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The Tip Of The Tail Needle Affects The Rate Of Dna Delivery By Bacteriophage P22., Justin C Leavitt, Lasha Gogokhia, Eddie B Gilcrease, Anshul Bhardwaj, Gino Cingolani, Sherwood R Casjens

Department of Biochemistry and Molecular Biology Faculty Papers

The P22-like bacteriophages have short tails. Their virions bind to their polysaccharide receptors through six trimeric tailspike proteins that surround the tail tip. These short tails also have a trimeric needle protein that extends beyond the tailspikes from the center of the tail tip, in a position that suggests that it should make first contact with the host's outer membrane during the infection process. The base of the needle serves as a plug that keeps the DNA in the virion, but role of the needle during adsorption and DNA injection is not well understood. Among the P22-like phages are needle …

Structural Implications For Selective Targeting Of Parps., Jamin D Steffen, Md, Jonathan Brody, Md, Roger S Armen, Md, John M Pascal, Md

Department of Biochemistry and Molecular Biology Faculty Papers

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD(+) as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins. PARPs have important cellular roles that include preserving genomic integrity, telomere maintenance, transcriptional regulation, and cell fate determination. The diverse biological roles of PARPs have made them attractive therapeutic targets, which have fueled the pursuit of small molecule PARP inhibitors. The design of PARP inhibitors has matured over the past several years resulting in several lead candidates in clinical trials. PARP inhibitors are mainly used in clinical trials to treat cancer, particularly as sensitizing agents …

Identification Of Phosphorylation Sites In The Cooh-Terminal Tail Of The Μ-Opioid Receptor., Ying-Ju Chen, Sue Oldfield, Adrian J. Butcher, Andrew B. Tobin, Kunal Saxena, Vsevolod V. Gurevich, Jeffrey L. Benovic, Graeme Henderson, Eamonn Kelly

Department of Biochemistry and Molecular Biology Faculty Papers

Phosphorylation is considered a key event in the signalling and regulation of the μ opioid receptor (MOPr). Here, we used mass spectroscopy to determine the phosphorylation status of the C-terminal tail of the rat MOPr expressed in human embryonic kidney 293 (HEK-293) cells. Under basal conditions, MOPr is phosphorylated on Ser(363) and Thr(370), while in the presence of morphine or [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin (DAMGO), the COOH terminus is phosphorylated at three additional residues, Ser(356) , Thr(357) and Ser(375). Using N-terminal glutathione S transferase (GST) fusion proteins of the cytoplasmic, C-terminal tail of MOPr and point mutations of the same, we …

Striking For The Guardians And Protectors Of The Mind: The Convention On The Rights Of Persons With Mental Disabilities And The Future Of Guardianship Law, Michael L. Perlin

Articles & Chapters

In many nations, entry of a guardianship order became the “civil death” of the person affected. It has been accurately characterized as “civil death” characterization because a person subjected to the measure is not only fully stripped of their legal capacity in all matters related to their finance and property, but is also deprived of, or severely restricted in, many other fundamental rights, [including] the right to vote, the right to consent or refuse medical treatment (including forced psychiatric treatment), freedom of association and the right to marry and have a family.

Guardianship is also frequently entered. In Hungary, for …

Online Mental Disability Law Education, A Disability Rights Tribunal, And The Creation Of An Asian Disability Law Database: Their Impact On Research, Training And Teaching Of Law, Criminology Criminal Justice In Asia, Michael L. Perlin, Heather Ellis Cucolo, Yoshikazu Ikehara

Articles & Chapters

Two professors at New York Law School (NYLS) and the director of the Tokyo Advocacy Law Office are engaged in initiatives with the potential to have major influences on the study of law, criminology, and criminal justice: the creation of a Disability Rights Tribunal for Asia and the Pacific (DRTAP), and expansion of NYLS’s online mental disability law program (OMDLP) to include numerous Asian venues.

DRTAP seeks to create a sub-regional body (a Commission and eventually a Court) to hear violations of the UN’s Convention on the Rights of Persons with Disabilities. This will explicitly inspire scholarship about issues such …

Predictors Of Drug Court Success In A Small City Drug Court, Melinda Sue Fangman

Criminal Justice and Political Science

This study examines the factors related to completion outcomes of the East Central Judicial District Drug Court (ECJDDC). The ECJDDC has a 71% graduation rate which far exceeds the national average of approximately 40-45%. The dataset included information on 250 participants who entered the drug court from 2003-2011. Factors included in the analysis include those related to living situation, family situation, socioeconomic status, veteran status, current offense, and prior criminal history in addition to sex, race, and age. Logistic regression determined that the strongest predictors of graduation relate to education, income, employment, and living situation. Policy implications, practice, and future …

Contractor Prequalification Practices In Bangladesh, Mohammad Mofigul Islam Molla

Construction Management and Engineering

Like many developing economies, the construction industry in Bangladesh is vital to its economic development and growth. However, the Bangladeshi construction industry is plagued by unethical practices, sub-standard construction work, and the inability of local contractors to partake in internationally funded (lucrative) contracts (as general contractors). A contractor prequalification process is proposed to address the problems facing the industry. In this work, an extensive literature review was used in combination with research surveys, statistical analyses of the literature and survey results, and the analytical hierarchy process to develop sets of factors and criteria pertinent to contractor prequalification/selection. A five-level framework …

Assessment Of Owner Risk Associated With Airport Capital And Maintenance Projects, Chidozie Ehiemere

Construction Management and Engineering

The thesis produces a risk management process that effectively determines risk and its effects on commercial airport owner activities. To achieve this goal, the thesis reviewed these objectives: 1) Determination of major risks in the US commercial aviation industry; 2) Assessment and analysis of these risks in US commercial facilities; and 3) Producing risk dynamic in a project cycle associated with airport owner activities. The owner of airport facilities faces multiple risks in planning, design & construction of commercial airports. Literature on airport risk and damages was reviewed and used to produce a survey sent to select facilities in the …

The Veracity Of Self-Reported Criminal Records Among Ndsu Students, Kelsey Anne Keimig

Criminal Justice and Political Science

Campus safety and security are important concerns for colleges and universities. One way security is addressed is through utilization of self-report questions about criminal backgrounds during the admissions process. The current study evaluates this admissions policy by using a systematic random sample of 1,400 students to compare self-reported criminal backgrounds with criminal records listed in four online databases. Results indicate that two individuals within the sample failed to report their criminal backgrounds which included simple assault, burglary, theft, possession of controlled substance, and drug paraphernalia. While the failed reporting rate appears low, caution should be taken interpreting the results. A …

State Of Bridge Management In Canada, Kamran Majeed Khanzada

Construction Management and Engineering

Bridges are key elements of all horizontal transportation networks. The primary objective of this paper is to investigate and document bridge-management practices in Canada at the federal, provincial/territorial, and municipal levels. The research methods used include a literature review, data collection (surveys), data analysis, and conclusions. The survey was sent to all provincial/territorial and federal jurisdictions. Nine of ten provincial, three of three territorial, and two of nine federal agencies responded to the survey. Currently, only four provinces have computerized Bridge Management Systems (BMS). The Ontario Structure Inspection Manual (OSIM), developed by province of Ontario, is the most widely used …

Study Of Factors Affecting Labor Productivity At A Building Construction Project In The Usa: Web Survey, Mahesh Madan Gundecha

Construction Management and Engineering

Construction projects suffer various problems and complex factors such as cost, duration, quality and safety. Construction sector is diverse as it contains, contractors, consultants, designers, owners, and others. The aim of this paper is to identify factors affecting labor productivity at a building construction project. A literature review and factors recommended by experts were considered to categorize the factors. 40 factors, categorized into 5 groups, were analyzed and ranked considering Relative Importance Index. The questionnaires were distributed to Project Manager, Project Engineer, Architecture, and Others (Scheduler, and Estimator). It was concluded, final cost of the projects were higher than estimated …

More Vitiating Paradoxes: A Response To Steven D. Smith - And Smith A Discussion Of Religious Freedom In America, Paul Horwitz

Articles

No abstract provided.

Alcohol And Academia: A Study Of The Association Between Student Housing Type And Alcohol Abuse At North Dakota State University, Charles Louis Lietaert

Education

The purpose of this study was to determine if student housing gender-type is significantly related to student alcohol consumption at North Dakota State University. The researcher examined whether the residence of students in coeducational residence halls or single-gender residence halls was related to the rate they consumed alcohol in an average week or the frequency they engaged in binge drinking. NDSU researchers allowed the researcher of this study to add an institutional question to the biannual Student CORE Alcohol and Other Drug Survey that gathered demographic information about what residence hall gender-type participants lived within. For the first time, this …

Supporting Transitions Of Homeless Youth: Evaluating Residential Program Frameworks, Structure And Educational Collaborations, Christopher Lowell Johnson

Education

With varying definitions and reports of appropriate transitions to independent living situations, it is difficult to decipher which residential models and approaches have the greatest impact on homeless youth. This project was guided by six research questions that focused on the residential structure and programming frameworks of programs serving runaway and homeless youth. Invited to participate in the study were 299 organizations operating 519 residential programs across the United States. Electronic surveys were sent to identified organizations and were followed by paper surveys. The researcher eventually received 71 completed surveys that were categorized as runaway minor and homeless youth programs. …

Adviser's Guide To Social Security : Unlocking The Mystery Of Retirement Planning, Theodore J. Sarenski, Elaine Floyd

Guides, Handbooks and Manuals

No abstract provided.

Using A Soc 1sm Report In A Financial Statement Audit; Practice Aid Series, American Institute Of Certified Public Accountants (Aicpa)

Guides, Handbooks and Manuals

No abstract provided.

Cpa’S Guide To Social Security Planning, American Institute Of Certified Public Accountants. Personal Financial Planning Section

Guides, Handbooks and Manuals

No abstract provided.

Strategic Business Management : From Planning To Performance, Gary Cokins

Guides, Handbooks and Manuals

No abstract provided.

Using A Soc 1sm Report In Audits Of Employee Benefit Plans; Aicpa Practice Aid Series, American Institute Of Certified Public Accountants (Aicpa)

Guides, Handbooks and Manuals

No abstract provided.

Overachiever's Guide To Getting Unstuck : Replan, Reprioritize, Reaffirm, William L. Reeb

Guides, Handbooks and Manuals

No abstract provided.

Informal Material Convergence Behavior And Emergency Management: Looking A Gift Horse In The Mouth, Aleczandre Nikoluas Cole-Corde

Emergency Management

Informal material convergence behavior is the spontaneous movement of unsolicited donations from donors to emergency management for disaster relief activities. This behavior is widely accepted as an appropriate social response after disasters. However, this behavior frequently results in excessive amounts of unsolicited donations which create numerous problems for emergency management. Most donors appear unaware of the issues associated with contributing unsolicited donations. The challenge is to reeducate the media and the public about what are considered the appropriate types of donations to contribute for disaster survivors. Informal material convergence behavior is a problem that can be resolved through social-psychological approaches. …

Developing Higher Education Programs In Emergency Management: Ghana's Experience, Mariama Bisongu Yakubu

Emergency Management

Ghana is highly vulnerable and threatened by several hazards and has sought ways of minimizing impacts of hazards events over time including demonstrating an interest in developing an emergency management training and an higher education degree program. Yet, as of 2013, the country has not developed a disaster management training program or a degree program. This study investigated Ghana’s efforts to see these programs develop with a particular focus on identifying the factors involved in explaining the current status of Ghana’s efforts. Purposive and snowball sampling were used to select 19 emergency management scholars and practitioners who have been involved …

Coordination In Disaster Recovery: Implications For Policy And Practice, Sarah Jo Bundy

Emergency Management

Disaster scholarship and recent disaster policy in the United States have suggested that coordination of efforts in the disaster recovery process will allow impacted jurisdictions to maximize positive recovery outcomes. Yet it remains unclear exactly who should be, or is, coordinating disaster recovery at the local level. This study explored the role of county elected officials in disaster recovery in an attempt to understand what role these elected officials currently play in the recovery process—particularly as related to the coordination of recovery efforts. During the initial data collection process, the researcher discovered that the role of county elected officials in …

Local Nonprofit And Government Organization Conceptualizations Of Disaster Response Effectiveness, Nazgul Borkosheva

Emergency Management

This study attempted to explore how nonprofit and government organizations conceptualize disaster response effectiveness using an internet survey. Unfortunately, the data collected through this method was insufficient for meaningful data analysis, and, therefore this study was unable to generate significant findings with respect to its research question. Thus, rather than focusing on a presentation of results from data collection and interpreting the significance of those results, this thesis focuses on justification of the need for research on this topic, review of the literature that suggests it is likely that nonprofits and government perceive disaster response effectiveness differently, recounting of the …

Tattoo Subculture: Creating A Personal Identity In The Context Of Social Stigma, Naomi Joy Tabassum

Education

Tattooing is a growing and diversifying practice in the United States (Roberts, 2012), yet mainstream society maintains negative stigmas (Bell, 1999). Nevertheless, individuals attach personal meaning to tattooing (Atkinson, 2002; Kosut, 2000). There is little literature on the tattooed individual’s experience of social stigmatization and its impact on identity construction. This study employed a phenomenological approach to address this gap in the literature. The researcher used a semi-structured protocol to interview seven tattooed individuals (five men, two women; age range 25 - 38 years). Data analysis extracted three main themes: “identity project,” “cultural context,” and “tattoo timeline.” Findings suggest stigmas …

Determining Factors That Serve As Barriers To Integrative Stem Methodology Implementation In K-12 Schools, Knut Peder Gjøvik

Education

The purpose of the correlational study was to determine factors that served as barriers to integrative science, technology, engineering and mathematics (iSTEM) implementation in K-12 schools. The sample studied (N = 153) was drawn from classroom teachers and administrators with training in iSTEM methodology or experience in iSTEM methods and subsequent experience regarding implementation barriers. The researcher developed the Integrative STEM Implementation Barriers Instrument (iSTEMIBI). The iSTEMIBI included a six-point Likert scale measuring levels of agreement to statements regarding implementation barriers. The research utilized the Embedded Design correlational model as detailed by Creswell and Plano Clark (2007). Likert items were …

A Case Study Of North Dakota Interactive Video Network At North Dakota State University, Tamara Annette Cummings

Education

North Dakota State University (NDSU) has delivered courses utilizing the North Dakota Interactive Video Network (IVN) since 1989. The technology used an Integrated Services Digital Network but switched to Internet Protocol in 2001, greatly expanding the locations served. NDSU student and institutional data was collected but never examined. The collected data examined for this study included course and credit numbers, undergraduate and graduate student enrollments, and IVN locations. An analysis of the data found that the student enrollments did not increase at the same rate as the IVN locations. There were differences in the findings of the undergraduate and graduate …

A Study About The Level Of A Teacher’S Content Knowledge, Pedagogical Content Knowledge, Instructional Practices, And Demographics And Their Effects On Students’ Literacy Achievement, Sue Luann Brunsberg

Education

It might be assumed that teachers’ content and pedagogical content knowledge affect student learning. However, most studies do not include observations of actual classroom instruction. This study provides empirical evidence that illustrates the significance of a teacher’s content knowledge; a teacher’s pedagogical content knowledge; instructional methods; a teacher’s demographic background; and what, if any, effects they have on students’ literacy achievement. This study was important because at this point in time, there was not any research that could be located that incorporated all these five areas. Teachers’ content knowledge, teachers’ pedagogical content knowledge, and teachers’ demographic data were obtained from …

Supply Chain Management And Lean Six Sigma In A Retail Environment, Brittain Cliff Ladd

Apparel Design and Hospitality Management

This qualitative research evaluated the as-is supply chain management and logistics retail processes of Dell, a manufacturing company that also has retail operations globally. Dell has an online channel capable of serving millions of customers annually. This research focused on Dell’s retail operations in Canada and the United States and the challenges of managing the supply chain requirements of meeting customer demand. The goal was to identify issues with process execution leading to decreased service to customers and increased costs to the manufacturer. A literature review provided information regarding best practices in supply chain management and the leading process-improvement methodology. …

Adolescent Food Consumption In Urban China: Factors Influencing Bmi And School Meals, Carl Allen Anfinson

Agribusiness and Applied Economics

China’s food consumption patterns are changing as the population becomes wealthier and more urban. As the country ages, today’s adolescents will be tomorrow’s consumers. Few studies have focused on this important demographic. This study intended to investigate what might be influencing adolescent BMI by examining what adolescents are eating at home and away from home along with socioeconomic factors. An increase in a mother’s education was found to have a positive influence on BMI. Another section focuses on what adolescents consume at school compared to at home and also examines their parent’s perception of these school meals by developing an …