Digital Commons Network^™

Lithium Ameliorates Open-Field And Elevated Plus Maze Behaviors, And Brain Phospho-Glycogen Synthase Kinase 3-Beta Expression In Fragile X Syndrome Model Mice, Xi Chen, Weiwen Sun, Ying Pan, Quan Yang, Kaiyi Cao, Jin Zhang, Yizhi Zhang, Mincong Chen, Feidi Chen, Yueling Huang, Lijun Dai, Shengqiang Chen

Neurosciences

OBJECTIVE: To investigate whether lithium modifies open-field and elevated plus maze behavior, and brain phospho-glycogen synthase kinase 3 (P-GSK3beta) expression in Fmr1 knockout mice. METHODS: One hundred and eighty FVB mice, including knockout and wild type, with an age of 30 days were used. An open-field and elevated plus maze was utilized to test behavior, while western blot was used to measure the P-GSK3beta expression. Six groups were formed: control (saline), lithium chloride 30, 60, 90, 120, and 200 mg/kg. The experiments were carried out in the Institute of Neuroscience, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China between …

Leukemia Inhibitory Factor Promotes Nestin-Positive Cells, And Increases Gp130 Levels In The Parkinson Disease Mouse Model Of 6-Hydroxydopamine, Ying Liu, Meiyu Peng, Dawei Zang, Benshu Zhang

Neurosciences

OBJECTIVE: To investigate the roles of leukemia inhibitory factor (LIF) in a 6-hydroxydopamine (6-OHDA) mouse model of Parkinson disease (PD), and explore how the LIF improves PD symptoms. METHODS: This study was performed in Tianjin Medical University, Tianjin, China, between April 2008 and January 2010. Seventy-two mice were allocated into a control group (CON), sham operation group (SHA), physiological saline (NS) treatment group (PD), and LIF treatment group (LIF), n=18 for each group. The 6-OHDA was injected into the mice’s left mid-striatum to build a 6-OHDA model of PD. The LIF or NS was slowly released into the CSF through …

Dravet Syndrome, What Is New?, Raidah S. Al-Baradie

Neurosciences

Dravet syndrome (DS) is one of the most severe genetic epilepsies of childhood. Charlotte Dravet described severe myoclonic epilepsy in infancy in 1978. Shortly after the initial report, many cases were published. Most of the cases have the SCN1A mutation. A variant of DS called borderline severe myoclonic epilepsy in infancy has similar clinical and electrographic features without myoclonus. The prevalence of DS is 3-6% of epilepsy cases in infancy, and the incidence is less than one per 40,000 infants. Also, there is a rare mutation in the GABARG2 and SCN1B genes. Usually, affected patients have normal developmental milestones during …

Induced Hypothermia To Treat Neonatal Hypoxic-Ischemic Encephalopathy. Review Of Literature With Meta-Analysis And Development Of National Protocol, Turki M. Alkharfy

Neurosciences

The efficacy of induced hypothermia to treat hypoxic-ischemic encephalopathy (HIE) in term infants has been evaluated in 6 multicenter randomized controlled trials. Meta-analysis of these trials shows that hypothermia in the first 6 hours after moderately severe HIE reduced the risk rate of death or neurological impairment at 18 months of age; risk ratio (RR): 0.81 (95% confidence interval [CI]: 0.71 to 0.93, p=0.002); risk difference -0.11 (95% CI: -0.18 to -0.04), with a number needed to treat of 9 (95% CI: 5-25). It also showed that treatment with hypothermia was associated with an increased rate of intact survival; RR: …

Temporal And Spatial Changes In Oligodendrocytes In Different Brain Regions Following Intrauterine Ischemia In Neonatal Wistar Rats, Hui Wu, Guohua Wang, Dongxuan Wang, Xin Mu, Cong Li

Neurosciences

No abstract provided.

Protective Effect Of Coenzyme Q10 In Paclitaxel-Induced Peripheral Neuropathy In Rats, Nalan Celebi, Hemra Cil, Onur Cil, Ozgur Canbay, Rustu Onur, Ulku Aypar

Neurosciences

OBJECTIVE: To investigate the possible protective effect of coenzyme Q10 (CQ10) on neuropathy in rats. METHODS: Experiments were conducted in the Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey between January and March 2012. Forty rats were divided into 4 groups: group 1 (control), group 2 (paclitaxel), group 3 (control + CQ10), and group 4 (paclitaxel + CQ10). Group 2 and 4 rats received paclitaxel (2 mg/kg, intraperitoneally, on days 0, 2, 4, 6). Group 3 and 4 rats were treated with CQ10 (10 mg/kg, intraperitoneally, on days 0, 1, 2, 3, 4, 5, 6, 7, 8, 9). …

Study On Serum Zinc And Selenium Levels In Epileptic Patients, Heidar N. Farahani, Alireza R. Ashthiani, Mher S. Masihi

Neurosciences

OBJECTIVE: To estimate serum zinc and selenium levels in a group of healthy subjects and correlate these with epileptic patients. METHODS: This case-control study was conducted in the Department of Neurology, Valiasr Hospital, Iran, between November 2011 and May 2012 on 40 patients aged 26.63+/-5.78 years who were diagnosed with generalized and a single epileptic form of epilepsy by a neurologist for the first time. The control group was selected from healthy individuals, and matched to the case group. Serum zinc was measured by the calorimetric method using a Randox kit. Selenium was measured by atomic absorption spectroscopy. RESULTS: The …

The Relationship Between Mean Platelet Volume And Severity Of Acute Ischemic Brain Stroke, Farahnaz Ghahremanfard, Nabiollah Asghari, Raheb Ghorbani, Afshin Samaei, Hadi Ghomi, Mohamadreza Tamadon

Neurosciences

OBJECTIVE: To determine whether an association exists between mean platelet volume (MPV) and severity of acute ischemic stroke. Also, to investigate the power of MPV for discriminating more severe ischemic stroke from mild events. METHODS: We divided 100 patients with first ischemic stroke presenting to the Neurology Department, Fatemieh Hospital, Semnan, Iran between January 2010 and January 2011 into 2 groups based on Rankin score (group 1: score 0-2, and group 2: score 3 or more). Blood samples were taken to measure MPV. Severity of ischemic stroke was assessed by the Modified Rankin scale. RESULTS: The MPV value was higher …

The Shrike: An Original Screenplay, Louis Fisk

All NMU Master's Theses

No abstract provided.

Rum Heart, Cameron Witbeck

All NMU Master's Theses

No abstract provided.

Morphological Variation Among Populations Of Mesalina Watsonana (Stoliczka, 1872) (Sauria: Lacertidae) In Iran, Seyyed Saeed Hosseinian Yousefkhani, Nasrullah Rastegar-Pouyani, Eskandar Rastegar Pouyani

Turkish Journal of Zoology

During extensive fieldwork surveys from August 2009 to September 2011, 60 specimens of Mesalina watsonana were collected from 10 localities representing 3 population groups in Iran. Owing to clear sexual dimorphism, a total of 39 males were selected and examined for various meristic and morphological characters. Statistical analyses (multivariate analyses such as principal component analysis, canonical variate analysis, and cluster analysis) were used to compare morphological variations among specimens from these 3 population groups in Iran. These groups were separated geographically, apparently due to barriers such as Dasht-e-Kavir and Dasht-e-Lut. According to the multivariate analyses, Mesalina watsonana can be divided …

Reproductive Biology Of The Greater Lizardfish, Saurida Tumbil (Bloch, 1795), In Bushehr Coastal Waters Of Iran, Akbar Abaszadeh, Yazdan Keivany, Nasrollah Mahboobi Soofiani, Ali Falahatimarvast

Turkish Journal of Zoology

A total of 691 specimens (114 males, 538 females, and 39 immature specimens) were collected from Bushehr coastal waters of the Persian Gulf from February 2007 to February 2008 to study the reproduction of this species along with its histological gonadal development. Mean absolute and relative fecundity was 263,162 ± 31,046 and 273 ± 27, respectively. The oogonia and oocyte diameter ranged between 6 µm and 875 µm with a mean of 318 µm. The relationship between fecundity and total weight was F = 192.85W + 69,291. Monthly changes in the gonadosomatic index exhibited a higher value in May and …

Devising Law: On The Philosophy Of Legal Emblems, Peter Goodrich

NYLS Law Review

No abstract provided.

Sharia-Compliant Wills: Principles, Recognition, And Enforcement, Omar T. Mohammedi

NYLS Law Review

No abstract provided.

Introduction To Graduate Writing (2nd Edition), Emily Heady

Faculty Publications and Presentations

No abstract provided.

Tennessee Ag Insider, A Guide The The State's Farms, Food, And Forestry, 2013 Edition, Tennessee. Department Of Agriculture.

Tennessee Ag Insider

No abstract provided.

Charter Schools, Vouchers, And The Public Good, Derek W. Black

Faculty Publications

Charter schools and vouchers have thus far been promoted or vilified based on their potential to improve academic achievement for those students enrolled in them. This debate, however, ignores a more important question: whether these educational policies serve the public good. Education as a public good cannot be reduced solely to questions of academic achievement, much less the academic achievement of a subset of students. Theoretically, charter schools and vouchers can serve the public good, but in practice, they have not. This shortcoming, however, is not necessarily due to an inherent flaw in charters or vouchers, but the failure of …

Communicable And Environmental Diseases And Emergency Preparedness 2010-2012 Annual Report, Tennessee. Department Of Health.

Immunization Rates

No abstract provided.

Child Fatalities In Tennessee 2011, Tennessee. Department Of Health.

Child Fatalities in Tennessee Report

No abstract provided.

The Role Of The Nucleosome Remodeling And Histone Deacetylase (Nurd) Complex In Fetal Γ-Globin Expression, Maria Amaya

Theses and Dissertations

An understanding of the human fetal to adult hemoglobin switch offers the potential to ameliorate β-type globin gene disorders such as sickle cell anemia and β-thalassemia through activation of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD play a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD complexes. In the studies presented in Chapter 2, we observed that the absence of MBD2 in a sickle cell mouse model leads to a decrease in the number of sickled cells observed in the peripheral blood, and significantly increases survival in these mice. Although …

Assessment Of The Feasibility Of Co-Administration Of Phenolic Dietary Compounds With Phenylephrine To Increase Its Bioavailability, Zhenxian Zhang

Theses and Dissertations

R-(-)-Phenylephrine (PE) is the most commonly used nonprescription oral nasal decongestant in the United States. It is a selective α1-adrenergic receptor agonist and has many years of safe usage. However, the efficacy of PE is controversial, due to its extensive pre-systemic metabolism, which leads to low and variable oral bioavailability (38 ± 9%, mean ± SD). Sulfation plays a very important role in pre-systemic metabolism of PE. The sulfation of PE occurs at its phenolic group, which is the preferred structural feature of many sulfotransferase (SULT) substrates. Compounds with phenolic groups have similar structures to PE, which may share the …

Effects Of Intravenous Diclofenac On Postoperative Sore Throat In Patients Undergoing Laparoscopic Surgery At Aga Khan University Hospital, Nairobi: A Prospective, Randomized, Double Blind Controlled Trial, Thang'a P., Dorothy Kamya, Vitalis Mung’Ayi

Anaesthesiology, East Africa

Background: Postoperative sore throat is the commonest complication after endotracheal intubation. The efficacy of intravenous non-steroidal anti-inflammatory drugs in alleviating postoperative sore throat has not been investigated.

Objective: To evaluate the effect of intravenous diclofenac sodium on the occurrence and severity of postoperative sore throat.

Methods: 42 in-patients scheduled for laparoscopic surgery were randomized into two equal groups to receive either a single dose of 75mg intravenous diclofenac sodium in addition to standard treatment taken at our hospital for the prevention of postoperative sore throat or to receive standard treatment only. All patients were interviewed postoperatively at 2, 6 and …

What Alex Kozinski And The Investigation Of Earl Bradley Teach About Searching And Seizing Computers And The Dangers Of Inevitable Discovery, Stephen E. Henderson

Faculty Articles

This paper tells two stories. One concerns the investigation of a Delaware physician named Earl B. Bradley that resulted in a conviction and sentence of fourteen consecutive life terms for the sexual abuse of children. The other concerns the computer problems, both judicial and extra-judicial, of Chief Judge Alex Kozinski of the United States Court of Appeals for the Ninth Circuit. Though in a sense unrelated, they share lessons about the practicalities of computers and their search that are worth telling. As courts continue to struggle with how to cabin the searches of computers in order to minimize privacy intrusion …

The Church And The Usurers: Unprofitable Lending For The Modern Economy, Brian Mccall

Faculty Books and Book Chapters

Professor McCall explains in a scholarly yet accessible manner the core principles of the usury doctrine. Tracing its history from Biblical texts, through Aristotelian philosophy and Roman law, to the great scholastic synthesis, Professor McCall separates the unchanging principles from the changes in their applications to new economic realities. With debt, personal, business and government spiraling out of control and massive insolvencies of ancient nations like Greece, contemporary economic theory has offered little in response. Professor McCall contributes the wisdom of the centuries in a concise and readable study.

Endorsements

"Professor McCall places the issues confronting our debt based economy …

To Ban Or Not To Ban Blasphemous Videos, Evelyn Aswad

Faculty Articles

No abstract provided.

Experience As An Experiment, James Walker

Theses and Dissertations

My work is an exploration of new media that demonstrates the influence a community has on visual communication. The community reveals content as objects go unnoticed after they become a permanent part of the landscape and assumptions are made from cultural archetypes. Through exploration, immersion, and reflection, I am able to recognize the invisible and expected, establish a familiarity with a community, and design responses that communicate directly to it.

Transforming Narratives, Lucia Weilein

Theses and Dissertations

Narrative, often considered synonymous with “story,” can be viewed from a structuralist perspective and analyzed independent of any particular content. Breaking narrative into categories of story and discourse, this autonomous structure makes possible a translation of content from one form to another. The various media and form types common in graphic design can serve as both recipient and translator of narratives, converting content into a framework that includes the concept of craftsmanship, aesthetic components and specifications, legibility and composition, and the physical form of the designed object. To examine how this framework functions in practice, I have developed a series …

Student Organization Officers 2013-14, Office Of Registrar

Materials from All Student Organizations

No abstract provided.

Student Organization Advisors 2013-14, Office Of Registrar

Materials from All Student Organizations

No abstract provided.

Technology Corner Visualising Forensic Data: Evidence (Part 1), Damian Schofield, Ken Fowle

Journal of Digital Forensics, Security and Law

Visualisation is becoming increasingly important for understanding information, such as investigative data (for example: computing, medical and crime scene evidence) and analysis (for example: network capability assessment, data file reconstruction and planning scenarios). Investigative data visualisation is used to reconstruct a scene or item and is used to assist the viewer (who may well be a member of the general public with little or no understanding of the subject matter) to understand what is being presented. Analysis visualisations, on the other hand, are usually developed to review data, information and assess competing scenario hypotheses for those who usually have an …