Digital Commons Network^™

A Genome-Wide Methylation Study On Essential Hypertension In Young African American Males., Xiaoling Wang, Bonita Falkner, Haidong Zhu, Huidong Shi, Shaoyong Su, Xiaojing Xu, Ashok Kumar Sharma, Yanbin Dong, Frank Treiber, Bernard Gutin, Gregory Harshfield, Harold Snieder

Department of Medicine Faculty Papers

OBJECTIVE: There is emerging evidence from animal studies suggesting a key role for methylation in the pathogenesis of essential hypertension. However, to date, very few studies have investigated the role of methylation in the development of human hypertension, and none has taken a genome-wide approach. Based on the recent studies that highlight the involvement of inflammation in the development of hypertension, we hypothesize that changes in DNA methylation of leukocytes are involved in the pathogenesis of hypertension.

METHOD & RESULTS: We conducted a genome-wide methylation analysis on 8 hypertensive cases and 8 normotensive age-matched controls aged 14-23 years and performed …

De Novo Fibrillary Glomerulonephritis (Fgn) In A Renal Transplant With Chronic Hepatitis C., E J Filippone, Christine Chmielewski, Rakesh Gulati, Eric Newman, John Farber

Department of Medicine Faculty Papers

Chronic hepatitis C viremia (HepC) has been associated with numerous renal manifestations both in native kidneys and in the setting of renal transplantation. Glomerulonephritis (GN) of the renal allograft in the setting of HepC most commonly manifests as type 1 membranoproliferative GN (MPGN), either representing recurrence of the original disease or arising de novo. Other GNs were reported after transplantation in the patient with HepC including membranous nephropathy and thrombotic microangiopathy, as well as an enhanced susceptibility to transplant glomerulopathy. We describe the first case of de novo fibrillary GN in a renal transplant patient with HepC where the primary …

Common Host-Derived Chemicals Increase Catches Of Disease-Transmitting Mosquitoes And Can Improve Early Warning Systems For Rift Valley Fever Virus, David P. Tchouassi, Rosemary Sang, Catherine L. Sole, Armanda D.S. Bastos, Peter E.A. Teal, Christian Borgemeister, Baldwyn Torto

All Peer-Reviewed Publications

Rift Valley fever (RVF), a mosquito-borne zoonosis, is a major public health and veterinary problem in sub-Saharan Africa. Surveillance to monitor mosquito populations during the inter-epidemic period (IEP) and viral activity in these vectors is critical to informing public health decisions for early warning and control of the disease. Using a combination of field bioassays, electrophysiological and chemical analyses we demonstrated that skin-derived aldehydes (heptanal, octanal, nonanal, decanal) common to RVF virus (RVFV) hosts including sheep, cow, donkey, goat and human serve as potent attractants for RVFV mosquito vectors. Furthermore, a blend formulated from the four aldehydes and combined with …

Donald Mcgavran And The City, Jeff K. Walters

Great Commission Research Journal

As the “father of the Church Growth Movement,” Donald A. McGavran’s impact on twentieth century missiology is undisputed. His teaching on missions in urban contexts holds great value for our rapidly urbanizing world, but those contributions have been studied very little. The purpose of this article is to survey McGavran’s urban missiology, especially as presented in his seminal work, Understanding Church Growth.

Blow Ups Or Grow Ups: Strategic Issues For Turnaround Churches, Kent R. Hunter

Great Commission Research Journal

This article addresses the theological and strategic issues affecting current turnaround churches in North America. In at least two scenarios, pastors can either “blow up” or “grow up” their church. The difference lies in the way change is introduced. Dr. Hunter explains that the biblical model of repentance, or metanoia, is always focused on turning towards God. To refocus the church’s mission on discipleship and away from the cultural drift, an understanding of the three most common church change strategies is essential. This discussion includes an analysis of the transition, extension, and organic models, along with an illustration of what …

An Educational Framework For Managing And Supporting Medication Adherence In Europe, S White, W Clyne, C Mshelia

Peninsula Medical School

Introduction: Decisions about taking medicines ultimately lie with patients, so health professionals need to engage with patients to manage and support medication adherence. Health professionals need appropriate education to do this. We aimed to develop an educational framework for health professionals in Europe for managing and supporting medication adherence. Description of the framework: The resulting educational framework comprises a competency framework, a curriculum, a diagnostic tool for competence assessment and a reading list. Quality assurance: Framework development started from a 2007 competency framework for shared decision-making. A literature review and a Europe-wide consultation were conducted and the ABC research team …

Evaluating The Strategic Impact Of Medical Revalidation. Building An Evaluation Framework., Julian Archer, Samantha Regan De Bere, Nick Lynn, Nicola Brennan

Peninsula Medical School

Executive Summary.1. BackgroundOn 3rd December 2012, the regulation of medical doctors in the UK by the GMC underwent its most radical reform in 150 years with the introduction of revalidation. This initiative presents a unique and exciting opportunity to evaluate the design features of an innovative regulatory system; in order to assure and potentially further develop revalidation as a robust regulatory process.Aims & objectives The aim of this research was to develop a framework for evaluation for consideration by the GMC encompassing suggestions/recommendations which could capture information about the key design features of revalidation over which the GMC has jurisdiction. …

Posttraumatic Stress Disorder (Ptsd) In The Latino Culture: A Proposed Culturally-Responsive Intervention Program For Latinas, Rochelle N. Welsh

CMC Senior Theses

The goal of this dissertation is to investigate the factors that increase risk for posttraumatic stress disorder (PTSD) in Latinos. Although the overall rates of psychiatric disorders in the Latino community are similar to Caucasian Americans, the risk for PTSD among Latinos is higher. This thesis discusses the general components of trauma and stress, as well as the prevalence of PTSD in various Latino subgroups. This thesis also covers a number of cultural-specific values, stressors, and help-seeking attitudes that increase the risk of PTSD among Latinos. Moreover, a culturally-responsive intervention program treating PTSD among Latinas who are victims of intimate …

Omni-Channel Retail And The New Age Consumer: An Empirical Analysis Of Direct-To-Consumer Channel Interaction In The Retail Industry, Alec J. Dorman

CMC Senior Theses

It is indisputable that the internet has become a necessary component of contemporary multi-channel retail, as more consumers are choosing to purchase goods online each year. As online spending continues to grow, many have called into question the future of brick-and-mortar retail. This thesis seeks to empirically prove that brick-and-mortar retail remains not only relevant, but indispensable in direct-to-consumer business models. The basis of this conjecture is the idea of channel synergism, in which online and brick-and-mortar operations are complementary. This theory is predicated on the emergence of the omni-channel retail, which is characterized by the integration of the various …

Heart Attack Experiences Described In Weblogs: An Analysis Of Sex Differences, Stephanie R. Morley

CMC Senior Theses

Heart disease is the leading cause of death for both men and women (Kochanek, Xu, Murphy, Miniño & Kung, 2011). Every year in the United States, more than 600,000 people die from heart disease, which amounts to roughly a quarter of all deaths (Kochanek et al., 2011). Heart attacks account for a large portion of the deaths attributed to heart disease, and include sudden cardiac arrest or chronic cases of heart trouble that develop into heart attack after an extended period of time. Heart attacks affect approximately 935,000 Americans each year, with roughly two-thirds of people experiencing them for a …

Evidence-Based Programs In Children's Services: A Critical Appraisal, Nick Axford, Louise Morpeth

Peninsula Medical School

No abstract provided.

Delivery And Use Of Individualised Feedback In Large Class Medical Teaching, Sa Burr, E Brodier, S Wilkinson

Peninsula Medical School

No abstract provided.

Sudden Unexpected Death In Epilepsy (Sudep): Development Of A Safety Checklist, Rohit Shankar, David Cox, Virupakshi Jalihal, Scott Brown, Jane Hanna, Brendan Mclean

Peninsula Medical School

Purpose The incidence of sudden death appears to be 20 times higher in patients with epilepsy compared with the general population. Epilepsy-related death, particularly sudden unexpected death in epilepsy (SUDEP), is still underestimated by healthcare professionals and this may reflect the mistaken belief that epilepsy is a benign condition. The risk of death associated with epilepsy appeared rarely to have been discussed with patients or their families. It appears the decision to discuss SUDEP and also to peg SUDEP risk is arbitrary and clinical. Unfortunately there is no structured evidenced mechanism at present to represent person centered risk of SUDEP …

Simulation And Assessment Of Dental Extraction Proficiency Type Of Project : Self Administered Postal Questionnaire, D. R. Moles, Nigel Honey, Tom Gale

Peninsula Medical School

This study aimed to determine the confidence of recently qualified Foundation Dentists (FDs) in elements of the dental extraction process and to compare this with the assessment of their Foundation Trainers. Also the study aimed to investigate the foundation dentists’ views of their undergraduate training relating to exodontia and any aspects of which they found lacking or alternatively any experiences which they found particularly useful. The dental extraction needs of the UK population are changing with the development of an elderly dentate generation (McHarg and Kay 2009). The 2009 Adult Dental Health Survey observed that a very significant proportion of …

Drought And Corn In Kentucky, Rezaul Mahmood

School of Natural Resources: Faculty Publications

No abstract provided.

Exercise Referral For Drug Users Aged 40 And Over: Results Of A Pilot Study In The Uk, Caryl M. Beynon, Amy Luxton, Rhiannon Whitaker, N. Tim Cable, Lucy Frith, Adrian H. Taylor, Lu Zou, Peter Angell, Scott Robinson, D Holland, S Holland, Mark Gabbay

Peninsula Medical School

No abstract provided.

A Systematic Review Of Educational Interventions To Change Behaviour Of Prescribers In Hospital Settings, With A Particular Emphasis On New Prescribers., Nicola Brennan, Karen Mattick

Peninsula Medical School

AIMS: Prescribing is a complex task and a high risk area of clinical practice. Poor prescribing occurs across staff grades and settings but new prescribers are attributed much of the blame. New prescribers may not be confident or even competent to prescribe and probably have different support and development needs than their more experienced colleagues. Unfortunately, little is known about what interventions are effective in this group. Previous systematic reviews have not distinguished between different grades of staff, have been narrow in scope and are now out of date. Therefore, to inform the design of educational interventions to change prescribing …

The Modern Day Corporation: A Philosophical Analysis Of How Corporations Behave And How They Should Behave, Daniel Shane

CMC Senior Theses

We seem to hold corporations to an impossible standard. We call for profit maximization, but at the same time want to place strict limits on the methods corporations may use to obtain them. In this thesis, I explore two popular theories of the corporation: stakeholder theory and shareholder theory. I examine the degree to which each theory explains the corporation as it exists today, as defined in the law and through its behavior, but also the theories‘ normative appeal. I conclude by positing what I find to be the best normative account of the corporation: a theory of how we …

Grand Strategy In U.S. Foreign Policy: The Carter, Bush, And Obama Doctrines, Sara M. Birkenthal

CMC Senior Theses

This paper seeks to determine under what conditions a U.S. president can implement a grand strategy given the nature of domestic and international opportunities and constraints. It will examine three comparative case studies: Jimmy Carter, George W. Bush, and Barack Obama, with the goal of determining what conditions are necessary at the individual, domestic, and systemic levels of analysis for grand strategy implementation. At the individual level, it will apply operational code analysis, as well as an examination of personal characteristics for each case study. At the domestic level, it will apply a five-prong test for examining factors that are …

Rape As A Weapon Of War: The Demystification Of The German Wehrmacht During The Second World War, Alisse Baumgarten

CMC Senior Theses

The German Armed Forces were originally thought to be completely innocent of all war crimes associated with unethical Nazi racial policies. This has been proven not to be the case. History has adjusted itself to show that Wehrmacht forces were guilty of virtually every war crime except for the sexual violation foreign women. Due to the long-standing assumption that Nazi racial ideology prevented the intermingling of the “Aryan” race with the “unworthy” Eastern European races, this myth was rarely questioned. Given the lack of hard evidence proving that civilian women were raped by invading Wehrmacht troops, a firm conclusion is …

Organized Crime Violence In Mexico, John E. Oliphant

CMC Senior Theses

The following thesis outlines the current social and political situation surrounding organized crime violence in Mexico. Using Samuel P. Huntington’s Political Order in Changing Societies and regression analysis, the purpose is to highlight the lack of subnational data within Mexico. Political science and economic theories guide the reader to better understanding what types of policy change or reform may need to occur in Mexico’s future years.

Indivisible And Inseparable: The Austro-Hungarian Army And The Question Of Decline And Fall, Kyle D. Woods

CMC Senior Theses

The title of this work is “Indivisible and Inseparable” the motto of the Austro-Hungarian Empire. This motto is just one of many ways in the Austro-Hungarian Empire fought against the centrifugal forces seeking to destroy it. I argue here that the historic theory of decline and fall is misguided as a model for understanding the collapse of the Austro-Hungarian Empire, and question its usefulness when applied to other nation states and empires as well. I suggest that the Austro-Hungarian military, specifically its condition prior to the First World War, is an ideal lens for exploring the dissolution of the Empire …

The Price Discounts Of Chinese Cross-Listed Companies And Their Variation Across Sectors, Tom Guo

CMC Senior Theses

This study builds on the paper by Arquette, Brown, and Burdekin (2008) and asks whether the factors which they find to be significant in influencing the differential between the share prices of Chinese securities traded on their home market in Shanghai versus share prices observed offshore in Hong Kong and New York have varying degrees of influence when compared across industries. This paper focuses on Chinese companies listed on both the Shanghai and Hong Kong Stock Exchanges and finds that the proxy variables of expected exchange rate change, relative market sentiment, and relative company sentiment are significant in determining the …

Conditional Cash Transfers And Child Health: The Case Of Malawi, Ryan F. Boone

CMC Senior Theses

This paper analyzes the impacts of the Malawi Social Cash Transfer Scheme. The goal of this paper is to help improve the design of cash transfers. First of all, I analyze whether the cash transfer positively affects child health variables despite occurring in a region with poor supply side health institutions. I find significant results for many child level variables, such as frequency of illnesses, but insignificant improvements in anthropometric measurements. Secondly, I examine whether female-headed households invest more in child health than male-headed households. The results show that the impacts of the cash transfer did not depend on the …

Contemporary Women's Employment In Japan: The Effects Of State-Mandated Gender Roles, Wars, And Japan, Inc., Megan Levonian

CMC Senior Theses

My research is centered around the questions: How can such a modernized country, considered by many to be the cleanest, friendliest, most welcoming place to visit (certainly surpassing the United States on such standards), not be more welcoming of women in employment? Further, what are the main problems hindering women in employment today, and from where do these problems originate? That is, how did the present situation for women’s employment in Japan come to light? I endeavor to answer these questions, beginning by uncovering the major issues in women’s employment and then tracing their origins back in history to discover …

An International Approach To Challenging Violence Against Women In India, Pyper Scharer

CMC Senior Theses

The objective of this thesis is to identify ways that international actors can be most effective in influencing policy change pertaining to women’s safety and security in India. Since the 1970s, domestic groups within India and international organizations have focused on promoting gender equality and combatting problematic social norms that beget discrimination and violence against women. This thesis examines some of the programs and campaigns that Indian governments and civil society actors – domestic and international – have implemented to promote the rights and protections of women. This thesis considers examples of finance, social networking, training, education, and information propagation, …

India: Subsidy State Or Developmental State?, Annie Jalota

CMC Senior Theses

India does not fit easily into existing models of thought on the nature of a state and defies ease of understanding. Though India is most often considered to be a subsidy state, I show in this thesis the notion of the subsidy state does not capture the true nature of the Indian state. Chapter two of the paper looks at various models of understanding the nature of the Indian state and draw out three essential features: competing interest groups, how economic liberalization facilitates corruption and works against India’s aim of equalizing the capabilities and freedoms of all its citizens, and …

The Philosophy Of Sex And The Morality Of Homosexual Conduct, Kyle C. Hansen

CMC Senior Theses

Homosexuality is an important and controversial topic in political, philosophical, ethical and religious spheres. We are exposed to the debate of homosexuality in the media on a regular basis and issues related to homosexuality have been taken up by the Supreme Court, politicians and religious institutions. Needless to say, the debate surrounding homosexuality has captured the attention of almost everyone in society to some degree. It is my goal in this thesis to give a candid overview and analysis of the arguments surrounding homosexual sexual conduct. First, I will present an argument by John Corvino, who posits that homosexual conduct …

The Impact Of Prior Performance On Leadership Appointment In A Merger Of Equals, David A. Hirsch

CMC Senior Theses

Leadership appointment during mergers has a logical and established precedent when there is a clear target and acquirer. However, in the extraordinary case of Merger Of Equals (MOEs) – where this is relative equal ownership, board representation, earnings contribution etc - this process is much less defined and can often have serious consequences on the merger, both in closing negotiations as well as post-merger performance. Intuition assumes the better performing CEO should and will be appointed. In practice, however, that is often not the case. It is arguable that performance can be defined through objective means (financially & operationally), yet …

Reforming Affirmative Action For The Future: A Constitutional And Consequentialist Approach, Quinn Chasan

CMC Senior Theses

In my analysis of affirmative action policy, I began the search without having formed any opinion whatsoever. The topic was interesting to me, and after reading a mass of news editorials and their op-eds, I decided to take up the argument for myself. Other than the fact that I am a student, I have no stake in affirmative action policy. This paper relies primarily on the foremost half-dozen or so notable mismatch theory scholars, a close reading of an innumerable number of Supreme Court opinions, affirmative action related studies from higher education academics and policy institutes, and how historical executive …