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Augg2013, Robert Kelly

Robert Kelly Manuscripts

From August 2013 Robert Kelly Archives

Augd2013, Robert Kelly

Robert Kelly Manuscripts

From August 2013 Robert Kelly Archives

Environmental Circadian Disruption Elevates The Il-6 Response To Lipopolysaccharide In Blood, Kandis L. Adams, Oscar Castanon-Cervantes, Jennifer A. Evans, Alec J. Davidson

Biomedical Sciences Faculty Research and Publications

The immune system is regulated by circadian clocks within the brain and immune cells. Environmental circadian disruption (ECD), consisting of a 6-h phase advance of the light:dark cycle once a week for 4 weeks, elevates the inflammatory response to lipopolysaccharide (LPS) both in vivo and in vitro. This indicates that circadian disruption adversely affects immune function; however, it remains unclear how the circadian system regulates this response under ECD conditions. Here, we develop an assay using ex vivo whole-blood LPS challenge to investigate the circadian regulation of immune responses in mice and to determine the effects of ECD on these …

Cross-Species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events In Zebrafish And Human Embryonal Rhabdomyosarcoma, Eleanor Y. Chen, Kimberly P. Dobrinski, Kim H. Brown, Ryan Clagg, Elena Edelman, Myron S. Ignatius, Jin Yun Helen Chen, Jillian Brockmann, G. Petur Nielsen, Sridhar Ramaswamy, Charles Keller, Charles Lee, David M. Langenau

Biology Faculty Publications and Presentations

Human cancer genomes are highly complex, making it challenging to identify specific drivers of cancer growth, progression, and tumor maintenance. To bypass this obstacle, we have applied array comparative genomic hybridization (array CGH) to zebrafish embryonal rhabdomyosaroma (ERMS) and utilized cross-species comparison to rapidly identify genomic copy number aberrations and novel candidate oncogenes in human disease. Zebrafish ERMS contain small, focal regions of low-copy amplification. These same regions were commonly amplified in human disease. For example, 16 of 19 chromosomal gains identified in zebrafish ERMS also exhibited focal, low-copy gains in human disease. Genes found in amplified genomic regions were …

Synthesis Of Ester Derivatives Of Resveratrol As Potential Anti-Cancer Drugs, Parasmani Pageni

Electronic Theses and Dissertations

Resveratrol is a naturally occurring phytoalexin of the stilbene family produced by various plants in response to stress, UV radiation, and fungal attack. It is primarily found in peanuts, berries, grape skin, and red wine. Resveratrol has been found to exhibit anti-cancer, anti-inflammatory, anti-aging, and anti-oxidant properties. Research indicates that diets enriched with resveratrol containing substances result in less incidence of cancer. Unfortunately, the low bioavailability and solubility has been a huge setback for its potential prospects. As a result, efforts have been made to synthesize derivatives of resveratrol with increased solubility and bioavailability. Three triester novel resveratrol derivatives 3, …

Slavery And Manumission In The Pre-Constantine Church, Joseph Francis Super

Liberty Theological Review

This paper looks at the church’s handling of the issue of slavery in the period before Constantine and the official recognition of Christianity. The time period is important because Christians had no political authority to end slavery, assuming they wanted to do so. Thus, the aim of the paper is discover how the Church as an institution alleviated the conditions of the slaves and how slaves were treated in the church and examine the relationship of slave to master in the church. This will be accomplished by examining certain doctrines of the faith church leaders applied to these problems as …

Contemplating Procession: Thomas Aquinas’ Analogy Of The Procession Of The Word In The Immanent Divine Life, Josh Waltman

Liberty Theological Review

Thomas Aquinas’ Trinitarian theology has been criticized as proposing an abstract notion of God that is divorced from salvation history and that is supported by tedious and ultimately incomprehensible explication. By showing the goals and limitations of Thomas’ approach and by analyzing one element of his theology, it will be shown that these criticisms are unfounded. Specifically, this article will attempt to analyze Aquinas’ view of the procession of the Word, or act of “generation,” in the divine immanent life. It can be seen that Aquinas actually provides a metaphysical analogy for contemplating generation that avoids heresy and that absolutely …

Factors And Motivations Behind Volunteering At Domestic Violence Emergency Shelters, Amy Fowler

HIM 1990-2015

Volunteerism is a commonly researched topic however, much scarcer is research into the factors or motivations behind volunteering at domestic violence emergency shelters. Knowing the motivating factors that lead people to dedicate their time to different organizations is important because it gives us an understanding of what can be done in order to get other people involved in pro-social activities that benefit society as a whole. Just as there are different types of individuals who volunteer their time, there are different factors and motivators that compel those individuals to do so. Research to date has identified some common motivators. One …

Fan Fiction, Fandoms, And Literature: Or, Why It’S Time To Pay Attention To Fan Fiction, Christina Yatrakis

College of Liberal Arts & Social Sciences Theses and Dissertations

The internet has revolutionized how we interact with the world around us. We now have access to information, creations, and people on such a scale previously impossible. A direct result of the rise of the internet age is the growing popularity and visibility of fandoms and their creation and dissemination of derivative works, such as fan fiction. While fan fiction in its modern form can easily be traced back to the early days of Star Trek and fan made "zines," it is now perhaps the most visible and well known fan creation. Fan fiction has evolved from the expansions or …

New Narratologies: An Examination Of The Interplay Between Life, Land, And Story, Dana Turner

College of Liberal Arts & Social Sciences Theses and Dissertations

The study of land and geographical place remains to be an important theoretical consideration in the field of Narratology studies. This thesis illustrates how land and geography play a role in the maintenance of traditional culture and narratives in the rural communities of DeKalb and Neshoba counties in Mississippi. The first chapter argues that memory through story can yield significant historical findings in narrative identity. It is here where the discussion on historiography, memory, and narrative introduces a cognitive narratological lens that helps structure the psychological processing of life stories and oral histories. Then, the issues of self and narration …

From Panels To Primetime: Made-For-Tv Movies Adapted From Marvel Comics Properties, Jef Burnham

College of Communication Theses and Dissertations

With Marvel Entertainment commanding worldwide audiences and saturating marketplaces with licensed merchandise through complex, multimedia brand awareness campaigns, understanding popular culture in the present moment demands that we trace the company’s rise from a simple comic book publisher to a powerhouse of the film industry. Yet, virtually nothing has been written in academia about the transitional phenomenon of made-for- TV movies adapted from Marvel Comics properties. These texts, although numbering only thirteen to date, dominated the company’s live action, feature-length output in audiovisual media prior to the success of Blade in 1998. In an effort to identify a suitable framework …

Divergent Mechanisms Of Interaction Of Helicobacter Pylori And Campylobacter Jejuni With Mucus And Mucins, Julie Ann Naughton, Karina Mariño, Brendan Dolan, Colm Reid, Ronan Gough, Mary Gallagher, Michelle Kilcoyne, Jared Gerlachscience,, Lokesh Joshi, Pauline Rudd, Stephen Carrington, Billy Bourke, Marguerite Clyne

Articles

Helicobacter pylori and Campylobacter jejuni colonize the stomach and intestinal mucus, respectively. Using a combination of mucus-secreting cells, purified mucins, and a novel mucin microarray platform, we examined the interactions of these two organisms with mucus and mucins. H. pylori and C. jejuni bound to distinctly different mucins. C. jejuni displayed a striking tropism for chicken gastrointestinal mucins compared to mucins from other animals and preferentially bound mucins from specific avian intestinal sites (in order of descending preference: the large intestine, proximal small intestine, and cecum). H. pylori bound to a number of animal mucins, including porcine stomach mucin, but …

Macromolecular Complexes Of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport In Inflammatory Bowel Disorders, Kavisha Arora

Theses and Dissertations (ETD)

Macromolecular complexes of cystic fibrosis transmembrane conductance regulator (CFTR) comprise of network of proteins that can regulate cAMP-/cGMP-activated CFTR chloride channel function. We report the physical and functional coupling of CFTR with nitric oxide (NO) producing enzyme-inducible nitric oxide synthase (iNOS) at the apical plasma membrane in inflammatory bowel disease (IBD). The complex formation requires the scaffolding protein Na+ /H+ exchanger regulatory factor 2 (NHERF2). We demonstrate that iNOS is overexpressed at or near the apical plasma membrane of gut epithelial cells in IBD and, through the stimulation of the NO-cGMP pathway, generates compartmentalized cGMP underneath the plasma membrane. This …

Metaphors Of Health And Disease In Nazi Film Propaganda, Melanie Wright

School of Law, Humanities and Social Sciences Theses

This study examines how propaganda imagery was used to reveal metaphors of health and disease in Nazi Germany from 1933 to 1945. Specifically, it explores how German medical and political authorities of this period entrenched biological explanations for social ills through medico-political discourses of disease, criminality and deviancy, in their efforts to exterminate particular populations. This propaganda was conversed with the idealised and beautified German Volk who, in turn, were graphically elevated to the realms of a supreme master race. I use a methodology composed of compositional and discourse analysis, and a theoretical framework that develops the work of Erving …

Sandcastles In The Sand: Liminality At The Seashore In Carolyn Wells's Marjorie At Seacote, Olivia Jeanne Bushardt

Master's Theses

The American beach at the turn of the twentieth century became a popular site for middle-class families to escape the urban squalor of the cities and play during the summer months. Although relatively unknown today, Carolyn Wells's 1912 novel Marjorie at Seacote depicts how the beach as a liminal space destabilizes the traditional adult and child roles and creates discomfon and ambivalence over these new roles. I first discuss Carolyn Wells and Marjorie at Seacote in terms of historical context and within the framework of girls' series fiction published at the turn of the century. I then explain how the …

Common Raven Density And Greater Sage-Grouse Nesting Success In Southern Wyoming: Potential Conservation And Management Implications, Jonathan B. Dinkins

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Declines in the distribution and abundance of greater sage-grouse (Centrocercus urophasianus; hereafter "sage-grouse") in western North America over the past century have been severe. The goal of my research was to increase the understanding of factors influencing where sage-grouse hens placed their nests, how common ravens (Corvus corax: hereafter "raven") impacted sage-grouse nest success, and whether high raptor densities negatively impacted hen survival of sage-grouse. I compared raven and raptor densities at sage-grouse nest and brood locations to available habitat. I also assessed how sage-grouse positioned their nests and broods relative to proximity to man-made structures, …

Modeling Habitat Use Of A Fringe Greater Sage-Grouse Population At Multiple Spatial Scales, Anya Cheyenne Burnett

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Greater sage-grouse (Centrocercus urophasianus; hereafter sage-grouse) are a prominent bird species of sagebrush-dominated landscapes across the western United States. Over the past 15 years, sage-grouse have gained international attention due to decreasing population trends despite management efforts. In 2010 the U.S. Fish and Wildlife Service designated this species as warranted for listing under the Endangered Species Act, but the listing was precluded by other species at higher conservation risk. Habitat loss, degradation, and fragmentation have been implicated as primary sources of declines in sage-grouse distribution and abundance. The Bald Hills population in southwestern Utah occupies an area with …

Human-Relevant Levels Of Added Sugar Consumption Increase Female Mortality And Lower Male Fitness In Mice, James Ruff, Amanda Suchy, Sara Hugentobler, Mirtha Sosa, Bradley Schwartz, Linda Morrison, Sin Gieng, Mark Shigenaga, Wayne Potts

Faculty Publications

Consumption of added sugar has increased over recent decades and is correlated with numerous diseases. Rodent models have elucidated mechanisms of toxicity, but only at concentrations beyond typical human exposure. Here we show that comparatively low levels of added sugar consumption have substantial negative effects on mouse survival, competitive ability, and reproduction. Using Organismal Performance Assays—in which mice fed human-relevant concentrations of added sugar (25% kcal from a mixture of fructose and glucose, modeling high fructose corn syrup) and control mice compete in seminatural enclosures for territories, resources and mates—we demonstrate that fructose/glucose-fed females experience a twofold increase in mortality …

Economic And Environmental Impacts Of Harmful Non-Indigenous Species In Southeast Asia, Le Nghiem, Tarek Soliman, Darren Yeo, Hugh Tan, Theodore A. Evans, John D. Mumford, Reuben P. Keller

School of Environmental Sustainability: Faculty Publications and Other Works

Harmful non-indigenous species (NIS) impose great economic and environmental impacts globally, but little is known about their impacts in Southeast Asia. Lack of knowledge of the magnitude of the problem hinders the allocation of appropriate resources for NIS prevention and management. We used benefit-cost analysis embedded in a Monte-Carlo simulation model and analysed economic and environmental impacts of NIS in the region to estimate the total burden of NIS in Southeast Asia. The total annual loss caused by NIS to agriculture, human health and the environment in Southeast Asia is estimated to be US$33.5 billion (5th and 95th percentile US$25.8–39.8 …

Polysaccharide-Based Nanocarriers For Improved Drug Delivery, Nan Zhang

Dissertations - ALL

The field of drug delivery has provided a solution to the limited efficacy and high toxicity of many drugs. Nano-sized drug carriers are popular because their size allows for selective accumulation in the diseased area. Polysaccharides are non-toxic and biodegradable natural polymers that can serve as the basis for these nano-sized carriers. Polysialic acid (PSA) is such a polysaccharide with strong hydrophilicity that may reduce uptake by the reticuloendothelial system and prolong drug circulation. In this study, we developed PSA-based nanocarriers, specifically micelles and nanoparticles, for improved drug delivery with improved efficacy and minimized toxicity. PSA-based micelle systems were developed …

Visitor Comments About Montana: 2012 Nonresident Survey, Norma Nickerson, Ashley Napier, Doris Cooley

Institute for Tourism and Recreation Research Publications

This report provdes an analysis of comments written by nonresident visitors to Montana in 2012. Eight general themes emerged from the comments. Nonresident visitors generally love Montana. Their experiences were positive, they enjoyed the scenery, open space, the friendly people, and they want to return. Full listing of all comments are provided in the appendix.

An Examination Of The Long Term Effects Of Exposure To Prescription Drugs On Infant Growth And Development, Annalisa Maurer

Masters Theses

The effects of prenatal exposure to many prescription medications are well known. However, little is known about the long term side effects early exposure to medications used to treat pain and sedate have on growth and development. This paper explores the long-term effects of postnatal exposure to prescription medication. The potential effects are applied to physical, cognitive, and social-emotional development as well as the overall health of an infant. Additionally, the options of the use of commonly used analgesics and sedatives are compared to other pain management options. Research surrounding long-term effects of early exposure to pain and generalizations/recommendations are …

Jack London: Landscape, Love, And Place, Kristin Yoshiko Ladd

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In Jack London: Landscape, Love, and Place, American Studies theories and methods formed the prime basis for analysis of London's biography, historical context, and literary significance. Particularly, the ideas of agrarianism, the Turner Thesis moment, Western literature, American masculinity, Victorian ideals, and sustainable farm practices in America were used to understand London's motivations for writing and creating his farm, his influence on American literature, and his texts' abilities to open avenues between literature and place-based education. Key concepts that influenced how London's works could be incorporated into and applied to didactic theory included David Sobel's seminal works in place-based education. …

Selected Neuropharmacology Of Resurgence, Adam D. Pyszczynski

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The reemergence of problem behavior (i.e., relapse) is a key concern in most behavioral interventions. Resurgence refers to the reappearance of a previously rewarded behavior when reward for an alternative behavior is also discontinued. It is especially relevant to the reappearance of problem behavior because many behavioral interventions discontinue reward for aberrant behavior while simultaneously rewarding an appropriate response.

Understanding the underlying neuropharmacology of behavioral phenomena such as resurgence is important because it helps elucidate the neural processes at the root of such behavior, and also has implications for pharmacotherapies. Existing information about the neuropharmacology of resurgence is scarce, but …

Preventative Behavioral Parent Training In A Primary Care Context: Initial Evaluation Of A Universal Prevention Program For Disruptive Behavior Disorders, Jessica L. Malmberg

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

One of the biggest challenges parents face is effectively managing their child’s engagement in various disruptive behaviors including noncompliance, tantrums, and aggression. Typically when children begin exhibiting disruptive behaviors, parents will express their concerns to their pediatricians; however, there are significant barriers to parents gaining adequate guidance due to clinic time constraints, insurance reimbursement issues, and the limited training pediatricians receive in addressing these concerns. As such, children are generally referred to outside mental health clinics where additional barriers arise including waitlist delays and mental health stigmatization. The treatment for conduct problems (CP) that has proven most effective is referred …

Characteristics Of 4-H Participants And Their Psychosocial Development, Lauralee Lyons

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Volunteerism is an important component in the 4-H program. It was initially used as a method to help agents reach the many youth interested in participating in 4-H. Community service has since become a required component for every club project. Research shows that volunteering can impact youth in many different ways. Other research shows that 4-H youth are more likely to contribute or do some type of community service.

The present study uses the Modified Extended Version of the Object Measure of Ego Identity Status (EOMEIS), the Cognitive Autonomy and Self-Evaluation (CASE) inventory, and an instrument specifically designed to study …

Conservation Genetics And Population Status Of The Flame Chub, Hemitremia Flammea, Kathlina Frances Alford

Masters Theses and Doctoral Dissertations

The southeastern United States has a rich geologic history that contributed to the evolution of an extremely diverse aquatic fauna throughout the region. The Flame Chub, Hemitremia flammea, is a brightly colored, spring endemic minnow species native to the Cumberland, Tennessee, and Coosa river drainages. In this study, the cytochrome-b gene region was analyzed for 230 individuals from 29 populations across the three drainages. Results from maximum parsimony and Bayesian analyses recovered shallow divergence between the 31 haplotypes. AMOVA analyses indicated that most gene tic variation distributed within and between populations, not between drainages. Based on these results, this species …

Toward A Global Organizational Public Sphere: Non-Governmental Organizing And Democratic Legitimacy In A Postmodern World, Rachel Stohr

Department of Communication Studies: Dissertations, Theses, and Student Research

This dissertation refigures Jürgen Habermas’s public sphere theory for the contemporary world in which organizations are key actors. I develop a concept of the “global organizational public sphere” to explore the role of non-governmental organizations (NGOs) in narrowing the democratic legitimacy gap currently prevailing in the international arena. A case study of the NGO, the Women’s Environment and Development Organization (WEDO), gauges the extent to which WEDO (and, by extension, NGOs) serves as a global intermediary that performs the double task of translating needs from the grassroots to global institutions and adapting international policies to local communities. Three problematics structure …

Assessment Of Competence For Caesarean Section With Global Rating Scale, Rahat Najam Qureshi, Syeda Kauser Ali

Department for Educational Development

Objective: To establish as reliable and valid the nine-point global rating scale for assessing residents\' independent performance of Caesarean Section.

Methods: The validation study was conducted at the Department of Obstetrics and Gynaecology, Aga Khan University Hospital, from April to December 2008, and comprised 15 residents during 40 Caesarean Sections over 9 months. Independently two evaluators rated each procedure and the difficulty of each case.

Results: The observations per faculty ranged from 1-8 (mean 4.07± 2.56). The Year 4 residents were observed the most i.e. 32 (40%), followed by Year 3, 30 (37.5%); Year 2; 14 (17.5%); and Year 1, …

Design Thinkers Can Save The World: How Understanding Their Interests, Goals, And Motivations Can Inform Engineering Educators, Jacqualyn Blizzard

All Dissertations

The need for more engineers equipped with new skill sets is essential for ensuring our national security, climate sustainability, and maintaining our position as a global leader in innovation and as an economic world power. The design challenges engineers face increasingly require a human-centered, creative, practical, and systems-based approach to find the most elegant solutions; i.e. they require design thinkers. According to Tim Brown of IDEO, the characteristics that distinguish design thinkers include: 'empathy--they imagine the world from multiple perspectives, integrative thinking--they can analyze at a detailed and holistic level to develop novel solutions, optimism--they don't back down from challenging …