transporters, including ATP-binding cassette transporter (BmrA) and Resistance-Nodulation-Cell Division transporter (MexA,B-OprM) in gram-positive and gram-negative bacteria ( Bacillus subtilis and Pseudomonas aeruginosa), respectively. We fused EGFP with N-terminus and C-terminus of …

New Tools For Real-Time Study Of Embryonic Development, Lauren M. Browning

Theses and Dissertations in Biomedical Sciences

Embryonic development represents one of the most complex and dynamic cellular processes in biology, and plays vital roles in understanding of functions of embryonic stem cells (ESCs) and design of ESC-based therapy. Conventional assays and fluorescence-based imaging methods have been widely used for the study of embryonic development. These conventional methods cannot effectively provide spatial and temporal resolutions with sufficient sensitivity and selectivity that are required to depict embryonic development in vivo in real-time at single-cell and single-molecule resolutions. In this dissertation, we have developed a wide range of innovative tools for real-time study of embryonic development. These new tools …

Experiences And Perceptions Of Mental Health Professionals Considered Effective In The Diagnosis And Treatment Of Adults With Attention Deficit Hyperactivity Disorder, Bonita H. Erb

Counseling & Human Services Theses & Dissertations

Attention Deficit Hyperactivity Disorder (ADHD) is a disorder that has been documented in medical and mental health literature for over 100 years (Still, 1902). ADHD is a neurobiological based disorder characterized by three major symptoms identified at clinical levels and validated by diagnostic criteria established for the diagnosis of children before the age of seven (Diagnostic and Statistical Manual of Mental Disorders, 4 th edition-Text Revision; DSM-IV; American Psychiatric Association, 2000). The three diagnostic criteria are inattention, impulsivity, and hyperactivity that have been observed at clinical levels.

Because many signs of the disorder were believed to discontinue …

The Effects Of Intent And Consequences On The Assignment Of Penalties Related To Hiv Non-Disclosure Situations, Yang Deng

Psychology Theses & Dissertations

Laws related to HIV require individuals infected with HIV to disclose their HIV-positive status before engaging in sexual behavior. These laws vary as to whether to include the intent of HIV non-disclosure as a criterion for prosecution. Penalty assignment for HIV non-disclosure is consistent with moral judgment. Literature regarding moral judgment has been inconsistent as to whether individuals process information regarding intent and consequences independently or interdependently when recommending penalties. The present study seeks to explore the effects of intent and consequences on recommended penalties in HIV non-disclosure situations. A 3(intent) × 2(consequence) ANOVA design was conducted with recommended penalties …

Watershed-Scale Hybrid Stochastic-Deterministic Modeling Framework And Diffused Sources Superpositioning, Ruby Juvah Damalie

Civil & Environmental Engineering Theses & Dissertations

Predicting hydrologic system behavior is imperative to planning and management of water resources. The study developed an integrated hybrid stochastic and deterministic framework to improve prediction accuracy for overland flow and diffused sources in a watershed. The methodology includes sampling input parameters at system level and contribution of nonpoint source from hydrologically disconnected areas (heretofore referred to as system-level approach and superpositioning respectively). System-level approach includes the integration of a topography-based sampling grid generalized linear model developed by the study and Monte Carlo methods. The superpositioning method adopts in-stream water quality equation for overland flow pollution estimation.

The system-level approach …

Exploring Travel And Activity Behavior In Transit-Oriented Developments: Insights Into Transportation Benefits And Travel Demand Modelling, Sanghoon Son

Civil & Environmental Engineering Theses & Dissertations

As a sustainable urban development and transportation planning strategy, researchers and planners are increasingly interested in transit-oriented development (TOD). By integrating transit system and neighborhood design, TOD aims to provide a livable environment that is alternative mode friendly, higher density, and mixed-use to residents and workers in the vicinity of transit stations. Despite the recent growing interest in TOE), however, transportation benefits of TOD are not well quantified and characteristics of TOD are not adequately reflected in travel demand models.

This dissertation contributes to understanding of the travel and activity behavior by comprehensively exploring them in the context of TOD. …

Reference Modelling In Support Of M&S—Foundations And Applications, Andreas Tolk, Saikou Diallo, Jose Padilla, H. Herencia-Zapana

Engineering Management & Systems Engineering Faculty Publications

Whether by design or by practice, systems engineering (SE) processes are used more and more often in Modeling and Simulation (M&S). While the two disciplines are very close, there are some differences that must be taken into account in order to successfully reuse practices from one community to another. In this paper, we introduce the M&S System Development Framework (MS-SDF) that unifies SE and M&S processes. The MS-SDF comprises the SE processes of requirements capture, conceptual modelling, and verification and validation (V&V), and extends them to M&S. We use model theory as a deductive apparatus in order to develop the …

The Only Thing That Stops A Guy With A Bad Policy Is A Guy With A Good Policy: An Examination Of The Nra’S “National School Shield” Proposal, Gordon A. Crews, Angela D. Crews, Catherine E. Burton

Criminal Justice Faculty Publications

With the recent tragedy at Sandy Hook Elementary in Newtown, CT, the public and the government are looking for solutions to school violence. The National Rifle Association (NRA), a Second Amendment, pro-gun advocacy group, has proposed an “education and training emergency response program” called The National School Shield, which advocates the placement of armed security in schools. Although the program sounds provocative, serious questions complicate its plausibility, necessity, motive, and effectiveness. Furthermore, the potential policy and practical ramifications of encouraging armed security forces in U.S. schools are complex. The authors examined the proposal’s key elements from a public policy …

Using Twitter To Facilitate Case-Based Instruction In A Nursing Classroom, Sherleena Ann Buchman, Patricia Burke Snider, Tian Luo, Kaboni Gondwe

STEMPS Faculty Publications

This paper is a report on the use of Twitter within a sophomore level course in the baccalaureate nursing program at a rural Appalachian university. Students enrolled in the Foundations of Nursing course were in their second year of a traditional nursing program. Meeting the challenge of providing students with a ubiquitous learning environment that extends beyond their rural environment is important in the education of many students in the Appalachian region. The preliminary study looks at the usability of Twitter as the medium that will assist nursing students to build the confidence that comes from completing a case study …

Annual Patterns Of Atmospheric Pollutions And Episodes Over Cairo Egypt, Y. Aboel Fetouh, Hesham El-Askary, Mohamed El Raey, Mohamed Allali, W. A. Sprigg, Menas Kafatos

Mathematics, Physics, and Computer Science Faculty Articles and Research

The Nile Delta major cities, particularly Cairo, experienced stagnant air pollution episodes, known as Black Cloud, every year over the past decade during autumn. Low-elevated thermal inversion layers play a crucial role in intensifying pollution impacts. Carbon monoxide, ozone, atmospheric temperature, water vapor, and methane measurements from the tropospheric emission spectrometer (TES) on board the Aura have been used to assess the dominant component below the inversion layer. In this study, time series analysis, autocorrelations, and cross correlations are performed to gain a better understanding of the connections between those parameters and their local effect. Satellite-based data were obtained for …

Mycoplasma Feriruminatoris Sp. Nov., A Fast Growing Mycoplasma Species Isolated From Wild Caprinae, Joerg Jores, Anne Fischer, Pascal Sirand-Pugnet, Andreas Thomann, Elisabeth M. Liebler-Tenorio, Christiane Schnee, Ivette Santana-Cruz, Martin Heller, Joachim Frey

All Peer-Reviewed Publications

Five Mycoplasma strains from wild Caprinae were analyzed: four from Alpine ibex (Capra ibex) which died at the Berlin Zoo between 1993 and 1994, one from a Rocky Mountain goat collected in the USA prior to 1987. These five strains represented a population different from the populations belonging to the 'Mycoplasma mycoides cluster' as tested using multi locus sequence typing, Matrix-assisted laser desorption/ionization time of flight mass spectrometry analysis and DNA-DNA hybridization. Analysis of the 16S rRNA gene (rrs), genomic sequence based in silico as well as laboratory DNA-DNA hybridization, and the analysis of phenotypic traits in particular their exceptionally …

First Record Of Calophya Schini (Hemiptera: Calophyidae) In Ethiopia And Kenya, William A. Overholt, Robert S. Copeland, Susan E. Halbert

All Peer-Reviewed Publications

A South American leaf galling psyllid, Calophya schini Tuthill, has recently been discovered attacking the South American tree Schinus molle L. in Kenya and Ethiopia. This represents the first record of the psyllid in each country and the only record of C. schini in Africa outside of South Africa. In Kenya, the psyllid was parasitized by an unidentified tetrastichine (Eulophidae), probably of the genus Tamarixia, while in Ethiopia C. schini nymphs were heavily parasitized by an unidentified hymenopteran. Copyright © icipe 2013.

A Genome-Wide Methylation Study On Essential Hypertension In Young African American Males., Xiaoling Wang, Bonita Falkner, Haidong Zhu, Huidong Shi, Shaoyong Su, Xiaojing Xu, Ashok Kumar Sharma, Yanbin Dong, Frank Treiber, Bernard Gutin, Gregory Harshfield, Harold Snieder

Department of Medicine Faculty Papers

OBJECTIVE: There is emerging evidence from animal studies suggesting a key role for methylation in the pathogenesis of essential hypertension. However, to date, very few studies have investigated the role of methylation in the development of human hypertension, and none has taken a genome-wide approach. Based on the recent studies that highlight the involvement of inflammation in the development of hypertension, we hypothesize that changes in DNA methylation of leukocytes are involved in the pathogenesis of hypertension.

METHOD & RESULTS: We conducted a genome-wide methylation analysis on 8 hypertensive cases and 8 normotensive age-matched controls aged 14-23 years and performed …

De Novo Fibrillary Glomerulonephritis (Fgn) In A Renal Transplant With Chronic Hepatitis C., E J Filippone, Christine Chmielewski, Rakesh Gulati, Eric Newman, John Farber

Department of Medicine Faculty Papers

Chronic hepatitis C viremia (HepC) has been associated with numerous renal manifestations both in native kidneys and in the setting of renal transplantation. Glomerulonephritis (GN) of the renal allograft in the setting of HepC most commonly manifests as type 1 membranoproliferative GN (MPGN), either representing recurrence of the original disease or arising de novo. Other GNs were reported after transplantation in the patient with HepC including membranous nephropathy and thrombotic microangiopathy, as well as an enhanced susceptibility to transplant glomerulopathy. We describe the first case of de novo fibrillary GN in a renal transplant patient with HepC where the primary …